噬血细胞综合征合并大B淋巴瘤及乙肝1例报道
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摘要
由噬血细胞综合征(hemophagocytic syndrome, HPS)合并大B淋巴瘤所致肝衰竭较罕见,该病发展迅速,死亡率极高,易误诊,现报道1例希望对此疾病有所认识。
Liver failure caused by hemophagocytic syndrome(HPS) combined with large B lymphoma is rare. The disease develops rapidly and the mortality rate is very high. It is easy to be misdiagnosed. One case was reported in this article.
Liver failure caused by hemophagocytic syndrome(HPS) combined with large B lymphoma is rare. The disease develops rapidly and the mortality rate is very high. It is easy to be misdiagnosed. One case was reported in this article.
引文
[1] JANKA G E,LEHMBERG K.Hemophagocytic lymphohistiocytosis:pathogenesis and treatment [J].Hematology Am Soc Hematol Educ Program,2013,(4):605-611.
[2] 噬血细胞综合征中国专家联盟,中华医学会儿科学分会血液学组.噬血细胞综合征诊治中国专家共识[J].中华医学杂志,2018,98(2):91-95.DOI:10.3760/cma.j.issn.0376-2491.2018.02.004.
[3] PAGEL J,BEUTEL K,LEHMBERG K,et al.Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5) [J].Blood,2012,119(25):6016-6024.DOI:10.1182/blood-2011-12-398958
[4] 吴梓梁.小儿噬血细胞综合征[J].中国实用儿科杂志,2001,16(4):244-246.DOI:10.3969/j.issn.1005-2224.2001.04.023.
[5] 张昭.噬血细胞综合症[J].大家健康,2014,8(1):178.
[6] 李小秋,李甘地,高子芬,等.中国淋巴瘤亚型分布:国内多中心性病例10002例分析[J].诊断学理论与实践,2012,11(2):111-115.DOI:10.3969/j.issn.1671-2870.2012.02.006.LI X Q,LI G D,GAO Z F,et al.Distribution pattern of lymphoma subtypes in China:a nationwide multicenter study of 10002 cases [J].J Diagn Concepts Pract,2012,11(2):111-115.DOI:10.3969/j.issn.1671-2870.2012.02.006.
[7] 陈灏珠,钟南山,等.内科学[M].8 版,北京:人民卫生出版社,2013.
[8] ZHANG L,ZHOU J,SOKOLl L.Hereditary and acquired hemophagocytic lymphohistiocytosis [J].Cancer Control,2014,21(4):301-312.DOI:10.1177/107327481402100406.
[9] WANG F,XU R H,HAN B,et al.High incidence of hepatitis B virus infection in B-cell subtype non-Hodgkin lymphoma compared with other cancers [J].Cancer,2007,109(7):1360-1364.DOI:10.1002/cncr.22549.
[10] CHEN M H,HSIAO L T,CHIOU T J,et al.High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin’s lymphoma [J].Ann Hematol,2008,87(6):475-480.DOI:10.1007/s00277-008-0469-9.
[11] WANG Y H,FAN L,WANG L,et al.Efficacy of prophylactic lamivudine to prevent hepatitis B virus reactivation in B-cell lymphoma treated with rituximab-containing chemotherapy [J].Support Care Cancer,2013,21(5):1265-1271.DOI:10.1007/s00520-012-1656-8.
[12] LEHMBERG K,NICHOLS K E,HENTER J I,et al.Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies [J].Haematologica,2015,100(8):997-1004.DOI:10.3324/haematol.2015.123562.
[2] 噬血细胞综合征中国专家联盟,中华医学会儿科学分会血液学组.噬血细胞综合征诊治中国专家共识[J].中华医学杂志,2018,98(2):91-95.DOI:10.3760/cma.j.issn.0376-2491.2018.02.004.
[3] PAGEL J,BEUTEL K,LEHMBERG K,et al.Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5) [J].Blood,2012,119(25):6016-6024.DOI:10.1182/blood-2011-12-398958
[4] 吴梓梁.小儿噬血细胞综合征[J].中国实用儿科杂志,2001,16(4):244-246.DOI:10.3969/j.issn.1005-2224.2001.04.023.
[5] 张昭.噬血细胞综合症[J].大家健康,2014,8(1):178.
[6] 李小秋,李甘地,高子芬,等.中国淋巴瘤亚型分布:国内多中心性病例10002例分析[J].诊断学理论与实践,2012,11(2):111-115.DOI:10.3969/j.issn.1671-2870.2012.02.006.LI X Q,LI G D,GAO Z F,et al.Distribution pattern of lymphoma subtypes in China:a nationwide multicenter study of 10002 cases [J].J Diagn Concepts Pract,2012,11(2):111-115.DOI:10.3969/j.issn.1671-2870.2012.02.006.
[7] 陈灏珠,钟南山,等.内科学[M].8 版,北京:人民卫生出版社,2013.
[8] ZHANG L,ZHOU J,SOKOLl L.Hereditary and acquired hemophagocytic lymphohistiocytosis [J].Cancer Control,2014,21(4):301-312.DOI:10.1177/107327481402100406.
[9] WANG F,XU R H,HAN B,et al.High incidence of hepatitis B virus infection in B-cell subtype non-Hodgkin lymphoma compared with other cancers [J].Cancer,2007,109(7):1360-1364.DOI:10.1002/cncr.22549.
[10] CHEN M H,HSIAO L T,CHIOU T J,et al.High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin’s lymphoma [J].Ann Hematol,2008,87(6):475-480.DOI:10.1007/s00277-008-0469-9.
[11] WANG Y H,FAN L,WANG L,et al.Efficacy of prophylactic lamivudine to prevent hepatitis B virus reactivation in B-cell lymphoma treated with rituximab-containing chemotherapy [J].Support Care Cancer,2013,21(5):1265-1271.DOI:10.1007/s00520-012-1656-8.
[12] LEHMBERG K,NICHOLS K E,HENTER J I,et al.Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies [J].Haematologica,2015,100(8):997-1004.DOI:10.3324/haematol.2015.123562.