新型超支化纳米聚合物缓释材料的合成及应用
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摘要
超支化聚合物及其纳米具有众多的官能团和高度支化的三维立体结构,显示出与线型分子完全不同的性质,具有重要研究价值。文章研究了一种新型的超支化纳米聚合物缓释材料的合成及其应用。首先通过可逆加成-断裂链转移(reversible addition-fragmentation chain transfer,RAFT)自由基活性聚合合成超支化聚合物,随后向超支化聚合物中加入甲醇,通过加热、冷却过程即可制备纳米聚合物颗粒的甲醇分散液,方法简单、无需自组装。所制备的纳米缓释材料结构稳定均匀,具有较高的疏水物质的装载和控释能力,可应用于医药生物等领域。
Hyperbranched polymers have a large number of functional groups and highly branched three-dimensional structures, showing a completely different nature comparing with linear polymers, which are of significant research value. In this paper, the synthesis of novel hyperbranched copolymer nanoparticles and their applications in controlled release were studied. The hyperbranched copolymers were synthesized through the reversible addition-fragmentation chain transfer(RAFT) polymerization, and the relevant nanoparticle suspensions could be easily obtained by a heating-cooling process in their methanol solution. This method is much easier than the conventional method in the preparation of polymer nanoparticles, in which the self-assembly process is not needed. The obtained hyperbranched copolymer nanoparticles are very stable with high capacities of the loading and controlled release of hydrophobic guest compounds. These nanoparticles can be applied in bio-medical fields.
Hyperbranched polymers have a large number of functional groups and highly branched three-dimensional structures, showing a completely different nature comparing with linear polymers, which are of significant research value. In this paper, the synthesis of novel hyperbranched copolymer nanoparticles and their applications in controlled release were studied. The hyperbranched copolymers were synthesized through the reversible addition-fragmentation chain transfer(RAFT) polymerization, and the relevant nanoparticle suspensions could be easily obtained by a heating-cooling process in their methanol solution. This method is much easier than the conventional method in the preparation of polymer nanoparticles, in which the self-assembly process is not needed. The obtained hyperbranched copolymer nanoparticles are very stable with high capacities of the loading and controlled release of hydrophobic guest compounds. These nanoparticles can be applied in bio-medical fields.
引文
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[17]杨耀华,廖建和,廖禄生,等.采用ATRP合成天然橡胶接枝共聚物:Ⅰ.ATRP大分子引发剂的制备[J].合成化学,2012,20(1):56-59.
[2]PETROV A I,ANTIPOV A A,SUKHORUKOV G B.Base-acid equilibria in polyelectrolyte systems:from weak polyelectrolytes to interpolyelectrolyte complexes and multilayered polyelectrolyte shells[J].Macromolecules,2003,36(26):10079-10086.
[3]SHUTAVA T,PROUTY M,KOMMIREDDY D,et al.pHresponsive decomposable layer-by-layer nanofilms and capsules on the basis of tannic acid[J].Macromolecules,2005,38(7):2850-2858.
[4]MENG F,ZHONG Z,FEIJEN J.Stimuli-responsive polymersomes for programmed drug delivery[J].Biomacromolecules,2009,10(2):197-209.
[5]YILGORI,MCGRATH J E.Polysiloxane containing copolymers:a survey of recent developments[C]//Macromolecules,Polysiloxane Copolymers/Anionic Polymerization.Berlin:Springer,1988:1-86.
[6]张小平,黄艳琴,任厚基,等.超支化聚合物研究最新进展[J].科学通报,2011,56(21):1683-1695.
[7]李战,吴敏.纳米技术和纳米中药的研究进展[J].上海中医药杂志,2003,37(1):61-64.
[8]平其能.纳米药物和纳米载体系统[J].中国新药杂志,2002,11(1):42-46.
[9]王廉卿,戎欣玉,刘魁,等.纳米药物晶体的制备技术及其应用[J].河北科技大学学报,2014,35(4):339-348.
[10]孙晋伟,王佃亮,杜娟,等.纳米微球药物缓释技术[J].生物技术通讯,2012,23(5):759-762.
[11]吴小婷,王小英,杜予民.羧甲基壳聚糖/有机累托石纳米复合材料及其药物缓释性能研究[J].高分子学报,2009(3):222-226.
[12]KIENLE R H,HOVEY A G.The polyhydric alcohol-polybasic acid reaction.Ⅰ.glycerol-phthalic anhydride[J].Journal of the American Chemical Society,1929,51(2):509-519.
[13]LIU J,HUANG W,ZHOU Y,et al.Synthesis of hyperbranched polyphosphates by self-condensing ring-opening polymerization of HEEP without catalyst[J].Macromolecules,2009,42(13):4394-4399.
[14]KIM Y H,WEBSTER O W.Water soluble hyperbranched polyphenylene:a unimolecular micelle[J].Journal of the American Chemical Society,1990,112(11):4592-4593.
[15]王斌,王文平.POSS/PS纳米复合材料的制备与热性能[J].高分子材料科学与工程,2008,24(8):97-99.
[16]BERGER S,SYNYTSKA A,IONOV L,et al.Stimuli-responsive bicomponent polymer janus particles by“grafting from”/“grafting to”approaches[J].Macromolecules,2008,41(24):9669-9676.
[17]杨耀华,廖建和,廖禄生,等.采用ATRP合成天然橡胶接枝共聚物:Ⅰ.ATRP大分子引发剂的制备[J].合成化学,2012,20(1):56-59.