健脾养血浓煎剂防治消化道肿瘤患者化疗后骨髓抑制疗效观察
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摘要
目的:观察健脾养血浓煎剂防治消化道肿瘤患者化疗后骨髓抑制的疗效。方法:将符合标准的43例消化道肿瘤患者使用随机方法分为2组,同时予常规3周方案化疗2周期。观察组从化疗第1天开始予中药健脾养血浓煎剂口服,50ml/次,2次/d。对照组单纯化疗。观察2组化疗2周期后血常规(包括白细胞、中性粒细胞、血红蛋白、血小板)的变化;化疗前后中医症状积分、KPS评分的变化;记录粒细胞集落刺激因子、白介素-11使用情况。结果:(1)观察组在外周血常规、KPS评分、中医症状积分明显优于对照组(P<0.05);(2)观察组化疗后粒细胞集落刺激因子、白介素-11使用明显少于对照组。结论:中药健脾养血浓煎剂能够有效防治肿瘤化疗后骨髓抑制,减轻化疗毒副反应。
Objective: To observe the effect of Jianpi Yangxue decoction in preventing and treating myelosuppression after chemotherapy in patients with gastrointestinal cancer. Methods: Forty-three patients with gastrointestinal cancer who met the criteria were randomly divided into two groups and treated with conventional 3-week chemotherapy for 2 cycles.Observation group from the first day of chemotherapy to Chinese medicine spleen nourishing concentrated decoction orally, 50 ml/time, 2 times/d. The control group was given chemotherapy alone. The changes of blood routine(including leukocyte, neutrophil, hemoglobin, platelet) after 2 cycles of chemotherapy were observed. TCM symptom scores before and after chemotherapy, KPS score changes were compared. Granulocyte colony stimulating factor, interleukin-11 usage is compared. Results: The observation group in the peripheral blood routine, KPS score, TCM symptom score was significantly better than the control group(P<0.05). Granulocyte colony-stimulating factor and interleukin-11 in the observation group were significantly less than those in the control group. Conclusion: Jianpi Yangxue decoction can effectively prevent and cure myelosuppression after chemotherapy and relieve the side effects of chemotherapy.
Objective: To observe the effect of Jianpi Yangxue decoction in preventing and treating myelosuppression after chemotherapy in patients with gastrointestinal cancer. Methods: Forty-three patients with gastrointestinal cancer who met the criteria were randomly divided into two groups and treated with conventional 3-week chemotherapy for 2 cycles.Observation group from the first day of chemotherapy to Chinese medicine spleen nourishing concentrated decoction orally, 50 ml/time, 2 times/d. The control group was given chemotherapy alone. The changes of blood routine(including leukocyte, neutrophil, hemoglobin, platelet) after 2 cycles of chemotherapy were observed. TCM symptom scores before and after chemotherapy, KPS score changes were compared. Granulocyte colony stimulating factor, interleukin-11 usage is compared. Results: The observation group in the peripheral blood routine, KPS score, TCM symptom score was significantly better than the control group(P<0.05). Granulocyte colony-stimulating factor and interleukin-11 in the observation group were significantly less than those in the control group. Conclusion: Jianpi Yangxue decoction can effectively prevent and cure myelosuppression after chemotherapy and relieve the side effects of chemotherapy.
引文
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[2]陈灏珠.实用内科学[M].12版.北京:人民卫生出版社,2005:2395.
[3]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:175.362.
[4]贾立群,朱世杰.肿瘤放化疗不良反应[M].北京:科学技术文献出版社,2004:12.
[5]李静,王亚平.当归多糖对骨髓巨噬细胞的影响及其与造血调控的关系[J].中草药,2005,36(1):69.
[6]吕艳,冯雪梅,祝彼得.黄芪注射液对骨髓抑制性贫血小鼠造血调控的实验研究[J].中药材,2005,28(9):792.
[7]李影迪,初杰,范颖,等.当归多糖与黄芪多糖配伍对骨髓造血干细胞增殖分化的影响[J].辽宁中医药大学学报,2016,18(6):34.
[8]刘培建,苗明三,高渐联.熟地黄多糖对气血双虚小鼠全血细胞及血清粒-巨噬细胞集落刺激因子水平的影响[J].中国组织工程研究与临床康复,2008,12(38):7546.
[9]严苏纯,祝彼得,韩英光,等.当归补血汤不同剂型及配伍对骨髓抑制小鼠造血调控的实验研究[J].中国药学杂志,2008,43(18):1386.
[10]陈志伟,许惠玉,王立红,等.四物汤配方颗粒对骨髓抑制小鼠造血损伤恢复作用的实验研究[J].中华中医药学刊,2009,27(10):2122.
[11]戴汉源,曹克俭,赵安斌,等.补肾、健脾、活血分别对骨髓抑制贫血小鼠造血的影响[J].中药材,2011,34(2):250.