ANCA相关性血管炎的诊治和疗效评估指标研究近况
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摘要
<正>抗中性粒细胞胞浆抗体(antineutrophil cytoplasmic autoantibody,ANCA)相关性血管炎(ANCA associated vasculiltis,AAV)是一组自身免疫性系统性疾病,其病理特征为小血管壁的炎症和纤维素样坏死,中、老年人多见,累及肾脏即为ANCA相关性肾小球肾炎(AAGN),免疫抑制剂为主要治疗药物,易导致严重感染等副作用,故须准确判断疾病的活动性和病情变化来决定治疗方案及疗程。现就目前研究评估疾病活动及疗效的指标如伯明翰血管炎活动度计分、肾脏病理类型、ANCA、C-反应蛋白等作一综述。
引文
1.胡伟新,黎磊石.系统性血管炎肾脏损害.见:黎磊石,刘志红主编.中国肾脏病学.北京:人民军医出版社,2008.523-554.
2 .Davies DJ,Moran ME,Niall JF,et al.Segmental necrotising glomerulonephritis with antineutrophil antibody:possible arbovirus aetiology.Br J Med,1982,285(6342):606.
3 .辛岗,赵明辉.抗中性粒细胞胞浆抗体及其靶抗原检测与临床意义.新医学,2004,35(5):272-273.
4 .Jennette JC,Falk RJ,Bacon PA,et al.2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.Arthritis Rheum,2013,65(1):1-11.
5 .牟翠萍,毛慧娟.ANCA相关性小血管炎发病机制研究进展.中国中西医结合肾病杂志,2012,13(1):89-91.
6 .Hellmich B,Flossmann O,Gross WL,et al.EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis:focus on anti-neutrophil cytoplasm antibodyassociated vasculitis.Ann Rheum Dis,2007,66(5):605-617.
7 .陈曼,赵明辉.抗中性粒细胞胞浆抗体相关性肾炎的循证治疗.中华肾病研究电子杂志,2012,1(2):90-93.
8 .de Groot K,Harper L,Jayne DR,et al.Pulse versus daily oral cyelophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis:a randomized trial.Ann Intern Med,2009,150(10):670-680.
9 .曾玲玲,胡章学.ANCA相关性小血管炎诱导缓解治疗进展.中国中西医结合肾病杂志,2015,16(1):85-87.
10 .李康,章海涛,杨柳.多靶点疗法治疗抗中性粒细胞细胞质抗体相关性血管炎肾损害的初步临床观察.医学研究生学报,2015,28(9):934-939.
11 .陈樱花,龚德华,刘正钊,等.双重血浆置换治疗抗中性粒细胞胞质抗体相关血管炎严重肾损害的临床疗效.肾脏病与透析肾移植杂志,2012,21(1):8-13.
12 .Jones RB,Tervaert JW,Hauser T,et al.Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis.N Engl J Med,2010,363(3):211-220.
13 .Stone JH,Merkel PA,Spiera R,et al.Rituximab versus cyclophosphamide for ANCA-associated vasculitis.N Engl J Med,2010,363(3):221-232.
14 .Luqmani RA,Bacon PA,Moots RJ,et al.Birmingham Vasculitis Activity Score(BVAS)in systemic necrotizing vasculitis.QJM,1994,87(11):671-678.
15 .Mukhtyar C,Lee R,Brown D,et al.Modification and validation of the Birmingham Vasculitis Activity Score(Version 3).Ann Rheum Dis,2009,68(12):1827-1832.
16 .Flossmann O,Berden A,de Groot K,et al.Long-term patient survival in ANCA-associated vasculitis.Ann Rheum Dis,2011,70(3):488-494.
17 .Kawai H,Banno S,Kikuchi S,et al.Retrospective analysis of factors predicting end-stage renal failure or death in patients with microscopic polyangiitis with mainly renal involvement.Clin Exp Nephrol,2014,18(5):795-802.
18 .Ford SL,Polkinghorne KR,Longano A,et al.Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis.Am J Kidney Dis,2014,63(2):227-235.
19 .Chang DY,Wu LH,Liu G,et al.Reevaluation of the histopathologic classification of ANCA associated glomerulonephritis:a study of 121 patients in a single center.Nephrol Dial Transplant,2012,27(6):2343-2349.
20 .Berden AE,Ferrario F,Hagen EC,et al.Histopathologic classification of ANCA associated glomerulonephritis.J Am Soc Nephrol,2010,21(10):1628-1636.
21 .陈樱花,杨柳,陈浩,等.抗中性粒细胞胞质抗体相关血管炎肾脏病理改变与肾脏预后的关系.肾脏病与透析肾移植杂志,2015,24(6):512-517.
22 .陈樱花,刘正钊,杨柳,等.激素联合吗替麦考酚酯治疗抗中性粒细胞胞质抗体相关血管炎肾脏损害患者的远期预后.肾脏病与透析肾移植杂志,2014,23(4):307-313.
23 .刘霞,陈樱花,刘正钊,等.抗中性粒细胞胞质抗体相关性新月体肾炎治疗反应及远期预后的影响因素.肾脏病与透析肾移植杂志,2016,25(2):113-118.
24 .Finkielman JD,Merkel PA,Sehroeder D,et al.Antiproteinase 3antineutrophil cytoplasmic antibodies and disease activity in Wegener granulomatosis.Ann Intern Med,2007,147(9):611-619.
25 .Jayne DR,Gaskin G,Pusey CD,et al.ANCA and predicting relapse in systemic vasculitis.QJM,1995,88(2):127-133.
26 .Girard T,Mahr A,Noel LH,et al.Are antineutrophil cytoplasmic antibodies a marker predictive of relapse in Wegener’s granulomatosis?A prospective study.Rheumatology,2001,40(2):147-151.
27 .Basu N,Mc Clean A,Harper L,et al.Explaining fatigue in ANCA-associated vasculitis.Rheumatology,2013,52(9):1680-1685.
28 .李毅,张燕,赵明,等.抗中性粒细胞胞浆抗体相关性血管炎患者血清C反应蛋白水平及临床意义.临床肾脏病杂志,2014,14(4):226-229.
29 .Woywodt A,Streiber F,de Groot K,et al.Circulating endothelial cells as markers for ANCA associated small-vessel vasculitis.Lancet,2003,361(9353):206-210.
30 .Woywodt A,Goldberg C,Kirsch T,et al.Circulating endothelial cells in relapse and limited granulomatous disease due to ANCA associated vasculitis.Ann Rheum Dis,2006,65(2):164-168.
31 .姚根宏,张国栋,栾建凤,等.抗中性粒细胞胞浆抗体相关血管炎患者循环内皮细胞的变化及其临床意义.临床内科杂志,2009,26(12):836-838.
32 .陈樱花,位红兰,隽晨霞,等.循环内皮细胞损伤标记物与抗中性粒细胞胞质抗体相关血管炎活动性的联系.肾脏病与透析肾移植杂志,2011,20(6):530-535.
33 .蔡娟,王卫黎,黄鑫,等.抗中性粒细胞胞浆抗体相关性血管炎患者白细胞介素18的水平及意义.临床肾脏病杂志,2015,15(9):530-534.
34 .Novick D,Elbirt D,Dinarello CA,et al.Interleukin-18 binding protein in the sera of patients with Wegener’s granulomatosis.J Clin Immunol,2009,29(1):38-45.
35 .Achenbach J,Mengel M,Tossidou I,et al.Parietal epithelia cells in the urine as a marker of disease activity in glomerular diseases.Nephrol Dial Transplant,2008,23(10):3138-3145.
36 .Melnikov VY,Ecder T,Fantuzzi G,et al.Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure.J Clin Invest,2001(9),107:1145-1152.
37 .Soni SS,Katz RN,Cruz DN.Early diagnosis of acute kidney injury:the promise of novel biomarkers.Blood Purif,2009,28(3):165-174.
38 .Borregaard N,Cowland JB.Neutrophil gelatinase-associated lipocalin,a siderophore-binding eukaryotic protein.Biol Met,2006,19(2):211-215.
39 .Ishihara R,Taketani S,Sasai-Takedatsu M,et al.ELISA for urinary trehalase with monoclonal antibodies:a technique for assessment of renal tubular damage.Clin Chem,2000,46(5):636-643.
2 .Davies DJ,Moran ME,Niall JF,et al.Segmental necrotising glomerulonephritis with antineutrophil antibody:possible arbovirus aetiology.Br J Med,1982,285(6342):606.
3 .辛岗,赵明辉.抗中性粒细胞胞浆抗体及其靶抗原检测与临床意义.新医学,2004,35(5):272-273.
4 .Jennette JC,Falk RJ,Bacon PA,et al.2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.Arthritis Rheum,2013,65(1):1-11.
5 .牟翠萍,毛慧娟.ANCA相关性小血管炎发病机制研究进展.中国中西医结合肾病杂志,2012,13(1):89-91.
6 .Hellmich B,Flossmann O,Gross WL,et al.EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis:focus on anti-neutrophil cytoplasm antibodyassociated vasculitis.Ann Rheum Dis,2007,66(5):605-617.
7 .陈曼,赵明辉.抗中性粒细胞胞浆抗体相关性肾炎的循证治疗.中华肾病研究电子杂志,2012,1(2):90-93.
8 .de Groot K,Harper L,Jayne DR,et al.Pulse versus daily oral cyelophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis:a randomized trial.Ann Intern Med,2009,150(10):670-680.
9 .曾玲玲,胡章学.ANCA相关性小血管炎诱导缓解治疗进展.中国中西医结合肾病杂志,2015,16(1):85-87.
10 .李康,章海涛,杨柳.多靶点疗法治疗抗中性粒细胞细胞质抗体相关性血管炎肾损害的初步临床观察.医学研究生学报,2015,28(9):934-939.
11 .陈樱花,龚德华,刘正钊,等.双重血浆置换治疗抗中性粒细胞胞质抗体相关血管炎严重肾损害的临床疗效.肾脏病与透析肾移植杂志,2012,21(1):8-13.
12 .Jones RB,Tervaert JW,Hauser T,et al.Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis.N Engl J Med,2010,363(3):211-220.
13 .Stone JH,Merkel PA,Spiera R,et al.Rituximab versus cyclophosphamide for ANCA-associated vasculitis.N Engl J Med,2010,363(3):221-232.
14 .Luqmani RA,Bacon PA,Moots RJ,et al.Birmingham Vasculitis Activity Score(BVAS)in systemic necrotizing vasculitis.QJM,1994,87(11):671-678.
15 .Mukhtyar C,Lee R,Brown D,et al.Modification and validation of the Birmingham Vasculitis Activity Score(Version 3).Ann Rheum Dis,2009,68(12):1827-1832.
16 .Flossmann O,Berden A,de Groot K,et al.Long-term patient survival in ANCA-associated vasculitis.Ann Rheum Dis,2011,70(3):488-494.
17 .Kawai H,Banno S,Kikuchi S,et al.Retrospective analysis of factors predicting end-stage renal failure or death in patients with microscopic polyangiitis with mainly renal involvement.Clin Exp Nephrol,2014,18(5):795-802.
18 .Ford SL,Polkinghorne KR,Longano A,et al.Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis.Am J Kidney Dis,2014,63(2):227-235.
19 .Chang DY,Wu LH,Liu G,et al.Reevaluation of the histopathologic classification of ANCA associated glomerulonephritis:a study of 121 patients in a single center.Nephrol Dial Transplant,2012,27(6):2343-2349.
20 .Berden AE,Ferrario F,Hagen EC,et al.Histopathologic classification of ANCA associated glomerulonephritis.J Am Soc Nephrol,2010,21(10):1628-1636.
21 .陈樱花,杨柳,陈浩,等.抗中性粒细胞胞质抗体相关血管炎肾脏病理改变与肾脏预后的关系.肾脏病与透析肾移植杂志,2015,24(6):512-517.
22 .陈樱花,刘正钊,杨柳,等.激素联合吗替麦考酚酯治疗抗中性粒细胞胞质抗体相关血管炎肾脏损害患者的远期预后.肾脏病与透析肾移植杂志,2014,23(4):307-313.
23 .刘霞,陈樱花,刘正钊,等.抗中性粒细胞胞质抗体相关性新月体肾炎治疗反应及远期预后的影响因素.肾脏病与透析肾移植杂志,2016,25(2):113-118.
24 .Finkielman JD,Merkel PA,Sehroeder D,et al.Antiproteinase 3antineutrophil cytoplasmic antibodies and disease activity in Wegener granulomatosis.Ann Intern Med,2007,147(9):611-619.
25 .Jayne DR,Gaskin G,Pusey CD,et al.ANCA and predicting relapse in systemic vasculitis.QJM,1995,88(2):127-133.
26 .Girard T,Mahr A,Noel LH,et al.Are antineutrophil cytoplasmic antibodies a marker predictive of relapse in Wegener’s granulomatosis?A prospective study.Rheumatology,2001,40(2):147-151.
27 .Basu N,Mc Clean A,Harper L,et al.Explaining fatigue in ANCA-associated vasculitis.Rheumatology,2013,52(9):1680-1685.
28 .李毅,张燕,赵明,等.抗中性粒细胞胞浆抗体相关性血管炎患者血清C反应蛋白水平及临床意义.临床肾脏病杂志,2014,14(4):226-229.
29 .Woywodt A,Streiber F,de Groot K,et al.Circulating endothelial cells as markers for ANCA associated small-vessel vasculitis.Lancet,2003,361(9353):206-210.
30 .Woywodt A,Goldberg C,Kirsch T,et al.Circulating endothelial cells in relapse and limited granulomatous disease due to ANCA associated vasculitis.Ann Rheum Dis,2006,65(2):164-168.
31 .姚根宏,张国栋,栾建凤,等.抗中性粒细胞胞浆抗体相关血管炎患者循环内皮细胞的变化及其临床意义.临床内科杂志,2009,26(12):836-838.
32 .陈樱花,位红兰,隽晨霞,等.循环内皮细胞损伤标记物与抗中性粒细胞胞质抗体相关血管炎活动性的联系.肾脏病与透析肾移植杂志,2011,20(6):530-535.
33 .蔡娟,王卫黎,黄鑫,等.抗中性粒细胞胞浆抗体相关性血管炎患者白细胞介素18的水平及意义.临床肾脏病杂志,2015,15(9):530-534.
34 .Novick D,Elbirt D,Dinarello CA,et al.Interleukin-18 binding protein in the sera of patients with Wegener’s granulomatosis.J Clin Immunol,2009,29(1):38-45.
35 .Achenbach J,Mengel M,Tossidou I,et al.Parietal epithelia cells in the urine as a marker of disease activity in glomerular diseases.Nephrol Dial Transplant,2008,23(10):3138-3145.
36 .Melnikov VY,Ecder T,Fantuzzi G,et al.Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure.J Clin Invest,2001(9),107:1145-1152.
37 .Soni SS,Katz RN,Cruz DN.Early diagnosis of acute kidney injury:the promise of novel biomarkers.Blood Purif,2009,28(3):165-174.
38 .Borregaard N,Cowland JB.Neutrophil gelatinase-associated lipocalin,a siderophore-binding eukaryotic protein.Biol Met,2006,19(2):211-215.
39 .Ishihara R,Taketani S,Sasai-Takedatsu M,et al.ELISA for urinary trehalase with monoclonal antibodies:a technique for assessment of renal tubular damage.Clin Chem,2000,46(5):636-643.