骨碎补中柚皮苷治疗股骨头坏死研究进展
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摘要
柚皮苷(Naringin,NG)为中药骨碎补主要活性单体成分,是一种双氢睾酮类黄酮化合物,具有愈骨折、强筋骨、温肾阳之功用,可调节骨质代谢。股骨头坏死是一种多因素骨病,治疗方式多样,早期治疗旨在延缓病程,防治塌陷,最大限度保留髋部功能。柚皮苷可用于股骨头坏死的治疗,既可促进成骨细胞增殖、分化益于骨形成,又可抑制破骨细胞对骨质的吸收,抑制成脂分化、炎症反应,抑制血管内皮细胞凋亡,促进内皮祖细胞增殖及血管形成,增加血管形成的长度和面积,利于骨坏死修复,降低股骨头坏死率。
Naringin is the main active monomer component of Gusuibu. It is a dihydrotestosterone flavonoid compound. It has the function of healing fractures,strengthening bones and warming kidney,and can regulate bone metabolism. Femoral head necrosis is a kind of multi-factor osteopathy with various treatment methods. Early treatment aims to delay the course of disease,prevent collapse,and retain hip function to the maximum extent. Naringin can be used for the treatment of osteonecrosis of the femoral head,which not only promotes the proliferation and differentiation of osteoblasts,but also inhibits the absorption of bone by ihibiting osteoclasts and adipogenic differentiation. Naringin can inhibit vascular endothelial cell apoptosis,promote endothelial progenitor cell proliferation and angiogenesis and increase the length and area of angiogenesis,which is conducive to the repair of osteonecrosis. It can facilitate the repair of osteonecrosis,reduce the rate of femoral head necrosis.
Naringin is the main active monomer component of Gusuibu. It is a dihydrotestosterone flavonoid compound. It has the function of healing fractures,strengthening bones and warming kidney,and can regulate bone metabolism. Femoral head necrosis is a kind of multi-factor osteopathy with various treatment methods. Early treatment aims to delay the course of disease,prevent collapse,and retain hip function to the maximum extent. Naringin can be used for the treatment of osteonecrosis of the femoral head,which not only promotes the proliferation and differentiation of osteoblasts,but also inhibits the absorption of bone by ihibiting osteoclasts and adipogenic differentiation. Naringin can inhibit vascular endothelial cell apoptosis,promote endothelial progenitor cell proliferation and angiogenesis and increase the length and area of angiogenesis,which is conducive to the repair of osteonecrosis. It can facilitate the repair of osteonecrosis,reduce the rate of femoral head necrosis.
引文
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[15]李念虎,徐展望.柚皮苷促进成骨细胞分化并有效改善卵巢切除所致的骨质疏松[J].中国骨质疏松杂志,2013(4):777-782,803.
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[17] LV J,SUN X,MA J,et al. Involvement of periostin-sclerostinWnt/beta-catenin signaling pathway in the prevention of neurectomy-induced bone loss by naringin[J]. Biochemical and Biophysical Research Communications,2015,468(4):587-593.
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[19]龚理.柚皮苷对骨质疏松模型大鼠MSCs增殖、骨向分化及凋亡影响的实验研究[D].广州:暨南大学,2006.
[20]柯可.淫羊藿苷、柚皮苷及川续断皂苷Ⅵ体外促成骨效应的比较研究[D].杭州:浙江大学,2015.
[21]翟远坤,牛银波,潘亚磊,等柚皮苷对体外培养乳鼠颅骨成骨细胞增殖和分化成熟的影响[J].中国中药杂志,2013(1):105-111.
[22]翟远坤,潘亚磊,牛银波,等.柚皮苷及其代谢物柚皮素对乳鼠颅骨成骨细胞分化成熟影响的比较研究[J].中国药学杂志,2013,(16):1373-1379.
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[24] HUANG D,LI Z,CHEN B,et al. Naringin protects against steroidinduced avascular necrosis of the femoral head through upregulation of PPARgamma and activation of the Notch signaling pathway[J]. Molecular Medicine Reports,2018,17(2):3328-3335.
[25] LI L,ZENG Z,CAI G. Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1[J].Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2011,18(11):985-989.
[26] WONG R W,RABIE A B. Effect of naringin collagen graft on bone formation[J]. Biomaterials,2006,27(9):1824-1831.
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