理气化瘀汤治疗气滞血瘀型原发性痛经
|
摘要
目的观察理气化瘀汤对气滞血瘀型原发性痛经患者疗效的影响。方法采用随机临床对照研究方法,将148例患者分为对照组74例,治疗组74例。对照组予常规隔下逐瘀汤,治疗组予理气化瘀汤,通过比较VAS疼痛评分、COX痛经症状积分及用药安全性来评价理气化瘀汤的临床疗效。结果经过3个月经周期的治疗,治疗组(理气化瘀汤)能明显降低患者VAS疼痛评分(3.83±1.52 vs 5.37±1.73),COX痛经症状积分(0.87±0.39 vs1.32±0.47;6.43±1.56 vs 8.87±1.73),与对照组比较差异具有统计学意义(P<0.05);同时治疗组对肝功能、肾功能无明显不良影响(P>0.05)。结论理气化瘀汤能有效安全缓解气滞血瘀型原发性痛经患者临床症状,改善患者生活质量。
Objective To observe the effect of Liqi Huayu decoction in treating qi stagnation and blood stasis type primary dysmenorrhea patients. Methods Using randomized controlled clinical trial method, 148 patients were divided into control group(n = 74) and treatment group(n = 74). The control group was received Gexiao zhuyu decoction; the treatment group was received Liqi Huayu decoction, by means of the index of VAS and COX of primary dysmenorrhea patients for evaluating curative effect. Results On 3 menstrual cycle of treatment, the index of VAS(3.83±1.52 vs. 5.37±1.73) and COX(0.87±0.39 vs. 1.32±0.47;6.43±1.56 vs. 8.87±1.73) with patients can be reduced, the diff erence was statistically significant compared with the control group(P < 0.05); Meanwhile, the treatment group cannot aff ect liver function and renal function of primary dysmenorrhea patients(P > 0.05). Conclusion Liqi Huayu decoction can effectively and safely alleviate the clinical symptoms of qi stagnation and blood stasis type primary dysmenorrhea patients.
Objective To observe the effect of Liqi Huayu decoction in treating qi stagnation and blood stasis type primary dysmenorrhea patients. Methods Using randomized controlled clinical trial method, 148 patients were divided into control group(n = 74) and treatment group(n = 74). The control group was received Gexiao zhuyu decoction; the treatment group was received Liqi Huayu decoction, by means of the index of VAS and COX of primary dysmenorrhea patients for evaluating curative effect. Results On 3 menstrual cycle of treatment, the index of VAS(3.83±1.52 vs. 5.37±1.73) and COX(0.87±0.39 vs. 1.32±0.47;6.43±1.56 vs. 8.87±1.73) with patients can be reduced, the diff erence was statistically significant compared with the control group(P < 0.05); Meanwhile, the treatment group cannot aff ect liver function and renal function of primary dysmenorrhea patients(P > 0.05). Conclusion Liqi Huayu decoction can effectively and safely alleviate the clinical symptoms of qi stagnation and blood stasis type primary dysmenorrhea patients.
引文
[1]Kazama M,Maruyama K,Nakamura K.Prevalence of dysmenorrhea and its correlating lifestyle factors in Japanese female junior high school students[J].Tohoku J Exp Med,2015,236(2):107-113.
[2]Al-Jefout M,Seham AF,Jameel H,et al.Dysmenorrhea:Prevalence and Impact on Quality of Life among Young Adult Jordanian Females[J].J Pediatr Adolesc Gynecol,2015,28(3):173-185.
[3]Ju H,Jones M,Mishra G.The prevalence and risk factors of dysmenorrhea[J].Epidemiologic Reviews,2014,36(1):104-113.
[4]Lanas A,Carrera-Lasfuentes P,Arguedas Y,et al.Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs,antiplatelet agents,or anticoagulants[J].Clin Gastroenterol Hepatol,2015,13(5):906-912.
[5]Simon LS.Nonsteroidal anti-inflammatory drugs and their risk:a story still in developme nt[J].Arthritis Res Ther,2013,15 Suppl 3:1.
[6]Woo P,Mc Eneaney M.J.New strategies to treat primary dysmenorrhea[J].The Clinical Advisor,2010,13(11):43-49.
[7]乐杰.妇产科学[M].7版.北京:人民卫生出版社,2011:318.
[8]罗颂平.中医妇科学[M].2版.北京:人民卫生出版社,2016:105.
[9]马素敏.痛经方内服联合痛经贴外敷治疗气滞血瘀型原发性痛经临床研究[J].中医药临床杂志,2016,28(11):1591-1593.
[10]马玉侠,马海洋,陈少宗,等.中文版COX痛经症状量表的信效度检验[J].山东中医药大学学报,2015,39(1):5.
[11]Momoeda M,Kondo M,Elliesen J,et al.Efficacy and safety of a flexible extended regimen of ethinylestradiol/d r o s p i r e n o n e f o r t h e t r e a t m e n t o f d y s m e n o r r h e a:a multicenter,randomized,open-label,active-controlled study[J].Int J Womens Health,2017,2(9):295-305.
[12]Tanaka E,Momoeda M,Osuga Y,et al.Burden of menstrual symptoms in Japanese women:results from a survey-based study[J].J Med Econ,2013,16(11):1255-1266.
[13]Bateson D,Butcher BE,Donovan C,et al.Risk of venous thromboembolism in women taking the combined oral contraceptive:a systematic review and meta-analysis[J].Aust Fam Physician,2016,45(1):59-64.
[14]Ou MC,Hsu TF,Lai AC,et al.Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea:A randomized,double-blind clinical trial[J].J Obstet Gynaecol Res,2012(38):817-822.
[15]Zahradnik HP,Hanjalic-Beck A,Groth K.Nonsteroidal antiinflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea:A review[J].Contraception,2010,81:185-196.[1 6]Tu C H,N i d d a m D M,C h a o H T,e t a l.A b n o r m a l cerebral metabolism during menstrual pain in primary dysmenorrhea[J].Neuroimage,2009,47(1):28-35.
[17]王殊秀,冷玉芳,高向梅,等.延胡索乙素对大鼠慢性神经病理性疼痛的影响[J].临床麻醉学杂志,2012,28(7):705-707.
[18]汪群红,胡敏,汪官富.乌药生物碱镇痛和抗炎作用研究[J].中华中医药学刊,2015,33(4):810-812.
[19]袁荣高,顾明华,古江勇.基于网络药理学研究大川芎方治疗偏头痛的作用机制[J].南京中医药大学学报,2016,32(6):571-576.
[20]Jin L,Yang X,Liu P.Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea[J].J Pain Res,2017,24(10):699-707.
[21]Wei SY,Chao HT,Tu CH,et al.Changes in functional connectivity of pain modulatory systems in women with primary dysmenorrhea.Pain,2016,157(1):92-102.
[2]Al-Jefout M,Seham AF,Jameel H,et al.Dysmenorrhea:Prevalence and Impact on Quality of Life among Young Adult Jordanian Females[J].J Pediatr Adolesc Gynecol,2015,28(3):173-185.
[3]Ju H,Jones M,Mishra G.The prevalence and risk factors of dysmenorrhea[J].Epidemiologic Reviews,2014,36(1):104-113.
[4]Lanas A,Carrera-Lasfuentes P,Arguedas Y,et al.Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs,antiplatelet agents,or anticoagulants[J].Clin Gastroenterol Hepatol,2015,13(5):906-912.
[5]Simon LS.Nonsteroidal anti-inflammatory drugs and their risk:a story still in developme nt[J].Arthritis Res Ther,2013,15 Suppl 3:1.
[6]Woo P,Mc Eneaney M.J.New strategies to treat primary dysmenorrhea[J].The Clinical Advisor,2010,13(11):43-49.
[7]乐杰.妇产科学[M].7版.北京:人民卫生出版社,2011:318.
[8]罗颂平.中医妇科学[M].2版.北京:人民卫生出版社,2016:105.
[9]马素敏.痛经方内服联合痛经贴外敷治疗气滞血瘀型原发性痛经临床研究[J].中医药临床杂志,2016,28(11):1591-1593.
[10]马玉侠,马海洋,陈少宗,等.中文版COX痛经症状量表的信效度检验[J].山东中医药大学学报,2015,39(1):5.
[11]Momoeda M,Kondo M,Elliesen J,et al.Efficacy and safety of a flexible extended regimen of ethinylestradiol/d r o s p i r e n o n e f o r t h e t r e a t m e n t o f d y s m e n o r r h e a:a multicenter,randomized,open-label,active-controlled study[J].Int J Womens Health,2017,2(9):295-305.
[12]Tanaka E,Momoeda M,Osuga Y,et al.Burden of menstrual symptoms in Japanese women:results from a survey-based study[J].J Med Econ,2013,16(11):1255-1266.
[13]Bateson D,Butcher BE,Donovan C,et al.Risk of venous thromboembolism in women taking the combined oral contraceptive:a systematic review and meta-analysis[J].Aust Fam Physician,2016,45(1):59-64.
[14]Ou MC,Hsu TF,Lai AC,et al.Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea:A randomized,double-blind clinical trial[J].J Obstet Gynaecol Res,2012(38):817-822.
[15]Zahradnik HP,Hanjalic-Beck A,Groth K.Nonsteroidal antiinflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea:A review[J].Contraception,2010,81:185-196.[1 6]Tu C H,N i d d a m D M,C h a o H T,e t a l.A b n o r m a l cerebral metabolism during menstrual pain in primary dysmenorrhea[J].Neuroimage,2009,47(1):28-35.
[17]王殊秀,冷玉芳,高向梅,等.延胡索乙素对大鼠慢性神经病理性疼痛的影响[J].临床麻醉学杂志,2012,28(7):705-707.
[18]汪群红,胡敏,汪官富.乌药生物碱镇痛和抗炎作用研究[J].中华中医药学刊,2015,33(4):810-812.
[19]袁荣高,顾明华,古江勇.基于网络药理学研究大川芎方治疗偏头痛的作用机制[J].南京中医药大学学报,2016,32(6):571-576.
[20]Jin L,Yang X,Liu P.Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea[J].J Pain Res,2017,24(10):699-707.
[21]Wei SY,Chao HT,Tu CH,et al.Changes in functional connectivity of pain modulatory systems in women with primary dysmenorrhea.Pain,2016,157(1):92-102.