珍珠层粉微量元素的检测及重金属限定标准的建立
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摘要
目的对珍珠层粉中的微量元素进行检测和分析,制定珍珠层粉重金属元素的限量标准,为珍珠层粉的安全用药提供保障。方法采用ICP-MS法,原子荧光光度法以及一米平面光栅摄谱仪法,对21批不同基原和产地的珍珠层粉中的29种微量元素进行检测,并采用主成分分析和聚类分析法分析检测结果,采用单因子污染指数法和Nemerow综合污染指数法评价珍珠层粉的重金属污染。结果得到了21批不同产地和基源的珍珠层粉中29种微量元素的含量,并通过主成分分析和聚类分析发现淡水珍珠层粉和海水珍珠层粉的微量元素含量存在较大的差异。结合相关的重金属限定标准,制定了珍珠层粉中重金属元素的限定标准。结论较为全面地检测并分析了珍珠层粉中的微量元素包括重金属元素,首次建立了珍珠层粉的重金属元素限定标准。
Objective To detect and analyze the trace elements in pearl layer powder, to formulate the limit standards for heavy metal elements in pearl layer powder, and to provide assurance for the safe use of pearl layer powder. Methods ICP-MS, atomic fluorescence spectrometry and one meter plane grating spectrograph were used to detect the 29 kinds of trace elements in pearl layer powder in 21 batches of pearl powder from different areas and species. Principal component analysis and cluster analysis were used to analyze the test results. The methods of single factor pollution index and nemerow comprehensive pollution index were used to evaluate the heavy metal pollution of pearl layer powder. Results The contents of 29 trace elements in pearl layer powder of 21 batches of different areas and species were obtained. By principal component analysis and cluster analysis, it was found that there were great differences in the contents of trace elements between freshwater pearl layer powder and seawater pearl layer powder. Combined with the related heavy metal limit standards, the limit standards of heavy metals in pearl layer powder has been worked out. Conclusion The trace elements in pearl layer powder were detected and analyzed comprehensively, and the limit standard for heavy metal elements in pearl layer powder was established for the first time.
Objective To detect and analyze the trace elements in pearl layer powder, to formulate the limit standards for heavy metal elements in pearl layer powder, and to provide assurance for the safe use of pearl layer powder. Methods ICP-MS, atomic fluorescence spectrometry and one meter plane grating spectrograph were used to detect the 29 kinds of trace elements in pearl layer powder in 21 batches of pearl powder from different areas and species. Principal component analysis and cluster analysis were used to analyze the test results. The methods of single factor pollution index and nemerow comprehensive pollution index were used to evaluate the heavy metal pollution of pearl layer powder. Results The contents of 29 trace elements in pearl layer powder of 21 batches of different areas and species were obtained. By principal component analysis and cluster analysis, it was found that there were great differences in the contents of trace elements between freshwater pearl layer powder and seawater pearl layer powder. Combined with the related heavy metal limit standards, the limit standards of heavy metals in pearl layer powder has been worked out. Conclusion The trace elements in pearl layer powder were detected and analyzed comprehensively, and the limit standard for heavy metal elements in pearl layer powder was established for the first time.
引文
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[9] 陈莹,王长生,况刚,等.微波消解ICP-OES法测定藏药珍宝类药物坐珠达西及其主要矿物药原料中26种无机元素及相关性分析[J].中草药,2016,47(13):2346-2352.
[10] 木士春,马红艳.养殖珍珠微量元素特征及其对珍珠生长环境的指示意义[J].矿物学报,2001,20(3):551-553.
[11] 郑丽.不同山药药材重金属及安全性评价[J].现代食品,2016,2(17):113-116.
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[13] 孔繁越.中药材重金属限量标准和农残限量标准研究及标准制定相关建议[D].北京:北京中医药大学,2017.
[14] 李朝峰.雄黄及含雄黄中成药的质量控制研究[D].北京:北京中医药大学,2017.
[2] 蒲月华,何锦锋,高振声,等.珍珠粉与珍珠层粉微量元素的对比研究[J].食品研究与开发,2016,37(16):125-128.
[3] 李翠珍,李结容.微波配合珍珠层粉治疗宫颈糜烂分析[J].广州医药,2008,(6):49-50.
[4] 王存,何吉彬,谢廷枢,等.我国产区的几种海水和淡水贝壳珍珠层粉成分的初步对比研究[J].矿物学报,2012,32(2):310-315.
[5] 黄甫,邓陈茂,宋文东,等.马氏珠母贝各部位及其插核珍珠层微量元素的含量及分布[J].广东微量元素科学,2005,12(10):38-41.
[6] 王宝丽.蒙药清血八味片质量控制方法研究[D].北京:北京中医药大学,2017.
[7] 包丽丽.三十种中成药元素含量分析及基于元素含量的中成药分类研究[D].大连:大连医科大学,2011.
[8] 刘小芳,薛长湖,王玉明,等.刺参中无机元素的聚类分析和主成分分析[J].光谱学与光谱分析,2011,31(11):3119-3122.
[9] 陈莹,王长生,况刚,等.微波消解ICP-OES法测定藏药珍宝类药物坐珠达西及其主要矿物药原料中26种无机元素及相关性分析[J].中草药,2016,47(13):2346-2352.
[10] 木士春,马红艳.养殖珍珠微量元素特征及其对珍珠生长环境的指示意义[J].矿物学报,2001,20(3):551-553.
[11] 郑丽.不同山药药材重金属及安全性评价[J].现代食品,2016,2(17):113-116.
[12] 韩小丽,张小波,郭兰萍,等.中药材重金属污染现状的统计分析[J].中国中药杂志,2008,53(18):2041-2048.
[13] 孔繁越.中药材重金属限量标准和农残限量标准研究及标准制定相关建议[D].北京:北京中医药大学,2017.
[14] 李朝峰.雄黄及含雄黄中成药的质量控制研究[D].北京:北京中医药大学,2017.