变应性鼻炎基于免疫学机制的药物治疗研究进展
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摘要
<正>变应性鼻炎(allergic rhinitis,AR)目前主要的治疗方法包括避免接触变应原、药物治疗和特异性免疫治疗(allergn immunotherapy,AIT)〔1〕。然而,在临床实践中变应原种类繁多,无法做到完全避免接触;药物治疗虽然可以快速有效地缓解AR的临床症状,但其并不能从根本上治疗AR,且具有依赖性,一旦停药易导致反复发作、病情加重等情况,且长期用药也会出现肝肾损伤等不良反应〔2〕。AIT对AR和哮喘的疗效近年来已被大量研究证实,AIT
The current treatment of allergic rhinitis remains a challeng for clinician while developing non-specific immunotherapy can make up the disadvantages of routine medications.It has solved the problems like long treatment course of specific immunotherapy or adverse reactions;It has improved the theoretical basis and treatment methods of airway allergic disease.This article reviwed the recent clinical studies about mechanisms of allergic rhinitis.
The current treatment of allergic rhinitis remains a challeng for clinician while developing non-specific immunotherapy can make up the disadvantages of routine medications.It has solved the problems like long treatment course of specific immunotherapy or adverse reactions;It has improved the theoretical basis and treatment methods of airway allergic disease.This article reviwed the recent clinical studies about mechanisms of allergic rhinitis.
引文
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[22]杜云艳,罗英,杨春平,等.IL-33及其受体ST2与变应性鼻炎发病机制的相关性探讨[J].临床耳鼻咽喉头颈外科杂志,2015,29(9):811-814.
[23]JE I G,KIM D S,KIM S W,et al.Tyrosol suppresses allergic inflammation by inhibiting the activation of phosphoinositide 3-Kinase in mast cells[J].PLoSOne,2015,10:e0129829-e0129829.
[24]SAMIVEL R,KIM D W,SON H R,et al.The role of TRPV1in the CD4+T cell-mediated inflammatory response of allergic rhinitis[J].Oncotarget,2016,7:148-160.
[25]MKINEN K,MUKHERJEE C,LEINO M,et al.Anovel mannoside-glycocluster adjuvant:Compared in vitro to CpG ODN and MPL and tested in vivo in mouse asthma model[J].Allergol Immunopathol(Madr),2016,44:9-17.
[26]KIM E H,KIM J H,SAMIVEL R,et al.Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis[J].Allergy,2016,11:171-174.
[27]王智勇,苏丽娟,熊玉林,等.卡介菌多糖核酸在治疗儿童常年性变应性鼻炎的研究[J].检验医学与临床,2015,12(17):2523-2525.
[2]KLIMEK L,MULLOL J,HELLINGS P,et al.Recent pharmacological developments in the treatment of perennial and persistent allergic rhinitis.[J].Expert Opin Pharmacother,2016,17:657-669.
[3]INCORVAIA C,ARIANO R,BERTO P,et al.Economic aspects of sublingual immunotherapy[J].Int JImmunopathol Pharmacol,2009,22:27-30.
[4]梁美君,徐睿,许庚,等.变应性鼻炎研究新进展[J].临床耳鼻咽喉头颈外科杂志,2015,29(3):202-206.
[5]张樊苹,佘翠萍.变应性鼻炎的非特异性免疫治疗进展[J].临床耳鼻咽喉头颈外科杂志,2013,27(15):857-860.
[6]MOHAPATRA S S,QAZI M,HELLERMANN G.Immunotherapy for allergies and asthma:present and future[J].Curr Opin Pharmacol,2010,10:276-288.
[7]PAJNO G B,NADEAU K C,PASSALACQUA G,et al.The evolution of allergen and non-specific immunotherapy:past achievements,current applications and future outlook[J].Expert Rev Clin Immunol,2015,11:141-154.
[8]陈姝瑾,王卫红,刘冰,等.氮卓斯汀喷雾剂合用玉屏风散对变应性鼻炎患者血清IgE、外周嗜酸粒细胞水平的影响[J].现代中西医结合杂志,2015,24(36):4040-4042.
[9]HAYASHI T,RAZ E.TLR9-based immunotherapy for allergic disease[J].Am J Med,2006,119:e1-6.
[10]LI D Q,ZHANG L,PFLUGFELDER S C,et al.Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways[J].J Allergy Clin Immunol,2011,128:1318-1325.
[11]CASALE T B,KESSLER J,ROMERO F A.Safety of the intranasal toll-like receptor 4agonist CRX-675in allergic rhinitis[J].Ann Allergy Asthma Immunol,2006,97:454-456.
[12]MELVIN T A,RAMANATHAN M J R.Role of innate immunity in the pathogenesis of allergic rhinitis[J].Curr Opin Otolaryngol Head Neck Surg,2012,20:194-198.
[13]ROSEWICH M,GIROD K,ZIELEN S,et al.Induction of bronchial tolerance after 1cycle of monophosphoryl-A-Adjuvanted specific immunotherapy in children with grass pollen allergies[J].Allergy Asthma Immunol Res,2016,8:257-263.
[14]庞湃,韩佳利,魏宏权.匹多莫德治疗过敏性鼻炎临床观察[J].解放军医药杂志,2016,28(1):101-105.
[15]TAKAHASHI G,ASANUMA F,SUZUKI N,et al.Effect of the potent and selective DP1receptor antagonist,asapiprant(S-555739),in animal models of allergic rhinitis and allergic asthma[J].Eur J Pharmacol,2015,765:15-23.
[16]NAGIRA Y,GOTO K,TANAKA H,et al.Prostaglandin D2 modulates neuronal excitation of the trigeminal ganglion to augment allergic rhinitis in guinea pigs[J].J Pharmacol Exp Ther,2016,357:273-280.
[17]KHODER A,SARVARIA A,ALSULIMAN A,et al.Regulatory B cells are enriched within the IgMmemory and transitional donors but are deficient in chronic GVHD[J].Blood,2014,124:2034-2045.
[18]王萌,曹志伟.调节性B细胞在变应性疾病中对T细胞免疫的调节作用及其调节因素[J].临床与病理杂志,2015,35(6):1137-1143.
[19]PETTERSON T,MANSSON A,RIESBECK K,et al.Nucleotide-binding and oligomerization domain-like receptors and retinoic acid inducible gene-like receptors in human tonsillar T lymphocytes[J].Immunology,2011,133:84-93.
[20]张沈华,刘艳慧,申聪香,等.NLRs模式识别受体在变应性鼻炎患者发病中的作用和意义[J].临床耳鼻喉头颈外科杂志,2015,29(15):1323-1328.
[21]张建辉,唐嗣泉.趋化因子受体CCR4与变应性鼻炎发病机制的相关性研究[J].中华临床医师杂志,2015,9(23):4331-4334.
[22]杜云艳,罗英,杨春平,等.IL-33及其受体ST2与变应性鼻炎发病机制的相关性探讨[J].临床耳鼻咽喉头颈外科杂志,2015,29(9):811-814.
[23]JE I G,KIM D S,KIM S W,et al.Tyrosol suppresses allergic inflammation by inhibiting the activation of phosphoinositide 3-Kinase in mast cells[J].PLoSOne,2015,10:e0129829-e0129829.
[24]SAMIVEL R,KIM D W,SON H R,et al.The role of TRPV1in the CD4+T cell-mediated inflammatory response of allergic rhinitis[J].Oncotarget,2016,7:148-160.
[25]MKINEN K,MUKHERJEE C,LEINO M,et al.Anovel mannoside-glycocluster adjuvant:Compared in vitro to CpG ODN and MPL and tested in vivo in mouse asthma model[J].Allergol Immunopathol(Madr),2016,44:9-17.
[26]KIM E H,KIM J H,SAMIVEL R,et al.Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis[J].Allergy,2016,11:171-174.
[27]王智勇,苏丽娟,熊玉林,等.卡介菌多糖核酸在治疗儿童常年性变应性鼻炎的研究[J].检验医学与临床,2015,12(17):2523-2525.