摘要
目的研究外周血中血管性血友病因子(vWF)水平与ST段抬高型心肌梗死(STEMI)患者冠状动脉(冠脉)病变程度的关系。方法以2016年2月至2018年2月于我院收治的STEMI患者109例为研究对象,记为研究组。另取同期于接受体检的健康人员60例为对照组,分别比较两组患者的各项生化指标水平,并将研究组患者按照SYNTAX评分的不同分为轻度病变组、中度病变组及重度病变组,分别比较三组患者外周血vWF水平,并分析外周血vWF与STEMI患者冠脉病变程度的相关性。结果研究组白细胞计数(WBC)、C反应蛋白(CRP)及vWF水平均高于对照组,差异均有统计学意义(P均<0.05)。重度病变组外周血vWF水平高于轻度病变组与中度病变组,且中度病变组高于轻度病变组,差异均有统计学意义(P<0.05)。经Pearson相关性分析可得:外周血vWF、CRP、WBC水平与STEMI患者冠脉病变程度呈正相关关系(P<0.05)。结论 STEMI患者外周血vWF水平存在明显高表达,且与患者冠脉病变程度存在密切相关,可作为临床上早期诊断及评估STEMI患者的有效指标。
Objective To investigate the relationship between the level of von Willebrand factor(vWF) in peripheral blood and the severity of coronary artery disease in patients with ST-segment elevation myocardial infarction(STEMI). Methods A total of 109 STEMI patients admitted to our hospital from February 2016 to February 2018 were enrolled in the study group. Another 60 healthy people who received physical examination in our hospital during the same period were recorded as the control group, and the biochemical indicators of the two groups were compared. Patients in the study group were divided into mild lesion group, moderate lesion group and severe lesion group according to the SYNTAX score. The vWF levels in peripheral blood of three groups were compared, and the correlation between peripheral blood vWF and severity of coronary artery disease in STEMI patients was analyzed. Results The white blood cell count(WBC), C-reactive protein(CRP) and vWF levels in the study group were higher than those in the control group, and the differences were statistically significant(P<0.05).The level of vWF in the peripheral blood of the severe disease group was higher than that of the mild disease group and the moderate disease group, and the moderate disease group was higher than the mild disease group, the difference was statistically significant(P<0.05). According to Pearson correlation analysis, the levels of vWF, CRP and WBC in peripheral blood were positively correlated with the degree of coronary artery lesions in STEMI patients(P<0.05). Conclusion The level of vWF in peripheral blood of patients with STEMI is highly expressed, and it is closely related to the degree of coronary artery disease. It can be used as an effective indicator for early diagnosis and evaluation of STEMI patients.
引文
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