儿童支气管哮喘常用中医外治法研究现状
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摘要
支气管哮喘是一种常见的呼吸系统疾病。中医注重辨证施治和整体观念,强调未病先防,既病防变,在治疗支气管哮喘方面具有独特的优势。中医外治法作为儿童支气管哮喘治疗方法的重要组成部分,具有悠久的历史和丰富的经验积累。近年来,因其治法安全、疗效显著、操作方便、患儿依从性好等优势,得到了愈加广泛的推广及应用,其临床疗效及作用机制研究也取得了一定的进步。
Bronchial asthma(BA) is a commonrespiratory disease. Traditional Chinese Medicine(TCM) has unique advantage in the treatment of BA, because it pays attention to concept of dialectical treatment and entirety and emphasizes the theory of‘preventing disease first'and‘preventing disease from exacerbating'. As an important part of the therapy of BA in children, the external treatment of TCM has a long history and a rich clinical experience. In recent years, external treatment has been widely promoted and applied for its safety, notable effect, convenient operation and good compliance. The research on its clinical efficacy and mechanism has made some progress.
Bronchial asthma(BA) is a commonrespiratory disease. Traditional Chinese Medicine(TCM) has unique advantage in the treatment of BA, because it pays attention to concept of dialectical treatment and entirety and emphasizes the theory of‘preventing disease first'and‘preventing disease from exacerbating'. As an important part of the therapy of BA in children, the external treatment of TCM has a long history and a rich clinical experience. In recent years, external treatment has been widely promoted and applied for its safety, notable effect, convenient operation and good compliance. The research on its clinical efficacy and mechanism has made some progress.
引文
1 Boulet L P,Fitzgerald J M,Reddel H K.Therevised 2014 GINA strategy report:opportunities for change Curr Opin Pulm Med,2015,21(1):1-7.
2 陈湘君.中医内科学.上海:上海科学技术出版社,2004:33.
3 杨华.针灸加拔罐治疗支气管哮喘28例.湖北中医杂志,2011,33(6):66.
4 别传军,张晓晖.针刺攒竹配合中药贴敷天突穴治疗小儿哮喘35例.光明中医,2015,30(5):1029-1030.
5 Ola A D,Mona M S,Nagwa H M,et al.Evaluation of the improvement effect of laser acupuncture biostimulation in asthmatic children by exhaled inflammatory biomarker level of nitric oxide.Lasers in Medical Science,2017,32(1):53-59.
6 Magda Y E,Nagwa H M,Asmaa AAlsharkawy,et al.Laser acupuncture in treatment of childhood bronchial asthma.Journal of complementary&integrative medicine,2013,10;10.1515/jcim-2012-0006.
7 范洪力,柯斌霞,陈颖琰,等.儿童支气管哮喘阿是穴定穴灸疗30例临床研究.云南中医中药杂志,2016,37(8):60-63.
8 钱海良,喜悦,程志昆,等.艾灸肺俞穴治疗儿童哮喘冷哮证急性发作的临床观察.南京中医药大学学报,2017,33(4):363-366.
9 高凌,马淑丽,常佳婧,等.“双药双穴”天灸疗法对改善儿童冷哮证的多因素方差分析.中国中医基础医学杂志,2017,23(6):845-847+853.
10 杨红新,张瑜,胡亚南,等.伏九贴灸对3种不同体质哮喘患儿免疫功能的影响.现代中西医结合杂志,2017,26(14):1498-1501.
11 石来军,赵旸.冬病夏治穴位敷贴法预防儿童哮喘复发92例临床观察.中国中医急症,2014,23(12):2342-2344.
12 马喜凤,张士卿,吴丽萍.冬病夏治咳喘贴穴位贴敷治疗小儿支气管哮喘缓解期临床观察.中国中医药信息杂志,2011,18(4):75-76.
13 任辉杰,黄超,陈丽亚,等.三伏贴改善哮喘儿童阳虚证候137例临床观察.中医儿科杂志,2016,12(3):32-34.
14 吴杰,虞坚尔,闵伟福,等.中药敷贴联合离子导入技术治疗小儿哮喘400例临床疗效观察.中国中西医结合杂志,2011,31(7):996-997.
15 胡元生,何秋芳,叶滨等.肺俞穴、足三里穴位注射辅助治疗小儿哮喘103例临床观察.中医药导报,2013,19(4):65-66.
16 罗娟娟,洪虹,钟小明,等.穴位注射喘可治注射液对支气管哮喘患儿细胞免疫的影响.赣南医学院学报,2017,37(6):920-922+924.
17 吴瑞华,邬燮炜.中药穴位注射防治儿童哮喘证近、远期疗效观察.上海中医药杂志,1992,(6):26-28.
18 钱家骅,鹿振辉,马子风,等.喘可治足三里穴位注射治疗对支气管哮喘的调控机制研究概况.内蒙古中医药,2017,36(3):140-142.
19 顾根仁,周志荣.中药敷脐治疗儿童哮喘163例疗效观察.实用中西医结合临床,2006,6(4):70-71.
20 于志芳.中药敷脐治疗儿童哮喘疗效观察与护理.中国农村卫生事业管理,2009,29(8):635-636.
21 王克.自拟平哮散敷脐配合西药治疗小儿哮喘40例.四川中医,2010,28(11):94-95.
22 孙萍.足反射区按摩疗法防治小儿哮喘50例.中国自然医学杂志,2003,5(1):34.
23 Wu J,Yang X W,Zhang M.Massage Therapy in Children with Asthma:A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine,2017,2017;10.1155/2017/5620568.
24 赵瑞英.耳压祛痰法治疗小儿哮喘30例.新疆中医药,1998,16(4):29.
25 文习玲.耳穴贴压加拔火罐治疗小儿哮喘.湖南中医学院学报,2000,20(2):59.
26 张肖瑾,赵琼,罗雅婷,等.耳穴贴压辅助治疗小儿哮喘发作期(痰热壅肺型)的疗效观察.中国中西医结合儿科学,2016,8(3):265-268
27 张梅馨.温肺平喘汤灌肠治疗小儿寒性哮喘32例.安徽中医学院学报,1998,17(5):28.
28 周志荣.中药直肠滴入治疗婴幼儿哮喘50例.浙江中医学院学报,2005,29(5):44.
29 姜之炎.儿童哮喘直肠凝胶剂治疗哮喘30例.上海中医药杂志,2001,35(5):29-30.
30 王丛礼,洪丽军,赵成彬,等.宁嗽二号微型灌肠剂治疗小儿哮喘50例临床观察.中国民间疗法,2017,25(7):29-30.
31 梁雪.细辛脑注射液雾化吸入治疗小儿支气管哮喘临床观察.中国中西医结合儿科学,2010,2(2):125-126.
32 傅强.细辛脑注射液雾化吸入与静脉滴注治疗儿童哮喘的效果比较.中国医药指南,2013,11(17):225.
33 秦秋霞.苦参液雾化吸人辅佐治疗小儿哮喘.中外医疗,2010,29(4):113.
34 姚敏,陈燕萍,夏一春.复方麻辛剂雾化吸入对哮喘患儿肺功能影响的研究.河南中医,2004,24(11):23-25.
35 王岩,郑健,潘旭东,等.中药雾化吸入治疗小儿哮喘30例.福建中医药,2014,45(1):38-39
36 Dong M,Xie S Y,Li F H,et al.Is acupuncture better than sham acupuncture for attenuated airway inflammation and regulated cytokines produced by diverse Th subtypes in chronic OVA inhalation in asthma induced mice.European Journal of Integrative Medicine,2015,7(5):485-491.
37 Wei Y,Dong M,Zhang H Y,et al.Acupuncture Attenuated Inflammation and Inhibited Th17 and Treg Activity in Experimental Asthma.Evidence-based complementary and alternative medicine,2015,2015;10.1155/2015/340126.
38 杨金华,赵叶,李双,等.针刺对支气管哮喘大鼠肺组织AKT蛋白表达的调控.中国针灸,2017,37(4):406-410.
39 韩君萍,李双,赵叶,等.针刺对哮喘模型大鼠肺组织中TGF-β1表达的调控.中国针灸,2017,37(7):741-746.
40 陈铭,康佩芝,董亚琴.ATP及P2X7受体在三伏灸治疗支气管哮喘的作用机制研究.中国中医药现代远程教育,2018,16(10):91-94.
41 陈铭,苏美玲,文婧,等.三伏灸不同灸量对哮喘型新西兰兔MMP-9表达的影响.中国中医药现代远程教育,2017,15(17):143-145.
42 文婧,苏美玲,李淑娟,等.三伏灸不同灸量对支气管哮喘新西兰兔细支气管形态的影响.中华中医药杂志,2017,32(11):4932-4935.
43 万力生,赵欣欣,王国斌,等.天灸疗法对支气管哮喘患儿TGF-β/Smads信号通路影响.辽宁中医药大学学报,2016,18(11):8-10.
44 陈争光,罗卉,万力生.天灸疗法对支气管哮喘缓解期患儿转化生长因子β/Smads信号通路关键分子基因表达的影响.河北中医,2018,40(3):442-445.
45 谢玲玲,李品纯,潘凤霞,等.艾炷灸抗哮喘小鼠气道炎症机制研究.中国中医基础医学杂志,2017,23(7):992-994.
46 王晓燕,武琪琳,刘玲,等.传统穴+神阙穴三伏贴敷防治小儿哮喘相关实验室指标的研究.时珍国医国药,2015,26(1):144-146.
47 乡世健,盛华芳,吕亚梅,等.冬病夏治方穴位贴敷对哮喘豚鼠气道炎症及肠道菌群的影响.中国实验方剂学杂志,2018,24(9):95-102
48 夏建波,胡天军.喘可治注射液治疗急性哮喘临床观察.中国中医急症,2012,21(5):836-837.
49 黄东晖,吴少丽,王慧贤,等.喘可治注射液通过调节Th17/Treg平衡抑制哮喘模型小鼠气道炎症的实验研究.中药材,2014,37(3):478-481.
50 夏敏,蔡宇波,费辛,等.喘可治抑制哮喘大鼠炎症反应的机制研究.上海中医药杂志,2013,47(1):70-73.
51 张敏,冯家银,黄少玲.推拿疗法治疗小儿哮喘的研究.江西中医药,2002,33(4):8.
52 叶优珊,马房柱.小儿推拿对小儿哮喘不同时期IL-17、IL-33、IL-6水平变化影响.吉林医学,2017,38(3):495-496.
53 王跃.小儿推拿疗法在小儿支气管哮喘慢性持续期的疗效.中国实用医药,2017,12(9):141-142.
54 刘潇,张伟,杨丽珍,等.感冒后哮喘发作患儿经小儿推拿干预后EOS、血清IL与Ig E相关性研究.针灸临床杂志,2017,33(6):15-17.
55 Chang H C,Gong C C,Chan C L,et al.A nebulized complex traditional Chinese medicine inhibits Histamine and IL-4 production by ovalbumin in guinea pigs and can stabilize mast cells in vitro.BMC Complementary and Alternative Medicine,2013,13;10.1186/1472-6882-13-174
56 杨珺.运用综合外治法.治疗小儿哮喘80例的临床分析.求医问药,2012,10(3):47.
57 杨亚东.小儿哮喘运用综合外治法临床疗效观察.大家健康(学术版),2014,8(21):11-12.
58 中医综合外治法治疗小儿哮喘临床观察.中外医学研究,2014,12(23):114-115.
2 陈湘君.中医内科学.上海:上海科学技术出版社,2004:33.
3 杨华.针灸加拔罐治疗支气管哮喘28例.湖北中医杂志,2011,33(6):66.
4 别传军,张晓晖.针刺攒竹配合中药贴敷天突穴治疗小儿哮喘35例.光明中医,2015,30(5):1029-1030.
5 Ola A D,Mona M S,Nagwa H M,et al.Evaluation of the improvement effect of laser acupuncture biostimulation in asthmatic children by exhaled inflammatory biomarker level of nitric oxide.Lasers in Medical Science,2017,32(1):53-59.
6 Magda Y E,Nagwa H M,Asmaa AAlsharkawy,et al.Laser acupuncture in treatment of childhood bronchial asthma.Journal of complementary&integrative medicine,2013,10;10.1515/jcim-2012-0006.
7 范洪力,柯斌霞,陈颖琰,等.儿童支气管哮喘阿是穴定穴灸疗30例临床研究.云南中医中药杂志,2016,37(8):60-63.
8 钱海良,喜悦,程志昆,等.艾灸肺俞穴治疗儿童哮喘冷哮证急性发作的临床观察.南京中医药大学学报,2017,33(4):363-366.
9 高凌,马淑丽,常佳婧,等.“双药双穴”天灸疗法对改善儿童冷哮证的多因素方差分析.中国中医基础医学杂志,2017,23(6):845-847+853.
10 杨红新,张瑜,胡亚南,等.伏九贴灸对3种不同体质哮喘患儿免疫功能的影响.现代中西医结合杂志,2017,26(14):1498-1501.
11 石来军,赵旸.冬病夏治穴位敷贴法预防儿童哮喘复发92例临床观察.中国中医急症,2014,23(12):2342-2344.
12 马喜凤,张士卿,吴丽萍.冬病夏治咳喘贴穴位贴敷治疗小儿支气管哮喘缓解期临床观察.中国中医药信息杂志,2011,18(4):75-76.
13 任辉杰,黄超,陈丽亚,等.三伏贴改善哮喘儿童阳虚证候137例临床观察.中医儿科杂志,2016,12(3):32-34.
14 吴杰,虞坚尔,闵伟福,等.中药敷贴联合离子导入技术治疗小儿哮喘400例临床疗效观察.中国中西医结合杂志,2011,31(7):996-997.
15 胡元生,何秋芳,叶滨等.肺俞穴、足三里穴位注射辅助治疗小儿哮喘103例临床观察.中医药导报,2013,19(4):65-66.
16 罗娟娟,洪虹,钟小明,等.穴位注射喘可治注射液对支气管哮喘患儿细胞免疫的影响.赣南医学院学报,2017,37(6):920-922+924.
17 吴瑞华,邬燮炜.中药穴位注射防治儿童哮喘证近、远期疗效观察.上海中医药杂志,1992,(6):26-28.
18 钱家骅,鹿振辉,马子风,等.喘可治足三里穴位注射治疗对支气管哮喘的调控机制研究概况.内蒙古中医药,2017,36(3):140-142.
19 顾根仁,周志荣.中药敷脐治疗儿童哮喘163例疗效观察.实用中西医结合临床,2006,6(4):70-71.
20 于志芳.中药敷脐治疗儿童哮喘疗效观察与护理.中国农村卫生事业管理,2009,29(8):635-636.
21 王克.自拟平哮散敷脐配合西药治疗小儿哮喘40例.四川中医,2010,28(11):94-95.
22 孙萍.足反射区按摩疗法防治小儿哮喘50例.中国自然医学杂志,2003,5(1):34.
23 Wu J,Yang X W,Zhang M.Massage Therapy in Children with Asthma:A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine,2017,2017;10.1155/2017/5620568.
24 赵瑞英.耳压祛痰法治疗小儿哮喘30例.新疆中医药,1998,16(4):29.
25 文习玲.耳穴贴压加拔火罐治疗小儿哮喘.湖南中医学院学报,2000,20(2):59.
26 张肖瑾,赵琼,罗雅婷,等.耳穴贴压辅助治疗小儿哮喘发作期(痰热壅肺型)的疗效观察.中国中西医结合儿科学,2016,8(3):265-268
27 张梅馨.温肺平喘汤灌肠治疗小儿寒性哮喘32例.安徽中医学院学报,1998,17(5):28.
28 周志荣.中药直肠滴入治疗婴幼儿哮喘50例.浙江中医学院学报,2005,29(5):44.
29 姜之炎.儿童哮喘直肠凝胶剂治疗哮喘30例.上海中医药杂志,2001,35(5):29-30.
30 王丛礼,洪丽军,赵成彬,等.宁嗽二号微型灌肠剂治疗小儿哮喘50例临床观察.中国民间疗法,2017,25(7):29-30.
31 梁雪.细辛脑注射液雾化吸入治疗小儿支气管哮喘临床观察.中国中西医结合儿科学,2010,2(2):125-126.
32 傅强.细辛脑注射液雾化吸入与静脉滴注治疗儿童哮喘的效果比较.中国医药指南,2013,11(17):225.
33 秦秋霞.苦参液雾化吸人辅佐治疗小儿哮喘.中外医疗,2010,29(4):113.
34 姚敏,陈燕萍,夏一春.复方麻辛剂雾化吸入对哮喘患儿肺功能影响的研究.河南中医,2004,24(11):23-25.
35 王岩,郑健,潘旭东,等.中药雾化吸入治疗小儿哮喘30例.福建中医药,2014,45(1):38-39
36 Dong M,Xie S Y,Li F H,et al.Is acupuncture better than sham acupuncture for attenuated airway inflammation and regulated cytokines produced by diverse Th subtypes in chronic OVA inhalation in asthma induced mice.European Journal of Integrative Medicine,2015,7(5):485-491.
37 Wei Y,Dong M,Zhang H Y,et al.Acupuncture Attenuated Inflammation and Inhibited Th17 and Treg Activity in Experimental Asthma.Evidence-based complementary and alternative medicine,2015,2015;10.1155/2015/340126.
38 杨金华,赵叶,李双,等.针刺对支气管哮喘大鼠肺组织AKT蛋白表达的调控.中国针灸,2017,37(4):406-410.
39 韩君萍,李双,赵叶,等.针刺对哮喘模型大鼠肺组织中TGF-β1表达的调控.中国针灸,2017,37(7):741-746.
40 陈铭,康佩芝,董亚琴.ATP及P2X7受体在三伏灸治疗支气管哮喘的作用机制研究.中国中医药现代远程教育,2018,16(10):91-94.
41 陈铭,苏美玲,文婧,等.三伏灸不同灸量对哮喘型新西兰兔MMP-9表达的影响.中国中医药现代远程教育,2017,15(17):143-145.
42 文婧,苏美玲,李淑娟,等.三伏灸不同灸量对支气管哮喘新西兰兔细支气管形态的影响.中华中医药杂志,2017,32(11):4932-4935.
43 万力生,赵欣欣,王国斌,等.天灸疗法对支气管哮喘患儿TGF-β/Smads信号通路影响.辽宁中医药大学学报,2016,18(11):8-10.
44 陈争光,罗卉,万力生.天灸疗法对支气管哮喘缓解期患儿转化生长因子β/Smads信号通路关键分子基因表达的影响.河北中医,2018,40(3):442-445.
45 谢玲玲,李品纯,潘凤霞,等.艾炷灸抗哮喘小鼠气道炎症机制研究.中国中医基础医学杂志,2017,23(7):992-994.
46 王晓燕,武琪琳,刘玲,等.传统穴+神阙穴三伏贴敷防治小儿哮喘相关实验室指标的研究.时珍国医国药,2015,26(1):144-146.
47 乡世健,盛华芳,吕亚梅,等.冬病夏治方穴位贴敷对哮喘豚鼠气道炎症及肠道菌群的影响.中国实验方剂学杂志,2018,24(9):95-102
48 夏建波,胡天军.喘可治注射液治疗急性哮喘临床观察.中国中医急症,2012,21(5):836-837.
49 黄东晖,吴少丽,王慧贤,等.喘可治注射液通过调节Th17/Treg平衡抑制哮喘模型小鼠气道炎症的实验研究.中药材,2014,37(3):478-481.
50 夏敏,蔡宇波,费辛,等.喘可治抑制哮喘大鼠炎症反应的机制研究.上海中医药杂志,2013,47(1):70-73.
51 张敏,冯家银,黄少玲.推拿疗法治疗小儿哮喘的研究.江西中医药,2002,33(4):8.
52 叶优珊,马房柱.小儿推拿对小儿哮喘不同时期IL-17、IL-33、IL-6水平变化影响.吉林医学,2017,38(3):495-496.
53 王跃.小儿推拿疗法在小儿支气管哮喘慢性持续期的疗效.中国实用医药,2017,12(9):141-142.
54 刘潇,张伟,杨丽珍,等.感冒后哮喘发作患儿经小儿推拿干预后EOS、血清IL与Ig E相关性研究.针灸临床杂志,2017,33(6):15-17.
55 Chang H C,Gong C C,Chan C L,et al.A nebulized complex traditional Chinese medicine inhibits Histamine and IL-4 production by ovalbumin in guinea pigs and can stabilize mast cells in vitro.BMC Complementary and Alternative Medicine,2013,13;10.1186/1472-6882-13-174
56 杨珺.运用综合外治法.治疗小儿哮喘80例的临床分析.求医问药,2012,10(3):47.
57 杨亚东.小儿哮喘运用综合外治法临床疗效观察.大家健康(学术版),2014,8(21):11-12.
58 中医综合外治法治疗小儿哮喘临床观察.中外医学研究,2014,12(23):114-115.