基于MRI的早期盲人海马体积分析研究
|
摘要
目的:采用3.0T磁共振对早期盲人与视力正常人的海马结构进行定量测量,探讨早期盲人与视力正常人之间海马结构的体积差异。方法:对早期盲人与视力正常人各22例行颅脑MRI扫描,获得3D-T1WI图像并对每个个体的两侧海马进行手动分割,测量海马体积并比较两组之间海马体积整体及前、中、后部体积差异。结果:早期盲人组及视力正常组的海马均有半球差异,表现为右侧海马总体积明显大于左侧,差异有统计学意义(P<0.05)。视力正常组左、右侧海马总体积大于早期盲人组,差异有统计学意义(P<0.05);且早期盲人组右侧海马后部和左侧海马中部体积小于视力正常组,差异有统计学意义(P<0.05)。结论:早期盲人组及视力正常组的右侧海马总体积均大于左侧,与视力正常组相比早期盲人组双侧海马总体积明显缩小,以右侧海马后部和左侧海马中部为著。
Objective:To investigate the difference of hippocampal volume between early blind subjects and normal sighted controls by using 3.0 T MR scanner.Methods:Twenty-two early blind subjects and an equal number of sighted controls were underwent 3 DT1-weighted scanning using GE3.0 T MR scanner.The bilateral hippocampi were manually segmented and the volumes of them were automatically calculated using ITK-SNAP and MATLAB software,respectively.The difference of whole hippocampal volume between the two groups were compared.Meanwhile,the volumes of anterior,middle and posterior parts of the hippocampus between the two groups were also compared.Results:The volumes of the hippocampal formation were statistically lager in right than in left in both groups(P<0.05),indication a hemisphere difference.Compared with early blind subjects,the bilateral hippocampal volumes of normal sighted controls were statistically larger(P<0.05).Moreover,the right posterior and the left middle parts of the hippocampus in blind group were significantly smaller than those of normal sighted controls.Conclusion:The whole volumes of right hippocampal were larger than those of the left side in both two groups.Volumes of bilateral hippocampus are substantially decreased in early blind group,which mostly involved the right posterior and the left middle parts of the hippocampus.
Objective:To investigate the difference of hippocampal volume between early blind subjects and normal sighted controls by using 3.0 T MR scanner.Methods:Twenty-two early blind subjects and an equal number of sighted controls were underwent 3 DT1-weighted scanning using GE3.0 T MR scanner.The bilateral hippocampi were manually segmented and the volumes of them were automatically calculated using ITK-SNAP and MATLAB software,respectively.The difference of whole hippocampal volume between the two groups were compared.Meanwhile,the volumes of anterior,middle and posterior parts of the hippocampus between the two groups were also compared.Results:The volumes of the hippocampal formation were statistically lager in right than in left in both groups(P<0.05),indication a hemisphere difference.Compared with early blind subjects,the bilateral hippocampal volumes of normal sighted controls were statistically larger(P<0.05).Moreover,the right posterior and the left middle parts of the hippocampus in blind group were significantly smaller than those of normal sighted controls.Conclusion:The whole volumes of right hippocampal were larger than those of the left side in both two groups.Volumes of bilateral hippocampus are substantially decreased in early blind group,which mostly involved the right posterior and the left middle parts of the hippocampus.
引文
[1]Burgess N,Maguire EA,O'Keefe J.The human hippocampus and spatial and episodic memory[J].Neuron,2002,35(4):625-641.
[2]Michael A,Fields TA,Isham EA,et al.Cellular networks underlying human spatial navigation[J].Nature,2003,425(6954):184-188.
[3]Hartley T,Maguire EA,Spiers HJ,et al.The well-worn route and the path less traveled:distinct neural bases of route following and wayfinding in Humans[J].Neuron,2003,37(5):877-888.
[4]Duarte IC,Ferreira C,Marques J,et al.Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3Dnavigation task[J].Plos One,2014,9(1):e86213.
[5]吴明祥,陈宇,凌人男,等.脑卒中后抑郁症患者的海马形态分析[J].放射学实践,2014,29(5):521-524.
[6]Kühn S,Gleich T,Lorenz RC,et al.Playing super mario induces structural brain plasticity:gray matter changes resulting from training with a commercial video game[J].Mol Psychiatry,2014,19(2):265-271.
[7]Jessberger S,Gage FH.Stem-cell-associated structural and functional plasticity in the aging hippocampus[J].Psychol Aging,2008,23(4):684-691.
[8]张雷,张明慧,卢振泰,等.基于多权重概率图谱的脑部图像分割[J].南方医科大学学报,2015,35(8):1143-1148.
[9]Maller J,Meslin C,Anstey K,et al.Sex and symmetry differences in hippocampal volumetrics:before and beyond the opening of the crus of the formix[J].Hippocampus,2010,16(1):80-90.
[10]Szabo CA,Xiong J,Lancaster JL,et al.Amygdalar and hippocampal volumetry in control participants:differences regarding handedness[J].AJNR Am J Neuroradiol,2001,22(7):1342-1345.
[11]Chebat DR,Chen JK,Schneider F,et al.Alterations in right posterior hippocampus in early blind individuals[J].Neuroreport,2007,18(4):329-333.
[12]Wei W,Chen C,Dong Q,et al.Sex differences in gray matter volume of the right anterior hippocampus explain sex differences in three-dimensional mental rotation[J].Front Hum Neurosci,2016,15(10):580.
[13]吴凡,王海宝,余永强.情绪记忆中杏仁核和海马作用的fMRI[J].放射学实践,2010,25(3):276-279.
[14]Chen WW,Wang N,Cai S,et al.Structural brain abnormalities in patients with primary open-angle glaucoma:a study with 3TMRimaging[J].Invest Ophthalmol Vis Sci,2013,54(1):545-554.
[15]Fortin M,Voss P,Lord C,et al.Wayfinding in the blind:larger hippocampal volume and supranormal spatial navigation[J].Brain,2008,131(11):2995-3005.
[16]Maller JJ,Thomson RH,Ng A,et al.Brain morphometry in blind and sighted subjects[J].J Clin Neurosci,2016,33(1):89-95.
[17]刘周,李丽,李天然,等.MRI在肺部感染性疾病中的应用初探[J].新发传染病电子杂志,2017,2(3):244-248.
[18]Malone IB,Leung KK,Clegg S,et al.Accurate automatic estimation of total intracranial volume:a nuisance variable with less nuisance[J].Neuroimage,2015,104(1):366-372.
[19]Kjelstrup KB,Solstad T,Brun VH,et al.Finite scale of spatial representation in the hippocampus[J].Science,2008,321(5885):140-143.
[20]Jordan P,Evensmoen HR,Morris M,et al.Long-axis specialization of the human hippocampus[J].Trends in Cogn Sci,2013,17(5):230-240.
[21]Wirth S,Baraduc P,PlantéA,et al.Gaze-informed,task-situated representation of space in primate hippocampus during virtual navigation[J].Plos Biol,2017,15(2):e2001045.
[22]Voss JL,Bridge DJ,Cohen NJ,et al.A Closer look at the hippocampus and memory[J].Trends Cogn Sci,2017,21(8):577-588.
[23]Kupers RR,Chebat DR,Madsen KH,et al.Neural correlates of virtual route recognition in congenital blindness[J].Proc Natl Acad Sci USA,2010,107(28):12716-12721.
[24]Passini R,Proulx G,Rainville C.The spatio-cognitive abilities of the visually impaired population[J].Environ Behav,1990,22(1):91-118.
[25]Persson J,Spreng RN,Turner G,et al.Sex differences in volume and structural covariance of the anterior and posterior hippocampus[J].Neuroimage,2014,99(10):215-225.
[26]Kravitz DJ,Saleem KS,Baker CI.A new neural framework for visuospatial processing[J].Nat Rev Neurosci,2011,12(4):217-230.
[27]Ma G,Yang D,Qin W,et al.Enhanced functional coupling of hippocampal sub-regions in congenitally and late blind subjects[J].Front Neurosci,2016,10(10):612.
[28]Burwell RD,Saddoris MP,Bucci DJ,et al.Corticohippocampal contributions to spatial and contextual learning[J].J Neurosci,2004,24(15):3826-3836.
[2]Michael A,Fields TA,Isham EA,et al.Cellular networks underlying human spatial navigation[J].Nature,2003,425(6954):184-188.
[3]Hartley T,Maguire EA,Spiers HJ,et al.The well-worn route and the path less traveled:distinct neural bases of route following and wayfinding in Humans[J].Neuron,2003,37(5):877-888.
[4]Duarte IC,Ferreira C,Marques J,et al.Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3Dnavigation task[J].Plos One,2014,9(1):e86213.
[5]吴明祥,陈宇,凌人男,等.脑卒中后抑郁症患者的海马形态分析[J].放射学实践,2014,29(5):521-524.
[6]Kühn S,Gleich T,Lorenz RC,et al.Playing super mario induces structural brain plasticity:gray matter changes resulting from training with a commercial video game[J].Mol Psychiatry,2014,19(2):265-271.
[7]Jessberger S,Gage FH.Stem-cell-associated structural and functional plasticity in the aging hippocampus[J].Psychol Aging,2008,23(4):684-691.
[8]张雷,张明慧,卢振泰,等.基于多权重概率图谱的脑部图像分割[J].南方医科大学学报,2015,35(8):1143-1148.
[9]Maller J,Meslin C,Anstey K,et al.Sex and symmetry differences in hippocampal volumetrics:before and beyond the opening of the crus of the formix[J].Hippocampus,2010,16(1):80-90.
[10]Szabo CA,Xiong J,Lancaster JL,et al.Amygdalar and hippocampal volumetry in control participants:differences regarding handedness[J].AJNR Am J Neuroradiol,2001,22(7):1342-1345.
[11]Chebat DR,Chen JK,Schneider F,et al.Alterations in right posterior hippocampus in early blind individuals[J].Neuroreport,2007,18(4):329-333.
[12]Wei W,Chen C,Dong Q,et al.Sex differences in gray matter volume of the right anterior hippocampus explain sex differences in three-dimensional mental rotation[J].Front Hum Neurosci,2016,15(10):580.
[13]吴凡,王海宝,余永强.情绪记忆中杏仁核和海马作用的fMRI[J].放射学实践,2010,25(3):276-279.
[14]Chen WW,Wang N,Cai S,et al.Structural brain abnormalities in patients with primary open-angle glaucoma:a study with 3TMRimaging[J].Invest Ophthalmol Vis Sci,2013,54(1):545-554.
[15]Fortin M,Voss P,Lord C,et al.Wayfinding in the blind:larger hippocampal volume and supranormal spatial navigation[J].Brain,2008,131(11):2995-3005.
[16]Maller JJ,Thomson RH,Ng A,et al.Brain morphometry in blind and sighted subjects[J].J Clin Neurosci,2016,33(1):89-95.
[17]刘周,李丽,李天然,等.MRI在肺部感染性疾病中的应用初探[J].新发传染病电子杂志,2017,2(3):244-248.
[18]Malone IB,Leung KK,Clegg S,et al.Accurate automatic estimation of total intracranial volume:a nuisance variable with less nuisance[J].Neuroimage,2015,104(1):366-372.
[19]Kjelstrup KB,Solstad T,Brun VH,et al.Finite scale of spatial representation in the hippocampus[J].Science,2008,321(5885):140-143.
[20]Jordan P,Evensmoen HR,Morris M,et al.Long-axis specialization of the human hippocampus[J].Trends in Cogn Sci,2013,17(5):230-240.
[21]Wirth S,Baraduc P,PlantéA,et al.Gaze-informed,task-situated representation of space in primate hippocampus during virtual navigation[J].Plos Biol,2017,15(2):e2001045.
[22]Voss JL,Bridge DJ,Cohen NJ,et al.A Closer look at the hippocampus and memory[J].Trends Cogn Sci,2017,21(8):577-588.
[23]Kupers RR,Chebat DR,Madsen KH,et al.Neural correlates of virtual route recognition in congenital blindness[J].Proc Natl Acad Sci USA,2010,107(28):12716-12721.
[24]Passini R,Proulx G,Rainville C.The spatio-cognitive abilities of the visually impaired population[J].Environ Behav,1990,22(1):91-118.
[25]Persson J,Spreng RN,Turner G,et al.Sex differences in volume and structural covariance of the anterior and posterior hippocampus[J].Neuroimage,2014,99(10):215-225.
[26]Kravitz DJ,Saleem KS,Baker CI.A new neural framework for visuospatial processing[J].Nat Rev Neurosci,2011,12(4):217-230.
[27]Ma G,Yang D,Qin W,et al.Enhanced functional coupling of hippocampal sub-regions in congenitally and late blind subjects[J].Front Neurosci,2016,10(10):612.
[28]Burwell RD,Saddoris MP,Bucci DJ,et al.Corticohippocampal contributions to spatial and contextual learning[J].J Neurosci,2004,24(15):3826-3836.