冠心病患者合并肺部感染与血清降钙素原、中性粒细胞淋巴细胞计数比值等指标相关性研究
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摘要
目的:探讨冠心病患者的血清降钙素原、中性粒细胞淋巴细胞计数比值等相关临床指标与肺部感染发生之间的关系,为冠心病患者合并肺部感染的临床诊治提供依据。方法:选取冠心病患者128例,根据患者是否发生肺部感染,分成了感染组和对照组各64例,检测并比较两组患者血清降钙素原(PCT)、血清前白蛋白(PA)、白细胞计数(WBC)、淋巴细胞计数(LyC)、中性粒细胞计数(NeuC)和中性粒细胞淋巴细胞计数比值(NLR)。结果:感染组PCT浓度(3.67±1.62)ng/ml,显著高于对照组(0.03±0.01)ng/ml,感染组PA浓度(164.34±45.45)mg/L,显著低于对照组(228.34±65.93)mg/L,感染组WBC、NeuC、LyC、CRP和NLR分别为(8.88±3.21)×109/L、(6.83±1.24)×109/L、(3.46±0.45)×109/L、(47.65±6.54)mg/L和(4.99±1.24),分别显著高于对照组(5.16±1.03)×109/L、(3.12±0.34)×109/L、(1.44±0.21)×109/L、(3.45±1.11)mg/L和(1.89±0.65)。结论:血清降钙素原、中性粒细胞淋巴细胞计数比值等相关临床指标的监测,对于冠心病患者肺部感染的诊断和鉴别具有重要的临床意义。
Objective:To investigate the relationship of serum procalcitonin,neutrophil lymphocyte counts and other clinical parameters in patients with coronary heart disease and pulmonary infection,so as to provide the basis for the clinical diagnosis and treatment in patients with coronary heart disease with pulmonary infection.Methods:128 cases of coronary heart disease in our hospital were chosen.According to whether pulmonary infection,they were divided into the infection group and the control group,and 64 cases in each group.The serum procalcitonin(PCT),prealbumin(PA),white blood cell count(WBC),lymphocyte count(LyC),neutrophil count(NeuC)and neutrophil lymphocyte count ratio(NLR)between the two groups were compared.Results:The PCT concentration of the infection patients was(3.67±1.62)ng/ml,significantly higher than the control group of(0.03±0.01)ng/ml,PA concentration in the infection patients was(164.34±45.45)mg/L,significantly lower than the control group of(228.34±65.93)mg/L,the WBC,NeuC,LyC,CRP and NLR in the infection group were respectively(8.88 ± 3.21)× 109/L,(6.83±1.24)× 109/L,(3.46±0.45)×109/L,(47.65±6.54)mg/L and(4.99±1.24),significantly higher than the control group of(5.16±1.03)×109/L,(3.12±0.34)×109/L,(1.44±0.21)×109/L,(3.45±1.11)mg/L and(1.89±0.65).Conclusions:The monitoring of the serum procalcitonin,neutrophil lymphocyte count and other clinical indicators ratio in patients with coronary heart disease has important clinical significance for the diagnosis of patients with coronary heart disease with lung infections.
Objective:To investigate the relationship of serum procalcitonin,neutrophil lymphocyte counts and other clinical parameters in patients with coronary heart disease and pulmonary infection,so as to provide the basis for the clinical diagnosis and treatment in patients with coronary heart disease with pulmonary infection.Methods:128 cases of coronary heart disease in our hospital were chosen.According to whether pulmonary infection,they were divided into the infection group and the control group,and 64 cases in each group.The serum procalcitonin(PCT),prealbumin(PA),white blood cell count(WBC),lymphocyte count(LyC),neutrophil count(NeuC)and neutrophil lymphocyte count ratio(NLR)between the two groups were compared.Results:The PCT concentration of the infection patients was(3.67±1.62)ng/ml,significantly higher than the control group of(0.03±0.01)ng/ml,PA concentration in the infection patients was(164.34±45.45)mg/L,significantly lower than the control group of(228.34±65.93)mg/L,the WBC,NeuC,LyC,CRP and NLR in the infection group were respectively(8.88 ± 3.21)× 109/L,(6.83±1.24)× 109/L,(3.46±0.45)×109/L,(47.65±6.54)mg/L and(4.99±1.24),significantly higher than the control group of(5.16±1.03)×109/L,(3.12±0.34)×109/L,(1.44±0.21)×109/L,(3.45±1.11)mg/L and(1.89±0.65).Conclusions:The monitoring of the serum procalcitonin,neutrophil lymphocyte count and other clinical indicators ratio in patients with coronary heart disease has important clinical significance for the diagnosis of patients with coronary heart disease with lung infections.
引文
[1]陈庭燕,杨晓强,官功昌.冠心病146例脂联素、超敏C反应蛋白、尿酸检测及其与冠心病的关系[J].陕西医学杂志,2013,42(1):102-103.
[2]Knudsen A,Christensen TE,Ghotbi AA,et al.Normal Myocardial Flow Reserve in HIV-Infected Patients on Stable Antiretroviral Therapy:A Cross-Sectional Study Using Rubidium-82 PET/CT[J].Medicine,2015,94(43):e1886.
[3]Lin PY,Chien KL,Chang HJ,et al.Unfinished Root Canal Treatments and the Risk of Cardiovascular Disease[J].Journal of Endodontics,2015,41(12):1991-1996.
[4]Lo J,Lu MT,Ihenachor EJ,et al.Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis:a randomised,double-blind,placebocontrolled trial[J].The Lancet HIV,2015,2(2):e52-63.
[5]Fernandez-Montero JV,Barreiro P,de Mendoza C,et al.Hepatitis C virus coinfection independently increases the risk of cardiovascular disease in HIV-positive patients[J].Journal of Viral Hepatitis,2016,23(1):47-52.
[6]杨萌,李丽娟,苏楠,等.动态监测外周血中性粒细胞/淋巴细胞比值能够预测血流感染患者的预后[J].中华危重病急救医学,2015,11(6):471-476.
[7]Siegel MO,Borkowska AG,Dubrovsky L,et al.HIV infection induces structural and functional changes in high density lipoproteins[J].Atherosclerosis,2015,243(1):19-29.
[8]邢铭芬,蔡云祥,屠春平,等.中性粒-淋巴细胞比值在成人急性上呼吸道感染病原鉴别诊断中的意义[J].现代实用医学,2015,27(6):791-793.
[9]季亚成,杨欢,戴坤鹏,等.冠心病患者阿托伐他汀和脂必泰对血脂及炎症因子的影响[J].陕西医学杂志,2014,43(5):573-574.
[10]Raggi P,Zona S,Scaglioni R,et al.Epicardial adipose tissue and coronary artery calcium predict incident myocardial infarction and death in HIV-infected patients[J].Journal of Cardiovascular Computed Tomography,2015,9(6):553-558.
[11]McKibben RA,Haberlen SA,Post WS,et al.A crosssectional study of the association between chronic hepatitis C virus infection and subclinical coronary atherosclerosis among participants in the multicenter AIDS cohort study[J].The Journal of infectious diseases,2016,213(2):257-265.
[12]李斌,张周良,杨珍珍,等.中性粒细胞与淋巴细胞计数比值在呼吸道感染性疾病中的应用价值[J].中国血液流变学杂志,2012,11(3):522-524.
[13]Ketlogetswe KS,McKibben R,Jacobson LP,et al.Osteoprotegerin,but not receptor activator for nuclear factor-kappaB ligand,is associated with subclinical coronary atherosclerosis in HIV-Infected men[J].JAIDS,2015,70(4):362-369.
[14]朱德才,祁彬,杨光耀,等.CRP、WBC计数与冠心病病情的相关分析[J].中华全科医学.2011,9(3):369-370.
[2]Knudsen A,Christensen TE,Ghotbi AA,et al.Normal Myocardial Flow Reserve in HIV-Infected Patients on Stable Antiretroviral Therapy:A Cross-Sectional Study Using Rubidium-82 PET/CT[J].Medicine,2015,94(43):e1886.
[3]Lin PY,Chien KL,Chang HJ,et al.Unfinished Root Canal Treatments and the Risk of Cardiovascular Disease[J].Journal of Endodontics,2015,41(12):1991-1996.
[4]Lo J,Lu MT,Ihenachor EJ,et al.Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis:a randomised,double-blind,placebocontrolled trial[J].The Lancet HIV,2015,2(2):e52-63.
[5]Fernandez-Montero JV,Barreiro P,de Mendoza C,et al.Hepatitis C virus coinfection independently increases the risk of cardiovascular disease in HIV-positive patients[J].Journal of Viral Hepatitis,2016,23(1):47-52.
[6]杨萌,李丽娟,苏楠,等.动态监测外周血中性粒细胞/淋巴细胞比值能够预测血流感染患者的预后[J].中华危重病急救医学,2015,11(6):471-476.
[7]Siegel MO,Borkowska AG,Dubrovsky L,et al.HIV infection induces structural and functional changes in high density lipoproteins[J].Atherosclerosis,2015,243(1):19-29.
[8]邢铭芬,蔡云祥,屠春平,等.中性粒-淋巴细胞比值在成人急性上呼吸道感染病原鉴别诊断中的意义[J].现代实用医学,2015,27(6):791-793.
[9]季亚成,杨欢,戴坤鹏,等.冠心病患者阿托伐他汀和脂必泰对血脂及炎症因子的影响[J].陕西医学杂志,2014,43(5):573-574.
[10]Raggi P,Zona S,Scaglioni R,et al.Epicardial adipose tissue and coronary artery calcium predict incident myocardial infarction and death in HIV-infected patients[J].Journal of Cardiovascular Computed Tomography,2015,9(6):553-558.
[11]McKibben RA,Haberlen SA,Post WS,et al.A crosssectional study of the association between chronic hepatitis C virus infection and subclinical coronary atherosclerosis among participants in the multicenter AIDS cohort study[J].The Journal of infectious diseases,2016,213(2):257-265.
[12]李斌,张周良,杨珍珍,等.中性粒细胞与淋巴细胞计数比值在呼吸道感染性疾病中的应用价值[J].中国血液流变学杂志,2012,11(3):522-524.
[13]Ketlogetswe KS,McKibben R,Jacobson LP,et al.Osteoprotegerin,but not receptor activator for nuclear factor-kappaB ligand,is associated with subclinical coronary atherosclerosis in HIV-Infected men[J].JAIDS,2015,70(4):362-369.
[14]朱德才,祁彬,杨光耀,等.CRP、WBC计数与冠心病病情的相关分析[J].中华全科医学.2011,9(3):369-370.