肠道菌群对结直肠癌发生、发展和诊疗影响的研究进展
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摘要
结直肠癌是全球三大恶性肿瘤之一,具有高发病率和高死亡率。肠道菌群失调会引发一系列疾病包括肠道肿瘤。大量研究结果表明结直肠癌的发生、发展和诊疗与肠道菌群密切相关。本文就肠道菌群在结直肠癌发生、发展中的作用以及益生菌在结直肠癌诊断和治疗中的应用作一综述。
Colorectal cancer( CRC) is one of the three major malignant tumors with high morbidity and mortality in the world. Disorder of gut microbiota will induce a series of diseases including colorectal neoplasm. A number of studies have shown that the development,progress,diagnosis and treatment of CRC are closely related to gut microbiota. This article reviewed the role of gut microbiota in the development of CRC and application of probiotics in diagnosis and treatment of CRC.
Colorectal cancer( CRC) is one of the three major malignant tumors with high morbidity and mortality in the world. Disorder of gut microbiota will induce a series of diseases including colorectal neoplasm. A number of studies have shown that the development,progress,diagnosis and treatment of CRC are closely related to gut microbiota. This article reviewed the role of gut microbiota in the development of CRC and application of probiotics in diagnosis and treatment of CRC.
引文
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14 Cao H,Luo S,Xu M,et al. The secondary bile acid,deoxycholate accelerates intestinal adenomaadenocarcinoma sequence in Apc(min/+)mice through enhancing Wnt signaling[J]. Fam Cancer,2014,13(4):563-571.
15 McCoy AN, Araújo-Pérez F, Azcárate-Peril A, et al.Fusobacterium is associated with colorectal adenomas[J].PLo S One,2013,8(1):e53653.
16 Wang X, Huycke MM. Colorectal cancer:role of commensal bacteria and bystander effects[J]. Gut Microbes,2015,6(6):370-376.
17 Chen ZF,Ai LY,Wang JL,et al. Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis[J]. Future Microbiol, 2015, 10(9):1433-1445.
18 Smith PM,Howitt MR,Panikov N,et al. The microbial metabolites,short-chain fatty acids,regulate colonic Treg cell homeostasis[J]. Science, 2013, 341(6145):569-573.
19 Mima K,Nishihara R,Qian ZR,et al. Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis[J]. Gut,2016,65(12):1973-1980.
20 Montassier E,Al-Ghalith GA,Ward T,et al. Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection[J]. Genome Med,2016,8(1):49.
21 Alexander JL,Wilson ID,Teare J,et al. Gut microbiota modulation of chemotherapy efficacy and toxicity[J]. Nat Rev Gastroenterol Hepatol,2017,14(6):356-365.
22 Iida N,Dzutsev A,Stewart CA,et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment[J]. Science, 2013, 342(6161):967-970.
23 Qin J,Li R,Raes J,et al. A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
24 Wang YH,Yao N,Wei KK,et al. The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer:a systematic review and meta-analysis[J]. Eur J Clin Nutr,2016,70(11):1246-1253.
25 Routy B,Le Chatelier E,Derosa L,et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors[J]. Science, 2018, 359(6371):91-97.
2 Dulal S, Keku TO. Gut microbiome and colorectal adenomas[J]. Cancer J,2014,20(3):225-231.
3 Moore WE,Moore LH. Intestinal floras of populations that have a high risk of colon cancer[J]. Appl Environ Microbiol,1995,61(9):3202-3207.
4 Swidsinski A,Khilkin M,Kerjaschki D,et al. Association between intraepithelial Escherichia coli and colorectal cancer[J]. Gastroenterology,1998,115(2):281-286.
5 Yu J,Feng Q,Wong SH,et al. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer[J]. Gut,2017,66(1):70-78.
6 Wong SH,Zhao L,Zhang X,et al. Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice[J]. Gastroenterology, 2017, 153(6):1621-1633. e6.
7 Baxter NT,Zackular JP,Chen GY,et al. Structure of the gut microbiome following colonization with human feces determines colonic tumor burden[J]. Microbiome,2014,2:20.
8 Cuevas-Ramos G,Petit CR,Marcq I,et al. Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells[J]. Proc Natl Acad Sci U S A,2010,107(25):11537-11542.
9 Wu S, Lim KC, Huang J, et al. Bacteroides fragilis enterotoxin cleaves the zonula adherens protein,E-cadherin[J]. Proc Natl Acad Sci U S A,1998,95(25):14979-14984.
10 Guidi R,Guerra L,Levi L,et al. Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response[J]. Cell Microbiol,2013,15(1):98-113.
11 Goodwin AC, Destefano Shields CE, Wu S, et al.Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis[J]. Proc Natl Acad Sci U S A,2011,108(37):15354-15359.
12 Azcárate-Peril MA, Sikes M, Bruno-Bárcena JM. The intestinal microbiota, gastrointestinal environment and colorectal cancer:a putative role for probiotics in prevention of colorectal cancer?[J]. Am J Physiol Gastrointest Liver Physiol,2011,301(3):G401-G424.
13 Lee SH, Hu LL, Gonzalez-Navajas J, et al. ERK activation drives intestinal tumorigenesis in Apc(min/+)mice[J]. Nat Med,2010,16(6):665-670.
14 Cao H,Luo S,Xu M,et al. The secondary bile acid,deoxycholate accelerates intestinal adenomaadenocarcinoma sequence in Apc(min/+)mice through enhancing Wnt signaling[J]. Fam Cancer,2014,13(4):563-571.
15 McCoy AN, Araújo-Pérez F, Azcárate-Peril A, et al.Fusobacterium is associated with colorectal adenomas[J].PLo S One,2013,8(1):e53653.
16 Wang X, Huycke MM. Colorectal cancer:role of commensal bacteria and bystander effects[J]. Gut Microbes,2015,6(6):370-376.
17 Chen ZF,Ai LY,Wang JL,et al. Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis[J]. Future Microbiol, 2015, 10(9):1433-1445.
18 Smith PM,Howitt MR,Panikov N,et al. The microbial metabolites,short-chain fatty acids,regulate colonic Treg cell homeostasis[J]. Science, 2013, 341(6145):569-573.
19 Mima K,Nishihara R,Qian ZR,et al. Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis[J]. Gut,2016,65(12):1973-1980.
20 Montassier E,Al-Ghalith GA,Ward T,et al. Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection[J]. Genome Med,2016,8(1):49.
21 Alexander JL,Wilson ID,Teare J,et al. Gut microbiota modulation of chemotherapy efficacy and toxicity[J]. Nat Rev Gastroenterol Hepatol,2017,14(6):356-365.
22 Iida N,Dzutsev A,Stewart CA,et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment[J]. Science, 2013, 342(6161):967-970.
23 Qin J,Li R,Raes J,et al. A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
24 Wang YH,Yao N,Wei KK,et al. The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer:a systematic review and meta-analysis[J]. Eur J Clin Nutr,2016,70(11):1246-1253.
25 Routy B,Le Chatelier E,Derosa L,et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors[J]. Science, 2018, 359(6371):91-97.