基于临床特征预判抗抑郁药物疗效反应的相关研究进展
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摘要
药物治疗是目前临床治疗抑郁症的主要途径,现阶段常用抗抑郁药的初始治疗有效率仅为50%,临床医生在选择药物时更多地依靠经验,这种"试错"用药模式的疗效不理想,甚至会引发不必要的不良反应。本文阐述了抗抑郁药物疗效预测方面的相关研究进展,帮助临床医生更好地根据患者特征选择适合的药物。临床特征方面主要围绕抑郁症症状特征、自杀史、合并精神病性症状、共病、病程、家族史、年龄、性别及早期治疗反应。对于抗抑郁药物疗效反应的早期预测能够提高治愈率,改善疾病预后,未来应在临床特征相关研究的基础上开展生物标记物研究。
引文
[1]Friedrich MJ.Depression is the leading cause of disability around the world[J].JAMA,2017,317(15):1517.
[2]Furukawa TA,Maruo K,Noma H,et al.Initial severity of major depression and efficacy of new generation antidepressants:individual participant data meta-analysis[J].Acta Psychiatr Scand,2018,137(6):450-458.
[3]王小泉.抑郁症疗效预测的研究进展[J].中华行为医学与脑科学杂志,2013,22(1):93-95.
[4]Angst J,Delini-Stula A,Stabl M,et al.Is a cut‐off score a suitable measure of treatment outcome in short-term trials in depression?A methodological meta-analysis[J].Hum Psychopharmacol,1993,8(5):311-317.
[5]Nierenberg AA.The treatment of severe depression:is there an efficacy gap between SSRI and TCA antidepressant generations?[J].J Clin Psychiatry,1994,55 Suppl A:55-59.
[6]Schatzberg AF.Treatment of severe depression with the selective serotonin reuptake inhibitors[J].Depress Anxiety,1996,4(4):182-189.
[7]Thase ME.Treatment of severe depression[J].J Clin Psychiatry,2000,61 Suppl 1:17-25.
[8]Jules A.Severity of depression and benzodiazepine comedication in relationship to effi cacy of antidepressants in acute trials.A metaanalysis of moclobemide trials[J].Hum Psychopharmacol,1993,8(6):401-407.
[9]Furukawa TA,Weitz ES,Tanaka S,et al.Initial severity of depression and efficacy of cognitive-behavioural therapy:individual-participant data meta-analysis of pill-placebo-controlled trials[J].Br J Psychiatry,2017,210(3):190-196.
[10]Uher R,Dernovsek MZ,Mors O,et al.Melancholic,atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline[J].J Affect Disord,2011,132(1-2):112-120.
[11]Mann JJ,Frances A,Kaplan RD,et al.The relative efficacy of l-deprenyl,a selective monoamine oxidase type B inhibitor,in endogenous and nonendogenous depression[J].J Clin Psychopharmacol,1982,2(1):54-57.
[12]Vlissides DN,Jenner FA.The response of endogenously and reactivity depressed patients to electroconvulsive therapy[J].Br JPsychiatry,1982,141:239-242.
[13]Macqueen G,Santaguida P,Keshavarz H,et al.Systematic review of clinical practice guidelines for failed antidepressant treatment response in major depressive disorder,dysthymia,and subthreshold depression in adults[J].Can J Psychiatry,2017,62(1):11-23.
[14]Canuso CM,Singh JB,Fedgchin M,et al.Efficacy and safety of intranasal esketamine for the rapid reduction of symptoms of depression and suicidality in patients at imminent risk for suicide:results of a double-blind,randomized,placebo-controlled study[J].Am J Psychiatry,2018,175(7):620-630.
[15]Debattista C,Belanoff J,Glass S,et al.Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression[J].Biol Psychiatry,2006,60(12):1343-1349.
[16]Gaudiano BA,Dalrymple KL,Zimmerman M.Prevalence and clinical characteristics of psychotic versus nonpsychotic major depression in a general psychiatric outpatient clinic[J].Depress Anxiety,2009,26(1):54-64.
[17]Nova VV,Fernandes S,Ponte GD,et al.P-538-Diagnostic consistency of major depression with psychotic features over 5years[J].Eur Psychiatry,2012,27:1.
[18]Tonna M,De Panfi lis C,Provini C,et al.The effect of severity and personality on the psychotic presentation of major depression[J].Psychiatry Res,2011,190(1):98-102.
[19]Andreescu C,Lenze EJ,Mulsant BH,et al.High worry severity is associated with poorer acute and maintenance efficacy of antidepressants in late-life depression[J].Depress Anxiety,2009,26(3):266-272.
[20]Seo HJ,Jung YE,Kim TS,et al.Distinctive clinical characteristics and suicidal tendencies of patients with anxious depression[J].JNerv Ment Dis,2011,199(1):42-48.
[21]Eskin M,Ertekin K,Demir H.Efficacy of a problem-solving therapy for depression and suicide potential in adolescents and young adults[J].Cogn Ther Res,2008,32(2):227-245.
[22]Schramm E,Hautzinger M,Zobel I,et al.Comparative effi cacy of the Cognitive Behavioral Analysis System of Psychotherapy versus supportive psychotherapy for early onset chronic depression:design and rationale of a multisite randomized controlled trial[J].BMC Psychiatry,2011,11:134.
[23]Klein DN,Santiago NJ.Dysthymia and chronic depression:introduction,classification,risk factors,and course[J].J Clin Psychol,2003,59(8):807-816.
[24]Driessen E,Cuijpers P,Hollon SD,et al.Does pretreatment severity moderate the effi cacy of psychological treatment of adult outpatient depression?A meta-analysis[J].J Consult Clin Psychol,2010,78(5):668-680.
[25]Agosti V,Ocepek-Welikson K.The efficacy of imipramine and psychotherapy in early-onset chronic depression:a reanalysis of the National Institute of Mental health Treatment of Depression Collaborative Research Program[J].J Affect Disord,1997,43(3):181-186.
[26]翟金国.影响抑郁症疗效的多因素分析[J].中国神经精神疾病杂志,2001,27(2):127-129.
[27]Keedwell PA,Chapman R,Christiansen K,et al.Cingulum white matter in young women at risk of depression:the effect of family history and anhedonia[J].Biol Psychiatry,2012,72(4):296-302.
[28]Saleh K,Carballedo A,Lisiecka D,et al.Impact of family history and depression on amygdala volume[J].Psychiatry Res,2012,203(1):24-30.
[29]Hammen C,Burge D,Burney E,et al.Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder[J].Arch Gen Psychiatry,1990,47(12):1112-1117.
[30]Grillon C,Warner V,Hille J,et al.Families at high and low risk for depression:a three-generation startle study[J].Biol Psychiatry,2005,57(9):953-960.
[31]Serretti A,Chiesa A,Calati R,et al.Family history of major depression and residual symptoms in responder and non-responder depressed patients[J].Compr Psychiatry,2014,55(1):51-55.
[32]Serretti A,Chiesa A,Calati R,et al.Infl uence of family history of major depression,bipolar disorder,and suicide on clinical features in patients with major depression and bipolar disorder[J].Eur Arch Psychiatry Clin Neurosci,2013,263(2):93-103.
[33]Prokofyeva E,Martins SS,Younes N,et al.The role of family history in mental health service utilization for major depression[J].J Affect Disord,2013,151(2):461-466.
[34]Nierenberg AA,Alpert JE,Gaynes BN,et al.Family history of completed suicide and characteristics of major depressive disorder:a STAR*D(sequenced treatment alternatives to relieve depression)study[J].J Affect Disord,2008,108(1-2):129-134.
[35]van Oostrom I,Franke B,Arias VA,et al.Never-depressed females with a family history of depression demonstrate affective bias[J].Psychiatry Res,2013,205(1-2):54-58.
[36]Kozel FA,Nahas Z,Debrux C,et al.How coil-cortex distance relates to age,motor threshold,and antidepressant response to repetitive transcranial magnetic stimulation[J].J Neuropsychiatry Clin Neurosci,2000,12(3):376-384.
[37]Aguirre I,Carretero B,Ibarra O,et al.Age predicts low-frequency transcranial magnetic stimulation effi cacy in major depression[J].JAffect Disord,2011,130(3):466-469.
[38]Mosca D,Zhang M,Prieto R,et al.Efficacy of Desvenlafaxine Compared With Placebo in Major Depressive Disorder Patients by Age Group and Severity of Depression at Baseline[J].J Clin Psychopharmacol,2017,37(2):182-192.
[39]Birkenhager TK,Pluijms EM,Ju MR,et al.Influence of age on the efficacy of electroconvulsive therapy in major depression:a retrospective study[J].J Affect Disord,2010,126(1-2):257-261.
[40]Yang SJ,Kim SY,Stewart R,et al.Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort:the CRESCEND study[J].Psychiatry Res,2011,189(1):82-90.
[41]Schiller CE,O'Hara MW,Rubinow DR,et al.Estradiol modulates anhedonia and behavioral despair in rats and negative affect in a subgroup of women at high risk for postpartum depression[J].Physiol Behav,2013,119:137-144.
[42]Boren T,Xiong Y,Hakam A,et al.MicroRNAs and their target messenger RNAs associated with endometrial carcinogenesis[J].Gynecol Oncol,2008,110(2):206-215.
[43]Wilhelm K,Roy K,Mitchell P,et al.Gender differences in depression risk and coping factors in a clinical sample[J].Acta Psychiatr Scand,2002,106(1):45-53.
[44]Kim JM,Kim SY,Stewart R,et al.Improvement within 2 weeks and later treatment outcomes in patients with depressive disorders:the CRESCEND study[J].J Affect Disord,2011,129(1-3):183-190.
[45]American Psychiatric Association.Practice guideline for the treatment of patients with major depressive disorder(revision)[J].Am J Psychiatry,2000,157(4 Suppl):1-45.
[46]NICE.Depression in adults:recognition and management[EB/OL].[2018-04-01].https://www.nice.org.uk/guidance/cg90.
[47]Szegedi A,Jansen WT,van Willigenburg AP,et al.Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder:a metaanalysis including 6562 patients[J].J Clin Psychiatry,2009,70(3):344-353.
[48]Bennett B,Sharma M,Bennett R,et al.Using social cognitive theory to predict medication compliance behavior in patients with depression in Southern United States in 2016 in a cross-sectional study[J].J Caring Sci,2018,7(1):1-8.
[2]Furukawa TA,Maruo K,Noma H,et al.Initial severity of major depression and efficacy of new generation antidepressants:individual participant data meta-analysis[J].Acta Psychiatr Scand,2018,137(6):450-458.
[3]王小泉.抑郁症疗效预测的研究进展[J].中华行为医学与脑科学杂志,2013,22(1):93-95.
[4]Angst J,Delini-Stula A,Stabl M,et al.Is a cut‐off score a suitable measure of treatment outcome in short-term trials in depression?A methodological meta-analysis[J].Hum Psychopharmacol,1993,8(5):311-317.
[5]Nierenberg AA.The treatment of severe depression:is there an efficacy gap between SSRI and TCA antidepressant generations?[J].J Clin Psychiatry,1994,55 Suppl A:55-59.
[6]Schatzberg AF.Treatment of severe depression with the selective serotonin reuptake inhibitors[J].Depress Anxiety,1996,4(4):182-189.
[7]Thase ME.Treatment of severe depression[J].J Clin Psychiatry,2000,61 Suppl 1:17-25.
[8]Jules A.Severity of depression and benzodiazepine comedication in relationship to effi cacy of antidepressants in acute trials.A metaanalysis of moclobemide trials[J].Hum Psychopharmacol,1993,8(6):401-407.
[9]Furukawa TA,Weitz ES,Tanaka S,et al.Initial severity of depression and efficacy of cognitive-behavioural therapy:individual-participant data meta-analysis of pill-placebo-controlled trials[J].Br J Psychiatry,2017,210(3):190-196.
[10]Uher R,Dernovsek MZ,Mors O,et al.Melancholic,atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline[J].J Affect Disord,2011,132(1-2):112-120.
[11]Mann JJ,Frances A,Kaplan RD,et al.The relative efficacy of l-deprenyl,a selective monoamine oxidase type B inhibitor,in endogenous and nonendogenous depression[J].J Clin Psychopharmacol,1982,2(1):54-57.
[12]Vlissides DN,Jenner FA.The response of endogenously and reactivity depressed patients to electroconvulsive therapy[J].Br JPsychiatry,1982,141:239-242.
[13]Macqueen G,Santaguida P,Keshavarz H,et al.Systematic review of clinical practice guidelines for failed antidepressant treatment response in major depressive disorder,dysthymia,and subthreshold depression in adults[J].Can J Psychiatry,2017,62(1):11-23.
[14]Canuso CM,Singh JB,Fedgchin M,et al.Efficacy and safety of intranasal esketamine for the rapid reduction of symptoms of depression and suicidality in patients at imminent risk for suicide:results of a double-blind,randomized,placebo-controlled study[J].Am J Psychiatry,2018,175(7):620-630.
[15]Debattista C,Belanoff J,Glass S,et al.Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression[J].Biol Psychiatry,2006,60(12):1343-1349.
[16]Gaudiano BA,Dalrymple KL,Zimmerman M.Prevalence and clinical characteristics of psychotic versus nonpsychotic major depression in a general psychiatric outpatient clinic[J].Depress Anxiety,2009,26(1):54-64.
[17]Nova VV,Fernandes S,Ponte GD,et al.P-538-Diagnostic consistency of major depression with psychotic features over 5years[J].Eur Psychiatry,2012,27:1.
[18]Tonna M,De Panfi lis C,Provini C,et al.The effect of severity and personality on the psychotic presentation of major depression[J].Psychiatry Res,2011,190(1):98-102.
[19]Andreescu C,Lenze EJ,Mulsant BH,et al.High worry severity is associated with poorer acute and maintenance efficacy of antidepressants in late-life depression[J].Depress Anxiety,2009,26(3):266-272.
[20]Seo HJ,Jung YE,Kim TS,et al.Distinctive clinical characteristics and suicidal tendencies of patients with anxious depression[J].JNerv Ment Dis,2011,199(1):42-48.
[21]Eskin M,Ertekin K,Demir H.Efficacy of a problem-solving therapy for depression and suicide potential in adolescents and young adults[J].Cogn Ther Res,2008,32(2):227-245.
[22]Schramm E,Hautzinger M,Zobel I,et al.Comparative effi cacy of the Cognitive Behavioral Analysis System of Psychotherapy versus supportive psychotherapy for early onset chronic depression:design and rationale of a multisite randomized controlled trial[J].BMC Psychiatry,2011,11:134.
[23]Klein DN,Santiago NJ.Dysthymia and chronic depression:introduction,classification,risk factors,and course[J].J Clin Psychol,2003,59(8):807-816.
[24]Driessen E,Cuijpers P,Hollon SD,et al.Does pretreatment severity moderate the effi cacy of psychological treatment of adult outpatient depression?A meta-analysis[J].J Consult Clin Psychol,2010,78(5):668-680.
[25]Agosti V,Ocepek-Welikson K.The efficacy of imipramine and psychotherapy in early-onset chronic depression:a reanalysis of the National Institute of Mental health Treatment of Depression Collaborative Research Program[J].J Affect Disord,1997,43(3):181-186.
[26]翟金国.影响抑郁症疗效的多因素分析[J].中国神经精神疾病杂志,2001,27(2):127-129.
[27]Keedwell PA,Chapman R,Christiansen K,et al.Cingulum white matter in young women at risk of depression:the effect of family history and anhedonia[J].Biol Psychiatry,2012,72(4):296-302.
[28]Saleh K,Carballedo A,Lisiecka D,et al.Impact of family history and depression on amygdala volume[J].Psychiatry Res,2012,203(1):24-30.
[29]Hammen C,Burge D,Burney E,et al.Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder[J].Arch Gen Psychiatry,1990,47(12):1112-1117.
[30]Grillon C,Warner V,Hille J,et al.Families at high and low risk for depression:a three-generation startle study[J].Biol Psychiatry,2005,57(9):953-960.
[31]Serretti A,Chiesa A,Calati R,et al.Family history of major depression and residual symptoms in responder and non-responder depressed patients[J].Compr Psychiatry,2014,55(1):51-55.
[32]Serretti A,Chiesa A,Calati R,et al.Infl uence of family history of major depression,bipolar disorder,and suicide on clinical features in patients with major depression and bipolar disorder[J].Eur Arch Psychiatry Clin Neurosci,2013,263(2):93-103.
[33]Prokofyeva E,Martins SS,Younes N,et al.The role of family history in mental health service utilization for major depression[J].J Affect Disord,2013,151(2):461-466.
[34]Nierenberg AA,Alpert JE,Gaynes BN,et al.Family history of completed suicide and characteristics of major depressive disorder:a STAR*D(sequenced treatment alternatives to relieve depression)study[J].J Affect Disord,2008,108(1-2):129-134.
[35]van Oostrom I,Franke B,Arias VA,et al.Never-depressed females with a family history of depression demonstrate affective bias[J].Psychiatry Res,2013,205(1-2):54-58.
[36]Kozel FA,Nahas Z,Debrux C,et al.How coil-cortex distance relates to age,motor threshold,and antidepressant response to repetitive transcranial magnetic stimulation[J].J Neuropsychiatry Clin Neurosci,2000,12(3):376-384.
[37]Aguirre I,Carretero B,Ibarra O,et al.Age predicts low-frequency transcranial magnetic stimulation effi cacy in major depression[J].JAffect Disord,2011,130(3):466-469.
[38]Mosca D,Zhang M,Prieto R,et al.Efficacy of Desvenlafaxine Compared With Placebo in Major Depressive Disorder Patients by Age Group and Severity of Depression at Baseline[J].J Clin Psychopharmacol,2017,37(2):182-192.
[39]Birkenhager TK,Pluijms EM,Ju MR,et al.Influence of age on the efficacy of electroconvulsive therapy in major depression:a retrospective study[J].J Affect Disord,2010,126(1-2):257-261.
[40]Yang SJ,Kim SY,Stewart R,et al.Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort:the CRESCEND study[J].Psychiatry Res,2011,189(1):82-90.
[41]Schiller CE,O'Hara MW,Rubinow DR,et al.Estradiol modulates anhedonia and behavioral despair in rats and negative affect in a subgroup of women at high risk for postpartum depression[J].Physiol Behav,2013,119:137-144.
[42]Boren T,Xiong Y,Hakam A,et al.MicroRNAs and their target messenger RNAs associated with endometrial carcinogenesis[J].Gynecol Oncol,2008,110(2):206-215.
[43]Wilhelm K,Roy K,Mitchell P,et al.Gender differences in depression risk and coping factors in a clinical sample[J].Acta Psychiatr Scand,2002,106(1):45-53.
[44]Kim JM,Kim SY,Stewart R,et al.Improvement within 2 weeks and later treatment outcomes in patients with depressive disorders:the CRESCEND study[J].J Affect Disord,2011,129(1-3):183-190.
[45]American Psychiatric Association.Practice guideline for the treatment of patients with major depressive disorder(revision)[J].Am J Psychiatry,2000,157(4 Suppl):1-45.
[46]NICE.Depression in adults:recognition and management[EB/OL].[2018-04-01].https://www.nice.org.uk/guidance/cg90.
[47]Szegedi A,Jansen WT,van Willigenburg AP,et al.Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder:a metaanalysis including 6562 patients[J].J Clin Psychiatry,2009,70(3):344-353.
[48]Bennett B,Sharma M,Bennett R,et al.Using social cognitive theory to predict medication compliance behavior in patients with depression in Southern United States in 2016 in a cross-sectional study[J].J Caring Sci,2018,7(1):1-8.