肠道微生态与2型糖尿病的关系
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摘要
<正>2型糖尿病是以胰岛素抵抗和胰腺β细胞分泌障碍为主要特征的一种代谢性疾病,患者多表现为超重和肥胖,并伴有脂质代谢紊乱。受遗传、生活习惯、环境等多种因素的影响,近年来临床新诊断为2型糖尿病的患者数量逐年增加。2型糖尿病及其并发症严重影响患者的生活质量,造成了巨大的经济压力和社会负担,已成为重要的公共卫生问题。肠道是人体重要的消化器官之一,在机体的代谢、
引文
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[2]McCreight LJ,Bailey CJ,Pearson ER.Metformin and the gastrointestinal tract[J].Diabetologia,2016,59(3):426-435.
[3]Medina-Vera I,Sanchez-Tapia M,Noriega-López L,et al.A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes[J].Diabetes Metab,2018,45(2):122-131.
[4]Vrieze A,Out C,Fuentes S,et al.Impact of oral vancomycin on gut microbiota,bile acid metabolism,and insulin sensitivity[J].JHepatol,2014,60(4):824-831.
[5]Tilg H,Moschen AR.Microbiota and diabetes:an evolving relationship[J].Gut,2014,63(9):1513-1521.
[6]Cruz NG,Sousa LP,Sousa MO,et al.The linkage between inflammation and type 2 diabetes mellitus[J].Diabetes Res Clin Pract,2013,99(2):85-92.
[7]Balakumar M,Prabhu D,Sathishkumar C,et al.Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice[J].Eur J Nutr,2018,57(1):279-295.
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[9]Cabreiro F.Metformin joins forces with microbes[J].Cell Host Microbe,2016,19(1):1-3.
[10]Koh A,De Vadder F,Kovatcheva-Datchary P,et al.From dietary fiber to host physiology:short-chain fatty acids as key bacterial metabolites[J].Cell,2016,165(6):1332-1345.
[11]Qin J,Li Y,Cai Z,et al.A metagenome-wide association study of gut microbiota in type 2 diabetes[J].Nature,2012,490(7418):55-60.
[12]Chang PV,Hao L,Offermanns S,et al.The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition[J].Proc Natl Acad Sci U S A,2014,111(6):2247-2252.
[13]Wang S,Zhu H,Lu C,et al.Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and immunity of host animals[J].J Dairy Sci,2012,95(9):4813-4822.
[14]蒋岚,陈果,高陈林,等.益生菌对T2DM患者肠道菌群和脂联素的影响[J].中国现代医学杂志,2018,28(11):84-87.
[15]Liu F,Prabhakar M,Ju J,et al.Effect of inulin-type fructans on blood lipid profile and glucose level:a systematic review and meta-analysis of randomized controlled trials[J].Eur J Clin Nutr,2017,71(1):9-20.
[16]Dehghan P,Pourghassem GB,Asgharijafarabadi M.Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes:a randomized,placebocontrolled clinical trial[J].Health Promot Perspect,2013,3(1):55-63.
[17]Walker AW,Ince J,Duncan SH,et al.Dominant and dietresponsive groups of bacteria within the human colonic microbiota[J].ISME J,2011,5(2):220-230.
[18]Shin NR,Lee JC,Lee HY,et al.An increase in the Akkermansia spp.population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice[J].Gut,2014,63(5):727-735.
[19]Lee H,Ko G.Effect of metformin on metabolic improvement and gut microbiota[J].Appl Environ Microbiol,2014,80(19):5935-5943.
[20]吴琳英,邓顺有,王毅飞,等.阿托伐他汀对2型糖尿病小鼠肠道菌群的影响[J].中国实用医药,2017,12(22):128-130.
[21]Zhang X,Zhao Y,Xu J,et al.Modulation of gut microbiota by berberine and metformin during the treatment of high-fat dietinduced obesity in rats[J].Sci Rep,2015,5:14405.
[22]刘丹英,叶小斌.阿奇霉素联合莫沙必利对糖尿病胃轻瘫患者肠道菌群的影响[J].中国微生态学杂志,2018,30(2):185-188.
[23]Schauer PR,Bhatt DL,Kirwan JP,et al.Bariatric surgery versus intensive medical therapy for diabetes--5-year outcomes[J].N Engl J Med,2017,376(7):641-651.
[24]Vrieze A,Van Nood E,Holleman F,et al.Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome[J].Gastroenterology,2012,143(4):913-916.