谷胱甘肽S-转移酶基因多态性与儿童急性淋巴细胞白血病遗传易感性的meta分析
|
摘要
目的:深入分析GST基因缺失与儿童ALL遗传易感性的关系。方法:基于纳入和排除标准计算机检索PubMed、Embase、中国期刊全文数据库(CNKI)和万方数据库。检索时间截止至2015年8月,检索过程中无语言限制。采用STATA 12.0软件计算OR及其95%CI,敏感性分析验证结论的稳健性,漏斗图检测发表偏倚。结果:本研究共纳入27项病例和对照研究,包括3736例患者和5549例对照。Meta分析结果显示,GSTM1和GSTT1缺失基因型与儿童ALL之间的总OR值分别为1.41(95%CI:1.21~1.65)和1.26(95%CI:1.05~1.50),均较对照组显著降低,差异具有统计学意义(P=0.000,P=0.012)。在亚组分析中,黑种人群、亚洲人群、PB组(来自普通人的对照)、HB组(来自医院的对照)、"≥100病例数"组和"<100病例数"组携带GSTM1基因突变的儿童发生ALL的风险显著增高。而对于GSTT1,其多态性仅与亚洲人群、PB组和"≥100病例数"组的发病风险有相关性。结论:GSTM1和GSTT1缺失基因型可能是儿童ALL的易感因素,但该结论有待进一步证实。
Objective:To analyze the relationship between GST polymorphism and childhood acute lymphoblastic leukemia(ALL) risk.Methods;The relevant references of this relationship in English or Chinese were extensively searched through PubMed,Embase,China National Knowledge Internet(CNKI) and Wanfang Database up to August2015 based on the inclusion and exclusion criteria.GST polymorphism-specific odd ratios(OR) with corresponding95%confidence intervals(CI) were calculated with the STATA statistical package.Heterogeneity across studies was assessed,and funnel plots were constructed to test the publication bias.Results:A total of 27 studies concerning the GST polymorphisms and the risk of ALL were evaluated,which included 3736 cases of childhood acute lymphoblastic leukemia and 5 549 controls.Significant summary OR of ALL were obtained for GSTM1(OR = 1.41,95%CI = 1.21- 1.65) and GSTT1(OR = 1.26,95%CI = 1.05- 1.50).Subgroup analysis showed that GSTM1 variant was associated with increased susceptibility to ALL in group of Blacks,Asians,PB(Population- based controls),HB(Hospital-based controls) ≥ 100 cases' and '< 100 cases;Regarding GSTT1 polymorphism,significant relation with ALL risk was found in subgroup of Asians,PB and ≥ 100 cases:Conclusion;The GSTM1 and GSTT1 polymorphisms may be cerrelated with an increased risk of ALL.Further investigations are needed to confirm the conclusions.
Objective:To analyze the relationship between GST polymorphism and childhood acute lymphoblastic leukemia(ALL) risk.Methods;The relevant references of this relationship in English or Chinese were extensively searched through PubMed,Embase,China National Knowledge Internet(CNKI) and Wanfang Database up to August2015 based on the inclusion and exclusion criteria.GST polymorphism-specific odd ratios(OR) with corresponding95%confidence intervals(CI) were calculated with the STATA statistical package.Heterogeneity across studies was assessed,and funnel plots were constructed to test the publication bias.Results:A total of 27 studies concerning the GST polymorphisms and the risk of ALL were evaluated,which included 3736 cases of childhood acute lymphoblastic leukemia and 5 549 controls.Significant summary OR of ALL were obtained for GSTM1(OR = 1.41,95%CI = 1.21- 1.65) and GSTT1(OR = 1.26,95%CI = 1.05- 1.50).Subgroup analysis showed that GSTM1 variant was associated with increased susceptibility to ALL in group of Blacks,Asians,PB(Population- based controls),HB(Hospital-based controls) ≥ 100 cases' and '< 100 cases;Regarding GSTT1 polymorphism,significant relation with ALL risk was found in subgroup of Asians,PB and ≥ 100 cases:Conclusion;The GSTM1 and GSTT1 polymorphisms may be cerrelated with an increased risk of ALL.Further investigations are needed to confirm the conclusions.
引文
1 McNeil DE,Cote TR,Clegg L,et al.SEER update of incidence and trends in pediatric malignancies:acute lymphoblastic leukemia.Med Pediatr Oncol,2002;39(6):554-557.
2 Wong O,Harris F,Armstrong TW,et al.A hospital-based casecontrol study of acute myeloid leukemia in Shanghai:analysis of environmental and occupational risk factors by subtypes of the WHO classification.Chem Biol Interact,2010;184(3):112-128.
3 Bolt HM,Thier R.Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology.Curr Drug Metab,2006;7(6):613-628.
4 Chen CL,Liu Q,Pui CH,et al.Higher frequency of glutathione S-ransferase deletions in black children with acute,lymphoblastic leukemia.Blood,1997;89(2):1701-1707.
5 Alves S,Amorim A,Ferreira F,et al.The GSTM1 and GSTT1 genetic polymorphisms and susceptibility to acute lymphoblastic leukemia in children from north Portugal.Leukemia,2002;16(8):1565-1567.
6 Pakakasama S,Mukda E,Sasanakul W,et al.Polymorphisms of drug-metabolizing enzymes and risk of childhood acute lymphoblastic leukemia.Am J Hematol,2005;79(3):202-205.
7 Aydin-Sayitoglu M,Hatirnaz O,Erensoy N,et al.Role of CYP2D6,CYP1A1,CYP2E1,GSTT1,and GSTM1 Genes in the Susceptibility to Acute Leukemias.Am J Hematol,2006;81(3):162-170.
8侯伟,陈保亮.GSTT1、GSTM1、MDR1基因多态性与儿童急性淋巴细胞白血病易感性及化疗反应的关系.海南医学院学报,2013;19(11):1493-1496.
9 Higgins JP,Thompson SG.Quantifying heterogeneity in a meta-analysis.Stat Med,2002;21(11):1539-1558.
10 Macaskill P,Walter SD,lrwig L.A comparison of methods to detect publication bias in meta-analysis.Stat Med,2001;20(4);641-654.
11 Duval S,Tweedie R.Trim and fill:a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.Biometrics,2000;56(2):455-463.
12 Krajinovic M,Labuda D,Richer C,et al.Susceptibility to Childhood Acute Lymphoblastic Leukemia:Influence of CYP1A1,CYP2D6,GSTM1,and GSTT1 Genetic Polymorphisms.Blood,1999;93(4):1496-1501.
13 Saadat I,Saadat M.The glutathione S-transferase mu polymorphism and susceptibility to acute lymphocytic leukemia.Cancer Letters,2000;158(1):43-45.
14 Woo MH,Shuster JJ,Chen C,et al.Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies.Leukemia,2000;14(2):232-237.
15 Davies SM,Bhatia S,Ross JA,et al.Glutathione S-transferase genotypes,genetic susceptibility,and outcome of therapy in childhood acute lymphoblastic leukemia.Blood,2002:100(1):67-71.
16 Krajinovic M,Labuda D,Sinnett D.Childhood acute lymphoblastic leukemia;genetic determinants of susceptibility and disease outcome.Rev Environ Health,2001;16(3):263-279.
17 Balta G,Yuksek N,Ozyurek E,et al.Characterization of MTHFR,GSTM1,GSTT1,GSTP1,and CYP1 Al Genotypes in Childhood Acute Leukemia.Am J Hematol,2003;73(3):154-160.
18 Barnette P,Scholl R,Blandford M,et al.High-Throughput Detection of Glutathione S-Transferase Polymorphic Alleles in a Pediatric Cancer Population.Cancer Epidemiol Biomarkers Prev,2004;13(4):304-313.
19 Joseph T,Kusumakurnary P,Chacko P,et al.Genetic polymorphism of CYP1A1,CYP2D6,GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children.Pediatr Blood Cancer,2004;43(6):560-567.
20 Canalle R,Burim RV,Tone LG,et al.Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia.Environ Mol Mutagen,2004;43(4):100-109.
21 Wang J,Zhang L,Feng JF,et al.Genetic Polymorphisms Analysis of Glutathione S transferase M1 and T1 in Children with Acute Lymphoblastic Leukemia.Journal of Huazhong Universit y of Science and T echnology,2004;24(3):243-244.
22 Clavel J,Bellec S,Rebouissou S,et al.Childhood leukaemia,polymorphisms of metabolism enzyme genes,and interactions with maternal tobacco,coffee and alcohol consumption during pregnancy.Eur J Cancer Prev,2005;14(2):531-540.
23 Haranatha RP,Jamil K.Polymorphisms in the GST(M1 and T1)gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in Indian population.African J.Biotechnol,2006;5(16):1454-1456.
24 Pigullo S,Haupt R,Dufour C,et al.Are genotypes of glutathione S-transferase superfamily a risk factor for childhood acute lymphoblastic leukemia?Results of an Italian case-control study.Leukemia,2007;21(5):1122-1124.
25 Rimando MG,Chua MN,Yuson E,et al.Prevalence of GSTT1,GSTM1 and NQ01(609C>T)in Filipino children with ALL(acute lymphoblastic leukaemia).Biosci Rep,2008;28(3):117-124.
26 Gra OA,Glotov AS,Kozhekbayeva ZM,et al.Genetic Polymorphism of GST,NAT2,and MTRR and Susceptibility to Childhood Acute Leukemia.Molecular Biology,2008;42(2):187-197.
27姜烈君,覃桂芳.细胞色素P4501A1、谷胱甘肽转硫酶基因多态性与儿童急性淋巴细胞白血病的相关性研究.中国临床新医学,2010;9(2):112-114.
28 Chan JY,Ugrasena DG,Lum DW,et al.Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children.Hematol Oncol,2011;29(3);116-123.
29李玉华,文飞球,肖智辉,等.儿童传染性单核细胞增多症与急性淋巴细胞白血病GST基因遗传多态性研究.中国当代儿科杂志,2012;14(4):260-263.
30 Moulik NR,Parveen F,Kumar A,et al.Glutathione-S-transferase polymorphism and acute lymphoblastic leukemia(ALL)in north Indian children:a case-control study and meta-analysis.Journal of Human Genetics,2014;59(9):526-529.
31 Ye Z,Song H.Glutathione s-transferase polymorphisms(GSTM1,GSTP1 and GSTT1)and the risk of acute leukaemia;a systematic review and meta-analysis.Eur J Cancer,2005;41(7):980-989.
32 Tang ZH,Zhang C,Cheng P,et al.Glutathione S-transferase polymorphisms(GSTM1,GSTT1 and GSTP1)and acute leukemia risk in Asians:a meta-analysis.Asian Pac.J.Cancer Prev,2014;15(2):2075-2081.
33 Vijayakrishnan J,Houlston RS.Candidate gene association studies and risk of childhood acute lymphoblastic leukemia;a systematic review and meta-analysis.Haematologica,2010;95(8);1405-1414.
2 Wong O,Harris F,Armstrong TW,et al.A hospital-based casecontrol study of acute myeloid leukemia in Shanghai:analysis of environmental and occupational risk factors by subtypes of the WHO classification.Chem Biol Interact,2010;184(3):112-128.
3 Bolt HM,Thier R.Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology.Curr Drug Metab,2006;7(6):613-628.
4 Chen CL,Liu Q,Pui CH,et al.Higher frequency of glutathione S-ransferase deletions in black children with acute,lymphoblastic leukemia.Blood,1997;89(2):1701-1707.
5 Alves S,Amorim A,Ferreira F,et al.The GSTM1 and GSTT1 genetic polymorphisms and susceptibility to acute lymphoblastic leukemia in children from north Portugal.Leukemia,2002;16(8):1565-1567.
6 Pakakasama S,Mukda E,Sasanakul W,et al.Polymorphisms of drug-metabolizing enzymes and risk of childhood acute lymphoblastic leukemia.Am J Hematol,2005;79(3):202-205.
7 Aydin-Sayitoglu M,Hatirnaz O,Erensoy N,et al.Role of CYP2D6,CYP1A1,CYP2E1,GSTT1,and GSTM1 Genes in the Susceptibility to Acute Leukemias.Am J Hematol,2006;81(3):162-170.
8侯伟,陈保亮.GSTT1、GSTM1、MDR1基因多态性与儿童急性淋巴细胞白血病易感性及化疗反应的关系.海南医学院学报,2013;19(11):1493-1496.
9 Higgins JP,Thompson SG.Quantifying heterogeneity in a meta-analysis.Stat Med,2002;21(11):1539-1558.
10 Macaskill P,Walter SD,lrwig L.A comparison of methods to detect publication bias in meta-analysis.Stat Med,2001;20(4);641-654.
11 Duval S,Tweedie R.Trim and fill:a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.Biometrics,2000;56(2):455-463.
12 Krajinovic M,Labuda D,Richer C,et al.Susceptibility to Childhood Acute Lymphoblastic Leukemia:Influence of CYP1A1,CYP2D6,GSTM1,and GSTT1 Genetic Polymorphisms.Blood,1999;93(4):1496-1501.
13 Saadat I,Saadat M.The glutathione S-transferase mu polymorphism and susceptibility to acute lymphocytic leukemia.Cancer Letters,2000;158(1):43-45.
14 Woo MH,Shuster JJ,Chen C,et al.Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies.Leukemia,2000;14(2):232-237.
15 Davies SM,Bhatia S,Ross JA,et al.Glutathione S-transferase genotypes,genetic susceptibility,and outcome of therapy in childhood acute lymphoblastic leukemia.Blood,2002:100(1):67-71.
16 Krajinovic M,Labuda D,Sinnett D.Childhood acute lymphoblastic leukemia;genetic determinants of susceptibility and disease outcome.Rev Environ Health,2001;16(3):263-279.
17 Balta G,Yuksek N,Ozyurek E,et al.Characterization of MTHFR,GSTM1,GSTT1,GSTP1,and CYP1 Al Genotypes in Childhood Acute Leukemia.Am J Hematol,2003;73(3):154-160.
18 Barnette P,Scholl R,Blandford M,et al.High-Throughput Detection of Glutathione S-Transferase Polymorphic Alleles in a Pediatric Cancer Population.Cancer Epidemiol Biomarkers Prev,2004;13(4):304-313.
19 Joseph T,Kusumakurnary P,Chacko P,et al.Genetic polymorphism of CYP1A1,CYP2D6,GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children.Pediatr Blood Cancer,2004;43(6):560-567.
20 Canalle R,Burim RV,Tone LG,et al.Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia.Environ Mol Mutagen,2004;43(4):100-109.
21 Wang J,Zhang L,Feng JF,et al.Genetic Polymorphisms Analysis of Glutathione S transferase M1 and T1 in Children with Acute Lymphoblastic Leukemia.Journal of Huazhong Universit y of Science and T echnology,2004;24(3):243-244.
22 Clavel J,Bellec S,Rebouissou S,et al.Childhood leukaemia,polymorphisms of metabolism enzyme genes,and interactions with maternal tobacco,coffee and alcohol consumption during pregnancy.Eur J Cancer Prev,2005;14(2):531-540.
23 Haranatha RP,Jamil K.Polymorphisms in the GST(M1 and T1)gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in Indian population.African J.Biotechnol,2006;5(16):1454-1456.
24 Pigullo S,Haupt R,Dufour C,et al.Are genotypes of glutathione S-transferase superfamily a risk factor for childhood acute lymphoblastic leukemia?Results of an Italian case-control study.Leukemia,2007;21(5):1122-1124.
25 Rimando MG,Chua MN,Yuson E,et al.Prevalence of GSTT1,GSTM1 and NQ01(609C>T)in Filipino children with ALL(acute lymphoblastic leukaemia).Biosci Rep,2008;28(3):117-124.
26 Gra OA,Glotov AS,Kozhekbayeva ZM,et al.Genetic Polymorphism of GST,NAT2,and MTRR and Susceptibility to Childhood Acute Leukemia.Molecular Biology,2008;42(2):187-197.
27姜烈君,覃桂芳.细胞色素P4501A1、谷胱甘肽转硫酶基因多态性与儿童急性淋巴细胞白血病的相关性研究.中国临床新医学,2010;9(2):112-114.
28 Chan JY,Ugrasena DG,Lum DW,et al.Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children.Hematol Oncol,2011;29(3);116-123.
29李玉华,文飞球,肖智辉,等.儿童传染性单核细胞增多症与急性淋巴细胞白血病GST基因遗传多态性研究.中国当代儿科杂志,2012;14(4):260-263.
30 Moulik NR,Parveen F,Kumar A,et al.Glutathione-S-transferase polymorphism and acute lymphoblastic leukemia(ALL)in north Indian children:a case-control study and meta-analysis.Journal of Human Genetics,2014;59(9):526-529.
31 Ye Z,Song H.Glutathione s-transferase polymorphisms(GSTM1,GSTP1 and GSTT1)and the risk of acute leukaemia;a systematic review and meta-analysis.Eur J Cancer,2005;41(7):980-989.
32 Tang ZH,Zhang C,Cheng P,et al.Glutathione S-transferase polymorphisms(GSTM1,GSTT1 and GSTP1)and acute leukemia risk in Asians:a meta-analysis.Asian Pac.J.Cancer Prev,2014;15(2):2075-2081.
33 Vijayakrishnan J,Houlston RS.Candidate gene association studies and risk of childhood acute lymphoblastic leukemia;a systematic review and meta-analysis.Haematologica,2010;95(8);1405-1414.