微量营养素和植物化合物对肺癌潜在作用的研究进展
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摘要
<正>肺癌的发病率及死亡率居各类恶性肿瘤的首位~([1])。由于不易被早期发现及治疗,预防肺癌发生对降低其死亡率具有举足轻重的作用。吸烟是肺癌发生的高危因素,虽然戒烟一定程度上有助于预防肺癌发生,但吸烟者戒烟后仍存在较高的肺癌发生风险~([2])。因此,仅仅通过戒烟这种生活方式的改变来预防肺癌是不够的,食物来源的天然物质对预防肺癌的作用引起人们的广泛关注。肺功能(1秒用力呼气容积,FEV1)下降是评估
引文
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[28] Bruns F,Buntzel J,Mucke R,et al.Selenium in the treatment of head and neck lymphedema[J].Med Princ Pract,2004,13(4):185-190.
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[34] Yao Q H,Zhang X C,Fu T,et al.Omega-3 polyunsaturated fatty acids inhibit the proliferation of the lungadenocarcinoma cell line A549 in vitro[J].Mol Med Rep,2014,9(2):401-406.
[35] 凌丽萍,张荣波.omega-3多不饱和脂肪酸在肺癌防治中的作用[J].卫生研究.2018,47(5):846-849.
[36] Lago J H,Toledo-Arruda A C,Mernak M,et al.Structure-activity association of flavonoids in lung diseases[J].Molecules,2014,19(3):3570-3595.
[37] Woo H D,Kim J.Dietary flavonoid intake and smoking-related cancer risk:A meta-analysis[J].PLoS One,2013,8(9):e75604.
[38] Tang N P,Zhou B,Wang B,et al.Flavonoids intake and risk of lung cancer:A meta-analysis[J].Jpn J Clin Oncol,2009,39(6):352-359.
[39] Mehta A J,Cassidy A,Litonjua A A,et al.Dietary anthocyanin intake and age-related decline in lung function:Longitudinal findings from the VA Normative Aging Study[J].Am J Clin Nutr,2016,103(2):542-550.
[40] Garcia-Larsen V,Amigo H,Bustos P,et al.Ventilatory function in young adults and dietary antioxidant intake[J].Nutrients,2015,7(4):2879-2896.
[41] Garcia-Larsen V,Thawer N,Charles D,et al.Dietary intake of flavonoids and ventilatory function in european adults:A GA(2)LEN study[J].Nutrients,2018,10(1):95.
[42] Ng T P,Niti M,Yap K B,et al.Curcumins-rich curry diet and pulmonary function in Asian older adults[J].PLoS One,2012,7(12):e51753.
[43] Kamholz S L.Wine,spirits and the lung:Good,bad or indifferent?[J].Trans Am Clin Climatol Assoc,2006,117:129-145.
[44] Mantle D,Preedy V R.Free radicals as mediators of alcohol toxicity[J].Adverse Drug React Toxicol Rev,1999,18(4):235-252.
[45] Siedlinski M,Boer J M,Smit H A,et al.Dietary factors and lung function in the general population:Wine and resveratrol intake[J].Eur Respir J,2012,39(2):385-391.
[2] World Cancer Research Fund International.Cancer facts and figures:Worldwide data[EB/OL].(2018-01-01).http:www.wcrf.org/int/cancer-facts-figures/worldwide-data.
[3] Reyfman P A,Washko G R,Dransfield M T,et al.Defining impaired respiratory health.A paradigm shift for pulmonary medicine[J].Am J Respir Crit Care Med,2018,198(4):440-446.
[4] World Cancer Research Fund/American Institute for Cancer Research.Continuous update project expert report 2018.Diet,nutrition,physical activity and lung cancer[EB/OL].(2018-06-01).http://dietandcancerreport.org.
[5] Jin Y R,Lee M S,Lee J H,et al.Intake of vitamin A-rich foods and lung cancer risk in Taiwan:With special reference to garland chrysanthemum and sweet potato leaf consumption[J].Asia Pac J Clin Nutr,2007,16(3):477-488.
[6] Satia J A,Littman A,Slatore C G,et al.Long-term use of beta-carotene,retinol,lycopene,and lutein supplements and lung cancer risk:Results from the Vitamins and Lifestyle(VITAL)study[J].Am J Epidemiol,2009,169(7):815-828.
[7] Omenn G S,Goodman G E,Thornquist M D,et al.Effects of a combination of beta carotene and vitamin a on lung cancer and cardiovascular disease[J].N Engl J Med,1996,334(18):1150-1155.
[8] Garcia-Larsen V,Potts J F,Omenaas E,et al.Dietary antioxidants and 10-year lung function decline in adults from the ECRHS survey[J].Eur Respir J,2017,50(6):1602286.
[9] Melo V L D,Leermakers E,Darweesh S,et al.The effects of lutein on respiratory health across the life course:A systematic review[J].Clin Nutr ESPEN,2016,13:e1-e7.
[10] Koo L C.Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked[J].Nutr Cancer,1988,11(3):155-172.
[11] 陈君石.抗氧化微量营养素的防癌作用[J].中国肿瘤,1994,3(6):17-19.
[12] Tsiligianni I G,van der Molen T.A systematic review of the role of vitamin insufficiencies and supplementation in COPD[J].Respir Res,2010,11:171.
[13] Bentley A R,Kritchevsky S B,Harris T B,et al.Dietary antioxidants and forced expiratory volume in 1 s decline:The health,aging and body composition study[J].Eur Respir J,2012,39(4):979-984.
[14] Cheng T Y,Lacroix A Z,Beresford S A,et al.Vitamin D intake and lung cancer risk in the women's health initiative[J].Am J Clin Nutr,2013,98(4):1002-1011.
[15] Zhou W,Heist R S,Liu G,et al.Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients[J].J Clin Oncol,2007,25(5):479-485.
[16] Feng Q,Zhang H,Dong Z,et al.Circulating 25-hydroxyvitamin D and lung cancer risk and survival:A dose-response meta-analysis of prospective cohort studies[J].Medicine(Baltimore),2017,96(45):e8613.
[17] Huang J D,Dong C H,Shao S W,et al.Circulating 25-hydroxyvitamin D level and prognosis of lung cancer patients:A systematic review and meta-analysis[J].Bull Cancer,2017,104(7/8):675-682.
[18] Meydani M,Cohn J S,Macauley J B,et al.Postprandial changes in the plasma concentration of alpha- and gamma-tocopherol in human subjects fed a fat-rich meal supplemented with fat-soluble vitamins[J].J Nutr,1989,119(9):1252-1258.
[19] Redlich C A,Grauer J N,van Bennekum A M,et al.Characterization of carotenoid,vitamin a,and alpha-tocopheral levels in human lung tissue and pulmonary macrophages[J].Am J Respir Crit Care Med,1996,154(5):1436-1443.
[20] Menkes M S,Comstock G W,Vuilleumier J P,et al.Serum beta-carotene,vitamins a and E,selenium,and the risk of lung cancer[J].N Engl J Med,1986,315(20):1250-1254.
[21] Connett J E,Kuller L H,Kjelsberg M O,et al.Relationship between carotenoids and cancer.The multiple risk factor intervention trial(MRFIT)study[J].Cancer,1989,64(1):126-134.
[22] Berdnikovs S,Abdala-Valencia H,Mccary C,et al.Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment[J].J Immunol,2009,182(7):4395-4405.
[23] Hanson C,Lyden E,Furtado J,et al.Serum tocopherol levels and vitamin E intake are associated with lung function in the normative aging study[J].Clin Nutr,2016,35(1):169-174.
[24] Bivona J R,Patel S,Vajdy M.Induction of cellular and molecular immunomodulatory pathways by vitamin E and vitamin C[J].Expert Opin Biol Ther,2017,17(12):1539-1551.
[25] Britton J R,Pavord I D,Richards K A,et al.Dietary antioxidant vitamin intake and lung function in the general population[J].Am J Respir Crit Care Med,1995,151(5):1383-1387.
[26] Combs G J,Clark L C.Can dietary selenium modify cancer risk?[J].Nutr Rev,1985,43(11):325-331.
[27] Coates R J,Weiss N S,Daling J R,et al.Serum levels of selenium and retinol and the subsequent risk of cancer[J].Am J Epidemiol,1988,128(3):515-523.
[28] Bruns F,Buntzel J,Mucke R,et al.Selenium in the treatment of head and neck lymphedema[J].Med Princ Pract,2004,13(4):185-190.
[29] Mckeever T M,Lewis S A,Smit H A,et al.A multivariate analysis of serum nutrient levels and lung function[J].Respir Res,2008,9:67.
[30] Mckeever T M,Scrivener S,Broadfield E,et al.Prospective study of diet and decline in lung function in a general population[J].Am J Respir Crit Care Med,2002,165(9):1299-1303.
[31] Pearson P,Britton J,Mckeever T,et al.Lung function and blood levels of copper,selenium,vitamin C and vitamin E in the general population[J].Eur J Clin Nutr,2005,59(9):1043-1048.
[32] Song J,Su H,Wang B L,et al.Fish consumption and lung cancer risk:Systematic review and meta-analysis[J].Nutr Cancer,2014,66(4):539-549.
[33] van der Meij B S,Langius J A,Spreeuwenberg M D,et al.Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment:An RCT[J].Eur J Clin Nutr,2012,66(3):399-404.
[34] Yao Q H,Zhang X C,Fu T,et al.Omega-3 polyunsaturated fatty acids inhibit the proliferation of the lungadenocarcinoma cell line A549 in vitro[J].Mol Med Rep,2014,9(2):401-406.
[35] 凌丽萍,张荣波.omega-3多不饱和脂肪酸在肺癌防治中的作用[J].卫生研究.2018,47(5):846-849.
[36] Lago J H,Toledo-Arruda A C,Mernak M,et al.Structure-activity association of flavonoids in lung diseases[J].Molecules,2014,19(3):3570-3595.
[37] Woo H D,Kim J.Dietary flavonoid intake and smoking-related cancer risk:A meta-analysis[J].PLoS One,2013,8(9):e75604.
[38] Tang N P,Zhou B,Wang B,et al.Flavonoids intake and risk of lung cancer:A meta-analysis[J].Jpn J Clin Oncol,2009,39(6):352-359.
[39] Mehta A J,Cassidy A,Litonjua A A,et al.Dietary anthocyanin intake and age-related decline in lung function:Longitudinal findings from the VA Normative Aging Study[J].Am J Clin Nutr,2016,103(2):542-550.
[40] Garcia-Larsen V,Amigo H,Bustos P,et al.Ventilatory function in young adults and dietary antioxidant intake[J].Nutrients,2015,7(4):2879-2896.
[41] Garcia-Larsen V,Thawer N,Charles D,et al.Dietary intake of flavonoids and ventilatory function in european adults:A GA(2)LEN study[J].Nutrients,2018,10(1):95.
[42] Ng T P,Niti M,Yap K B,et al.Curcumins-rich curry diet and pulmonary function in Asian older adults[J].PLoS One,2012,7(12):e51753.
[43] Kamholz S L.Wine,spirits and the lung:Good,bad or indifferent?[J].Trans Am Clin Climatol Assoc,2006,117:129-145.
[44] Mantle D,Preedy V R.Free radicals as mediators of alcohol toxicity[J].Adverse Drug React Toxicol Rev,1999,18(4):235-252.
[45] Siedlinski M,Boer J M,Smit H A,et al.Dietary factors and lung function in the general population:Wine and resveratrol intake[J].Eur Respir J,2012,39(2):385-391.