蛤类多糖的研究进展
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摘要
蛤类品种繁多,富含活性多糖和蛋白质等营养成分。本研究中综述了蛤类多糖的提取方法、纯化方法、化学组成及其生物活性,并针对蛤类多糖研究中存在的问题,提出了应在提高多糖纯度、创新提取工艺、实现工厂化生产、深入研究多糖结构对其活性机制的影响等方面加强研究,旨在为蛤类养殖、加工及其功能食品开发提供理论参考。
Clams are rich in varieties of bioactive polysaccharides and protein. The clam polysaccharides extraction methods,polysaccharides purification methods,polysaccharides compositions and polysaccharides bioactivities are reviewed,and some problems about the study of clam polysaccharides are discussed. The improvement of polysaccharides purity,and optimization of extraction process,commercialization of production,and the impact of polysaccharides composition on the mechanism of bioactivities. This study aims to provide theoretical references for clams production,processing and developing functional food.
Clams are rich in varieties of bioactive polysaccharides and protein. The clam polysaccharides extraction methods,polysaccharides purification methods,polysaccharides compositions and polysaccharides bioactivities are reviewed,and some problems about the study of clam polysaccharides are discussed. The improvement of polysaccharides purity,and optimization of extraction process,commercialization of production,and the impact of polysaccharides composition on the mechanism of bioactivities. This study aims to provide theoretical references for clams production,processing and developing functional food.
引文
[1]张士军.海洋蛤类产业价值链及价值增值的实证研究—以红岛蛤蜊为例[J].世界农业,2014(12):38-44.
[2]慕永通,张红智.中国在世界软体动物产业中的地位:产量视角[J].世界农业,2012(11):126-133.
[3]冯锦龙.世界蛤类市场概述[J].国外水产,1991(4):35-37.
[4]杨东敏,张艳丽,丁鉴锋,等.高温、低盐对菲律宾蛤子免疫能力的影响[J].大连海洋大学学报,2017,32(5):302-309.
[5]高鑫,闫喜武,张辉,等.蛤仔南北方养殖群体杂交子代早期生长发育的研究[J].大连海洋大学学报,2013,28(1):39-43.
[6]Ghosh J,Lun C M,Majeske A J,et al.Invertebrate immune diversity[J].Developmental&Comparative Immunology,2011,35(9):959-974.
[7]蒋长兴.青蛤多糖分离鉴定、硫酸酯化及其生物活性研究[D].南京:南京农业大学,2011.
[8]金燕,吴皓,常念,等.四角蛤蜊多糖的提取工艺与单糖组分研究[J].中华中医药学刊,2010,28(3):479-481.
[9]Wang L C,Zhang K,Di L Q,et al.Isolation and structural elucidation of novel homogenous polysaccharide from Mactra veneriformis[J].Carbohydrate Polymers,2011,86(2):982-987.
[10]胡伟,唐小牛.超声辅助法在亚洲日月蛤多糖提取工艺优化中的应用[J].皖南医学院学报,2016,35(6):515-518.
[11]Cheung Y C,Siu K C,Liu Y S,et al.Molecular properties and antioxidant activities of polysaccharide-protein complexes from selected mushrooms by ultrasound-assisted extraction[J].Process Biochemistry,2012,47(5):892-895.
[12]陈丽叶,王令充,吴皓,等.正交试验优化文蛤水溶性多糖的水提醇沉工艺[J].中国实验方剂学杂志,2016,22(5):18-21.
[13]尹华,袁强,储云月.文蛤多糖的提取及含量测定[J].中国海洋药物,2006,25(1):48-51.
[14]向维,丁馨,张薛磊,等.响应曲面法优化微波辅提彩虹明樱蛤多糖的提取工艺[J].中药材,2013,36(3):349-353.
[15]吴红棉,叶志国,范秀萍,等.菲律宾蛤仔糖蛋白的分离纯化与理化性质的研究[J].中国食品学报,2008,8(5):80-85.
[16]胡聪聪,杨永芳,丁国芳,等.青蛤多糖提取的条件优化及其抗肿瘤活性研究[J].中国民族民间医药,2010,19(10):28-29.
[17]向维,丁馨,张薛磊,等.彩虹明樱蛤酸性多糖的提取与纯化[J].浙江大学学报:医学版,2012,41(5):569-575.
[18]李莉.文蛤多糖的提取纯化、结构分析及抗氧化、免疫活性初步研究[D].无锡:江南大学,2015.
[19]范秀萍,吴红棉,卞小丽.菲律宾蛤仔氨基多糖的分离纯化及化学性质[J].现代食品科技,2005,21(2):97-99.
[20]舒留泉,姚晶,杨苏梅,等.四角蛤蜊多糖分离提取工艺优化[J].食品研究与开发,2012,33(6):71-74.
[21]Liao N B,Zhong J J,Ye X Q,et al.Ultrasonic-assisted enzymatic extraction of polysaccharide from Corbicula fluminea:characterization and antioxidant activity[J].LWT-Food Science and Technology,2015,60(2):1113-1121.
[22]孙晓朋.四角蛤蜊糖胺聚糖的提取、纯化及生理活性研究[D].天津:天津科技大学,2011.
[23]董晓静.波纹巴非蛤糖胺聚糖抗氧化与降血脂活性研究[D].湛江:广东海洋大学,2010.
[24]廖宁波.河蚬多糖结构特征、生物活性及其对人体肠道菌群的影响[D].杭州:浙江大学,2014.
[25]Yan J K,Wang Y Y,Qiu W Y,et al.Three-phase partitioning for efficient extraction and separation of polysaccharides from Corbicula fluminea[J].Carbohydrate Polymers,2017,163:10-19.
[26]Coenen G J,Bakx E J,Verhoef R P,et al.Identification of the connecting linkage between homo-or xylogalacturonan and rhamnogalacturonan type I[J].Carbohydrate Polymers,2007,70(2):224-235.
[27]林华婷.鼠曲草类黄酮制备及其抗氧化抑菌活性研究[D].福州:福建农林大学,2016.
[28]Dai Z Y,Zhang H,Zhang Y P,et al.Chemical properties and immunostimulatory activity of a water-soluble polysaccharide from the clam of Hyriopsis cumingii Lea[J].Carbohydrate Polymers,2009,77(2):365-369.
[29]王瑞芳.两种贝类糖胺聚糖的理化及结构特征研究[D].湛江:广东海洋大学,2009.
[30]Albans S,Schauerte A,Franz G.Anticoagulant sulfated polysaccharides:Part I.Synthesis and structure-activity relationships of new pullulan sulfates[J].Carbohydrate Polymers,2002,47(3):267-276.
[31]吴红棉,范秀萍,雷晓凌,等.波纹巴非蛤氨基多糖的分离纯化及其理化性质的初步研究[J].食品与发酵工业,2005,31(7):133-136.
[32]郭振宇.菲律宾蛤仔蒸煮液多糖的提取、分离及其性质的研究[D].大连:大连海洋大学,2015.
[33]Wang L C,Wu H,Ji J,et al.Preparation,analysis and antioxidant evaluation of the controlled product of polysaccharide from Mactra veneriformis by mild acid hydrolysis[J].Carbohydrate Polymers,2016,137:709-718.
[34]Lu Y,Wang D Y,Hu Y L,et al.Sulfated modification of epimedium polysaccharide and effects of the modifiers on cellular infectivity of IBDV[J].Carbohydrate Polymers,2008,71(2):180-186.
[35]窦昌贵,黄芳,黄罗生,等.文蛤多糖抗癌免疫药理作用的研究[J].中国海洋药物,1999,18(2):15-19.
[36]向维,陈松华,李朝品.彩虹明樱蛤多糖对小鼠的免疫调节作用[J].中国生化药物杂志,2011,32(5):393-395.
[37]郑文文,王令充,吴皓,等.四角蛤蜊粗多糖的免疫调节作用研究[J].中国药师,2011,14(2):151-154.
[38]郭雷,许福泉,樊鑫桐,等.青蛤多糖的提取工艺优化及其抗氧化活性[J].食品研究与开发,2014,35(21):10-14.
[39]蒋长兴,焦云鹏,熊清平,等.海蚬多糖性质及抗氧化活性研究[J].食品与生物技术学报,2013,32(10):1091-1096.
[40]范秀萍,董晓静,吴红棉,等.波纹巴非蛤多糖对高脂模型小鼠血脂的影响[J].现代食品科技,2014,30(1):7-10,21.
[41]董文南,柴尧,刘睿,等.四角蛤蜊粗多糖对四氧嘧啶诱导ICR小鼠糖尿病模型的降血糖作用[J].南京中医药大学学报,2015,31(2):134-137.
[42]向维,陈松华,吴媛媛,等.彩虹明樱蛤多糖对转染HBV的Hep G2细胞表达功能的影响[J].解放军医学杂志,2012,37(2):109-112.
[43]Woo E R,Kim W S,Kim Y S.Virus-cell fusion inhibitory activity for the polysaccharides from various Korean edible clams[J].Archives of Pharmacal Research,2001,24(6):514-517.
[44]向维,陈松华,李朝品.彩虹明樱蛤多糖对小鼠急性化学性肝损伤的保护作用[J].中国生化药物杂志,2012,33(1):43-45.
[45]徐律,李连军,杨最素,等.菲律宾蛤仔提取物及生物活性的研究进展[J].浙江海洋学院学报:自然科学版,2013,32(4):357-361.
[46]张绵松,史亚萍,袁文鹏,等.青柳蛤酶解条件优化及辅助降血压活性的研究[J].食品工业,2017,38(3):52-56.
[47]张倩,刘睿,王欣之,等.高效液相色谱法测定四角蛤蜊、菲律宾蛤仔中呈味核苷酸[J].食品与发酵工业,2017,43(3):224-228.
[48]董晶,慕永通.从产量视角看中国在世界蛤类产业中的地位[J].中国渔业经济,2017,35(1):12-17.
[49]苑旭洲,崔毅,陈碧鹃,等.菲律宾蛤仔对6种重金属的生物富集动力学[J].渔业科学进展,2012,33(4):49-56.
[50]张林宝,吴惠丰,孙伟,等.菲律宾蛤仔对镉、铜暴露的蓄积作用及其抗氧化酶系统的响应研究[J].南方水产科学,2013,9(5):64-70.
[2]慕永通,张红智.中国在世界软体动物产业中的地位:产量视角[J].世界农业,2012(11):126-133.
[3]冯锦龙.世界蛤类市场概述[J].国外水产,1991(4):35-37.
[4]杨东敏,张艳丽,丁鉴锋,等.高温、低盐对菲律宾蛤子免疫能力的影响[J].大连海洋大学学报,2017,32(5):302-309.
[5]高鑫,闫喜武,张辉,等.蛤仔南北方养殖群体杂交子代早期生长发育的研究[J].大连海洋大学学报,2013,28(1):39-43.
[6]Ghosh J,Lun C M,Majeske A J,et al.Invertebrate immune diversity[J].Developmental&Comparative Immunology,2011,35(9):959-974.
[7]蒋长兴.青蛤多糖分离鉴定、硫酸酯化及其生物活性研究[D].南京:南京农业大学,2011.
[8]金燕,吴皓,常念,等.四角蛤蜊多糖的提取工艺与单糖组分研究[J].中华中医药学刊,2010,28(3):479-481.
[9]Wang L C,Zhang K,Di L Q,et al.Isolation and structural elucidation of novel homogenous polysaccharide from Mactra veneriformis[J].Carbohydrate Polymers,2011,86(2):982-987.
[10]胡伟,唐小牛.超声辅助法在亚洲日月蛤多糖提取工艺优化中的应用[J].皖南医学院学报,2016,35(6):515-518.
[11]Cheung Y C,Siu K C,Liu Y S,et al.Molecular properties and antioxidant activities of polysaccharide-protein complexes from selected mushrooms by ultrasound-assisted extraction[J].Process Biochemistry,2012,47(5):892-895.
[12]陈丽叶,王令充,吴皓,等.正交试验优化文蛤水溶性多糖的水提醇沉工艺[J].中国实验方剂学杂志,2016,22(5):18-21.
[13]尹华,袁强,储云月.文蛤多糖的提取及含量测定[J].中国海洋药物,2006,25(1):48-51.
[14]向维,丁馨,张薛磊,等.响应曲面法优化微波辅提彩虹明樱蛤多糖的提取工艺[J].中药材,2013,36(3):349-353.
[15]吴红棉,叶志国,范秀萍,等.菲律宾蛤仔糖蛋白的分离纯化与理化性质的研究[J].中国食品学报,2008,8(5):80-85.
[16]胡聪聪,杨永芳,丁国芳,等.青蛤多糖提取的条件优化及其抗肿瘤活性研究[J].中国民族民间医药,2010,19(10):28-29.
[17]向维,丁馨,张薛磊,等.彩虹明樱蛤酸性多糖的提取与纯化[J].浙江大学学报:医学版,2012,41(5):569-575.
[18]李莉.文蛤多糖的提取纯化、结构分析及抗氧化、免疫活性初步研究[D].无锡:江南大学,2015.
[19]范秀萍,吴红棉,卞小丽.菲律宾蛤仔氨基多糖的分离纯化及化学性质[J].现代食品科技,2005,21(2):97-99.
[20]舒留泉,姚晶,杨苏梅,等.四角蛤蜊多糖分离提取工艺优化[J].食品研究与开发,2012,33(6):71-74.
[21]Liao N B,Zhong J J,Ye X Q,et al.Ultrasonic-assisted enzymatic extraction of polysaccharide from Corbicula fluminea:characterization and antioxidant activity[J].LWT-Food Science and Technology,2015,60(2):1113-1121.
[22]孙晓朋.四角蛤蜊糖胺聚糖的提取、纯化及生理活性研究[D].天津:天津科技大学,2011.
[23]董晓静.波纹巴非蛤糖胺聚糖抗氧化与降血脂活性研究[D].湛江:广东海洋大学,2010.
[24]廖宁波.河蚬多糖结构特征、生物活性及其对人体肠道菌群的影响[D].杭州:浙江大学,2014.
[25]Yan J K,Wang Y Y,Qiu W Y,et al.Three-phase partitioning for efficient extraction and separation of polysaccharides from Corbicula fluminea[J].Carbohydrate Polymers,2017,163:10-19.
[26]Coenen G J,Bakx E J,Verhoef R P,et al.Identification of the connecting linkage between homo-or xylogalacturonan and rhamnogalacturonan type I[J].Carbohydrate Polymers,2007,70(2):224-235.
[27]林华婷.鼠曲草类黄酮制备及其抗氧化抑菌活性研究[D].福州:福建农林大学,2016.
[28]Dai Z Y,Zhang H,Zhang Y P,et al.Chemical properties and immunostimulatory activity of a water-soluble polysaccharide from the clam of Hyriopsis cumingii Lea[J].Carbohydrate Polymers,2009,77(2):365-369.
[29]王瑞芳.两种贝类糖胺聚糖的理化及结构特征研究[D].湛江:广东海洋大学,2009.
[30]Albans S,Schauerte A,Franz G.Anticoagulant sulfated polysaccharides:Part I.Synthesis and structure-activity relationships of new pullulan sulfates[J].Carbohydrate Polymers,2002,47(3):267-276.
[31]吴红棉,范秀萍,雷晓凌,等.波纹巴非蛤氨基多糖的分离纯化及其理化性质的初步研究[J].食品与发酵工业,2005,31(7):133-136.
[32]郭振宇.菲律宾蛤仔蒸煮液多糖的提取、分离及其性质的研究[D].大连:大连海洋大学,2015.
[33]Wang L C,Wu H,Ji J,et al.Preparation,analysis and antioxidant evaluation of the controlled product of polysaccharide from Mactra veneriformis by mild acid hydrolysis[J].Carbohydrate Polymers,2016,137:709-718.
[34]Lu Y,Wang D Y,Hu Y L,et al.Sulfated modification of epimedium polysaccharide and effects of the modifiers on cellular infectivity of IBDV[J].Carbohydrate Polymers,2008,71(2):180-186.
[35]窦昌贵,黄芳,黄罗生,等.文蛤多糖抗癌免疫药理作用的研究[J].中国海洋药物,1999,18(2):15-19.
[36]向维,陈松华,李朝品.彩虹明樱蛤多糖对小鼠的免疫调节作用[J].中国生化药物杂志,2011,32(5):393-395.
[37]郑文文,王令充,吴皓,等.四角蛤蜊粗多糖的免疫调节作用研究[J].中国药师,2011,14(2):151-154.
[38]郭雷,许福泉,樊鑫桐,等.青蛤多糖的提取工艺优化及其抗氧化活性[J].食品研究与开发,2014,35(21):10-14.
[39]蒋长兴,焦云鹏,熊清平,等.海蚬多糖性质及抗氧化活性研究[J].食品与生物技术学报,2013,32(10):1091-1096.
[40]范秀萍,董晓静,吴红棉,等.波纹巴非蛤多糖对高脂模型小鼠血脂的影响[J].现代食品科技,2014,30(1):7-10,21.
[41]董文南,柴尧,刘睿,等.四角蛤蜊粗多糖对四氧嘧啶诱导ICR小鼠糖尿病模型的降血糖作用[J].南京中医药大学学报,2015,31(2):134-137.
[42]向维,陈松华,吴媛媛,等.彩虹明樱蛤多糖对转染HBV的Hep G2细胞表达功能的影响[J].解放军医学杂志,2012,37(2):109-112.
[43]Woo E R,Kim W S,Kim Y S.Virus-cell fusion inhibitory activity for the polysaccharides from various Korean edible clams[J].Archives of Pharmacal Research,2001,24(6):514-517.
[44]向维,陈松华,李朝品.彩虹明樱蛤多糖对小鼠急性化学性肝损伤的保护作用[J].中国生化药物杂志,2012,33(1):43-45.
[45]徐律,李连军,杨最素,等.菲律宾蛤仔提取物及生物活性的研究进展[J].浙江海洋学院学报:自然科学版,2013,32(4):357-361.
[46]张绵松,史亚萍,袁文鹏,等.青柳蛤酶解条件优化及辅助降血压活性的研究[J].食品工业,2017,38(3):52-56.
[47]张倩,刘睿,王欣之,等.高效液相色谱法测定四角蛤蜊、菲律宾蛤仔中呈味核苷酸[J].食品与发酵工业,2017,43(3):224-228.
[48]董晶,慕永通.从产量视角看中国在世界蛤类产业中的地位[J].中国渔业经济,2017,35(1):12-17.
[49]苑旭洲,崔毅,陈碧鹃,等.菲律宾蛤仔对6种重金属的生物富集动力学[J].渔业科学进展,2012,33(4):49-56.
[50]张林宝,吴惠丰,孙伟,等.菲律宾蛤仔对镉、铜暴露的蓄积作用及其抗氧化酶系统的响应研究[J].南方水产科学,2013,9(5):64-70.