术前中性粒细胞与淋巴细胞计数比值对469例结直肠腺癌患者预后影响
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  • 英文篇名:Effect of preoperative neutrophil lymphocyte count ratio on prognosis in 469 patients with colorectal adenocarcinoma
  • 作者:侯智俐 ; 袁维堂 ; 孙振强 ; 王贵宪
  • 英文作者:HOU Zhi-li;YUAN Wei-tang;SUN Zhen-qiang;WANG Gui-xian;Department of Colorectal Surgery,First Affiliated Hospital of Zhengzhou University;
  • 关键词:结直肠腺癌 ; 中性粒细胞淋巴细胞计数比 ; 预后
  • 英文关键词:colorectal tumor;;neutrophils lymphocyte count ratio;;prognosis
  • 中文刊名:QLZL
  • 英文刊名:Chinese Journal of Cancer Prevention and Treatment
  • 机构:郑州大学第一附属医院结直肠肛门外科;
  • 出版日期:2019-05-14
  • 出版单位:中华肿瘤防治杂志
  • 年:2019
  • 期:v.26
  • 语种:中文;
  • 页:QLZL201909011
  • 页数:4
  • CN:09
  • ISSN:11-5456/R
  • 分类号:48-51
摘要
目的术前中性粒细胞与淋巴细胞计数比值(neutrophils lymphocyte count ratio,NLR)是系统炎症反应的标志,对某些肿瘤估计预后有价值,但在结直肠腺癌中研究较少。本研究探讨术前NLR对结直肠腺癌患者预后的影响。方法回顾性分析2012-11-01-2013-09-30郑州大学第一附属医院经术后病理确诊为结直肠腺癌的469例患者病例资料,以NLR第75百分位数2.84为临界点,分析其术前NLR水平以及各临床病理因素与生存预后的关系。结果术前NLR与性别(HR=0.568,P=0.016)、术前癌胚抗原(carcinoembryonic antigen,CEA)水平(HR=1.829,P=0.011)和肿瘤位置(HR=2.171,P=0.002)有关联,与分化程度、T分期、年龄、术前糖类抗原19-9(carbohydrate antigen 19-9,CAl9-9)水平、有无神经脉管侵犯、N分期和M分期无关联,P>0.05。术前不同NLR水平的结直肠癌患者预后差异有统计学意义(χ~2=5.052,P=0.025),术前NLR升高(HR=1.537,P=0.046)、术前CEA水平升高(HR=1.654,P=0.011)、右半结肠癌(HR=1.721,P=0.014)、淋巴结转移(HR=3.311,P<0.001)和远处转移(HR=7.705,P<0.001)是患者不良预后的独立危险因素。结论 NLR是一种易于检测且价格低廉的检测方式,有望作为评估结直肠腺癌患者预后的参考指标。
        OBJECTIVE Preoperative neutrophil lymphocyte count ratio(NLR)is a marker of systemic inflammatory response and is valuable in predicting prognosis for some tumors,but few studies have been conducted in colorectal adenocarcinoma.This article aimed to investigate the influence of preoperative NLR for the prognosis of patients with colorectal adenocarcinoma.METHODS We collected data from 469 patients diagnosed with colorectal adenocarcinoma from the First Affiliated Hospital of Zhengzhou University from November 1 st,2012 to September 30 th,2013.Analysis of the relationship between preoperative NLR level and clinicopathological factors and survival prognosis of patients with colorectal adenocarcinoma was conducted.RESULTS Preoperative NLR level was associated with gender(HR=0.568,P=0.016),preoperative carcinoembryonic antigen(CEA)level(HR=1.829,P=0.011),and tumor location(HR=2.171,P=0.002)and had no relationship with differentiation,T stage,age,preoperative CA199 level,presence or absence of neurovascular invasion,N stage and M stage(P>0.05).There was a difference in prognosis between patients with colorectal cancer of different NLR levels before surgery(χ~2=5.052,P<0.05).Preoperative NLR levels(HR=1.537,P=0.046),preoperative CEA levels(HR=1.654,P=0.011),right colon cancer(HR=1.721,P=0.014),lymph node metastasis(HR=3.311,P<0.001)and distant metastasis(HR=7.705,P<0.001)were independent risk factors for poor prognosis.CONCLUSION NLR is an easy and inexpensive detection method,which is expected to be used as a reference index to evaluate the prognosis of patients with colorectal adenocarcinoma.
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