结合病理生理机制探讨动脉硬化之中医疗护原则（英文）
|
摘要
动脉硬化是心血管疾病的主要危险因素。糖化终产物则是导致动脉发生硬化的原因之一,它使得动脉基质中的胶原蛋白产生交互连结,造成动脉壁延展性降低而导致动脉发生硬化。糖化终产物的形成,与氧化压力有很大的关系,而氧化压力又与生活中压力所导致的情志不畅,以及饮食型态、生活习惯有关。对于动脉硬化,中医的治疗与护理原则多以活血化瘀、软坚散结为主,依据辨证的基础,给予相应的治疗及护理措施。
One of the major risk factors for cardiovascular disease is arterial stiffness. There are several mechanisms associated with the development of arterial stiffness, including the involvement of advanced glycation end products. Arterial stiffness results from altered distensibility of arterial walls and is associated with advanced glycation end product-related cross-linking of collagen in the artery matrix. Oxidative stress is associated with advanced glycation end products formation and triggered by moodiness, feeding mode, and lifestyle. In TCM and care, the major treatment for arterial stiffness includes activating blood, resolving stasis, softening hardness, and dissipating binds. Depending on the particular syndrome, variations on these major approaches to TCM therapy and related auxiliary nursing care are applied.
One of the major risk factors for cardiovascular disease is arterial stiffness. There are several mechanisms associated with the development of arterial stiffness, including the involvement of advanced glycation end products. Arterial stiffness results from altered distensibility of arterial walls and is associated with advanced glycation end product-related cross-linking of collagen in the artery matrix. Oxidative stress is associated with advanced glycation end products formation and triggered by moodiness, feeding mode, and lifestyle. In TCM and care, the major treatment for arterial stiffness includes activating blood, resolving stasis, softening hardness, and dissipating binds. Depending on the particular syndrome, variations on these major approaches to TCM therapy and related auxiliary nursing care are applied.
引文
[1] NICOLL R,HENEIN MY.Caloric Restriction and Its Effect on Blood Pressure,Heart Rate Variability and Arterial Stiffness and Dilatation:A Review of the Evidence [J].Int J Mol Sci,2018,19(3):751-768.
[2] PALOMBO C,KOZAKOVA M.Arterial stiffness,atherosclerosis and cardiovascular risk:Pathophysiologic mechanisms and emerging clinical indications [J].Vascul Pharmacol,2016,77:1-7.
[3] VANDERBURGH JA,REINHART-KING CA.The role of age-related intimal remodeling and stiffening in atherosclerosis [J].Adv Pharmacol,2018,81:365-391.
[4] NILSSON PN.Early vascular ageing-A concept in development [J].Eur Endocrinol,2015,11(1):26-31.
[5] DI PINO A,CURRENTI W,URBANO F,et al.High intake of dietary advanced glycation end-products is associated with increased arterial stiffness and inflammation in subjects with type 2 diabetes [J].Nutrit Metabol Cardiovascul Dis,2017,27(11):978-984.
[6] GALE J,AIELLO L P,SEBAG J.2014.IE Diabetic Vitreopathy[M].Vitreous:Springer,2014:57-79.
[7] CHUANG YC,WU MS,SU YK,et al.Effects of olmesartan on arterial stiffness in rats with chronic renal failure [J].Cardiovasc Diabetol,2012,11:66.
[8] CAI YX,LI XL,QUAN MH,et al.Analysis of the intervention effect of preventive treatment for early arteriosclerosis[J].Nei Mongol J Tradit Chin Med,2017,36(4):50.
[9] FENG JC.The experience of cardiovascular disease treatment from liver[J].Zhejiang J Tradit Chin Med,2016,51(10):761-762.
[10] LI GP.Clinical application on acupuncture method of regulating spirit and soothe liver[J].Nei Mongol J Tradit Chin Med,2015,34(10):59.
[11] LI MY,LOU YQ.The origin of vessel impediment and related historical literature review[J].Rheumat Arthrit,2014,3(10):54-61.
[12] YAN BC.The clinical application of Xuefu Zhuyu decoction on vessel impediment[J].China Med Heral,2008,5(14):97.
[13] PAN JX,ANG SF,ANG XD,et al.The treatment effect of Buyanghuanwu Decoction on ultrasonic hemodynamics of type2 diabetic lower limb ischemia[J].J Jinan Univ(Nat Sci Med Edit),2017,38(1):75-78.
[14] LYU P,TONG X,PENG Q,et al.Treatment with the herbal medicine,naoxintong improves the protective effect of high-density lipoproteins on endothelial function in patients with type 2 diabetes [J].Mol Med Rep,2016,13(3):2007-2016.
[15] QU Z,ZHANG J,HUO L,et al.Antihypertensive and vasorelaxant effects of Rhizoma corydalis and its active component tetrahydropalmatine via NO/cGMP pathway and calcium channel blockade in isolated rat thoracic aorta [J].RSC Adv,2015,5(114):94130-94143.
[16] WANG YY,WEI HY,WANG ZY,et al.The research overview of treatment of atherosclerosis with soften hardness and dissipate binds[J].Chin J Integr Med Cardio-Cerebrovascul Dis,2016,14(3):276-278.
[17] MAO WB,LU H,XU YN,et al.Literature study on acupuncture-moxibustion for Bi-impediment syndrome in Ming and Qing dynasties[J].Shanghai J Acupunct Moxib,2017,36(9):1125-1129.
[18] HUANG S,CHEN Z,WU W,et al.MicroRNA-31 promotes arterial smooth muscle cell proliferation and migration by targeting mitofusin-2 in arteriosclerosis obliterans of the lower extremitie [J].Exp Ther Med,2018,15(1):633-640.
[19] ZHANG CQ,XU B.Research on framework of etiology and pathogenesis theory of gangrene[J].J Zhejiang Chin Med Univ,2017,41(10):800-802.
[20] ZHANG CY,GAO Z.The experience of TCM treatment for digital gangrene[J].China J Exp Traditi Med Formul,2011,17(9):289-291.
[21] DU XX,NIU WG,YAN M,et al.Emotional nursing care for negative emotions cause blood sugar rise in 44 diabetes cases[J].Hebei J Tradit Chin Med,2010,32(2):286-287.
[22] LI YY,LYU SC,ZHONG AQ,et al.Discussion on treatment of atherosclerosis from spleen and kidney[J].Glob Tradit Chin Med,2014,7(3):204-205.
[23] BONNEFONT-ROUSSELOT D.Resveratrol and cardiovascular diseases[J].Nutrients,2016,8(5):250.
[24] XING CZ,TAN HQ.Pay attention to living care follow the TCM concept[J].Glob Tradit Chin Med,2014,29(3):604-605.
[25] YAO JC.Foot bath treatment by Huoxuetongluo prescription on diabetes foot[J].Jilin J Tradit Chin Med,2016,36(1):50-53.
[26] LIU HY,WANG W.Application of preventive treatment on the atherosclerosis[J].Mod J Integr Tradit Chin West Med,2012,21(7):745-746.
[2] PALOMBO C,KOZAKOVA M.Arterial stiffness,atherosclerosis and cardiovascular risk:Pathophysiologic mechanisms and emerging clinical indications [J].Vascul Pharmacol,2016,77:1-7.
[3] VANDERBURGH JA,REINHART-KING CA.The role of age-related intimal remodeling and stiffening in atherosclerosis [J].Adv Pharmacol,2018,81:365-391.
[4] NILSSON PN.Early vascular ageing-A concept in development [J].Eur Endocrinol,2015,11(1):26-31.
[5] DI PINO A,CURRENTI W,URBANO F,et al.High intake of dietary advanced glycation end-products is associated with increased arterial stiffness and inflammation in subjects with type 2 diabetes [J].Nutrit Metabol Cardiovascul Dis,2017,27(11):978-984.
[6] GALE J,AIELLO L P,SEBAG J.2014.IE Diabetic Vitreopathy[M].Vitreous:Springer,2014:57-79.
[7] CHUANG YC,WU MS,SU YK,et al.Effects of olmesartan on arterial stiffness in rats with chronic renal failure [J].Cardiovasc Diabetol,2012,11:66.
[8] CAI YX,LI XL,QUAN MH,et al.Analysis of the intervention effect of preventive treatment for early arteriosclerosis[J].Nei Mongol J Tradit Chin Med,2017,36(4):50.
[9] FENG JC.The experience of cardiovascular disease treatment from liver[J].Zhejiang J Tradit Chin Med,2016,51(10):761-762.
[10] LI GP.Clinical application on acupuncture method of regulating spirit and soothe liver[J].Nei Mongol J Tradit Chin Med,2015,34(10):59.
[11] LI MY,LOU YQ.The origin of vessel impediment and related historical literature review[J].Rheumat Arthrit,2014,3(10):54-61.
[12] YAN BC.The clinical application of Xuefu Zhuyu decoction on vessel impediment[J].China Med Heral,2008,5(14):97.
[13] PAN JX,ANG SF,ANG XD,et al.The treatment effect of Buyanghuanwu Decoction on ultrasonic hemodynamics of type2 diabetic lower limb ischemia[J].J Jinan Univ(Nat Sci Med Edit),2017,38(1):75-78.
[14] LYU P,TONG X,PENG Q,et al.Treatment with the herbal medicine,naoxintong improves the protective effect of high-density lipoproteins on endothelial function in patients with type 2 diabetes [J].Mol Med Rep,2016,13(3):2007-2016.
[15] QU Z,ZHANG J,HUO L,et al.Antihypertensive and vasorelaxant effects of Rhizoma corydalis and its active component tetrahydropalmatine via NO/cGMP pathway and calcium channel blockade in isolated rat thoracic aorta [J].RSC Adv,2015,5(114):94130-94143.
[16] WANG YY,WEI HY,WANG ZY,et al.The research overview of treatment of atherosclerosis with soften hardness and dissipate binds[J].Chin J Integr Med Cardio-Cerebrovascul Dis,2016,14(3):276-278.
[17] MAO WB,LU H,XU YN,et al.Literature study on acupuncture-moxibustion for Bi-impediment syndrome in Ming and Qing dynasties[J].Shanghai J Acupunct Moxib,2017,36(9):1125-1129.
[18] HUANG S,CHEN Z,WU W,et al.MicroRNA-31 promotes arterial smooth muscle cell proliferation and migration by targeting mitofusin-2 in arteriosclerosis obliterans of the lower extremitie [J].Exp Ther Med,2018,15(1):633-640.
[19] ZHANG CQ,XU B.Research on framework of etiology and pathogenesis theory of gangrene[J].J Zhejiang Chin Med Univ,2017,41(10):800-802.
[20] ZHANG CY,GAO Z.The experience of TCM treatment for digital gangrene[J].China J Exp Traditi Med Formul,2011,17(9):289-291.
[21] DU XX,NIU WG,YAN M,et al.Emotional nursing care for negative emotions cause blood sugar rise in 44 diabetes cases[J].Hebei J Tradit Chin Med,2010,32(2):286-287.
[22] LI YY,LYU SC,ZHONG AQ,et al.Discussion on treatment of atherosclerosis from spleen and kidney[J].Glob Tradit Chin Med,2014,7(3):204-205.
[23] BONNEFONT-ROUSSELOT D.Resveratrol and cardiovascular diseases[J].Nutrients,2016,8(5):250.
[24] XING CZ,TAN HQ.Pay attention to living care follow the TCM concept[J].Glob Tradit Chin Med,2014,29(3):604-605.
[25] YAO JC.Foot bath treatment by Huoxuetongluo prescription on diabetes foot[J].Jilin J Tradit Chin Med,2016,36(1):50-53.
[26] LIU HY,WANG W.Application of preventive treatment on the atherosclerosis[J].Mod J Integr Tradit Chin West Med,2012,21(7):745-746.