更昔洛韦与阿昔洛韦治疗小儿病毒性脑炎临床观察
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摘要
目的探讨更昔洛韦与阿昔洛韦在小儿病毒性脑炎中的临床治疗效果。方法选取2014-11—2017-01医院收治小儿病毒性脑炎患者62例,随机数字法分为对照组(n=31)和观察组(n=31)。对照组采用阿昔洛韦片治疗,观察组采用更昔洛韦治疗,采用酶联免疫吸附试验测定2组治疗前、后神经元特异性烯醇化酶(NSE)、白介素-6(IL-6)和白介素1β(IL-1β)水平,比较2组临床疗效。结果观察组治疗后7 d发热、头痛、呕吐、抽搐及意识恢复症状消失时间,短于对照组(P<0.05);观察组治疗后7 d炎症因子NSE、IL-6、IL-1β水平低于对照组(P<0.05);2组治疗后7 d并发症发生率差异无统计学意义(P>0.05)。结论小儿病毒性脑炎患者采用更昔洛韦治疗效果理想,能缩短症状改善时间,降低炎症因子水平。
Objective To investigate the clinical effects of ganciclovir and acyclovir in children with viral encephalitis.Methods A total of 62 patients with viral encephalitis in the hospital from November 2014 to January 2017 were enrolled.The random number method was divided into control group(n=31) and observation group(n=31).The control group was treated with acyclovir tablets,and the observation group was treated with ganciclovir.The enzyme-linked immunosorbent assay was used to determine the neuron-specific enolase(NSE) and interleukin-6(IL-6) before and after treatment.And interleukin-1β(IL-1β) levels,comparing the clinical efficacy of the two groups.Results The disappearance time of fever,headache,vomiting,convulsion and consciousness recovery in the observation group was shorter than that in the control group(P<0.05).The inflammatory factors NSE,IL-6 and IL-1β were low in the observation group 7 days after treatment.There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The treatment of ganciclovir in children with viral encephalitis is ideal,which can shorten the time of symptom improvement and reduce the level of inflammatory factors.It is worthy of popularization and application.
Objective To investigate the clinical effects of ganciclovir and acyclovir in children with viral encephalitis.Methods A total of 62 patients with viral encephalitis in the hospital from November 2014 to January 2017 were enrolled.The random number method was divided into control group(n=31) and observation group(n=31).The control group was treated with acyclovir tablets,and the observation group was treated with ganciclovir.The enzyme-linked immunosorbent assay was used to determine the neuron-specific enolase(NSE) and interleukin-6(IL-6) before and after treatment.And interleukin-1β(IL-1β) levels,comparing the clinical efficacy of the two groups.Results The disappearance time of fever,headache,vomiting,convulsion and consciousness recovery in the observation group was shorter than that in the control group(P<0.05).The inflammatory factors NSE,IL-6 and IL-1β were low in the observation group 7 days after treatment.There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The treatment of ganciclovir in children with viral encephalitis is ideal,which can shorten the time of symptom improvement and reduce the level of inflammatory factors.It is worthy of popularization and application.
引文
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[19] BAQUERO-ARTIGAO F.Update on congenital and neonatal herpes infections:infection due to cytomegalovirus and herpes simplex[J].Rev Neurol,2017,64(s03):S29-S33.
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[23] 苏玲.更昔洛韦联合神经节苷脂在病毒性脑炎患儿中的效果观察[J].中国实用神经疾病杂志,2014,17(23):27-28.
[24] 殷卫兵,严鸣光.病毒性脑炎患儿脑脊液和血清中NSE、MBP 和S-100 的变化及临床意义[J].中国卫生检验杂志,2015,34(22):3 899-3 902.
[25] 龙春根.更昔洛韦联合纳洛酮治疗小儿病毒性脑炎60例临床分析[J].中国当代医药,2016,23(33):111-113.
[26] 薛亚君.更昔洛韦与阿昔洛韦治疗带状疱疹的临床效果观察[J].临床合理用药杂志,2016,9(32):73-74.
[27] 石继宗.阿昔洛韦与更昔洛韦治疗小儿水痘的疗效对比[J].临床医药文献电子杂志,2016,3(11):2 193-2 193.
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