316例男性急性痛风性关节炎中医证候分类研究
|
摘要
目的通过数据挖掘探索男性急性痛风性关节炎的中医证候特点。方法采集316例男性急性痛风性关节炎病例症状信息,将每一症状作为一个统计变量,有赋值为1、无赋值为0,计算各症状的频次和频率,对主要症状进行因子分析并提取公因子,以公因子作为变量进行聚类分析。结果频率超过30%的症状为舌红(62. 0%)、舌胖大(56. 3%)、疲劳(45. 6%)、关节灼痛(42. 7%)、口苦(38. 3%)、脉数(36. 1%)、关节冷痛(32. 6%)、胃胀(32. 3%)、畏寒(30. 1%),提取公因子共10项,总贡献率累计69. 667%。聚类分析获得男性急性痛风性关节炎辨证分型5种,分别为脾肾阳虚型、痰热内蕴型、热毒炽盛型、肝肾亏虚型、阳虚湿阻型。结论男性急性痛风性关节炎的主要中医证型可分为5种,但临证应注意结合患者的病程、年龄、体质等因素具体论治。
Objective To explore the characteristics of traditional Chinese medicine( TCM) syndrome of male acute gout arthritis by data mining. Methods The symptom information of 316 male patients with acute gout arthritis was collected. Each symptom was used as a statistical variable,assigning value 1 or 0 for "with"or "without"a symptom. The frequency and frequency rate of each symptom were calculated. Factor analysis was performed on the main symptoms and common factors were extracted. Clustering analysis was performed using the common factor as a variable. Results The symptoms with a frequency rate more than 30% were red tongue( 62. 0%),fat tongue( 56. 3%),fatigue( 45. 6%),joint burning( 42. 7%),bitter mouth( 38. 3%),rapid pulse( 36. 1%),joint cold pain( 32. 6%),stomach distension( 32. 3%),and aversion to cold( 30. 1%). A total of 10 common factors were extracted. The total contribution rate was 69. 667%. Clustering analysis obtained 5 types of male acute gout arthritis syndrome differentiation including spleen-kidney yang deficiency type,internal accumulation of phlegm-heat type,heat-toxic flaming type,liver-kidney deficiency type,and yang deficiency and damp obstruction type. Conclusion The main TCM syndrome differentiation pattern of male acute gout arthritis can be divided into 5 types,but the clinical syndrome should be combined with the specific treatment of the patient's disease course,age,physical constitution and other factors.
Objective To explore the characteristics of traditional Chinese medicine( TCM) syndrome of male acute gout arthritis by data mining. Methods The symptom information of 316 male patients with acute gout arthritis was collected. Each symptom was used as a statistical variable,assigning value 1 or 0 for "with"or "without"a symptom. The frequency and frequency rate of each symptom were calculated. Factor analysis was performed on the main symptoms and common factors were extracted. Clustering analysis was performed using the common factor as a variable. Results The symptoms with a frequency rate more than 30% were red tongue( 62. 0%),fat tongue( 56. 3%),fatigue( 45. 6%),joint burning( 42. 7%),bitter mouth( 38. 3%),rapid pulse( 36. 1%),joint cold pain( 32. 6%),stomach distension( 32. 3%),and aversion to cold( 30. 1%). A total of 10 common factors were extracted. The total contribution rate was 69. 667%. Clustering analysis obtained 5 types of male acute gout arthritis syndrome differentiation including spleen-kidney yang deficiency type,internal accumulation of phlegm-heat type,heat-toxic flaming type,liver-kidney deficiency type,and yang deficiency and damp obstruction type. Conclusion The main TCM syndrome differentiation pattern of male acute gout arthritis can be divided into 5 types,but the clinical syndrome should be combined with the specific treatment of the patient's disease course,age,physical constitution and other factors.
引文
[1]GRASSI D,FERRI L,DESIDERI G,et al. Chronic hyperuricemia,uric acid deposit and cardiovascular risk[J]. Curr Pharm Des,2013,19(13):2432-2438.
[2]夏璇,黄清春.黄清春教授中西医结合治疗痛风性关节炎经验[J].新中医,2014,46(6):26-27.
[3]盛磊.从阳明论治急性痛风性关节炎临床观察[J].中国中医急症,2015,24(2):327-329.
[4]中华医学会.临床诊疗指南:风湿病学分册[M].北京:人民卫生出版社,2005:123.
[5]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:9.
[6]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:26.
[7]党万太,周京国,谢文光,等. NLRP3炎性体在痛风性关节炎患者炎症反应中的机制研究[J].中国免疫学杂志,2014,30(3):373-377,382.
[8]张峰,池继敏.急性痛风患者血清中免疫球蛋白和补体水平的探讨[J].检验医学与临床,2013,17(A2):156-157.
[9]孟庆良,张子扬,苗喜云.朱良春泄浊化瘀法治疗痛风性关节炎经验[J].中医杂志,2017,58(16):1368-1370.
[10]朱远飞.痛风性关节炎急性期中医治疗的规律探究[J].医药前沿,2016,6(2):321-322.
[11]王新贤,殷海波,陈亚光,等.从伏气学说探讨痛风的发病特点及临床辨治[J].中医杂志,2016,57(13):1168-1170.
[12]朱婉华,张爱红,顾冬梅,等.痛风性关节炎中医证候分布规律探讨[J].中医杂志,2012,53(19):1667-1670.
[13]张汝卫.健脾祛湿清热凉血方配合消瘀止痛药膏治疗急性痛风性关节炎48例临床观察[J].中医杂志,2013,54(24):2121-2123.
[14]袁晓,范永升,谢冠群,等.加味四妙丸联合西药治疗急性痛风性关节炎28例临床研究[J].中医杂志,2017,58(24):2107-2110.
[15]高祥祥,王海峰,张红.秦艽对尿酸钠痛风模型大鼠的保护作用[J].中药药理与临床,2015,31(4):141-144.
[16]郑德勇,刘峻承.红藤虎杖汤治疗急性痛风性关节炎43例[J].中医杂志,2013,54(3):250-251.
[17]王鑫,唐今扬,周彩云,等.房定亚运用“治未病”思想防治痛风性关节炎经验[J].中医杂志,2017,58(15):1274-1277.
[2]夏璇,黄清春.黄清春教授中西医结合治疗痛风性关节炎经验[J].新中医,2014,46(6):26-27.
[3]盛磊.从阳明论治急性痛风性关节炎临床观察[J].中国中医急症,2015,24(2):327-329.
[4]中华医学会.临床诊疗指南:风湿病学分册[M].北京:人民卫生出版社,2005:123.
[5]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:9.
[6]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:26.
[7]党万太,周京国,谢文光,等. NLRP3炎性体在痛风性关节炎患者炎症反应中的机制研究[J].中国免疫学杂志,2014,30(3):373-377,382.
[8]张峰,池继敏.急性痛风患者血清中免疫球蛋白和补体水平的探讨[J].检验医学与临床,2013,17(A2):156-157.
[9]孟庆良,张子扬,苗喜云.朱良春泄浊化瘀法治疗痛风性关节炎经验[J].中医杂志,2017,58(16):1368-1370.
[10]朱远飞.痛风性关节炎急性期中医治疗的规律探究[J].医药前沿,2016,6(2):321-322.
[11]王新贤,殷海波,陈亚光,等.从伏气学说探讨痛风的发病特点及临床辨治[J].中医杂志,2016,57(13):1168-1170.
[12]朱婉华,张爱红,顾冬梅,等.痛风性关节炎中医证候分布规律探讨[J].中医杂志,2012,53(19):1667-1670.
[13]张汝卫.健脾祛湿清热凉血方配合消瘀止痛药膏治疗急性痛风性关节炎48例临床观察[J].中医杂志,2013,54(24):2121-2123.
[14]袁晓,范永升,谢冠群,等.加味四妙丸联合西药治疗急性痛风性关节炎28例临床研究[J].中医杂志,2017,58(24):2107-2110.
[15]高祥祥,王海峰,张红.秦艽对尿酸钠痛风模型大鼠的保护作用[J].中药药理与临床,2015,31(4):141-144.
[16]郑德勇,刘峻承.红藤虎杖汤治疗急性痛风性关节炎43例[J].中医杂志,2013,54(3):250-251.
[17]王鑫,唐今扬,周彩云,等.房定亚运用“治未病”思想防治痛风性关节炎经验[J].中医杂志,2017,58(15):1274-1277.