多模态功能MRI对血管性认知障碍的研究进展
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摘要
血管性认知障碍(VCI)目前已成为继阿尔茨海默病之后的全球第二大认知障碍类型。利用功能MRI对VCI病人的脑形态和功能进行评价,有利于VCI的早期诊断、治疗和预后评估,同时也对揭示VCI病程演变中病理特征的改变、神经功能预测、行为改变等具有重要意义。综述多模态功能MRI对VCI的研究现状,阐明该技术对探究脑形态、功能与血管性认知改变间关系的作用,为寻求VCI早期诊断的影像诊断标准提供思路。
Vascular cognitive impairment(VCI) has now become the second largest category of cognitive impairment after Alzheimer's disease in the world. The functional MRI can be used to evaluate the brain morphology and functions of VCI patients, and can facilitate early diagnosis, treatment and prognosis evaluation in VCI patients. Moreover, it has an important implication for revealing the change of pathological features, prediction of neural functions and behavioral change during the course of VCI. In this paper, we reviewed the current status of researches on the application of functional MRI in VCI, explained the role of such technology in exploring the correlations between brain morphology, functions and vascular cognitive changes, and provided an idea to develop the imaging standard for early diagnosis of VCI.
Vascular cognitive impairment(VCI) has now become the second largest category of cognitive impairment after Alzheimer's disease in the world. The functional MRI can be used to evaluate the brain morphology and functions of VCI patients, and can facilitate early diagnosis, treatment and prognosis evaluation in VCI patients. Moreover, it has an important implication for revealing the change of pathological features, prediction of neural functions and behavioral change during the course of VCI. In this paper, we reviewed the current status of researches on the application of functional MRI in VCI, explained the role of such technology in exploring the correlations between brain morphology, functions and vascular cognitive changes, and provided an idea to develop the imaging standard for early diagnosis of VCI.
引文
[1]Smith E E.Cl inical presentations and epidemiology of vascular dementia[J].Clin Sci(Lond),2017,131:1059-1068.
[2]Rockwood K.Vascular cognitive impairment and vascular dementia[J].J Neuro Sci,2002,23:203-204.
[3]Jia J,Zhou A,Wei C,et al.The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese[J].Alzheimers Dement,2014,10:439-447.
[4]Heiss WD,Rosenberg GA,Thiel A,et al.Neuroimaging in vascular cognitive impairment:a state-of-the-art review[J].BMC Med,2016,14:174-181.
[5]Saggu R,Schumacher T,Gerich F,et al.Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia[J].Acta Neuropathol Commun,2016,4:76-86.
[6]Kim YJ,Kwon HK,Lee JM,et al.White matter microstructural changes in pure Alzheimer’s disease and subcortical vascular dementia[J].Eur J Neurol,2015,22:709-716.
[7]郭会映,孙芳,张宗军,等.皮质下缺血性血管性认知损害扩散张量成像研究[J].中国现代神经疾病杂志,2014,14:309-315.
[8]支楠,柴文,卢东,等.皮质下血管性认知障碍患者弥散张量成像和脑血流量的研究[J].中国卒中杂志,2017,12:105-111.
[9]López-Gil X,Amat-Roldan I,Tudela R,et al.DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests[J].Front Aging Neurosci,2014,6:167-180.
[10]Liu Q,Zhu Z,Teipel SJ,et al.White matter damage in the cholinergic system contributes to cognitive impairment in subcortical vascular cognitive impairment,no dementia[J].Front Aging Neurosci,2017,9:47-56.
[11]芮文婷,姚振威.多发性硬化的MRI研究进展[J].国际医学放射学杂志,2018,41:27-31.
[12]Zhu X,Cao L,Hu X,et al.Brain metabolism assessed via proton magnetic resonance spectroscopy in patients with amnestic or vascular mild cognitive impairment[J].Clin Neurol Neurosurg,2015,130:80-85.
[13]刘娟,王润榕,李文,等.无痴呆型血管性认知障碍患者多体素质子磁共振波谱的诊断价值[J].中华神经科杂志,2010,43:607-611.
[14]陆强彬,张慧萍,朱祖福,等.血管性认知功能障碍磁共振波谱成像研究[J].蚌埠医学院学报,2016,41:1673-1675.
[15]Amadoro G,Corsetti V,Sancesario GM,et al.Cerebrospinal fluid levels of a 20-22 kDa NH2 fragment of human tau provide a novel neuronal injury biomarker in Alzheimer’s disease and other dementias[J].J Alzheimers Dis,2014,42:211-226.
[16]Pilatus U,Lais C,Rochmont AM,et al.Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy[J].Psychiatry Res,2009,173:1-7.
[17]Chen SQ,Cai Q,Shen YY,et al.Hydrogen proton magnetic resonance spectroscopy in multidomain amnestic mild cognitive impairment and vascular cognitive impairment without dementia[J].Am JAlzheimers Dis Other Demen,2016,31:422-429.
[18]Chen J,Shu H,Wang Z,et al.Convergent and divergent intranetwork and internetwork connectivity patterns in patients with remitted late-life depression and amnestic mild cognitive impairment[J].Cortex,2016,83:194-211.
[19]Leuthardt EC,Allen M,Kamran M,et al.Resting-state blood oxygen level-dependent functional MRI:a paradigm shift in preoperative brain mapping[J].Stereotact Funct Neurosurg,2015,93:427-439.
[20]Mormina E,Petracca M,Bommarito,G,et al.Cerebellum and neurodegenerative diseases:beyond conventional magnetic resonance imaging[J].World J Radiol,2017,9:371-388.
[21]林海龙,薛蕴菁,康正武,等.静息态fMRI在无痴呆型血管性认知障碍基线脑活动变化中的初步研究[J].临床放射学杂志,2013,32:1070-1074.
[22]陈雪,丁伟娜,孙雅文,等.血管性认知功能障碍分数低频振幅的fMRI研究[J].实用放射学杂志,2015,31:177-181.
[23]Lei Y,Li Y,Ni W,et al.Spontaneous brain activity in adult patients with moyamoya disease:a resting-state fMRI study[J].Brain Res,2014,1546:27-33.
[24]Halefoglu AM,Yousem DM.Susceptibility weighted imaging:clinical applications and future directions[J].World J Radiol,2018,10:30-45.
[25]Ii Y,Maeda M,Kida H,et al.In vivo detection of cortical microinfarcts on ultrahigh-field MRI[J].J Neuroimaging,2013,23:28-32.
[26]Liu C,Li C,Yang J,et al.Characterizing brain iron deposition in subcortical ischemic vascular dementia using susceptibility-weighted imaging:an in vivo MR study[J].Behav Brain Res,2015,288:33-38.
[27]Sun Y,Cao W,Ding W,et al.Cerebral blood flow alterations as assessed by 3D ASL in cognitive impairment in patients with subcortical vascular cognitive impairment:a marker for disease severity[J].Front Aging Neurosci,2016,8:211-220.
[28]Malojcic B,Giannakopoulos P,Sorond FA,et al.Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer’s disease[J].Medicine,2017,15:27-43.
[29]Steel RM,Bastin ME,Mcconnell S,et al.Diffusion tensor imaging(DTI)and proton magnetic resonance spectroscopy(1H MRS)in schizophrenic subjects and normal controls[J].Psychiatry Res,2001,106:161-170.
[2]Rockwood K.Vascular cognitive impairment and vascular dementia[J].J Neuro Sci,2002,23:203-204.
[3]Jia J,Zhou A,Wei C,et al.The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese[J].Alzheimers Dement,2014,10:439-447.
[4]Heiss WD,Rosenberg GA,Thiel A,et al.Neuroimaging in vascular cognitive impairment:a state-of-the-art review[J].BMC Med,2016,14:174-181.
[5]Saggu R,Schumacher T,Gerich F,et al.Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia[J].Acta Neuropathol Commun,2016,4:76-86.
[6]Kim YJ,Kwon HK,Lee JM,et al.White matter microstructural changes in pure Alzheimer’s disease and subcortical vascular dementia[J].Eur J Neurol,2015,22:709-716.
[7]郭会映,孙芳,张宗军,等.皮质下缺血性血管性认知损害扩散张量成像研究[J].中国现代神经疾病杂志,2014,14:309-315.
[8]支楠,柴文,卢东,等.皮质下血管性认知障碍患者弥散张量成像和脑血流量的研究[J].中国卒中杂志,2017,12:105-111.
[9]López-Gil X,Amat-Roldan I,Tudela R,et al.DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests[J].Front Aging Neurosci,2014,6:167-180.
[10]Liu Q,Zhu Z,Teipel SJ,et al.White matter damage in the cholinergic system contributes to cognitive impairment in subcortical vascular cognitive impairment,no dementia[J].Front Aging Neurosci,2017,9:47-56.
[11]芮文婷,姚振威.多发性硬化的MRI研究进展[J].国际医学放射学杂志,2018,41:27-31.
[12]Zhu X,Cao L,Hu X,et al.Brain metabolism assessed via proton magnetic resonance spectroscopy in patients with amnestic or vascular mild cognitive impairment[J].Clin Neurol Neurosurg,2015,130:80-85.
[13]刘娟,王润榕,李文,等.无痴呆型血管性认知障碍患者多体素质子磁共振波谱的诊断价值[J].中华神经科杂志,2010,43:607-611.
[14]陆强彬,张慧萍,朱祖福,等.血管性认知功能障碍磁共振波谱成像研究[J].蚌埠医学院学报,2016,41:1673-1675.
[15]Amadoro G,Corsetti V,Sancesario GM,et al.Cerebrospinal fluid levels of a 20-22 kDa NH2 fragment of human tau provide a novel neuronal injury biomarker in Alzheimer’s disease and other dementias[J].J Alzheimers Dis,2014,42:211-226.
[16]Pilatus U,Lais C,Rochmont AM,et al.Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy[J].Psychiatry Res,2009,173:1-7.
[17]Chen SQ,Cai Q,Shen YY,et al.Hydrogen proton magnetic resonance spectroscopy in multidomain amnestic mild cognitive impairment and vascular cognitive impairment without dementia[J].Am JAlzheimers Dis Other Demen,2016,31:422-429.
[18]Chen J,Shu H,Wang Z,et al.Convergent and divergent intranetwork and internetwork connectivity patterns in patients with remitted late-life depression and amnestic mild cognitive impairment[J].Cortex,2016,83:194-211.
[19]Leuthardt EC,Allen M,Kamran M,et al.Resting-state blood oxygen level-dependent functional MRI:a paradigm shift in preoperative brain mapping[J].Stereotact Funct Neurosurg,2015,93:427-439.
[20]Mormina E,Petracca M,Bommarito,G,et al.Cerebellum and neurodegenerative diseases:beyond conventional magnetic resonance imaging[J].World J Radiol,2017,9:371-388.
[21]林海龙,薛蕴菁,康正武,等.静息态fMRI在无痴呆型血管性认知障碍基线脑活动变化中的初步研究[J].临床放射学杂志,2013,32:1070-1074.
[22]陈雪,丁伟娜,孙雅文,等.血管性认知功能障碍分数低频振幅的fMRI研究[J].实用放射学杂志,2015,31:177-181.
[23]Lei Y,Li Y,Ni W,et al.Spontaneous brain activity in adult patients with moyamoya disease:a resting-state fMRI study[J].Brain Res,2014,1546:27-33.
[24]Halefoglu AM,Yousem DM.Susceptibility weighted imaging:clinical applications and future directions[J].World J Radiol,2018,10:30-45.
[25]Ii Y,Maeda M,Kida H,et al.In vivo detection of cortical microinfarcts on ultrahigh-field MRI[J].J Neuroimaging,2013,23:28-32.
[26]Liu C,Li C,Yang J,et al.Characterizing brain iron deposition in subcortical ischemic vascular dementia using susceptibility-weighted imaging:an in vivo MR study[J].Behav Brain Res,2015,288:33-38.
[27]Sun Y,Cao W,Ding W,et al.Cerebral blood flow alterations as assessed by 3D ASL in cognitive impairment in patients with subcortical vascular cognitive impairment:a marker for disease severity[J].Front Aging Neurosci,2016,8:211-220.
[28]Malojcic B,Giannakopoulos P,Sorond FA,et al.Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer’s disease[J].Medicine,2017,15:27-43.
[29]Steel RM,Bastin ME,Mcconnell S,et al.Diffusion tensor imaging(DTI)and proton magnetic resonance spectroscopy(1H MRS)in schizophrenic subjects and normal controls[J].Psychiatry Res,2001,106:161-170.