我国抗菌剂的应用与发展现状
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摘要
介绍了抗菌剂的抗菌机理,分析了有机抗菌剂、天然抗菌剂和无机抗菌剂的特点。在不同类型的抗菌剂中,传统的有机抗菌剂占据了主要的市场份额,应用领域也最为广泛;天然抗菌剂的使用安全性最高,资源充足,但提取工艺复杂,生产成本较高;无机抗菌剂是目前研究的热点之一,可基于无机抗菌剂研发新型抗菌涂料、抗菌医疗用品等抗菌产品。在此基础上,综述了各类抗菌剂在工业领域的应用和发展现状,同时展望了未来新型抗菌剂的发展方向。
This paper introduces the principle of anti-bacterial agent and analyses the feature of organic antibacterial agent,natural anti-bacterial agent and inorganic anti-bacterial agent.As we all know,traditional organic antibacterial agent has accounted for the majority of market shares and been widely applied in walks of life,while natural anti-bacterial agent has the best security and is derived from the nature with the disadvantage of complicated extraction process and expensive cost.Inorganic anti-bacterial agent is one of the hot topics at present,which could be used for researching and developing new emerging anti-bacterial coating,anti-bacterial medical supplies and the other anti-bacterial products.We also introduce the current situation of anti-bacterial agent′s application and development,and prospect the developing orientation of anti-bacterial agent in the future.
This paper introduces the principle of anti-bacterial agent and analyses the feature of organic antibacterial agent,natural anti-bacterial agent and inorganic anti-bacterial agent.As we all know,traditional organic antibacterial agent has accounted for the majority of market shares and been widely applied in walks of life,while natural anti-bacterial agent has the best security and is derived from the nature with the disadvantage of complicated extraction process and expensive cost.Inorganic anti-bacterial agent is one of the hot topics at present,which could be used for researching and developing new emerging anti-bacterial coating,anti-bacterial medical supplies and the other anti-bacterial products.We also introduce the current situation of anti-bacterial agent′s application and development,and prospect the developing orientation of anti-bacterial agent in the future.
引文
1 Wu Y.Synthesis and surface modification of new antibacterial agent nano-ZnO[D].Dalian:Dalian University of Technology,2013(in Chinese)吴疑.新型抗菌剂Nano-ZnO的合成及表面改性[D].大连:大连理工大学,2013
2 Luo M.The Preparation of silver-loaded nano silica coating and the characterization of its antimicrobial activity and biosafety[D].Changchun:Jilin University,2013(in Chinese)罗梦.纳米二氧化硅载银抗菌涂料制备及其抗菌性和生物安全性研究[D].长春:吉林大学,2013
3 Zhang X W.Study on the influence of nano-Ag/TiO2base inorganic antibacterial agents on antibacterial and mechanical property of room curing polymethylmethacrylate material[D].Changchun:Jilin University,2013(in Chinese)张潇文.纳米Ag/TiO2无机抗菌剂对室温固化型PMMA材料抗菌及力学性能影响的研究[D].长春:吉林大学,2013
4 Shao Q,Huang D G,Yang K.Research headway of antibacterial paint[J].Mater Rev,2008,22(3):60(in Chinese)邵青,黄旦光,杨魁.抗菌涂料研究新进展[J].材料导报,2008,22(3):60
5 Dai X Y,Xu X,Chen Z B,et al.General situation of nano-antibacterial[J].Modern Preventive Med,2008(13):2513(in Chinese)代小英,许欣,陈昭斌,等.纳米抗菌剂的概况[J].现代预防医学,2008(13):2513
6 Gao X H,Xu B S,Wei L Q.Preparation of Ag-carrying zeolite antimicrobial and the study of its properties[J].J Taiyuan University of Technology,2008(5):455(in Chinese)高向华,许并社,魏丽乔.银型沸石抗菌剂的制备与性能研究[J].太原理工大学学报,2008(5):455
7 Tan S,Guo J H,Cui J F.Research status and development trend of antibacterial coatings[J].Chin Coatings,2011(2):16(in Chinese)谭生,郭军红,崔锦峰.抗菌涂料的研究现状及发展趋势[J].中国涂料,2011(2):16
8 Li C,Sun R,Zeng Q Y.Preparation and antimicrobial mechanism of organic polymeric biocides[J].Polym Bull,2011(3):79(in Chinese)李淳,孙蓉,曾秋苑.有机高分子抗菌剂的制备及抗菌机理[J].高分子通报,2011(3):79
9 Li Y,Yang G P,Qian J F.Reviews of research on natural biological[J].Chin J Ethnomed Ethnopharm,2011(21):34(in Chinese)李杨,杨国平,钱金栿.天然生物抗菌剂研究概况[J].中国民族民间医药,2011(21):34
10 Qin J X,Zhang Y T,Chen Y F.Inorganic nano-antibacterial agent and its carriers[J].Mater Rev,2011,25(S2):67(in Chinese)秦嘉旭,张亚涛,陈义丰.无机纳米抗菌剂及其载体[J].材料导报,2011,25(专辑18):67
11 Xu R F,Xu X Y,Fu G Z.Antimicrobial property of nano-TiO2in coatings[J].J Beijing University of Chemical Technology:Nat Sci Ed,2002(5):45(in Chinese)徐瑞芬,许秀艳,付国柱.纳米TiO2在涂料中的抗菌性能研究[J].北京化工大学学报:自然科学版,2002(5):45
12 Jiang S,Wang L,Yu H J.Novel organic polymeric biocides[J].Polym Bull,2002(6):57(in Chinese)江山,王立,俞豪杰.新型有机高分子抗菌剂[J].高分子通报,2002(6):57
13 Yuan P,He H P.Advances of Ag-type inorganic antibacterial agents research[J].Ind Miner Process,2002(10):5(in Chinese)袁鹏,何宏平.银系无机抗菌剂的研究进展[J].化工矿物与加工,2002(10):5
14 Hu B,Liu G J,Liu S H.Research progress in inorganic antibacterial agent applied in antibacterial coatings[J].Mod Paint Finishing,2009(1):18(in Chinese)胡滨,刘国军,刘素花.抗菌涂料中无机抗菌剂的研究进展[J].现代涂料与涂装,2009(1):18
15 Long Q,Zhao G J,Zheng B Z.Study on the antimicrobial activities of nanometer inorganic antibacterial agents TiO2 and ZnO[J].J Yunnan University:Nat Sci,2007(2):173(in Chinese)隆泉,赵革建,郑保忠.新型纳米无机抗菌剂TiO2和ZnO的广谱抗菌性研究[J].云南大学学报:自然科学版,2007(2):173
16 Sun J,Qiao X L,Chen J G.Advancement in research on inorganic antibacterial materials[J].Mater Rev,2007,21(S1):344(in Chinese)孙剑,乔学亮,陈建国.无机抗菌剂的研究进展[J].材料导报,2007,21(专辑Ⅷ):344
17 Su X J,Wang J J.Study Progress of cationic polyacrylamide flocculant agent[J].Tianjin Chem Ind,2007(4):4(in Chinese)苏学军,王建军.抗菌剂在抗菌涂料中的应用进展[J].天津化工,2007(4):4
18 Zhang C H,Xie Y,Xu X.Research and development of antibacterial agent[J].Chem Ind Eng Prog,2007(9):1237(in Chinese)张昌辉,谢瑜,徐旋.抗菌剂的研究进展[J].化工进展,2007(9):1237
19 Zhang K H,Lin S B,Tan S Z.Current research situation and developing trend of organic antibacterial agent[J].Paint Coat Ind,2005(5):45(in Chinese)张葵花,林松柏,谭绍早.有机抗菌剂研究现状及发展趋势[J].涂料工业,2005(5):45
20 Feng D C,Liu X L,Yang Q.Progress in antibacterial agents and antibacteiral fibers[J].Chin Synth Fiber Ind,2005(4):40(in Chinese)冯德才,刘小林,杨其.抗菌剂与抗菌纤维的研究进展[J].合成纤维工业,2005(4):40
21 Zhu W J,Zhang J,Zhu Z Q.Synthesis and properties of modification organic antibacterial[J].J Funct Mater,2005(12):1872(in Chinese)朱文杰,张谨,朱忠其.改性季铵盐抗菌剂的制备及性能研究[J].功能材料,2005(12):1872
22 Ma W,Tuo T T,Zhang S F.Research development of antibacterial agents[J].Fine Chem,2012(6):521(in Chinese)马威,拓婷婷,张淑芬.抗菌剂研究进展[J].精细化工,2012(6):521
23 Wang H S,Qiao X L,Wang X J.Preparation of Ag loaded zeolite antimicrobial and antibacterial property[J].J Mater Sci Eng,2006(1):40(in Chinese)王洪水,乔学亮,王小健.载银沸石抗菌剂的制备及其抗菌性能[J].材料科学与工程学报,2006(1):40
24 Wang Q P,Wu W H.Current research progress and prospect of new type of inorganic antibacterial agent[J].Ceramics,2006(3):3(in Chinese)王黔平,吴卫华.新型无机抗菌剂的研究现状和展望[J].陶瓷,2006(3):3
25 Chen Y B,Shi Q S,Zou H Q.Common antibacterial agent used in fabric[J].Knitting Ind,2006(8):25(in Chinese)陈仪本,施庆珊,邹海清.纺织品常用抗菌剂[J].针织工业,2006(8):25
26 Sun H,Xia Y,Chen L.Present situation and development trend of Research on antibacterial agent at home and abroad[J].Chin Plast Ind,2006(9):1(in Chinese)孙洪,夏英,陈莉.国内外抗菌剂的研究现状及发展趋势[J].塑料工业,2006(9):1
27 She W J,Hu B,Zhang F Q.Influence of nano-silver base inorganic antimicrobial on denture base resin[J].J Shanghai Jiaotong University:Med Sci,2006(10):1096(in Chinese)佘文珺,胡滨,张富强.纳米载银无机抗菌剂对义齿基托树脂抗菌性能的影响[J].上海交通大学学报:医学版,2006(10):1096
28 Yang C,Wang Y P,Guo J S.Study on environmentally friendly nano-silver modified fluorocarbon antibacterial paint[J].Moder Paint Finishing,2008(2):21(in Chinese)杨超,王云普,郭金山.环境友好型纳米银/氟碳抗菌涂料的研究[J].现代涂料与涂装,2008(2):21
29 Yin J.Study on preparation and antibacterial application of silver nanoparticles[D].Chengdu:Sichuan University,2006(in Chinese)殷杰.纳米银粉的制备工艺及抗菌应用研究[D].成都:四川大学,2006
30 Ji X F,Li Y P,Yang L Q.The development and application of antibacterial agents and antibacterial materials[J].J Taiyuan University of Technology,2003(1):11(in Chinese)吉向飞,李玉平,杨柳青.抗菌剂及抗菌材料的发展和应用[J].太原理工大学学报,2003(1):11
31 Wang X J,Qiao X L,Chen J G.Advancement in research on inorganic antibacterial materias[J].J Ceram,2003(4):239(in Chinese)王小健,乔学亮,陈建国.无机抗菌剂的研究现状及发展趋势[J].陶瓷学报,2003(4):239
32 Chen Y J,Li B G,Wang Y Q.Advances in organic antibacterial agents[J].Petrol Process Petrochem,2003(1):56(in Chinese)陈拥军,李本高,汪燮卿.有机抗菌剂研究的新进展[J].石油炼制与化工,2003(1):56
33 Lu Y T,Zhu Y G,Qu J M.Study on the antibaterial effect in vitro and security of silver-containing zirconium phosphate antibacterial agents of nanometer level[J].Chin J Clinical Pharm,2010(1):18(in Chinese)陆运涛,朱迎钢,瞿介明.磷酸锆纳米载银抗菌剂的体外抗菌效果及安全性评价[J].中国临床药学杂志,2010(1):18
34 Xia H M,Sun B,Feng X X.Classification,application and development of the inorganic antibacterial materials[J].China Textile Leader,2010(6):115(in Chinese)夏海民,孙斌,冯新星.无机抗菌剂的分类应用及发展[J].纺织导报,2010(6):115
35 Ding S.Natural anti-bacterial agent and its application[J].Shandong Textile Sci Technol,2010(5):50(in Chinese)丁帅.天然抗菌剂及其应用[J].山东纺织科技,2010(5):50
36 Zuo H J,Wen W H,Wu D C.State-of-the-art of antibacterial polymers[J].Chem Ind Eng Prog,2013(3):604(in Chinese)左华江,温婉华,吴丁财.高分子抗菌剂的研究现状[J].化工进展,2013(3):604
37 Xiao Q H,Li B W,Wang N.Current research progress and developing trend of inorganic antibacterial agent loaded Ag[J].Chin Nonmetallic Mining Ind,2002(6):5(in Chinese)肖清华,李博文,王宁.载银无机抗菌剂的研究现状和发展趋势[J].中国非金属矿工业导刊,2002(6):5
38 Chen Lin,Chen Zhiming,Xue Zhenglian,et al.Synthesis and antibacillus of Fe3O4nanomaterials[J].J Chongqing Institute of Technology:Nat Sci Ed,2013,27(4):7(in Chinese)陈林,陈志明,薛正莲,等.Fe3O4纳米材料的制备及其抗菌性[J].重庆理工大学学报:自然科学版,2013,27(4):7
2 Luo M.The Preparation of silver-loaded nano silica coating and the characterization of its antimicrobial activity and biosafety[D].Changchun:Jilin University,2013(in Chinese)罗梦.纳米二氧化硅载银抗菌涂料制备及其抗菌性和生物安全性研究[D].长春:吉林大学,2013
3 Zhang X W.Study on the influence of nano-Ag/TiO2base inorganic antibacterial agents on antibacterial and mechanical property of room curing polymethylmethacrylate material[D].Changchun:Jilin University,2013(in Chinese)张潇文.纳米Ag/TiO2无机抗菌剂对室温固化型PMMA材料抗菌及力学性能影响的研究[D].长春:吉林大学,2013
4 Shao Q,Huang D G,Yang K.Research headway of antibacterial paint[J].Mater Rev,2008,22(3):60(in Chinese)邵青,黄旦光,杨魁.抗菌涂料研究新进展[J].材料导报,2008,22(3):60
5 Dai X Y,Xu X,Chen Z B,et al.General situation of nano-antibacterial[J].Modern Preventive Med,2008(13):2513(in Chinese)代小英,许欣,陈昭斌,等.纳米抗菌剂的概况[J].现代预防医学,2008(13):2513
6 Gao X H,Xu B S,Wei L Q.Preparation of Ag-carrying zeolite antimicrobial and the study of its properties[J].J Taiyuan University of Technology,2008(5):455(in Chinese)高向华,许并社,魏丽乔.银型沸石抗菌剂的制备与性能研究[J].太原理工大学学报,2008(5):455
7 Tan S,Guo J H,Cui J F.Research status and development trend of antibacterial coatings[J].Chin Coatings,2011(2):16(in Chinese)谭生,郭军红,崔锦峰.抗菌涂料的研究现状及发展趋势[J].中国涂料,2011(2):16
8 Li C,Sun R,Zeng Q Y.Preparation and antimicrobial mechanism of organic polymeric biocides[J].Polym Bull,2011(3):79(in Chinese)李淳,孙蓉,曾秋苑.有机高分子抗菌剂的制备及抗菌机理[J].高分子通报,2011(3):79
9 Li Y,Yang G P,Qian J F.Reviews of research on natural biological[J].Chin J Ethnomed Ethnopharm,2011(21):34(in Chinese)李杨,杨国平,钱金栿.天然生物抗菌剂研究概况[J].中国民族民间医药,2011(21):34
10 Qin J X,Zhang Y T,Chen Y F.Inorganic nano-antibacterial agent and its carriers[J].Mater Rev,2011,25(S2):67(in Chinese)秦嘉旭,张亚涛,陈义丰.无机纳米抗菌剂及其载体[J].材料导报,2011,25(专辑18):67
11 Xu R F,Xu X Y,Fu G Z.Antimicrobial property of nano-TiO2in coatings[J].J Beijing University of Chemical Technology:Nat Sci Ed,2002(5):45(in Chinese)徐瑞芬,许秀艳,付国柱.纳米TiO2在涂料中的抗菌性能研究[J].北京化工大学学报:自然科学版,2002(5):45
12 Jiang S,Wang L,Yu H J.Novel organic polymeric biocides[J].Polym Bull,2002(6):57(in Chinese)江山,王立,俞豪杰.新型有机高分子抗菌剂[J].高分子通报,2002(6):57
13 Yuan P,He H P.Advances of Ag-type inorganic antibacterial agents research[J].Ind Miner Process,2002(10):5(in Chinese)袁鹏,何宏平.银系无机抗菌剂的研究进展[J].化工矿物与加工,2002(10):5
14 Hu B,Liu G J,Liu S H.Research progress in inorganic antibacterial agent applied in antibacterial coatings[J].Mod Paint Finishing,2009(1):18(in Chinese)胡滨,刘国军,刘素花.抗菌涂料中无机抗菌剂的研究进展[J].现代涂料与涂装,2009(1):18
15 Long Q,Zhao G J,Zheng B Z.Study on the antimicrobial activities of nanometer inorganic antibacterial agents TiO2 and ZnO[J].J Yunnan University:Nat Sci,2007(2):173(in Chinese)隆泉,赵革建,郑保忠.新型纳米无机抗菌剂TiO2和ZnO的广谱抗菌性研究[J].云南大学学报:自然科学版,2007(2):173
16 Sun J,Qiao X L,Chen J G.Advancement in research on inorganic antibacterial materials[J].Mater Rev,2007,21(S1):344(in Chinese)孙剑,乔学亮,陈建国.无机抗菌剂的研究进展[J].材料导报,2007,21(专辑Ⅷ):344
17 Su X J,Wang J J.Study Progress of cationic polyacrylamide flocculant agent[J].Tianjin Chem Ind,2007(4):4(in Chinese)苏学军,王建军.抗菌剂在抗菌涂料中的应用进展[J].天津化工,2007(4):4
18 Zhang C H,Xie Y,Xu X.Research and development of antibacterial agent[J].Chem Ind Eng Prog,2007(9):1237(in Chinese)张昌辉,谢瑜,徐旋.抗菌剂的研究进展[J].化工进展,2007(9):1237
19 Zhang K H,Lin S B,Tan S Z.Current research situation and developing trend of organic antibacterial agent[J].Paint Coat Ind,2005(5):45(in Chinese)张葵花,林松柏,谭绍早.有机抗菌剂研究现状及发展趋势[J].涂料工业,2005(5):45
20 Feng D C,Liu X L,Yang Q.Progress in antibacterial agents and antibacteiral fibers[J].Chin Synth Fiber Ind,2005(4):40(in Chinese)冯德才,刘小林,杨其.抗菌剂与抗菌纤维的研究进展[J].合成纤维工业,2005(4):40
21 Zhu W J,Zhang J,Zhu Z Q.Synthesis and properties of modification organic antibacterial[J].J Funct Mater,2005(12):1872(in Chinese)朱文杰,张谨,朱忠其.改性季铵盐抗菌剂的制备及性能研究[J].功能材料,2005(12):1872
22 Ma W,Tuo T T,Zhang S F.Research development of antibacterial agents[J].Fine Chem,2012(6):521(in Chinese)马威,拓婷婷,张淑芬.抗菌剂研究进展[J].精细化工,2012(6):521
23 Wang H S,Qiao X L,Wang X J.Preparation of Ag loaded zeolite antimicrobial and antibacterial property[J].J Mater Sci Eng,2006(1):40(in Chinese)王洪水,乔学亮,王小健.载银沸石抗菌剂的制备及其抗菌性能[J].材料科学与工程学报,2006(1):40
24 Wang Q P,Wu W H.Current research progress and prospect of new type of inorganic antibacterial agent[J].Ceramics,2006(3):3(in Chinese)王黔平,吴卫华.新型无机抗菌剂的研究现状和展望[J].陶瓷,2006(3):3
25 Chen Y B,Shi Q S,Zou H Q.Common antibacterial agent used in fabric[J].Knitting Ind,2006(8):25(in Chinese)陈仪本,施庆珊,邹海清.纺织品常用抗菌剂[J].针织工业,2006(8):25
26 Sun H,Xia Y,Chen L.Present situation and development trend of Research on antibacterial agent at home and abroad[J].Chin Plast Ind,2006(9):1(in Chinese)孙洪,夏英,陈莉.国内外抗菌剂的研究现状及发展趋势[J].塑料工业,2006(9):1
27 She W J,Hu B,Zhang F Q.Influence of nano-silver base inorganic antimicrobial on denture base resin[J].J Shanghai Jiaotong University:Med Sci,2006(10):1096(in Chinese)佘文珺,胡滨,张富强.纳米载银无机抗菌剂对义齿基托树脂抗菌性能的影响[J].上海交通大学学报:医学版,2006(10):1096
28 Yang C,Wang Y P,Guo J S.Study on environmentally friendly nano-silver modified fluorocarbon antibacterial paint[J].Moder Paint Finishing,2008(2):21(in Chinese)杨超,王云普,郭金山.环境友好型纳米银/氟碳抗菌涂料的研究[J].现代涂料与涂装,2008(2):21
29 Yin J.Study on preparation and antibacterial application of silver nanoparticles[D].Chengdu:Sichuan University,2006(in Chinese)殷杰.纳米银粉的制备工艺及抗菌应用研究[D].成都:四川大学,2006
30 Ji X F,Li Y P,Yang L Q.The development and application of antibacterial agents and antibacterial materials[J].J Taiyuan University of Technology,2003(1):11(in Chinese)吉向飞,李玉平,杨柳青.抗菌剂及抗菌材料的发展和应用[J].太原理工大学学报,2003(1):11
31 Wang X J,Qiao X L,Chen J G.Advancement in research on inorganic antibacterial materias[J].J Ceram,2003(4):239(in Chinese)王小健,乔学亮,陈建国.无机抗菌剂的研究现状及发展趋势[J].陶瓷学报,2003(4):239
32 Chen Y J,Li B G,Wang Y Q.Advances in organic antibacterial agents[J].Petrol Process Petrochem,2003(1):56(in Chinese)陈拥军,李本高,汪燮卿.有机抗菌剂研究的新进展[J].石油炼制与化工,2003(1):56
33 Lu Y T,Zhu Y G,Qu J M.Study on the antibaterial effect in vitro and security of silver-containing zirconium phosphate antibacterial agents of nanometer level[J].Chin J Clinical Pharm,2010(1):18(in Chinese)陆运涛,朱迎钢,瞿介明.磷酸锆纳米载银抗菌剂的体外抗菌效果及安全性评价[J].中国临床药学杂志,2010(1):18
34 Xia H M,Sun B,Feng X X.Classification,application and development of the inorganic antibacterial materials[J].China Textile Leader,2010(6):115(in Chinese)夏海民,孙斌,冯新星.无机抗菌剂的分类应用及发展[J].纺织导报,2010(6):115
35 Ding S.Natural anti-bacterial agent and its application[J].Shandong Textile Sci Technol,2010(5):50(in Chinese)丁帅.天然抗菌剂及其应用[J].山东纺织科技,2010(5):50
36 Zuo H J,Wen W H,Wu D C.State-of-the-art of antibacterial polymers[J].Chem Ind Eng Prog,2013(3):604(in Chinese)左华江,温婉华,吴丁财.高分子抗菌剂的研究现状[J].化工进展,2013(3):604
37 Xiao Q H,Li B W,Wang N.Current research progress and developing trend of inorganic antibacterial agent loaded Ag[J].Chin Nonmetallic Mining Ind,2002(6):5(in Chinese)肖清华,李博文,王宁.载银无机抗菌剂的研究现状和发展趋势[J].中国非金属矿工业导刊,2002(6):5
38 Chen Lin,Chen Zhiming,Xue Zhenglian,et al.Synthesis and antibacillus of Fe3O4nanomaterials[J].J Chongqing Institute of Technology:Nat Sci Ed,2013,27(4):7(in Chinese)陈林,陈志明,薛正莲,等.Fe3O4纳米材料的制备及其抗菌性[J].重庆理工大学学报:自然科学版,2013,27(4):7