胸腔镜手术和开胸术治疗肺癌的效果对比及对患者术后应激反应的影响
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摘要
目的:比较胸腔镜手术和开胸术治疗肺癌的效果及对患者术后应激反应的影响。方法:选取2017年4月～2018年1月就诊于某院外一科的肺癌患者30例,将其随机分为观察组与对照组各15例。对照组采用传统开胸手术治疗,观察组采用胸腔镜手术治疗,术后比较两组患者的治疗效果及应激反应相关指标。结果:观察组手术时间、术中出血量、术后引流时间、术后住院时间低于对照组,差异具有统计学意义(P<0.05);观察组术后7d应激反应指标(皮质醇、前列腺素E2及P物质)水平低于对照组,差异具有统计学意义(P<0.05)。结论:对肺癌患者进行胸腔镜手术治疗,临床效果更好,其具有创伤小、对术后应激反应的影响较低、恢复快、治疗效果可靠等优势,值得临床推广应用。
Objective: To compare the effect of thoracoscopic surgery and thoracotomy in the treatment of lung cancer and its effect on postoperative stress response. Methods: 30 cases of lung cancer patients admitted to a hospital from April 2017 to January 2018 were selected and randomly divided into observation group and control group, 15 cases each. The control group was treated with conventional thoracotomy, while the observation group was treated with video-assisted thoracoscopic surgery. The therapeutic effects and related indicators of stress response were compared between the two groups after operation. Results: The time of operation, the amount of bleeding, the time of postoperative drainage and the time of postoperative hospitalization in the observation group were lower than those of the control group(P<0.05), and the level of 7 D stress response(cortisol, prostaglandin E_2 and P substance) in the observation group was lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion: The clinical effect of thoracoscopic surgery for patients with lung cancer is better. It has the advantages of low trauma, low effect on stress reaction after operation, quick recovery, reliable treatment effect and so on. It is worthy of clinical application.
Objective: To compare the effect of thoracoscopic surgery and thoracotomy in the treatment of lung cancer and its effect on postoperative stress response. Methods: 30 cases of lung cancer patients admitted to a hospital from April 2017 to January 2018 were selected and randomly divided into observation group and control group, 15 cases each. The control group was treated with conventional thoracotomy, while the observation group was treated with video-assisted thoracoscopic surgery. The therapeutic effects and related indicators of stress response were compared between the two groups after operation. Results: The time of operation, the amount of bleeding, the time of postoperative drainage and the time of postoperative hospitalization in the observation group were lower than those of the control group(P<0.05), and the level of 7 D stress response(cortisol, prostaglandin E_2 and P substance) in the observation group was lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion: The clinical effect of thoracoscopic surgery for patients with lung cancer is better. It has the advantages of low trauma, low effect on stress reaction after operation, quick recovery, reliable treatment effect and so on. It is worthy of clinical application.
引文
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2 郝志鹏,蔡奕欣,付圣灵,等.单孔与三孔胸腔镜肺癌根治术对患者术后疼痛及短期生活质量的对比研究.中国肺癌杂志,2016,19(3):122～128.
3 Chen RS,Ko JC,Chiu HC,et al.Pemetrexed Downregulates ERCC1 Expression and Enhances Cytotoxicity Effected by Resveratrol in Human Nonsmall Cell Lung Cancer Cells.Naunyn Schmiedebergs Arch Pharmacol,2013,386 (12):1047～1059.
4 银世杰.围手术期应激反应及防治研究进展.中国临床新医学,2017,10(3):283～285.
5 王琼育,李标,李富,等.胸腔镜肺癌手术治疗对患者术后应激反应的影响观察.中华腔镜外科杂志(电子版),2016,9(4):232～235.
6 陈宇,郑红葵,钱琳,等.单孔胸腔镜与三孔胸腔镜进行肺叶切除术的对比分析.中国现代医生,2016,54(35):40～43.