实时剪切波弹性成像检测肾脏弹性模量与原发性肾小球肾炎病理相关性研究
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摘要
目的探究实时剪切波弹性成像检测肾脏弹性模量与原发性肾小球肾炎病理的相关性。方法选择200例原发性肾小球肾炎患者作为观察组,同时选择50例健康体检者为对照组。取观察组肾活体组织进行病理检查,使用实时剪切波弹性成像技术检测观察组和对照组的肾脏弹性模量。结果观察组的杨氏模量显著性的高于对照组(P<0.05);随着观察组肾小球硬化程度和肾间质纤维化程度的增加,杨氏模量显著性增加(P<0.05);杨氏模量与肾小球硬化和肾间质纤维化程度呈正相关(P<0.05)。结论实时剪切波弹性成像检测肾脏弹性模量与原发性肾小球肾炎的病理有相关性,该检测技术可以应用于原发性肾小球肾炎的检查。
Objective To explore the correlation between kidney modulusofelasticity examined by real-time shear wave elastography and pathology of primary lomerulonephritis. Methods 200 cases of primary lomerulonephritis were taken as research group,while 50 cases of health people were as control group. We got the tissue sample of kidney in research group to do examination of pathology and got the kidney modulusofelasticity of both research group and control group by real-time shear wave elastography. Results The modulusofelasticity of research was significantly more highly than the modulusofelasticity of control group( P< 0. 05); With the increase of the degree of glomerulosclerosis and degree of renal interstitial fibrosis in the study group,modulusofelasticity increased significantly( P < 0. 05). There was positive correlation between kidney modulusofelasticity and glomerulosclerosis and renal interstitial fibrosis( P < 0. 05). Conclusion Kidney modulusofelasticity examined by real-time shear wave elastography and pathology of primary lomerulonephritis have positive coreelation. Real-time shear wave elastography can be used to examine primary lomerulonephritis.
Objective To explore the correlation between kidney modulusofelasticity examined by real-time shear wave elastography and pathology of primary lomerulonephritis. Methods 200 cases of primary lomerulonephritis were taken as research group,while 50 cases of health people were as control group. We got the tissue sample of kidney in research group to do examination of pathology and got the kidney modulusofelasticity of both research group and control group by real-time shear wave elastography. Results The modulusofelasticity of research was significantly more highly than the modulusofelasticity of control group( P< 0. 05); With the increase of the degree of glomerulosclerosis and degree of renal interstitial fibrosis in the study group,modulusofelasticity increased significantly( P < 0. 05). There was positive correlation between kidney modulusofelasticity and glomerulosclerosis and renal interstitial fibrosis( P < 0. 05). Conclusion Kidney modulusofelasticity examined by real-time shear wave elastography and pathology of primary lomerulonephritis have positive coreelation. Real-time shear wave elastography can be used to examine primary lomerulonephritis.
引文
[1]刘武岩,孙建新,齐卡,等.超声心动图评价肾移植术前不同血液透析时间对尿毒症患者心脏结构和功能的影响[J].中华医学超声杂志(电子版),2013,10(4):313-317.
[2]叶增纯,黎燕,张俊,等.原发性肾小球肾炎患者高同型半胱氨酸血症的发生率及与靶器官损害之间的关系[J].中山大学学报(医学科学版),2016,37(6):869-874.
[3]孔丽丽,贾冶,崔英春,等.2型糖尿病合并原发性肾小球肾炎8例临床病理分析[J].中国实验诊断学,2011,15(7):1192-1194.
[4]林建松,郑智勇,武一曼.IgA肾病发病机制研究进展[J].医学综述,2009,16(23):3608-3610.
[5]杨煜,王学梅,姜镔,等.实时剪切波弹性成像对慢性右心功能不全患者肝脏弹性评价的临床研究[J].中国超声医学杂志,2015,31(10):923-926.
[6]黄浪,朱才义.实时剪切波弹性成像的临床应用进展[J].临床超声医学杂志,2013,26(7):483-485.
[7]潘艳子,陈新政,马宝梅.黄芪对原发性肾小球肾炎患者血清白细胞介素-17和肿瘤坏死因子-α水平的影响[J].新乡医学院学报,2015,32(12):1098-1100.
[8]贾晓媛,王伟铭.IgA肾病的治疗进展[J].上海交通大学学报(医学版),2012,55(3):361-365.
[9]刘娟.超声图像定量诊断肾小球肾炎的临床分析[J].当代医学,2012,19(24):74-75.
[10]李龙海,王建,李庆士,等.经皮肾穿刺活检病理检查700例分析[J].蚌埠医学院学报,2013,38(4):443-445.
[11]刘保娴,梁瑾瑜,谢晓燕,等.剪切波弹性成像与实时组织弹性成像技术在甲状腺结节良恶性鉴别诊断中的应用价值[J].中华医学超声杂志(电子版),2014,11(11):925-931.
[12]徐建红,刘智惠,靳霞,等.剪切波定量超声弹性成像技术在慢性肾病中应用的初步研究[J].中华超声杂志(电子版),2012,9(5):405-407.
[13]Derieppe M,Delmas Y,Gennisson JL,et al.Detection of intrarenal microstructural changes with supersonic shear wave elastography in rats[J].Eur Radiol,2012,22(1):243-250.
[14]Arndt R,Schmidt S,Loddenkemper C,et al.Noninvasive evaluation of renal allogrft fibrosin by transient elastography-apilot study[J].Transpl Int,2010,23(9):871-877.
[2]叶增纯,黎燕,张俊,等.原发性肾小球肾炎患者高同型半胱氨酸血症的发生率及与靶器官损害之间的关系[J].中山大学学报(医学科学版),2016,37(6):869-874.
[3]孔丽丽,贾冶,崔英春,等.2型糖尿病合并原发性肾小球肾炎8例临床病理分析[J].中国实验诊断学,2011,15(7):1192-1194.
[4]林建松,郑智勇,武一曼.IgA肾病发病机制研究进展[J].医学综述,2009,16(23):3608-3610.
[5]杨煜,王学梅,姜镔,等.实时剪切波弹性成像对慢性右心功能不全患者肝脏弹性评价的临床研究[J].中国超声医学杂志,2015,31(10):923-926.
[6]黄浪,朱才义.实时剪切波弹性成像的临床应用进展[J].临床超声医学杂志,2013,26(7):483-485.
[7]潘艳子,陈新政,马宝梅.黄芪对原发性肾小球肾炎患者血清白细胞介素-17和肿瘤坏死因子-α水平的影响[J].新乡医学院学报,2015,32(12):1098-1100.
[8]贾晓媛,王伟铭.IgA肾病的治疗进展[J].上海交通大学学报(医学版),2012,55(3):361-365.
[9]刘娟.超声图像定量诊断肾小球肾炎的临床分析[J].当代医学,2012,19(24):74-75.
[10]李龙海,王建,李庆士,等.经皮肾穿刺活检病理检查700例分析[J].蚌埠医学院学报,2013,38(4):443-445.
[11]刘保娴,梁瑾瑜,谢晓燕,等.剪切波弹性成像与实时组织弹性成像技术在甲状腺结节良恶性鉴别诊断中的应用价值[J].中华医学超声杂志(电子版),2014,11(11):925-931.
[12]徐建红,刘智惠,靳霞,等.剪切波定量超声弹性成像技术在慢性肾病中应用的初步研究[J].中华超声杂志(电子版),2012,9(5):405-407.
[13]Derieppe M,Delmas Y,Gennisson JL,et al.Detection of intrarenal microstructural changes with supersonic shear wave elastography in rats[J].Eur Radiol,2012,22(1):243-250.
[14]Arndt R,Schmidt S,Loddenkemper C,et al.Noninvasive evaluation of renal allogrft fibrosin by transient elastography-apilot study[J].Transpl Int,2010,23(9):871-877.