脑电生物反馈联合帕罗西汀治疗恐惧症的疗效观察
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摘要
目的:探讨脑电生物反馈联合帕罗西汀治疗恐惧症的临床疗效。方法:选取2014年1月—2015年12月湖北省公安县人民医院收治的恐惧症患者90例作为研究对象,以随机数字表法分为观察组和对照组,每组45例。对照组患者给予帕罗西汀治疗,观察组患者给予脑电生物反馈联合帕罗西汀治疗。观察两组患者的疗效,比较两组患者的治愈时间、住院时间及治疗前后焦虑恐惧因子评分、回避因子评分、Liebowitz社交焦虑量表评分。结果:观察组患者的总有效率明显高于对照组,治愈时间、住院时间明显少于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者的焦虑恐惧因子评分、回避因子评分、Liebowitz社交焦虑量表评分明显优于对照组,差异均有统计学意义(P<0.05)。结论:脑电生物反馈联合帕罗西汀治疗恐惧症的疗效显著,可有效改善患者症状,缩短治愈时间和住院时间。
OBJECTIVE: To probe into the clinical efficacy of EEG biofeedback combined with paroxetine in treatment of phobia. METHODS: 90 patients with phobia admitted into Hubei Gong‘an County People's Hospital from Jan. 2014 to Dec. 2015 were selected to be divided into observation group and control group via the random number table,with 45 cases in each. The control group was treated with paroxetine,while the observation group was given EEG biofeedback combined with paroxetine. The efficacy of two groups were observed,the cure time,length of hospital and anxiety and fear factor score and avoidance factor score,Liebowitz social anxiety scale of two groups were compared. RESULTS: The total effective rate of observation group was significantly higher than that of control group;yet the cure time,length of hospital in observation group was significantly shorter than those of control group,with statistical significance( P < 0. 05). After treatment,the anxiety and fear factor score and avoidance factor score,Liebowitz social anxiety scale in observation group were better than those of control group,with statistical significance( P < 0. 05). CONCLUSIONS: The efficacy of EEG biofeedback combined with paroxetine in treatment of phobia is remarkable,which can effectively improve the symptoms of patients and shorten the cure time and length of hospital.
OBJECTIVE: To probe into the clinical efficacy of EEG biofeedback combined with paroxetine in treatment of phobia. METHODS: 90 patients with phobia admitted into Hubei Gong‘an County People's Hospital from Jan. 2014 to Dec. 2015 were selected to be divided into observation group and control group via the random number table,with 45 cases in each. The control group was treated with paroxetine,while the observation group was given EEG biofeedback combined with paroxetine. The efficacy of two groups were observed,the cure time,length of hospital and anxiety and fear factor score and avoidance factor score,Liebowitz social anxiety scale of two groups were compared. RESULTS: The total effective rate of observation group was significantly higher than that of control group;yet the cure time,length of hospital in observation group was significantly shorter than those of control group,with statistical significance( P < 0. 05). After treatment,the anxiety and fear factor score and avoidance factor score,Liebowitz social anxiety scale in observation group were better than those of control group,with statistical significance( P < 0. 05). CONCLUSIONS: The efficacy of EEG biofeedback combined with paroxetine in treatment of phobia is remarkable,which can effectively improve the symptoms of patients and shorten the cure time and length of hospital.
引文
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[9]杨薇,陈怡兰,陈雪,等.帕罗西汀联合氨磺必利治疗伴精神病症状抑郁发作的效果评价[J].中国医院用药评价与分析,2015,15(4):515-516.
[10]王中清.丁螺环酮联合帕罗西汀治疗焦虑症的临床疗效[J].中外医疗,2016,35(11):122-123.
[11]杨春方.丁螺环酮联合帕罗西汀治疗焦虑症临床疗效分析[J].医药前沿,2016,6(10):179-180.
[12]代凤琴.生物反馈在焦虑症治疗中的研究和应用[J].内蒙古中医药,2014,33(8):84-85.
[13]李日光,李国文,李惠香,等.螺环酮联合帕罗西汀治疗焦虑症的疗效及安全性分析[J].现代生物医学进展,2014,14(22):4312-4314,4322.
[14]谢琴红,何静,欧微,等.生物反馈在焦虑症治疗中的研究和应用[J].医学信息:中旬刊,2011,33(9):4307.
[15]杨薇,叶凡,陈雪.帕罗西汀联合脑电生物反馈治疗恐惧症的疗效评价[J].临床医药文献电子杂志,2015,2(18):3804.
[2]Goes FS,Mc Cusker MG,Bienvenu OJ,et al.Co-morbid anxiety disorders in bipolar disorder and major depression:Familial aggregation and clinical characteristics of co-morbid panic disorder,social phobia,specific phobia and obsessive-compulsive disorder[J].Psychol Med,2012,42(7):1449-1459.
[3]李陈成,陈旺,王莉,等.帕罗西汀与尼莫地平对大鼠创伤后应激障碍的预防作用[J].中华创伤杂志,2015,31(11):1045-1049.
[4]李荔,王玉凤.神经生物反馈治疗在精神神经疾病中的应用进展[J].中国康复医学杂志,2012,27(6):583-586.
[5]任灵敏,张赟,和慧丽,等.视听整合连续测试对脑电生物反馈治疗ADHD疗效的评估[J].首都医科大学学报,2014,35(5):667-670.
[6]Del-Monte J,Raffard S,Salesse RN,et al.Nonverbal expressive behaviour in schizophrenia and social phobia[J].Psychiatry Res,2013,210(1):29-35.
[7]张海军.帕罗西汀联合治疗帕金森病合并抑郁和焦虑症状的疗效分析[J].现代中西医结合杂志,2015,24(6):649-651.
[8]赵鑫,周仁来.生物反馈对抑郁症干预研究的元分析[J].北京师范大学学报:自然科学版,2012,48(1):101-104.
[9]杨薇,陈怡兰,陈雪,等.帕罗西汀联合氨磺必利治疗伴精神病症状抑郁发作的效果评价[J].中国医院用药评价与分析,2015,15(4):515-516.
[10]王中清.丁螺环酮联合帕罗西汀治疗焦虑症的临床疗效[J].中外医疗,2016,35(11):122-123.
[11]杨春方.丁螺环酮联合帕罗西汀治疗焦虑症临床疗效分析[J].医药前沿,2016,6(10):179-180.
[12]代凤琴.生物反馈在焦虑症治疗中的研究和应用[J].内蒙古中医药,2014,33(8):84-85.
[13]李日光,李国文,李惠香,等.螺环酮联合帕罗西汀治疗焦虑症的疗效及安全性分析[J].现代生物医学进展,2014,14(22):4312-4314,4322.
[14]谢琴红,何静,欧微,等.生物反馈在焦虑症治疗中的研究和应用[J].医学信息:中旬刊,2011,33(9):4307.
[15]杨薇,叶凡,陈雪.帕罗西汀联合脑电生物反馈治疗恐惧症的疗效评价[J].临床医药文献电子杂志,2015,2(18):3804.