冬凌草甲素抗炎作用参与多种疾病治疗的新进展
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摘要
冬凌草甲素是冬凌草的主要活性成分,具有广泛的药理作用。研究表明,冬凌草甲素在炎症性疾病方面表现出较好的疗效。综述国内外关于冬凌草甲素抗炎作用参与多种疾病治疗的研究进展,并分析研究的方向,为研究与开发以冬凌草为原料的抗炎新药提供参考。
Oridonin is the main active ingredientwhich has extensive pharmacological action,was found to exhibit satisfactorytherapeutic effects in inflammatory diseases.Here, we summarize the research progress on anti-inflammatory effects of oridoninon various diseases, and analyze the research direction in the future, which can provide a reference for the research and development of anti-inflammatory drugs based on oridonin.
Oridonin is the main active ingredientwhich has extensive pharmacological action,was found to exhibit satisfactorytherapeutic effects in inflammatory diseases.Here, we summarize the research progress on anti-inflammatory effects of oridoninon various diseases, and analyze the research direction in the future, which can provide a reference for the research and development of anti-inflammatory drugs based on oridonin.
引文
[1] 戴一,贾晓益,宋祖荣,等.冬凌草抗炎有效部位筛选及初步表征[J].中国医药学杂志,2015,35(6):495-498.
[2] 抗晶晶,刘晓宁,殷志敏.牛蒡子苷元抗炎机制的新进展[J].南京师大学报(自然科学版),2017,40(2):83-88.
[3] 卞秋桂,林征,罗丹,等.炎症性肠病患者健康教育现状综述[J].实用临床医药杂志,2018,22(6):129-132.
[4] 臧凯宏,杜丽东,刘晓梅,等.冬凌草甲素片对醋酸诱导的小鼠溃疡性结肠炎的治疗作用(英文)[J].中国现代应用药学,2012,29(9):781-785.
[5] LIU Q Q,WANG H L,CHEN K,et al.Oridonin derivative ameliorates experimental colitis by inhibiting activated T‐cells and translocation of nuclear factor‐kappa B[J].Journal of Digestive Diseases,2015,17(2):104-112.
[6] 郐一贺,顾取良,邓慧君,等.冬凌草甲素对LPS诱导Raw264.7巨噬细胞炎症反应的抑制作用[J].广东药科大学学报,2017,33(2):250-254.
[7] 杜海涛,陈峥,万军.肠易激综合征的病理机制研究进展[J].解放军医学院学报,2017,38(1):85-88.
[8] ZANG K H,SHAO Y Y,ZUO X,et al.Oridonin Alleviates Visceral Hyperalgesia in a Rat Model of Postinflammatory Irritable Bowel Syndrome:Role of Colonic Enterochromaffin Cell and Serotonin Availability[J].Journal of Medicinal Food,2016,19(6):586-592.
[9] JING W,LI F,DING J,et al.Investigation of the anti-asthmatic activity of Oridonin on a mouse model of asthma[J].Molecular Medicine Reports,2016,14(3):2000-2006.
[10] GAN Z,TAO Z,MA X,et al.Oridonin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-induced RAW264.7 cells and acute lung injury[J].Oncotarget,2017,8(60):68153-68164.
[11] JIANG J,SHAN X,ZHU L.Effects and mechanisms of oridonin in the treatment of acute respiratory distress syndrome mice[J].International Journal of Clinical & Experimental Medicine,2017,10(4):6191-6197.
[12] NASICA-LABOUZE J,NGUYEN P H,STERPONE F,et al.Amyloid β Protein and Alzheimer's Disease:When Computer Simulations Complement Experimental Studies[J].Chemical Reviews,2015,115(9) :3518-3563.
[13] WANG S L,YANGH,YU L J,et al.Oridonin Attenuates A beta(1-42)-Induced Neuroinflammation and Inhibits NF-kappa B Pathway[J].Plos One,2014(9) :1-7.
[14] XU Y,XUE Y,WANG Y,et al.Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia.[J].International Immunopharmacology,2009,9(3):360-365.
[15] 历明辉,陈黎,梁欢.温阳益气养阴活血方对2型糖尿病肾病患者血糖肾功能及24 h尿白蛋白量的影响与药学分析[J].山西医药杂志,2018,47(4):469-471.
[16] LI J,BAO L,ZHA D,et al.Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-?oB signaling pathways[J].International Immunopharmacology,2017,55:9-19.
[17] Huang W,Huang M,Hui O,et al.Oridonin inhibits vascular inflammation by blocking NF-κB and MAPK activation[J].European Journal of Pharmacology,2018,826:133-139.
[18] CHEN R Y,XU B,CHEN S F,et al.Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells.[J].World Journal of Gastroenterology,2014,20(40):14895.
[19] 冯耀荣,陈红淑.冬凌草甲素抗肿瘤活性研究进展[J].中国中医药科技,2016,23(1):125-126.
[2] 抗晶晶,刘晓宁,殷志敏.牛蒡子苷元抗炎机制的新进展[J].南京师大学报(自然科学版),2017,40(2):83-88.
[3] 卞秋桂,林征,罗丹,等.炎症性肠病患者健康教育现状综述[J].实用临床医药杂志,2018,22(6):129-132.
[4] 臧凯宏,杜丽东,刘晓梅,等.冬凌草甲素片对醋酸诱导的小鼠溃疡性结肠炎的治疗作用(英文)[J].中国现代应用药学,2012,29(9):781-785.
[5] LIU Q Q,WANG H L,CHEN K,et al.Oridonin derivative ameliorates experimental colitis by inhibiting activated T‐cells and translocation of nuclear factor‐kappa B[J].Journal of Digestive Diseases,2015,17(2):104-112.
[6] 郐一贺,顾取良,邓慧君,等.冬凌草甲素对LPS诱导Raw264.7巨噬细胞炎症反应的抑制作用[J].广东药科大学学报,2017,33(2):250-254.
[7] 杜海涛,陈峥,万军.肠易激综合征的病理机制研究进展[J].解放军医学院学报,2017,38(1):85-88.
[8] ZANG K H,SHAO Y Y,ZUO X,et al.Oridonin Alleviates Visceral Hyperalgesia in a Rat Model of Postinflammatory Irritable Bowel Syndrome:Role of Colonic Enterochromaffin Cell and Serotonin Availability[J].Journal of Medicinal Food,2016,19(6):586-592.
[9] JING W,LI F,DING J,et al.Investigation of the anti-asthmatic activity of Oridonin on a mouse model of asthma[J].Molecular Medicine Reports,2016,14(3):2000-2006.
[10] GAN Z,TAO Z,MA X,et al.Oridonin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-induced RAW264.7 cells and acute lung injury[J].Oncotarget,2017,8(60):68153-68164.
[11] JIANG J,SHAN X,ZHU L.Effects and mechanisms of oridonin in the treatment of acute respiratory distress syndrome mice[J].International Journal of Clinical & Experimental Medicine,2017,10(4):6191-6197.
[12] NASICA-LABOUZE J,NGUYEN P H,STERPONE F,et al.Amyloid β Protein and Alzheimer's Disease:When Computer Simulations Complement Experimental Studies[J].Chemical Reviews,2015,115(9) :3518-3563.
[13] WANG S L,YANGH,YU L J,et al.Oridonin Attenuates A beta(1-42)-Induced Neuroinflammation and Inhibits NF-kappa B Pathway[J].Plos One,2014(9) :1-7.
[14] XU Y,XUE Y,WANG Y,et al.Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia.[J].International Immunopharmacology,2009,9(3):360-365.
[15] 历明辉,陈黎,梁欢.温阳益气养阴活血方对2型糖尿病肾病患者血糖肾功能及24 h尿白蛋白量的影响与药学分析[J].山西医药杂志,2018,47(4):469-471.
[16] LI J,BAO L,ZHA D,et al.Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-?oB signaling pathways[J].International Immunopharmacology,2017,55:9-19.
[17] Huang W,Huang M,Hui O,et al.Oridonin inhibits vascular inflammation by blocking NF-κB and MAPK activation[J].European Journal of Pharmacology,2018,826:133-139.
[18] CHEN R Y,XU B,CHEN S F,et al.Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells.[J].World Journal of Gastroenterology,2014,20(40):14895.
[19] 冯耀荣,陈红淑.冬凌草甲素抗肿瘤活性研究进展[J].中国中医药科技,2016,23(1):125-126.