网膜素-1与老年2型糖尿病合并大面积脑梗死患者预后的相关性分析
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摘要
目的探讨网膜素-1与老年2型糖尿病合并大面积脑梗死患者预后的相关性。方法选取老年2型糖尿病合并大面积脑梗死患者112例,分为生存组88例和死亡组24例。分析2组患者临床资料,采用ELISA法测定血浆网膜素-1、脂联素水平及代谢参数,并对各变量行相关分析、多元逐步回归分析及Logistic回归分析。结果生存组血浆网膜素-1和脂联素水平均明显高于死亡组(P均<0. 05)。血浆网膜素-1水平与APACHEⅡ评分、HbA1c、hs-CRP、HOMA-IR呈负相关(P均<0. 05),与脂联素呈正相关(P <0. 05)。多元逐步回归分析显示,APACHEⅡ评分、HbA1c、脂联素是血清网膜素-1的独立影响因素。Logistic回归分析结果显示,HbA1c、APACHEⅡ评分、网膜素-1、hs-CRP是老年2型糖尿病合并大面积脑梗死患者死亡的影响因素。结论血清网膜素-1与老年2型糖尿病合并脑梗死患者的死亡密切相关。网膜素-1的表达可能受到糖脂代谢和疾病预后的影响。
Objective It is to investigate the correlation between omentin-1 and prognosis in elderly patients with type 2diabetes mellitus complicated with large-area cerebral infarction. Methods A total of 112 elderly patients with type 2 diabetes mellitus complicated with large-area cerebral infarction were enrolled,including 88 in the survival group and 24 in the death group. The clinical data of each group were analyzed. Plasma omentin-1 level,adiponectin and metabolic parameters were determined by ELISA. Correlation analysis,multiple stepwise regression analysis and logistic regression analysis were performed for each variable. Results Plasma omentin-1 levels gradually decreased in the survival group and the death group( P < 0. 05). Plasma omentin-1 level was negatively correlated with APACHEⅡscore,Hb A1 c,hs-CRP and HOMA-IR( P <0. 05),and positively correlated with adiponectin( P < 0. 05). Multivariate stepwise regression analysis showed that APACHEⅡ score,Hb A1 c and adiponectin were independent factors influencing serum omentin-1. Logistic regression analysis showed that Hb A1 c,APACHEⅡ score,omentin-1 and hs-CRP were the influencing factors of death in elderly patients with type 2 diabetes mellitus complicated with large-area cerebral infarction. Conclusion Serum omentin-1 is closely related to the death of elderly patients with type 2 diabetes complicated with cerebral infarction. The expression of omentin-1 may be affected by glycolipid metabolism and disease prognosis.
Objective It is to investigate the correlation between omentin-1 and prognosis in elderly patients with type 2diabetes mellitus complicated with large-area cerebral infarction. Methods A total of 112 elderly patients with type 2 diabetes mellitus complicated with large-area cerebral infarction were enrolled,including 88 in the survival group and 24 in the death group. The clinical data of each group were analyzed. Plasma omentin-1 level,adiponectin and metabolic parameters were determined by ELISA. Correlation analysis,multiple stepwise regression analysis and logistic regression analysis were performed for each variable. Results Plasma omentin-1 levels gradually decreased in the survival group and the death group( P < 0. 05). Plasma omentin-1 level was negatively correlated with APACHEⅡscore,Hb A1 c,hs-CRP and HOMA-IR( P <0. 05),and positively correlated with adiponectin( P < 0. 05). Multivariate stepwise regression analysis showed that APACHEⅡ score,Hb A1 c and adiponectin were independent factors influencing serum omentin-1. Logistic regression analysis showed that Hb A1 c,APACHEⅡ score,omentin-1 and hs-CRP were the influencing factors of death in elderly patients with type 2 diabetes mellitus complicated with large-area cerebral infarction. Conclusion Serum omentin-1 is closely related to the death of elderly patients with type 2 diabetes complicated with cerebral infarction. The expression of omentin-1 may be affected by glycolipid metabolism and disease prognosis.
引文
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[11]Qi D,Tang X,He J,et al.Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/e NOS-dependent mechanism[J].Cell Death Dis,2016,7(9):e2360
[12]Sonomi Maruyama,Rei Shibata,Ryosuke Kikuchi,et al.Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism[J].J Biol Chem,2012,287(1):408-417
[2]陈智伟,陆士娟.网膜素与心血管疾病关系的研究进展[J].海南医学,2014,25(15):2255-2257
[3]Luedde M,Benz F,Niedeggen J,et al.Elevated Omentin Serum Levels Predict Long-Term Survival in CriticallyⅢPatients[J].Dis Markers,2016,2016:3149243
[4]中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中国全科医学,2011,2(35):16-19
[5]Kyoung JK,Eun JL,Min KK,et al.Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death:Implication of cilostazol for diabetes mellitus-induced dementia[J].Neurobiol Dis,2015,73(1):12-23
[6]张洁,邸阜生.2型糖尿病合并下肢血管病变患者血浆网膜素-1水平与炎症因子的相关性研究[J].中国糖尿病杂志,2015,23(10):877-880
[7]Narumi T,Watanabe T,Kadowaki S,et al.Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure[J].Cardiovasc Diabetol,2014,13:84
[8]Tuttolomondo A,Di Sciacca R,Di Raimondo D,et al.Arterial stiffness indexes in acute ischemic stroke:relationship with stroke subtype[J].Atherosclerosis,2010,211(1):187-194
[9]Tan BK,Adya R,Farhatullah S,et al.Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome[J].Diabetes,2010,59(12):3023-3031
[10]Kazama K,Usui T,Okada M,et al.Omentin plays an antiinflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells[J].Eur J Pharmacol.2012,686(1/3):116-123
[11]Qi D,Tang X,He J,et al.Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/e NOS-dependent mechanism[J].Cell Death Dis,2016,7(9):e2360
[12]Sonomi Maruyama,Rei Shibata,Ryosuke Kikuchi,et al.Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism[J].J Biol Chem,2012,287(1):408-417