通痹胶囊联合常规综合疗法治疗早期类风湿关节炎42例临床观察
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摘要
目的:观察通痹胶囊联合常规综合疗法治疗早期类风湿关节炎的临床疗效。方法:将84例早期类风湿关节炎患者随机分为治疗组和对照组,每组42例。对照组给予常规综合疗法(药物治疗+理疗+健康教育及心理护理等)治疗,治疗组在对照组治疗基础上加用通痹胶囊和抗肿瘤坏死因子-α。2组均以3个月为1个疗程。观察2组治疗前后关节肿胀指数、关节疼痛指数及红细胞沉降率(ESR)、C-反应蛋白(CRP)水平。结果:治疗后,2组关节肿胀指数、关节疼痛指数、ESR、CRP较治疗前均有改善(P <0.05);且治疗组优于对照组(P <0.05)。结论:通痹胶囊联合常规综合疗法治疗早期类风湿关节炎可提高疗效,利于疾病恢复,减轻患者痛苦,提高生活质量。
Objective:To observe the clinical effect of Tongbi Jiaonang(通痹胶囊)combined with routine comprehensive therapy for early rheumatoid arthritis.Methods:Eighty-four patients with early rheumatoid arthritis were randomly divided into a treatment group and a control group,42 cases in each group.The control group was given routine treatment(i.e.drug,physiotherapy,health education and psychological nursing),while the treatment group was given Tongbi Jiaonang and anti-TNF-α based on the treatment for the control group.The course of treatment was three months for both groups.Joint swelling index,joint pain index,erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)were observed before and after treatment in both groups.Results:After treatment,joint swelling index,joint pain index,ESR and CRP in both groups were improved compared with those before treatment(P < 0.05),and the treatment group was better than the control group(P < 0.05).Conclusion:Modified Tongbi Jiaonang combined with routine comprehensive therapy can improve the curative effect of early rheumatoid arthritis,help the recovery of disease,alleviate the pain of patients,and improve the quality of their lives.
Objective:To observe the clinical effect of Tongbi Jiaonang(通痹胶囊)combined with routine comprehensive therapy for early rheumatoid arthritis.Methods:Eighty-four patients with early rheumatoid arthritis were randomly divided into a treatment group and a control group,42 cases in each group.The control group was given routine treatment(i.e.drug,physiotherapy,health education and psychological nursing),while the treatment group was given Tongbi Jiaonang and anti-TNF-α based on the treatment for the control group.The course of treatment was three months for both groups.Joint swelling index,joint pain index,erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)were observed before and after treatment in both groups.Results:After treatment,joint swelling index,joint pain index,ESR and CRP in both groups were improved compared with those before treatment(P < 0.05),and the treatment group was better than the control group(P < 0.05).Conclusion:Modified Tongbi Jiaonang combined with routine comprehensive therapy can improve the curative effect of early rheumatoid arthritis,help the recovery of disease,alleviate the pain of patients,and improve the quality of their lives.
引文
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[3]张协君,朱开昕,赵明惠,等.不同寄主来源的桑寄生药材槲皮苷与槲皮素含量分析[J].时珍国医国药,2011,22(7):1604-1606.
[4]李永平,李向阳,王树林,等.“秦艽止痛”方抗炎镇痛作用的实验研究[J].时珍国医国药,2011,22(4):867.
[5]廖森泰,何雪梅,邹宇晓,等.广东桑枝条黄酮含测定及抗氧化活性研究[J].北方蚕业,2005,26(106):37-38.
[6]唐艳丽,谢映梅,王少慧,等.中药组方羌活、独活、防风及木瓜联合甲氨蝶呤对佐剂性关节炎新西兰白兔TNF-α、IL-1β、VEGF分子及mRNA的影响[J].免疫学杂志,2014,31(3):235-239.
[7]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2010:36,170,179.
[8]陆志夫,吴清琳,刘永利.蠲痹汤加减结合中药熏洗治疗髌骨软化症57例疗效观察[J].中医药导报,2014,20(8):68-70.
[9]王冬梅,王珍,黄林芳.栽培与野生羌活中4种化合物含量及抗炎作用比较[J].中国药房,2014,25(3):199-202.
[10]高咏莉.生药防风的化学成分与药理作用研究进展[J].山西医科大学学报,2004,35(2):216-218.
[11]柳永青.当归的化学成分与生物活性[J].航空航天医药,2009,20(11):127-128.
[12]李炜,刘培,段金廒.香附四物汤对气滞血瘀证雌性大鼠神经-内分泌-免疫网络的调控与影响[J].中国实验方剂学杂志,2014,20(2):99-104.
[13]贾天柱.中药炮制学[M].上海:上海科学技术出版社,2008:175-176.
[14]秦建鲜,黄锁义.鸡血藤药理作用的研究进展[J].时珍国医国药,2014,24(1):180-183.
[15]杨芳,岳正刚,王欣,等.杜仲叶化学成分的研究[J].中国中药杂志,2014,67(8):1445-1449.
[16]贾献慧,王晓,张永清.忍冬藤酚酸类化学成分分离[J].中国实验方剂学杂志,2015,21(5):67-71.