中药及复方减少阿尔茨海默病氧化损伤研究探析
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摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种常见的神经系统变性性疾病。氧化应激在AD疾病发生与发展中起着重要作用,从健康人到AD疾病中,抗氧化系统与氧化系统失衡逐渐加重,调节氧化应激水平对AD疾病的进程有积极的意义。中药及复方可通过提高体内抗氧化酶活性,减少自由基生成,来减少Aβ聚集,从而减轻炎症反应及细胞毒性。本文通过综述中药及复方减少AD氧化损伤的研究进展,为临床防治AD提供依据。
Alzheimer’s disease(AD) is a common neurodegenerative disease in nervous system. Oxidative stress plays an important role in the occurrence and development of AD. From healthy people to AD patients, the imbalance of antioxidant system and oxidation system is gradually increasing. It is of positive significance to regulate the level of oxidative stress to the process of AD. Traditional Chinese Medicine and compound can reduce the accumulation of Aβ by increasing the activity of antioxidant enzymes in the body and reducing the formation of free radicals, thus reducing the inflammatory reaction and cycotoxicity. In this paper, we reviewed the research progress of Chinese medicine and compound prescription to reduce oxidative damage, and provided evidence for clinical prevention and treatment of AD.
Alzheimer’s disease(AD) is a common neurodegenerative disease in nervous system. Oxidative stress plays an important role in the occurrence and development of AD. From healthy people to AD patients, the imbalance of antioxidant system and oxidation system is gradually increasing. It is of positive significance to regulate the level of oxidative stress to the process of AD. Traditional Chinese Medicine and compound can reduce the accumulation of Aβ by increasing the activity of antioxidant enzymes in the body and reducing the formation of free radicals, thus reducing the inflammatory reaction and cycotoxicity. In this paper, we reviewed the research progress of Chinese medicine and compound prescription to reduce oxidative damage, and provided evidence for clinical prevention and treatment of AD.
引文
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2 Christen Y.Oxidative stress and Alzheimer disease.American Journal of Clinical Nutrition,2000,71(2):621S-629S.
3许湘,石和元,孔明望,等.补肾化痰益智法对APP/PS1双转基因小鼠学习记忆及抗氧化能力的影响.中国实验方剂学杂志,2015,21(8):102-105.
4宋敏洁,杨毅,叶俊杰,等.怡心健脑颗粒对D-半乳糖合β-AP_(25-35)诱导AD小鼠的药效研究.中国现代应用药学,2011,28(11):977-980.
5刘晓.从痰论治老年性痴呆及化痰方对APP/PS1转基因小鼠LTP和抗氧化的研究.武汉:湖北中医药大学硕士研究生学位论文,2016.
6梁琳,田芳,刘剑刚,等.还脑益聪方对D-半乳糖结合半高脂饲料致认知障碍模型大鼠学习记忆和抗氧化作用的影响.中国药学杂志,2013,48(11):867-868.
7陈骐,张宇燕.远志、石菖蒲配伍抗阿尔茨海默病模型大鼠脑自由基损伤的实验研究.世界中西医结合杂志,2010,5(7):579-581.
8贾春霞,张宇燕,杨洁红,等.补肾通络涤痰方治疗AD模型大鼠的实验研究.中华中医药学刊,2010,28(8):1642-1644.
9白振忠,靳国恩,芦殿香,等.藏药七十味珍珠丸对老年痴呆模型大鼠学习记忆和超氧化物歧化酶、丙二醛的影响.青海医学院学报,2011,32(1):29-31.
10李海龙,王虎平,刘建鸿,等.黑逍遥散对Aβ(25-35)诱导AD大鼠模型脑组织和血清SOD,GSH-Px及MDA的影响.中国实验方剂学杂志,2013,19(21):186-189.
11吴红彦,李海龙,顾静,等.黑逍遥散对Aβ(25-35)诱导AD模型大鼠脑组织神经递质及海马病理改变的影响.中国老年学杂志,2015,35(16):4417-4420.
12石荣伟.参七汤对阿尔茨海默病模型大鼠行为学和抗氧化作用的实验研究.太原:山西中医学院硕士研究生学位论文,2015.
13蔡标,谢道俊,王艳,等.黄蒲通窍胶囊对阿尔茨海默病大鼠海马氧化应激和线粒体凋亡途径的影响.中国中西医结合杂志,2018,38(6):707-711.
14张忠立,左月明.延龄草提取物对异质性及多因性阿尔茨海默病模型大鼠学习记忆与抗氧化能力的影响.中国老年学杂志,2016,36(14):3362-3364.
15杨坦.肉桂改善阿尔茨海默病大鼠学习记忆通过抑制海马氧化应激.中医临床研究,2017,9(2):8-11.
16王涛涛.黄精水煎剂对β-淀粉样蛋白诱导的大鼠学习记忆能力下降的保护作用及其机理研究.合肥:安徽医科大学硕士研究生学位论文,2013.
17 Motohashi H,Yamamoto M.Nrf2-Keap1 defines a physiologically important stress response mechanism.Trends Mol Med,2004,10(11):549-557.
18曹惠敏,余刚.Nrf2在阿尔茨海默病中的研究现状.生物化学与生物物理进展,2015,42(6):533-539.
19于淼.地黄饮子对Aβ(25-35)诱导PC12细胞损伤氧化应激及Ca2+通道的影响.哈尔滨:黑龙江中医药大学硕士研究生学位论文,2010.
20吴小凡,马斌,侯训尧,等.柿叶提取物对HEK293-APPswe转基因细胞模型的抗氧化作用及对Nrf2/HO-1途径的影响.中国免疫学杂志,2017,33(6):854-858.
21姜洋.补肾祛瘀化痰法对轻度认知功能损害患者认知功能及氧化应激影响的研究.北京:北京中医药大学博士研究生学位论文,2014.
22王澍,张雪,马樱芮,等.补肾化痰益智方联合丁苯酞对阿尔茨海默病患者氧化应激、血流变学及认知功能的影响.中国实验方剂学杂志,2018,24(7):212-216.
23 Hardy J A,Higgins G A.Alzheimer's disease:the amyloid cascade hypothesis.Science,1992,256(5054):184-185.
24 Cai Z,Zhao B,Ratka A.Oxidative stress and beta-amyloid protein in Alzheimer’s disease.Neuro Molecular Medicine.2011,13(4):223-250.
25 Misonou H,Morishima-Kawashima M,Ihara Y.Oxidative stress induces intracellular accumulation of amyloidβ-protein(Aβ)in human neuroblastoma cells.Biochemistry,2000,39(23):6951-6959.
26姜招峰.阿尔茨海默病发病机理及其相关生物活性物质研究.北京:中国轻工业出版社.2016:23.
27 Wojsiat J,Zoltowska K M,Laskowskakaszub K,et al.Oxidant/Antioxidant imbalance in Alzheimer's Disease:Therapeutic and diagnostic prospects.Oxidative Medicine&Cellular Longevity,2018,2018(13):6435861.
28周玲.补肾活血化痰法对秀丽线虫抗氧化及Aβ蛋白毒性作用研究.武汉:湖北中医药大学博士研究生学位论文,2017.
29 Clausen A,Xu X,Bi X,et al.Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer’s Disease:Protection against and interruption of progression of amyloid and tau pathology and cognitive decline.J Alzheimers Dis,2012,30(1):183-208.
30 Behl C,Davis J,Cole G M,et al.Vitamin E protects nerve cells from amyloidβprotein toxicity.Biochemical&Biophysical Research Communications,1992,186(2):944.
31 Meng F,Li J,Rao Y,et al.A Chinese herbal formula,gengnianchun,amelioratesβ-amyloid peptide toxicity in a Caenorhabditis elegans model of Alzheimer's Disease.Evid Based Complement Alternat Med.2017,7480980.
32邱昕,陈国华,汪弢,等.黄连解毒汤对APP/PS1双转基因阿尔茨海默病小鼠自由基代谢及海马区病理形态学影响.中国中西医结合杂志,2011,31(10):1379-1382.
33 Muriach M,Floresbellver M,Romero F J,et al.Diabetes and the brain:oxidative stress,inflammation,and autophagy.Oxidative Medicine&Cellular Longevity,2014,2014(102158):102158.
34 Perry G,Castellani R J,Hirai K,et al.Reactive oxygen species mediate cellular damage in Alzheimer Disease.Journal of Alzheimers Disease Jad,1998,1(1):45.
35黄作义,许志刚,吴成吉,等.远志对Aβ25-35诱导AD模型大鼠海马区NF-κB活化研究.黑龙江医药科学,2010,33(2):6-7.
36蒋辉,徐运,姜亚军.远志皂苷元对AD模型小鼠学习记忆能力的影响及其机制研究.现代中西医结合杂志,2013,22(11):1153-1155.
37石成男,李秀国,许青松,等.远志水提物对阿尔茨海默病模型小鼠学习记忆的影响.中风与神经疾病杂志,2011,28(7):620-622.
38樊云峰.远志提取物对阿尔采末病模型大鼠学习记忆能力的影响.中国新药与临床杂志,2015,34(7):517-521.
39王改凤.补肾益智方对D-半乳糖联合β-淀粉样蛋白25-35致老年痴呆模型大鼠的作用及机制.中国组织工程研究,2016,20(49):7307-7313.
40胡小军,余长江,李俊,等.补肾通络汤治疗阿尔茨海默病40例的临床分析.中国实验方剂学杂志,2015,21(11):182-185.
41梁少瑜,曾永长,俞励平,等.天泰1号对Aβ(1-40)诱导PC12神经毒性的保护作用及其机制研究.中药药理与临床,2017,33(2):140-144.
42周鸿,霍利琴,张静泽,等.舒脑欣滴丸对D-半乳糖致阿尔茨海默病早期模型大鼠的神经保护作用及机制研究.中草药,2016,47(17):3074-3078.
43 Huang S W,Wang W,et.al.The effect of ethyl acetate extract from persimmon leaves on Alzheimer's Disease and its underlying mechanism.Phytomedicine,2016,15,23(7):694-704.
44史殿志.阿尔茨海默病患者血清氧化应激相关指标及Aβ水平测定的临床意义.中国医药导报,2017,14(7):117-120.
45 Omar R A,Chyan Y J,Andorn A C,et al.Increased expression but reduced activity of antioxidant enzymes in Alzheimer's disease.J Alzheimers Dis,1999,1:139-145.
46 Wojsiat J,Zoltowska K M,Laskowskakaszub K,et al.Oxidant/Antioxidant imbalance in Alzheimer's Disease:therapeutic and diagnostic prospects.Oxidative Medicine&Cellular Longevity,2018,2018(13):6435861.
47 Butterfield D A;Reed T;Perluigi M,et al.Elevated protein-bound levels of the lipid peroxidation product,4-hydroxy-2-nonenal,in brain from persons with mild cognitive impairment.Neuroscience Letters,2006,397(3):170-173.
48 Nunomura A.Oxidative stress hypothesis for Alzheimer's disease and its potential therapeutic implications.Rinshōshinkeigaku=Clinical neurology,2013,53(11):1043-1045.
49 Clausen A,Xu X,Bi X,et al.Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer’s disease:protection against and interruption of progression of amyloid and tau pathology and cognitive decline.J Alzheimers Dis,2012,30(1):183-208.
50 de Leeuw F A,Cfw P,Kester M I,et al.Blood-based metabolic signatures in Alzheimer's disease.Alzheimers&Dementia,2017,8:196.
2 Christen Y.Oxidative stress and Alzheimer disease.American Journal of Clinical Nutrition,2000,71(2):621S-629S.
3许湘,石和元,孔明望,等.补肾化痰益智法对APP/PS1双转基因小鼠学习记忆及抗氧化能力的影响.中国实验方剂学杂志,2015,21(8):102-105.
4宋敏洁,杨毅,叶俊杰,等.怡心健脑颗粒对D-半乳糖合β-AP_(25-35)诱导AD小鼠的药效研究.中国现代应用药学,2011,28(11):977-980.
5刘晓.从痰论治老年性痴呆及化痰方对APP/PS1转基因小鼠LTP和抗氧化的研究.武汉:湖北中医药大学硕士研究生学位论文,2016.
6梁琳,田芳,刘剑刚,等.还脑益聪方对D-半乳糖结合半高脂饲料致认知障碍模型大鼠学习记忆和抗氧化作用的影响.中国药学杂志,2013,48(11):867-868.
7陈骐,张宇燕.远志、石菖蒲配伍抗阿尔茨海默病模型大鼠脑自由基损伤的实验研究.世界中西医结合杂志,2010,5(7):579-581.
8贾春霞,张宇燕,杨洁红,等.补肾通络涤痰方治疗AD模型大鼠的实验研究.中华中医药学刊,2010,28(8):1642-1644.
9白振忠,靳国恩,芦殿香,等.藏药七十味珍珠丸对老年痴呆模型大鼠学习记忆和超氧化物歧化酶、丙二醛的影响.青海医学院学报,2011,32(1):29-31.
10李海龙,王虎平,刘建鸿,等.黑逍遥散对Aβ(25-35)诱导AD大鼠模型脑组织和血清SOD,GSH-Px及MDA的影响.中国实验方剂学杂志,2013,19(21):186-189.
11吴红彦,李海龙,顾静,等.黑逍遥散对Aβ(25-35)诱导AD模型大鼠脑组织神经递质及海马病理改变的影响.中国老年学杂志,2015,35(16):4417-4420.
12石荣伟.参七汤对阿尔茨海默病模型大鼠行为学和抗氧化作用的实验研究.太原:山西中医学院硕士研究生学位论文,2015.
13蔡标,谢道俊,王艳,等.黄蒲通窍胶囊对阿尔茨海默病大鼠海马氧化应激和线粒体凋亡途径的影响.中国中西医结合杂志,2018,38(6):707-711.
14张忠立,左月明.延龄草提取物对异质性及多因性阿尔茨海默病模型大鼠学习记忆与抗氧化能力的影响.中国老年学杂志,2016,36(14):3362-3364.
15杨坦.肉桂改善阿尔茨海默病大鼠学习记忆通过抑制海马氧化应激.中医临床研究,2017,9(2):8-11.
16王涛涛.黄精水煎剂对β-淀粉样蛋白诱导的大鼠学习记忆能力下降的保护作用及其机理研究.合肥:安徽医科大学硕士研究生学位论文,2013.
17 Motohashi H,Yamamoto M.Nrf2-Keap1 defines a physiologically important stress response mechanism.Trends Mol Med,2004,10(11):549-557.
18曹惠敏,余刚.Nrf2在阿尔茨海默病中的研究现状.生物化学与生物物理进展,2015,42(6):533-539.
19于淼.地黄饮子对Aβ(25-35)诱导PC12细胞损伤氧化应激及Ca2+通道的影响.哈尔滨:黑龙江中医药大学硕士研究生学位论文,2010.
20吴小凡,马斌,侯训尧,等.柿叶提取物对HEK293-APPswe转基因细胞模型的抗氧化作用及对Nrf2/HO-1途径的影响.中国免疫学杂志,2017,33(6):854-858.
21姜洋.补肾祛瘀化痰法对轻度认知功能损害患者认知功能及氧化应激影响的研究.北京:北京中医药大学博士研究生学位论文,2014.
22王澍,张雪,马樱芮,等.补肾化痰益智方联合丁苯酞对阿尔茨海默病患者氧化应激、血流变学及认知功能的影响.中国实验方剂学杂志,2018,24(7):212-216.
23 Hardy J A,Higgins G A.Alzheimer's disease:the amyloid cascade hypothesis.Science,1992,256(5054):184-185.
24 Cai Z,Zhao B,Ratka A.Oxidative stress and beta-amyloid protein in Alzheimer’s disease.Neuro Molecular Medicine.2011,13(4):223-250.
25 Misonou H,Morishima-Kawashima M,Ihara Y.Oxidative stress induces intracellular accumulation of amyloidβ-protein(Aβ)in human neuroblastoma cells.Biochemistry,2000,39(23):6951-6959.
26姜招峰.阿尔茨海默病发病机理及其相关生物活性物质研究.北京:中国轻工业出版社.2016:23.
27 Wojsiat J,Zoltowska K M,Laskowskakaszub K,et al.Oxidant/Antioxidant imbalance in Alzheimer's Disease:Therapeutic and diagnostic prospects.Oxidative Medicine&Cellular Longevity,2018,2018(13):6435861.
28周玲.补肾活血化痰法对秀丽线虫抗氧化及Aβ蛋白毒性作用研究.武汉:湖北中医药大学博士研究生学位论文,2017.
29 Clausen A,Xu X,Bi X,et al.Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer’s Disease:Protection against and interruption of progression of amyloid and tau pathology and cognitive decline.J Alzheimers Dis,2012,30(1):183-208.
30 Behl C,Davis J,Cole G M,et al.Vitamin E protects nerve cells from amyloidβprotein toxicity.Biochemical&Biophysical Research Communications,1992,186(2):944.
31 Meng F,Li J,Rao Y,et al.A Chinese herbal formula,gengnianchun,amelioratesβ-amyloid peptide toxicity in a Caenorhabditis elegans model of Alzheimer's Disease.Evid Based Complement Alternat Med.2017,7480980.
32邱昕,陈国华,汪弢,等.黄连解毒汤对APP/PS1双转基因阿尔茨海默病小鼠自由基代谢及海马区病理形态学影响.中国中西医结合杂志,2011,31(10):1379-1382.
33 Muriach M,Floresbellver M,Romero F J,et al.Diabetes and the brain:oxidative stress,inflammation,and autophagy.Oxidative Medicine&Cellular Longevity,2014,2014(102158):102158.
34 Perry G,Castellani R J,Hirai K,et al.Reactive oxygen species mediate cellular damage in Alzheimer Disease.Journal of Alzheimers Disease Jad,1998,1(1):45.
35黄作义,许志刚,吴成吉,等.远志对Aβ25-35诱导AD模型大鼠海马区NF-κB活化研究.黑龙江医药科学,2010,33(2):6-7.
36蒋辉,徐运,姜亚军.远志皂苷元对AD模型小鼠学习记忆能力的影响及其机制研究.现代中西医结合杂志,2013,22(11):1153-1155.
37石成男,李秀国,许青松,等.远志水提物对阿尔茨海默病模型小鼠学习记忆的影响.中风与神经疾病杂志,2011,28(7):620-622.
38樊云峰.远志提取物对阿尔采末病模型大鼠学习记忆能力的影响.中国新药与临床杂志,2015,34(7):517-521.
39王改凤.补肾益智方对D-半乳糖联合β-淀粉样蛋白25-35致老年痴呆模型大鼠的作用及机制.中国组织工程研究,2016,20(49):7307-7313.
40胡小军,余长江,李俊,等.补肾通络汤治疗阿尔茨海默病40例的临床分析.中国实验方剂学杂志,2015,21(11):182-185.
41梁少瑜,曾永长,俞励平,等.天泰1号对Aβ(1-40)诱导PC12神经毒性的保护作用及其机制研究.中药药理与临床,2017,33(2):140-144.
42周鸿,霍利琴,张静泽,等.舒脑欣滴丸对D-半乳糖致阿尔茨海默病早期模型大鼠的神经保护作用及机制研究.中草药,2016,47(17):3074-3078.
43 Huang S W,Wang W,et.al.The effect of ethyl acetate extract from persimmon leaves on Alzheimer's Disease and its underlying mechanism.Phytomedicine,2016,15,23(7):694-704.
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