昆虫神经肽抑咽侧体素及其类似物的研究进展
|
摘要
抑咽侧体素(ASTs)是一类由昆虫脑神经细胞分泌,通过作用于咽侧体进而抑制保幼激素(JH)合成与释放的昆虫神经肽。因其具有调控昆虫生长、发育和生殖等生理过程的功能,被认为是一类潜在的害虫控制剂。本文在简介了昆虫神经肽在害虫防治中的应用基础上,综述了昆虫神经肽抑咽侧体素的发现、类别和功能,并结合本研究组的工作,重点介绍抑咽侧体素及其类似物的结构修饰和优化、活性构象及构效关系研究,同时也介绍了抑咽侧体素及其类似物的受体和作用机制研究进展。最后,展望了该领域的未来发展趋势,期望为新的生态友好型农药的研发提供一定的参考作用。
Allatostatins(ASTs) are a kind of insect neuropeptides secreted from insect brain nerve cells.ASTs can inhibit the biosynthesis and release of juvenile hormone(JH) by influencing corpora allata(CA). Given their influence on the insect growth, development, reproduction and other physiological processes, ASTs are considered as potential pest control agents. Based on a brief introduction of insect neuropeptides' potential application in the field of pest control, the discovery, classification and function of allatostatins have been reviewed in this paper. According to the recent studies on ASTs and their analogues in our research group, the research progress in the area of structure modification and optimization of allatostatins, active conformation and the structure-activity relationship of ASTs analogues and their receptor and mode of action were summarized. The outlook of ASTs and their analogues as the candidates of eco-friendly pesticide is also proposed in this review, which were expected to provide a reference for the development of novel eco-friendly pesticides.
Allatostatins(ASTs) are a kind of insect neuropeptides secreted from insect brain nerve cells.ASTs can inhibit the biosynthesis and release of juvenile hormone(JH) by influencing corpora allata(CA). Given their influence on the insect growth, development, reproduction and other physiological processes, ASTs are considered as potential pest control agents. Based on a brief introduction of insect neuropeptides' potential application in the field of pest control, the discovery, classification and function of allatostatins have been reviewed in this paper. According to the recent studies on ASTs and their analogues in our research group, the research progress in the area of structure modification and optimization of allatostatins, active conformation and the structure-activity relationship of ASTs analogues and their receptor and mode of action were summarized. The outlook of ASTs and their analogues as the candidates of eco-friendly pesticide is also proposed in this review, which were expected to provide a reference for the development of novel eco-friendly pesticides.
引文
[1]AHMAD V, KHAN M S, JAMAL Q M S, et al. Antimicrobial potential of bacteriocins:in therapy, agriculture and food preservation[J]. Int J Antimicrob Agents, 2017, 49(1):1-11.
[2]燕晓翠,杨春蕾,姚大为,等.抗菌肽的国内外研究进展[J].天津农业科学, 2017, 23(5):35-41.YAN X C, YANG C L, YAO D W, et al. Research progress on domestic and abroad of antibacterial peptides[J]. Tianjin Agric Sci,2017, 23(5):35-41.
[3]严沁,张传强,智达夫,等.抗菌肽在动物生产上的应用[J].畜牧与饲料科学, 2015, 36(12):92-94.YAN Q, ZHANG C Q, ZHI D F, et al. Application of antimicrobial peptides in animal production[J]. Animal Husb Feed Sci, 2015,36(12):92-94.
[4]WANG S, ZENG X F, YANG Q, et al. Antimicrobial peptides as potential alternatives to antibiotics in food animal industry[J]. IJMS,2016, 17(5):603.
[5]蒋细兵,余迪求.植物多肽激素研究概况[J].云南植物研究, 2008,30(3):333-339.JIANG X B, YU D Q. Peptide hormones in plants[J]. Acta Bot Yunnanica, 2008, 30(3):333-339.
[6]王莲存,朱大权,刘德能,等.多肽保对病害防控及其增产效果初探[J].云南农业, 2014(5):20-22.WANG L C, ZHU D Q, LIU D N, et al. Preliminary study on disease control and yield increase effect of DUOTAIBAO[J].Yunnan Agriculture, 2014(5):20-22.
[7]何正春,刘光明,王晓雨,等.美洲大蠊神经肽的研究进展[J].天然产物研究与开发, 2008, 20(1):180-186.HE Z C, LIU G M, WANG X Y, et al. Research advance on neuropeptides from Periplaneta americana[J]. Nat Prod Res Dev,2008, 20(1):180-186.
[8]GADE G, HOFFMANN K H. Neuropeptides regulating development and reproduction in insects[J]. Physiol Entomol, 2005,30(2):103-121.
[9]KATAOKA H, NAGASAWA H, ISOGAI A, et al.Prothoracicotropic hormone of the silkworm, Bombyx Mori:Amino acid sequence and dimeric structure[J]. Agric Biol Chem, 1991,55(1):73-86.
[10]HUA Y J, TANAKA Y, NAKAMURA K, et al. Identification of a prothoracicostatic peptide in the larval brain of the silkworm,Bombyx Mori[J]. J Biol Chem, 1999, 274(44):31169-31173.
[11]STAY B. A review of the role of neurosecretion in the control of juvenile hormone synthesis:a tribute to Berta Scharrer[J]. Insect Biochem Mol Biol, 2000, 30(8-9):653-662.
[12]KATAOKA H, TROETSCHLER R G, KRAMER S J, et al.Isolation and primary structure of the eclosion hormone of the tobacco hornworm, Manduca sexta[J]. Biochem Biophys Res Commun, 1987, 146(2):746-750.
[13]GIRARDIE J, RICHARD O, HUET J C, et al. Physical characterization and sequence identification of the ovary maturating parsin[J]. European Journal of Biochemistry, 1991, 202(3):1121-1126.
[14]NACHMAN R J, HOLMAN G M, HADDON W F. Leads for insect neuropeptide mimetic development[J]. Arch Insect Biochem Physiol, 1993, 22(1-2):181-197.
[15]PREDEL R, NACHMAN R J. The FXPRLamide(pyrokinin/PBAN)peptide family[M/OL]//Handbook of biologically active peptides,elsevier, 2006:207-212. DOI:10.1016/b978-012369442-3/50035-0
[16]COAST G M, ORCHARD I, PHILLIPS J E, et al. Insect diuretic and antidiuretic hormones[M/OL]//Advances in insect physiology.Elsevier, 2002:279-409. DOI:10.1016/s0065-2806(02)29004-9
[17]STONE J V, MORDUE W, BATLEY K E, et al. Structure of locust adipokinetic hormone, a neurohormone that regulates lipid utilisation during flight[J]. Nature, 1976, 263(5574):207-211.
[18]BROWN B E. Proctolin:A peptide transmitter candidate in insects[J]. Life Sci, 1975, 17(8):1241-1252.
[19]HOLMAN G M, NACHMAN R J, COAST G M. Isolation,characterization and biological activity of a diuretic myokinin neuropeptide from the housefly, Musca domestica[J]. Peptides,1999, 20(1):1-10.
[20]NACHMAN R J, HOLMAN G M. Myotropic insect neuropeptide families from the cockroach Leucophaea maderae[M]//ACS symposium series. Washington, DC:American Chemical Society,1991:194-214. DOI:10.1021/bk-1991-0453.ch018
[21]MAGGIO E. Tachykinins[J]. Annu Rev Neurosci, 1988, 11(1):13-28.
[22]EVANS P D, ROBB S, CUTHBERT B A. Insect neuropeptidesidentification, establishment of functional roles and novel target sites for pesticides[J]. Pestic Sci, 1989, 25(1):71-83.
[23]a)MASLER E P, KELLY T J, MENN J J. Insect neuropeptides:Discovery and application in insect management[J]. Arch Insect Biochem Physiol, 1993, 22(1-2):87-111.b)BLAND J M, EDWARD J W, EATON S R, et al. Potential of natural peptidic compounds as leads for novel pesticides[J]. Pestic Sci, 1993, 39(4):331-340.
[24]G?DE G, GOLDSWORTHY G J. Insect peptide hormones:a selective review of their physiology and potential application for pest control[J]. Pest Manag Sci, 2003, 59(10):1063-1075.
[25]SCHOOFS L, DE LOOF A, VAN HIEL M B. Neuropeptides as regulators of behavior in insects[J]. Annu Rev Entomol, 2017, 62(1):35-52.
[26]NACHMAN R J. Neuropeptides and receptors as targets for bioinsecticides. Abstracts of Papers[C]//246th ACS National Meeting&Exposition, Indianapolis, IN, United States, September 8-12, 2013, AGRO-137.
[27]SCHERKENBECK J, ZDOBINSKY T. Insect neuropeptides:Structures, chemical modifications and potential for insect control[J]. Bioorg Med Chem, 2009, 17(12):4071-4084.
[28]SCHWARTZ E F, MOUR?O C B, MOREIRA K G, et al.Arthropod venoms:a vast arsenal of insecticidal neuropeptides[J].Biopolymers, 2012, 98(4):385-405.
[29]GILON C, ALTSTEIN M. Backbone cyclic peptide fragments derived from pheromone biosynthesis activating neuropeptide PBAN and their use as insecticides:WO 9928339[P]. 1999-06-10.
[30]SCHWARZ M A. Novel neuropeptides useful as insecticides:WO2015052701[P]. 2015-04-16.
[31]CHOI M Y, VANDER M, ROBERT K. Bioactive peptides having insecticide activity:US 20160262388[P]. 2016-09-15.
[32]SEINSCHE A, DYKER H, LOSEL P, et al. Effect of helicokinins and ACE inhibitors on water balance and development of Heliothis virescens larvae[J]. Journal of Insect Physiology, 2000, 46(11):1423-1431.
[33]MA M, EMERY S B, WONG W K R, et al. Effects of Manduca diuresin on neonates of the tobacco hornworm, Manduca sexta[J].Gen Comp Endocrinol, 2000, 118:1-7.
[34]MATTHEWS H J, AUDSLEY N, WEAVER R J. In vitro and in vivo effects of myo-active peptides on larvae of the tomato moth Lacanobia oleraceaand the Cotton leafworm Spodoptera littoralis(Lepidoptera; Noctuidae)[J]. Arch Insect Biochem Physiol, 2008,69(2):60-69.
[35]SMAGGHE G, MAHDIAN K, ZUBRZAK P, et al. Antifeedant activity and high mortality in the pea aphid Acyrthosiphon Pisum(Hemiptera:Aphidae)induced by biostable insect kinin analogs[J].Peptides, 2010, 31(3):498-505.
[36]a)WOODHEAD A P, STAY B, SEIDEL S L, et al. Primary structure of four allatostatins:neuropeptide inhibitors of juvenile hormone synthesis[J]. Proc Natl Acad Sci, 1989, 86(15):5997-6001.b)WOODHEAD A P, STAY B. Neural inhibition of corpora allata in protein-deprived Diploptera punctata[J]. J Insect Physiol, 1989,35(5):415-421.
[37]PRATT G E, FARNSWORTH D E, FOK K F, et al. Identity of a second type of allatostatin from cockroach brains:an octadecapeptide amide with a tyrosine-rich address sequence[J].Proc Natl Acad Sci, 1991, 88(6):2412-2416.
[38]PRATT G E, FARNSWORTH D E, SIEGEL N R, et al.Identification of an allatostatin from adult Diploptera punctata[J].Biochem Biophys Res Commun, 1989, 163(3):1243-1247.
[39]曾辉明,黄俊生.昆虫神经肽allatostatin的研究进展[J].生命科学, 2003, 15(3):168-172, 191.ZENG H M, HUANG J S. Advances of research on insect neuropeptide allatostatin[J]. Chin Bull Life Sci, 2003, 15(3):168-172, 191.
[40]NATHOO A N, MOELLER R A, WESTLUND B A, et al.Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species[J]. Proc Natl Acad Sci USA, 2001, 98(24):14000-14005.
[41]HULT E F, WEADICK C J, CHANG B S W, et al. Reconstruction of ancestral FGLamide-type insect allatostatins:A novel approach to the study of allatostatin function and evolution[J]. J Insect Physiol,2008, 54(6):959-968.
[42]DONLY B C, DING Q, TOBE S S, et al. Molecular cloning of the gene for the allatostatin family of neuropeptides from the cockroach Diploptera punctata[J]. Proc Natl Acad Sci, 1993, 90(19):8807-8811.
[43]DING Q, DONLY B C, TOBE S S, et al. Comparison of the allatostatin neuropeptide precursors in the distantly related cockroaches, Periplaneta americana and Diploptera punctata[J].Eur J Biochem, 1995, 234(3):737-746.
[44]PREDEL R, KELLNER R, RAPUS J, et al. Allatostatins from the retrocerebral complex and antennal pulsatile organ of the American cockroach:structural elucidation aided by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry[J]. Regul Pept, 1999, 82(1-3):81-89.
[45]LORENZ M W, KELLNER R, HOFFMANN K H. Identification of two allatostatins from the cricket, Gryllus bimaculatus de Geer(Ensifera, Gryllidae):additional members of a family of neuropeptides inhibiting juvenile hormone biosynthesis[J]. RegulPept, 1995, 57(3):227-236.
[46]YOON J G, STAY B. Immunocytochemical localization of Diploptera punctataallatostatin-like peptide in Drosophila melanogaster[J]. J Comp Neurol, 1995, 363(3):475-488.
[47]ALTARATZ M, APPLEBAUM S W, RICHARD D S, et al.Regulation of juvenile hormone synthesis in wild-type and apterous mutant Drosophila[J]. Mol Cell Endocrinol, 1991, 81(1-3):205-216.
[48]ABDEL-LATIEF M, MEYERING-VOS M, HOFFMANN K H.Type-A allatostatins from the fall armyworm, Spodoptera frugiperda:Molecular cloning, expression and tissue-specific localization[J]. Arch Insect Biochem Physiol, 2004, 56(3):120-132.
[49]ABDEL-LATIEF M, MEYERING-VOS M, HOFFMANN K H.Molecular characterisation of cDNAs from the fall armyworm Spodoptera frugiperda encoding Manduca sexta allatotropin and allatostatin preprohormone peptides[J]. Insect Biochem Mol Biol,2003, 33(5):467-476.
[50]CLARK L, LANGE A B, ZHANG J R, et al. The roles of Dippuallatostatin in the modulation of hormone release in Locusta migratoria[J]. J Insect Physiol, 2008, 54(6):949-958.
[51]DUVE H, JOHNSEN A H, SCOTT A G, et al. Callatostatins:neuropeptides from the blowfly Calliphora vomitoria with sequence homology to cockroach allatostatins[J]. Proc Natl Acad Sci, 1993,90(6):2456-2460.
[52]KWOK R, JIN R Z, TOBE S S. Regulation of methyl farnesoate production by mandibular organs in the crayfish, Procambarus clarkii:A possible role for allatostatins[J]. J Insect Physiol, 2005,51(4):367-378.
[53]DUVE H, JOHNSEN A H, SCOTT A G, et al. Allatostatins of the tiger prawn, Penaeus monodon(Crustacea:Penaeidea)[J]. Peptides,2002, 23(6):1039-1051.
[54]KASTIN A. Handbook of biologically active peptides(second edition)[M]. Burlington:Academic Press, 2013.
[55]STAY B, TOBE S S, BENDENA W G. Allatostatins:identification,primary structures, functions and distribution[M/OL]//Advances in insect physiology. Elsevier, 1995:267-337. DOI:10.1016/s0065-2806(08)60066-1
[56]WOODHEAD A P, ASANO W Y, STAY B. Allatostatins in the haemolymph of Diploptera punctata and their effect in vivo[J]. J Insect Physiol, 1993, 39(12):1001-1005.
[57]FUSéM, ZHANG J R, PARTRIDGE E, et al. Effects of an allatostatin and a myosuppressin on midgut carbohydrate enzyme activity in the cockroach Diploptera punctata[J]. Peptides, 1999,20(11):1285-1293.
[58]YU C G, HAYES T K, STREY A, et al. Identification and partial characterization of receptors for allatostatins in brain and corpora allata of the cockroach Diploptera punctata using a binding assay and photoaffinity labeling[J]. Regul Pept, 1995, 57(3):347-358.
[59]STAY B, SEREG BACHMANN J A, STOLTZMAN C A, et al.Factors affecting allatostatin release in a cockroach(Diploptera punctata):Nerve section, juvenile hormone analog and ovary[J]. J Insect Physiol, 1994, 40(5):365-372.
[60]关雪辰.昆虫神经肽allatostatin与allatotropin的研究新近展[J].昆虫学报, 1996, 39(2):214-218.GUAN X C. Recent advances in research on insect neuropeptides allatostatin and allatotropin[J]. Acta Entomol Sin, 1996, 39(2):214-218.
[61]HERNáNDEZ-MARTíNEZ S, LI Y P, LANZ-MENDOZA H, et al.Immunostaining for allatotropin and allatostatin-A and-C in the mosquitoes Aedes aegypti and Anopheles albimanus[J]. Cell Tissue Res, 2005, 321(1):105-113.
[62]a)STAY B, FAIRBAIRN S, YU C G. Role of allatostatins in the regulation of juvenile hormone synthesis[J]. Arch Insect Biochem Physiol, 1996, 32(3-4):287-297.b)STAY B, TOBE S S. The role of allatostatins in juvenile hormone synthesis in insects and crustaceans[J]. Annu Rev Entomol, 2007,52(1):277-299.
[63]MAESTRO J L, PASCUAL N, TREIBLMAYR K, et al. Juvenile hormone and allatostatins in the German cockroach embryo[J].Insect Biochem Mol Biol, 2010, 40(9):660-665.
[64]TOBE S S, ZHANG J R, BOWSER P R F, et al. Biological activities of the allatostatin family of peptides in the cockroach,Diploptera punctata, and potential interactions with receptors[J]. J Insect Physiol, 2000, 46(3):231-242.
[65]LANGE A B, BENDENA W G, TOBE S S. The effect of the thirteen Dip-allatostatins on myogenic and induced contractions of the cockroach(Diploptera punctata)hindgut[J]. J Insect Physiol,1995, 41(7):581-588.
[66]AUDSLEY N, MATTHEWS J, NACHMAN R J, et al.Transepithelial flux of an allatostatin and analogs across the anterior midgut of Manduca sexta larvae in vitro[J]. Peptides, 2008, 29(2):286-294.
[67]MARTíN D, PIULACHS M D, BELLéS X. Inhibition of vitellogenin production by allatostatin in the German cockroach[J].Mol Cell Endocrinol, 1996, 121(2):191-196.
[68]JOHNSON G D, STAY B, CHAN K K. Structure-activity relationships in corpora allata of the cockroach Diploptera punctata:roles of mating and the ovary[J]. Cell Tissue Res, 1993, 274(2):279-293.
[69]VILAPLANA L, MAESTRO J L, PIULACHS M D, et al.Modulation of cardiac rhythm by allatostatins in the cockroach Blattella germanica(L.)(Dictyoptera, Blattellidae)[J]. J Insect Physiol, 1999, 45(12):1057-1064.
[70]NACHMAN R J, GARSIDEB C S, TOBEB S S. Hemolymph and tissue-bound peptidase-resistant analogs of the insect allatostatins[J].Peptides, 1999, 20(1):23-29.
[71]周家驹,王亭.药物设计中的分子模型化方法[M].科学出版社,2001.ZHOU J J, WANG T. Molecular modoling in drug design[M].Science Press, 2001.
[72]STAY B, WOODHEAD A P, JOSHI S, TOBE S S, et al.Allatostatins. Neuropeptide inhibitors of juvenile hormone synthesis in brain and corpora allata of the cockroach Diploptera punctata[J].ACS Symp Ser, 1991, 453(Insect Neuropept.):164-176.
[73]HAYES T K, GUAN X C, JOHNSON V, et al. Structure-activity studies of allatostatin 4 on the inhibition of juvenile hormone biosynthesis by corpora allata:the importance of individual side chains and stereochemistry[J]. Peptides, 1994, 15(7):1165-1171.
[74]MATTHEWS H J, AUDSLEY N, WEAVER R J. Alanine substitution and deletion analogues of Manduca sexta allatostatin:Structure-activity relationship on the spontaneous contractions of the foregut of larval Lacanobia oleracea[J]. J Insect Physiol, 2006,52(2):128-135.
[75]a)开振鹏.运用模拟肽学创制新型昆虫生长调节剂:抑咽侧体素类似物的设计、合成与生物活性研究[D].北京:中国农业大学,2009. KAI Z P. Discovery of new insect growth regulators with peptidomimetics:design, synthesis and bioactivity of allatostatinanalogs[D]. Beijing:China Agricultural University, 2009.b)黄娟.蜚蠊型抑咽侧体素核心五肽类似物的设计与合成[D].北京:中国农业大学, 2010.HUANG J. Design and synthesis of pentapeptide analogs of cockroach allatostatin[D]. Beijing:China Agricultural University, 2010.c)谢勇.抑咽侧体素类似物的设计、合成、生物活性及构象研究[D].北京:中国农业大学, 2012.XIE Y. Design, synthesis, biological activity and conformation of allatostatin analogs[D]. Beijing:China Agricultural University, 2012.d)王献伟.抑咽侧体素类似物B1的结构优化[D].北京:中国农业大学, 2014.WANG X W. Structural optimization of B1, an AST analog[D].Beijing:China Agricultural University, 2014.e)张传亮.运用模拟肽学创制新型生态杀虫剂:昆虫激肽类似物的设计、合成与生物活性研究[D].北京:中国农业大学, 2015.ZHANG C L. Discovery of novel eco-insecticide via peptidomimetics:design, synthesis and bioactivity of insect kinin analogs[D].Beijing:China Agricultural University, 2015.f)吴小庆.抑咽侧体素类似物的设计、合成、生物活性及与构效关系的研究[D].北京:中国农业大学, 2016.WU X Q. Design, synthesis, bioactivity and structure-activity relationship of allatostatin analogs[D]. Beijing:China Agricultural University, 2016.g)汪梅子.基于3D-QSAR的抑咽侧体素类似物的设计、合成及生物活性研究[D].北京:中国农业大学, 2019.WANG M Z. Design, synthesis and bioactivity of allatostatin analogs based on 3D-QSAR research[D]. Beijing:China Agricultural University, 2019.
[76]a)KAI Z P, HUANG J, XIE Y, et al. Synthesis, biological activity,and hologram quantitative structure-activity relationships of novel allatostatin analogues[J]. J Agric Food Chem, 2010, 58(5):2652-2658.b)KAI Z P, XIE Y, HUANG J, et al. Peptidomimetics in the discovery of new insect growth regulators:studies on the structureactivity relationships of the core Pentapeptide region of allatostatins[J]. J Agric Food Chem, 2011, 59(6):2478-2485.c)XIE Y, ZHANG L, ZHANG C L, et al. Synthesis, biological activity, and conformational study of N-methylated allatostatin analogues inhibiting juvenile hormone biosynthesis[J]. J Agric Food Chem, 2015, 63(11):2870-2876.d)XIE Y, ZHANG L, WU X Q, et al. Probing the active conformation of FGLamide allatostatin analogs with N-terminal modifications using NMR spectroscopy and molecular modeling[J].Peptides, 2015, 68:214-218.e)WU X Q, HUANG J, WANG M Z, et al. Synthesis, bioactivity and functional evaluation of linker-modified allatostatin analogs as potential insect growth regulators[J]. Chin Chem Lett, 2016, 27(4):559-562.f)WU X Q, WANG M Z, HUANG J, et al. A potential insect growth regulator for cockroach control:Design, synthesis and bioactivity of N-terminal-modified allatostatin analogues[J]. Pest Manag Sci, 2017, 73(3):500-505.g)WANG M Z, ZHANG L, WANG X W, et al. Exploring the Nterminus region:Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators[J]. Chin Chem Lett, 2018,29(9):1375-1378.h)WANG M Z, LI X L, CHEN M T, et al. 3D-QSAR based optimization of insect neuropeptide allatostatin analogs[J]. Bioorg Med Chem Lett, 2019, 29(7):890-895.
[77]a)KAI Z P, LING Y, LIU W J, et al. The study of solution conformation of allatostatins by 2-D NMR and molecular modeling[J]. Biochim Biophys Acta, Proteins Proteomics, 2006,1764(1):70-75.b)KAI Z P, HUANG J, TOBE S S, et al. A potential insect growth regulator:synthesis and bioactivity of an allatostatin mimic[J].Peptides, 2009, 30(7):1249-1253.c)XIE Y, KAI Z P, TOBE S S, et al. Design, synthesis and biological activity of peptidomimetic analogs of insect allatostatins[J]. Peptides, 2011, 32(3):581-586.d)XIE Y, WANG M Z, ZHANG L, et al. Synthesis and biological activity of FGLamide allatostatin analogs with Phe3 residue modifications[J]. J Pept Sci, 2016, 22(9):600-606.e)汪梅子,王献伟,吴小庆,等. N端结构改造的抑咽侧体素拟肽类化合物的设计、合成及生物活性研究[J].中国科学:化学.2016, 46(11):1235-1241.WANG M Z, WANG X W, WU X Q, et al. Design, synthesis and biological activity of peptidomimetic analogs with allatostatin at Nterminus[J]. Scientia Sinica(Chimica), 2016, 46(11):1235-1241.
[78]PIULACHS M D, VILAPLANA L, BARTOLOMéJ M, et al.Ketomethylene and methyleneamino pseudopeptide analogues of insect allatostatins inhibit juvenile hormone and vitellogenin production in the cockroach Blattella germanica[J]. Insect Biochem Mol Biol, 1997, 27(10):851-858.
[79]NACHMAN R J, MOYNA G, WILLIAMS H J, et al. Synthesis,biological activity, and conformational studies of insect allatostatin neuropeptide analogues incorporating turn-promoting moieties[J].Bioorg Med Chem, 1998, 6(8):1379-1388.
[80]GARSIDE C S, NACHMAN R J, TOBE S S. Injection of Dipallatostatin or Dip-allatostatin pseudopeptides into mated female Diploptera punctata inhibits endogenous rates of JH biosynthesis and basal oocyte growth[J]. Insect Biochem Mol Biol, 2000, 30(8-9):703-710.
[81]HUANG S S, CHEN S S, KAI Z P, et al. Structure-based discovery of non-peptide allatostatin analogs for pest control[J]. J Agric Food Chem, 2018, 66(14):3644-3650.
[82]YANG H J, YOUNG J M, LEE E J, et al. Structure in solution of Diploptera punctata allatostatin-2[J]. J Appl Biol, 2006, 49(4):186-188.
[83]YANG H J, LIM Y. Solution structure determination of four Diploptera punctataallatostatins by NMR spectroscopy and molecular modeling[J]. Bull Korean Chem Soc, 2005, 26(5):845-848.
[84]BANERJEE M, MEYEROWITZ E, HUANG C D, et al. Probing the conformation and dynamics of allatostatin neuropeptides:a structural model for functional differences[J]. Peptides, 2008, 29(3):375-385.
[85]BIRGUL N. Reverse physiology in Drosophila:identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family[J]. Embo J, 1999, 18(21):5892-5900.
[86]LENZ C, S?NDERGAARD L, GRIMMELIKHUIJZEN C J P.Molecular cloning and genomic organization of a novel receptor from Drosophila melanogaster structurally related to mammalian galanin receptors[J]. Biochem Biophys Res Commun, 2000, 269(1):91-96.
[87]LENZ C, WILLIAMSON M, GRIMMELIKHUIJZEN C J P.Molecular cloning and genomic organization of a second probable allatostatin receptor from Drosophila melanogaster[J]. Biochem Biophys Res Commun, 2000, 273(2):571-577.
[88]AUERSWALD L, BIRGüL N, G?DE G, et al. Structural,functional, and evolutionary characterization of novel members of the allatostatin receptor family from insects[J]. Biochem Biophys Res Commun, 2001, 282(4):904-909.
[89]SECHER T, LENZ C, CAZZAMALI G, et al. Molecular cloning of a functional allatostatin gut/brain receptor and an allatostatin preprohormone from the Silkworm Bombyx Mori[J]. J Biol Chem,2001, 276(50):47052-47060.
[90]LUNGCHUKIET P, DONLY B C, ZHANG J R, et al. Molecular cloning and characterization of an allatostatin-like receptor in the cockroach Diploptera punctata[J]. Peptides, 2008, 29(2):276-285.
[91]LARSEN M J, BURTON K J, ZANTELLO M R, et al. Type A allatostatins from Drosophila melanogaster and Diplotera puncata activate two drosophila allatostatin receptors, DAR-1 and DAR-2,expressed in CHO cells[J]. Biochem Biophys Res Commun, 2001,286(5):895-901.
[92]PALCZEWSKI K. Crystal structure of rhodopsin:A G proteincoupled receptor[J]. Science, 2000, 289(5480):739-745.
[93]CHEREZOV V, ROSENBAUM D M, HANSON M A, et al. Highresolution crystal structure of an engineered human 2-adrenergic G protein-coupled receptor[J]. Science, 2007, 318(5854):1258-1265.
[94]张莉,开振鹏,谢勇,等.抑咽侧体素受体结构的同源模建及与Allastostain类似物的分子对接研究.[C]//第十届全国农药学科教学科研研讨会,中国:青岛, 2008.ZHANG L, KAI Z P, XIE Y, et al. Homologous modeling of the allastostain receptor structure and molecular docking with allastostain analogs.[C]//The 10th national meeting of pesticide teaching and research, Qingdao, China, 2008.
[95]MANGLIK A, KRUSE A C, KOBILKA T S, et al. Crystal structure of theμ-opioid receptor bound to a morphinan antagonist[J]. Nature,2012, 485(7398):321-326.
[96]THOMPSON A A, LIU W, CHUN E, et al. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic[J]. Nature, 2012, 485(7398):395-399.
[97]刘影,胜振涛,李胜.保幼激素的分子作用机制[J].昆虫学报,2008, 51(9):974-978.LIU Y, SHENG Z T, LI S. Molecular mechanisms of juvenile hormone action[J]. Acta Entomol Sin, 2008, 51(9):974-978.
[98]HUANG J, MARCHAL E, HULT E F, et al. Characterization of the juvenile hormone pathway in the viviparous cockroach, Diploptera punctata[J]. PLoS One, 2015, 10(2):e0117291.
[99]HUANG J, MARCHAL E, HULT E F, et al. Mode of action of allatostatins in the regulation of juvenile hormone biosynthesis in the cockroach, Diploptera punctata[J]. Insect Biochem Mol Biol, 2014,54:61-68.
[100]NOUZOVA M, RIVERA-PEREZ C, NORIEGA F G. Allatostatin-C reversibly blocks the transport of citrate out of the mitochondria and inhibits juvenile hormone synthesis in mosquitoes[J]. Insect Biochem Mol Biol, 2015, 57:20-26.
[2]燕晓翠,杨春蕾,姚大为,等.抗菌肽的国内外研究进展[J].天津农业科学, 2017, 23(5):35-41.YAN X C, YANG C L, YAO D W, et al. Research progress on domestic and abroad of antibacterial peptides[J]. Tianjin Agric Sci,2017, 23(5):35-41.
[3]严沁,张传强,智达夫,等.抗菌肽在动物生产上的应用[J].畜牧与饲料科学, 2015, 36(12):92-94.YAN Q, ZHANG C Q, ZHI D F, et al. Application of antimicrobial peptides in animal production[J]. Animal Husb Feed Sci, 2015,36(12):92-94.
[4]WANG S, ZENG X F, YANG Q, et al. Antimicrobial peptides as potential alternatives to antibiotics in food animal industry[J]. IJMS,2016, 17(5):603.
[5]蒋细兵,余迪求.植物多肽激素研究概况[J].云南植物研究, 2008,30(3):333-339.JIANG X B, YU D Q. Peptide hormones in plants[J]. Acta Bot Yunnanica, 2008, 30(3):333-339.
[6]王莲存,朱大权,刘德能,等.多肽保对病害防控及其增产效果初探[J].云南农业, 2014(5):20-22.WANG L C, ZHU D Q, LIU D N, et al. Preliminary study on disease control and yield increase effect of DUOTAIBAO[J].Yunnan Agriculture, 2014(5):20-22.
[7]何正春,刘光明,王晓雨,等.美洲大蠊神经肽的研究进展[J].天然产物研究与开发, 2008, 20(1):180-186.HE Z C, LIU G M, WANG X Y, et al. Research advance on neuropeptides from Periplaneta americana[J]. Nat Prod Res Dev,2008, 20(1):180-186.
[8]GADE G, HOFFMANN K H. Neuropeptides regulating development and reproduction in insects[J]. Physiol Entomol, 2005,30(2):103-121.
[9]KATAOKA H, NAGASAWA H, ISOGAI A, et al.Prothoracicotropic hormone of the silkworm, Bombyx Mori:Amino acid sequence and dimeric structure[J]. Agric Biol Chem, 1991,55(1):73-86.
[10]HUA Y J, TANAKA Y, NAKAMURA K, et al. Identification of a prothoracicostatic peptide in the larval brain of the silkworm,Bombyx Mori[J]. J Biol Chem, 1999, 274(44):31169-31173.
[11]STAY B. A review of the role of neurosecretion in the control of juvenile hormone synthesis:a tribute to Berta Scharrer[J]. Insect Biochem Mol Biol, 2000, 30(8-9):653-662.
[12]KATAOKA H, TROETSCHLER R G, KRAMER S J, et al.Isolation and primary structure of the eclosion hormone of the tobacco hornworm, Manduca sexta[J]. Biochem Biophys Res Commun, 1987, 146(2):746-750.
[13]GIRARDIE J, RICHARD O, HUET J C, et al. Physical characterization and sequence identification of the ovary maturating parsin[J]. European Journal of Biochemistry, 1991, 202(3):1121-1126.
[14]NACHMAN R J, HOLMAN G M, HADDON W F. Leads for insect neuropeptide mimetic development[J]. Arch Insect Biochem Physiol, 1993, 22(1-2):181-197.
[15]PREDEL R, NACHMAN R J. The FXPRLamide(pyrokinin/PBAN)peptide family[M/OL]//Handbook of biologically active peptides,elsevier, 2006:207-212. DOI:10.1016/b978-012369442-3/50035-0
[16]COAST G M, ORCHARD I, PHILLIPS J E, et al. Insect diuretic and antidiuretic hormones[M/OL]//Advances in insect physiology.Elsevier, 2002:279-409. DOI:10.1016/s0065-2806(02)29004-9
[17]STONE J V, MORDUE W, BATLEY K E, et al. Structure of locust adipokinetic hormone, a neurohormone that regulates lipid utilisation during flight[J]. Nature, 1976, 263(5574):207-211.
[18]BROWN B E. Proctolin:A peptide transmitter candidate in insects[J]. Life Sci, 1975, 17(8):1241-1252.
[19]HOLMAN G M, NACHMAN R J, COAST G M. Isolation,characterization and biological activity of a diuretic myokinin neuropeptide from the housefly, Musca domestica[J]. Peptides,1999, 20(1):1-10.
[20]NACHMAN R J, HOLMAN G M. Myotropic insect neuropeptide families from the cockroach Leucophaea maderae[M]//ACS symposium series. Washington, DC:American Chemical Society,1991:194-214. DOI:10.1021/bk-1991-0453.ch018
[21]MAGGIO E. Tachykinins[J]. Annu Rev Neurosci, 1988, 11(1):13-28.
[22]EVANS P D, ROBB S, CUTHBERT B A. Insect neuropeptidesidentification, establishment of functional roles and novel target sites for pesticides[J]. Pestic Sci, 1989, 25(1):71-83.
[23]a)MASLER E P, KELLY T J, MENN J J. Insect neuropeptides:Discovery and application in insect management[J]. Arch Insect Biochem Physiol, 1993, 22(1-2):87-111.b)BLAND J M, EDWARD J W, EATON S R, et al. Potential of natural peptidic compounds as leads for novel pesticides[J]. Pestic Sci, 1993, 39(4):331-340.
[24]G?DE G, GOLDSWORTHY G J. Insect peptide hormones:a selective review of their physiology and potential application for pest control[J]. Pest Manag Sci, 2003, 59(10):1063-1075.
[25]SCHOOFS L, DE LOOF A, VAN HIEL M B. Neuropeptides as regulators of behavior in insects[J]. Annu Rev Entomol, 2017, 62(1):35-52.
[26]NACHMAN R J. Neuropeptides and receptors as targets for bioinsecticides. Abstracts of Papers[C]//246th ACS National Meeting&Exposition, Indianapolis, IN, United States, September 8-12, 2013, AGRO-137.
[27]SCHERKENBECK J, ZDOBINSKY T. Insect neuropeptides:Structures, chemical modifications and potential for insect control[J]. Bioorg Med Chem, 2009, 17(12):4071-4084.
[28]SCHWARTZ E F, MOUR?O C B, MOREIRA K G, et al.Arthropod venoms:a vast arsenal of insecticidal neuropeptides[J].Biopolymers, 2012, 98(4):385-405.
[29]GILON C, ALTSTEIN M. Backbone cyclic peptide fragments derived from pheromone biosynthesis activating neuropeptide PBAN and their use as insecticides:WO 9928339[P]. 1999-06-10.
[30]SCHWARZ M A. Novel neuropeptides useful as insecticides:WO2015052701[P]. 2015-04-16.
[31]CHOI M Y, VANDER M, ROBERT K. Bioactive peptides having insecticide activity:US 20160262388[P]. 2016-09-15.
[32]SEINSCHE A, DYKER H, LOSEL P, et al. Effect of helicokinins and ACE inhibitors on water balance and development of Heliothis virescens larvae[J]. Journal of Insect Physiology, 2000, 46(11):1423-1431.
[33]MA M, EMERY S B, WONG W K R, et al. Effects of Manduca diuresin on neonates of the tobacco hornworm, Manduca sexta[J].Gen Comp Endocrinol, 2000, 118:1-7.
[34]MATTHEWS H J, AUDSLEY N, WEAVER R J. In vitro and in vivo effects of myo-active peptides on larvae of the tomato moth Lacanobia oleraceaand the Cotton leafworm Spodoptera littoralis(Lepidoptera; Noctuidae)[J]. Arch Insect Biochem Physiol, 2008,69(2):60-69.
[35]SMAGGHE G, MAHDIAN K, ZUBRZAK P, et al. Antifeedant activity and high mortality in the pea aphid Acyrthosiphon Pisum(Hemiptera:Aphidae)induced by biostable insect kinin analogs[J].Peptides, 2010, 31(3):498-505.
[36]a)WOODHEAD A P, STAY B, SEIDEL S L, et al. Primary structure of four allatostatins:neuropeptide inhibitors of juvenile hormone synthesis[J]. Proc Natl Acad Sci, 1989, 86(15):5997-6001.b)WOODHEAD A P, STAY B. Neural inhibition of corpora allata in protein-deprived Diploptera punctata[J]. J Insect Physiol, 1989,35(5):415-421.
[37]PRATT G E, FARNSWORTH D E, FOK K F, et al. Identity of a second type of allatostatin from cockroach brains:an octadecapeptide amide with a tyrosine-rich address sequence[J].Proc Natl Acad Sci, 1991, 88(6):2412-2416.
[38]PRATT G E, FARNSWORTH D E, SIEGEL N R, et al.Identification of an allatostatin from adult Diploptera punctata[J].Biochem Biophys Res Commun, 1989, 163(3):1243-1247.
[39]曾辉明,黄俊生.昆虫神经肽allatostatin的研究进展[J].生命科学, 2003, 15(3):168-172, 191.ZENG H M, HUANG J S. Advances of research on insect neuropeptide allatostatin[J]. Chin Bull Life Sci, 2003, 15(3):168-172, 191.
[40]NATHOO A N, MOELLER R A, WESTLUND B A, et al.Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species[J]. Proc Natl Acad Sci USA, 2001, 98(24):14000-14005.
[41]HULT E F, WEADICK C J, CHANG B S W, et al. Reconstruction of ancestral FGLamide-type insect allatostatins:A novel approach to the study of allatostatin function and evolution[J]. J Insect Physiol,2008, 54(6):959-968.
[42]DONLY B C, DING Q, TOBE S S, et al. Molecular cloning of the gene for the allatostatin family of neuropeptides from the cockroach Diploptera punctata[J]. Proc Natl Acad Sci, 1993, 90(19):8807-8811.
[43]DING Q, DONLY B C, TOBE S S, et al. Comparison of the allatostatin neuropeptide precursors in the distantly related cockroaches, Periplaneta americana and Diploptera punctata[J].Eur J Biochem, 1995, 234(3):737-746.
[44]PREDEL R, KELLNER R, RAPUS J, et al. Allatostatins from the retrocerebral complex and antennal pulsatile organ of the American cockroach:structural elucidation aided by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry[J]. Regul Pept, 1999, 82(1-3):81-89.
[45]LORENZ M W, KELLNER R, HOFFMANN K H. Identification of two allatostatins from the cricket, Gryllus bimaculatus de Geer(Ensifera, Gryllidae):additional members of a family of neuropeptides inhibiting juvenile hormone biosynthesis[J]. RegulPept, 1995, 57(3):227-236.
[46]YOON J G, STAY B. Immunocytochemical localization of Diploptera punctataallatostatin-like peptide in Drosophila melanogaster[J]. J Comp Neurol, 1995, 363(3):475-488.
[47]ALTARATZ M, APPLEBAUM S W, RICHARD D S, et al.Regulation of juvenile hormone synthesis in wild-type and apterous mutant Drosophila[J]. Mol Cell Endocrinol, 1991, 81(1-3):205-216.
[48]ABDEL-LATIEF M, MEYERING-VOS M, HOFFMANN K H.Type-A allatostatins from the fall armyworm, Spodoptera frugiperda:Molecular cloning, expression and tissue-specific localization[J]. Arch Insect Biochem Physiol, 2004, 56(3):120-132.
[49]ABDEL-LATIEF M, MEYERING-VOS M, HOFFMANN K H.Molecular characterisation of cDNAs from the fall armyworm Spodoptera frugiperda encoding Manduca sexta allatotropin and allatostatin preprohormone peptides[J]. Insect Biochem Mol Biol,2003, 33(5):467-476.
[50]CLARK L, LANGE A B, ZHANG J R, et al. The roles of Dippuallatostatin in the modulation of hormone release in Locusta migratoria[J]. J Insect Physiol, 2008, 54(6):949-958.
[51]DUVE H, JOHNSEN A H, SCOTT A G, et al. Callatostatins:neuropeptides from the blowfly Calliphora vomitoria with sequence homology to cockroach allatostatins[J]. Proc Natl Acad Sci, 1993,90(6):2456-2460.
[52]KWOK R, JIN R Z, TOBE S S. Regulation of methyl farnesoate production by mandibular organs in the crayfish, Procambarus clarkii:A possible role for allatostatins[J]. J Insect Physiol, 2005,51(4):367-378.
[53]DUVE H, JOHNSEN A H, SCOTT A G, et al. Allatostatins of the tiger prawn, Penaeus monodon(Crustacea:Penaeidea)[J]. Peptides,2002, 23(6):1039-1051.
[54]KASTIN A. Handbook of biologically active peptides(second edition)[M]. Burlington:Academic Press, 2013.
[55]STAY B, TOBE S S, BENDENA W G. Allatostatins:identification,primary structures, functions and distribution[M/OL]//Advances in insect physiology. Elsevier, 1995:267-337. DOI:10.1016/s0065-2806(08)60066-1
[56]WOODHEAD A P, ASANO W Y, STAY B. Allatostatins in the haemolymph of Diploptera punctata and their effect in vivo[J]. J Insect Physiol, 1993, 39(12):1001-1005.
[57]FUSéM, ZHANG J R, PARTRIDGE E, et al. Effects of an allatostatin and a myosuppressin on midgut carbohydrate enzyme activity in the cockroach Diploptera punctata[J]. Peptides, 1999,20(11):1285-1293.
[58]YU C G, HAYES T K, STREY A, et al. Identification and partial characterization of receptors for allatostatins in brain and corpora allata of the cockroach Diploptera punctata using a binding assay and photoaffinity labeling[J]. Regul Pept, 1995, 57(3):347-358.
[59]STAY B, SEREG BACHMANN J A, STOLTZMAN C A, et al.Factors affecting allatostatin release in a cockroach(Diploptera punctata):Nerve section, juvenile hormone analog and ovary[J]. J Insect Physiol, 1994, 40(5):365-372.
[60]关雪辰.昆虫神经肽allatostatin与allatotropin的研究新近展[J].昆虫学报, 1996, 39(2):214-218.GUAN X C. Recent advances in research on insect neuropeptides allatostatin and allatotropin[J]. Acta Entomol Sin, 1996, 39(2):214-218.
[61]HERNáNDEZ-MARTíNEZ S, LI Y P, LANZ-MENDOZA H, et al.Immunostaining for allatotropin and allatostatin-A and-C in the mosquitoes Aedes aegypti and Anopheles albimanus[J]. Cell Tissue Res, 2005, 321(1):105-113.
[62]a)STAY B, FAIRBAIRN S, YU C G. Role of allatostatins in the regulation of juvenile hormone synthesis[J]. Arch Insect Biochem Physiol, 1996, 32(3-4):287-297.b)STAY B, TOBE S S. The role of allatostatins in juvenile hormone synthesis in insects and crustaceans[J]. Annu Rev Entomol, 2007,52(1):277-299.
[63]MAESTRO J L, PASCUAL N, TREIBLMAYR K, et al. Juvenile hormone and allatostatins in the German cockroach embryo[J].Insect Biochem Mol Biol, 2010, 40(9):660-665.
[64]TOBE S S, ZHANG J R, BOWSER P R F, et al. Biological activities of the allatostatin family of peptides in the cockroach,Diploptera punctata, and potential interactions with receptors[J]. J Insect Physiol, 2000, 46(3):231-242.
[65]LANGE A B, BENDENA W G, TOBE S S. The effect of the thirteen Dip-allatostatins on myogenic and induced contractions of the cockroach(Diploptera punctata)hindgut[J]. J Insect Physiol,1995, 41(7):581-588.
[66]AUDSLEY N, MATTHEWS J, NACHMAN R J, et al.Transepithelial flux of an allatostatin and analogs across the anterior midgut of Manduca sexta larvae in vitro[J]. Peptides, 2008, 29(2):286-294.
[67]MARTíN D, PIULACHS M D, BELLéS X. Inhibition of vitellogenin production by allatostatin in the German cockroach[J].Mol Cell Endocrinol, 1996, 121(2):191-196.
[68]JOHNSON G D, STAY B, CHAN K K. Structure-activity relationships in corpora allata of the cockroach Diploptera punctata:roles of mating and the ovary[J]. Cell Tissue Res, 1993, 274(2):279-293.
[69]VILAPLANA L, MAESTRO J L, PIULACHS M D, et al.Modulation of cardiac rhythm by allatostatins in the cockroach Blattella germanica(L.)(Dictyoptera, Blattellidae)[J]. J Insect Physiol, 1999, 45(12):1057-1064.
[70]NACHMAN R J, GARSIDEB C S, TOBEB S S. Hemolymph and tissue-bound peptidase-resistant analogs of the insect allatostatins[J].Peptides, 1999, 20(1):23-29.
[71]周家驹,王亭.药物设计中的分子模型化方法[M].科学出版社,2001.ZHOU J J, WANG T. Molecular modoling in drug design[M].Science Press, 2001.
[72]STAY B, WOODHEAD A P, JOSHI S, TOBE S S, et al.Allatostatins. Neuropeptide inhibitors of juvenile hormone synthesis in brain and corpora allata of the cockroach Diploptera punctata[J].ACS Symp Ser, 1991, 453(Insect Neuropept.):164-176.
[73]HAYES T K, GUAN X C, JOHNSON V, et al. Structure-activity studies of allatostatin 4 on the inhibition of juvenile hormone biosynthesis by corpora allata:the importance of individual side chains and stereochemistry[J]. Peptides, 1994, 15(7):1165-1171.
[74]MATTHEWS H J, AUDSLEY N, WEAVER R J. Alanine substitution and deletion analogues of Manduca sexta allatostatin:Structure-activity relationship on the spontaneous contractions of the foregut of larval Lacanobia oleracea[J]. J Insect Physiol, 2006,52(2):128-135.
[75]a)开振鹏.运用模拟肽学创制新型昆虫生长调节剂:抑咽侧体素类似物的设计、合成与生物活性研究[D].北京:中国农业大学,2009. KAI Z P. Discovery of new insect growth regulators with peptidomimetics:design, synthesis and bioactivity of allatostatinanalogs[D]. Beijing:China Agricultural University, 2009.b)黄娟.蜚蠊型抑咽侧体素核心五肽类似物的设计与合成[D].北京:中国农业大学, 2010.HUANG J. Design and synthesis of pentapeptide analogs of cockroach allatostatin[D]. Beijing:China Agricultural University, 2010.c)谢勇.抑咽侧体素类似物的设计、合成、生物活性及构象研究[D].北京:中国农业大学, 2012.XIE Y. Design, synthesis, biological activity and conformation of allatostatin analogs[D]. Beijing:China Agricultural University, 2012.d)王献伟.抑咽侧体素类似物B1的结构优化[D].北京:中国农业大学, 2014.WANG X W. Structural optimization of B1, an AST analog[D].Beijing:China Agricultural University, 2014.e)张传亮.运用模拟肽学创制新型生态杀虫剂:昆虫激肽类似物的设计、合成与生物活性研究[D].北京:中国农业大学, 2015.ZHANG C L. Discovery of novel eco-insecticide via peptidomimetics:design, synthesis and bioactivity of insect kinin analogs[D].Beijing:China Agricultural University, 2015.f)吴小庆.抑咽侧体素类似物的设计、合成、生物活性及与构效关系的研究[D].北京:中国农业大学, 2016.WU X Q. Design, synthesis, bioactivity and structure-activity relationship of allatostatin analogs[D]. Beijing:China Agricultural University, 2016.g)汪梅子.基于3D-QSAR的抑咽侧体素类似物的设计、合成及生物活性研究[D].北京:中国农业大学, 2019.WANG M Z. Design, synthesis and bioactivity of allatostatin analogs based on 3D-QSAR research[D]. Beijing:China Agricultural University, 2019.
[76]a)KAI Z P, HUANG J, XIE Y, et al. Synthesis, biological activity,and hologram quantitative structure-activity relationships of novel allatostatin analogues[J]. J Agric Food Chem, 2010, 58(5):2652-2658.b)KAI Z P, XIE Y, HUANG J, et al. Peptidomimetics in the discovery of new insect growth regulators:studies on the structureactivity relationships of the core Pentapeptide region of allatostatins[J]. J Agric Food Chem, 2011, 59(6):2478-2485.c)XIE Y, ZHANG L, ZHANG C L, et al. Synthesis, biological activity, and conformational study of N-methylated allatostatin analogues inhibiting juvenile hormone biosynthesis[J]. J Agric Food Chem, 2015, 63(11):2870-2876.d)XIE Y, ZHANG L, WU X Q, et al. Probing the active conformation of FGLamide allatostatin analogs with N-terminal modifications using NMR spectroscopy and molecular modeling[J].Peptides, 2015, 68:214-218.e)WU X Q, HUANG J, WANG M Z, et al. Synthesis, bioactivity and functional evaluation of linker-modified allatostatin analogs as potential insect growth regulators[J]. Chin Chem Lett, 2016, 27(4):559-562.f)WU X Q, WANG M Z, HUANG J, et al. A potential insect growth regulator for cockroach control:Design, synthesis and bioactivity of N-terminal-modified allatostatin analogues[J]. Pest Manag Sci, 2017, 73(3):500-505.g)WANG M Z, ZHANG L, WANG X W, et al. Exploring the Nterminus region:Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators[J]. Chin Chem Lett, 2018,29(9):1375-1378.h)WANG M Z, LI X L, CHEN M T, et al. 3D-QSAR based optimization of insect neuropeptide allatostatin analogs[J]. Bioorg Med Chem Lett, 2019, 29(7):890-895.
[77]a)KAI Z P, LING Y, LIU W J, et al. The study of solution conformation of allatostatins by 2-D NMR and molecular modeling[J]. Biochim Biophys Acta, Proteins Proteomics, 2006,1764(1):70-75.b)KAI Z P, HUANG J, TOBE S S, et al. A potential insect growth regulator:synthesis and bioactivity of an allatostatin mimic[J].Peptides, 2009, 30(7):1249-1253.c)XIE Y, KAI Z P, TOBE S S, et al. Design, synthesis and biological activity of peptidomimetic analogs of insect allatostatins[J]. Peptides, 2011, 32(3):581-586.d)XIE Y, WANG M Z, ZHANG L, et al. Synthesis and biological activity of FGLamide allatostatin analogs with Phe3 residue modifications[J]. J Pept Sci, 2016, 22(9):600-606.e)汪梅子,王献伟,吴小庆,等. N端结构改造的抑咽侧体素拟肽类化合物的设计、合成及生物活性研究[J].中国科学:化学.2016, 46(11):1235-1241.WANG M Z, WANG X W, WU X Q, et al. Design, synthesis and biological activity of peptidomimetic analogs with allatostatin at Nterminus[J]. Scientia Sinica(Chimica), 2016, 46(11):1235-1241.
[78]PIULACHS M D, VILAPLANA L, BARTOLOMéJ M, et al.Ketomethylene and methyleneamino pseudopeptide analogues of insect allatostatins inhibit juvenile hormone and vitellogenin production in the cockroach Blattella germanica[J]. Insect Biochem Mol Biol, 1997, 27(10):851-858.
[79]NACHMAN R J, MOYNA G, WILLIAMS H J, et al. Synthesis,biological activity, and conformational studies of insect allatostatin neuropeptide analogues incorporating turn-promoting moieties[J].Bioorg Med Chem, 1998, 6(8):1379-1388.
[80]GARSIDE C S, NACHMAN R J, TOBE S S. Injection of Dipallatostatin or Dip-allatostatin pseudopeptides into mated female Diploptera punctata inhibits endogenous rates of JH biosynthesis and basal oocyte growth[J]. Insect Biochem Mol Biol, 2000, 30(8-9):703-710.
[81]HUANG S S, CHEN S S, KAI Z P, et al. Structure-based discovery of non-peptide allatostatin analogs for pest control[J]. J Agric Food Chem, 2018, 66(14):3644-3650.
[82]YANG H J, YOUNG J M, LEE E J, et al. Structure in solution of Diploptera punctata allatostatin-2[J]. J Appl Biol, 2006, 49(4):186-188.
[83]YANG H J, LIM Y. Solution structure determination of four Diploptera punctataallatostatins by NMR spectroscopy and molecular modeling[J]. Bull Korean Chem Soc, 2005, 26(5):845-848.
[84]BANERJEE M, MEYEROWITZ E, HUANG C D, et al. Probing the conformation and dynamics of allatostatin neuropeptides:a structural model for functional differences[J]. Peptides, 2008, 29(3):375-385.
[85]BIRGUL N. Reverse physiology in Drosophila:identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family[J]. Embo J, 1999, 18(21):5892-5900.
[86]LENZ C, S?NDERGAARD L, GRIMMELIKHUIJZEN C J P.Molecular cloning and genomic organization of a novel receptor from Drosophila melanogaster structurally related to mammalian galanin receptors[J]. Biochem Biophys Res Commun, 2000, 269(1):91-96.
[87]LENZ C, WILLIAMSON M, GRIMMELIKHUIJZEN C J P.Molecular cloning and genomic organization of a second probable allatostatin receptor from Drosophila melanogaster[J]. Biochem Biophys Res Commun, 2000, 273(2):571-577.
[88]AUERSWALD L, BIRGüL N, G?DE G, et al. Structural,functional, and evolutionary characterization of novel members of the allatostatin receptor family from insects[J]. Biochem Biophys Res Commun, 2001, 282(4):904-909.
[89]SECHER T, LENZ C, CAZZAMALI G, et al. Molecular cloning of a functional allatostatin gut/brain receptor and an allatostatin preprohormone from the Silkworm Bombyx Mori[J]. J Biol Chem,2001, 276(50):47052-47060.
[90]LUNGCHUKIET P, DONLY B C, ZHANG J R, et al. Molecular cloning and characterization of an allatostatin-like receptor in the cockroach Diploptera punctata[J]. Peptides, 2008, 29(2):276-285.
[91]LARSEN M J, BURTON K J, ZANTELLO M R, et al. Type A allatostatins from Drosophila melanogaster and Diplotera puncata activate two drosophila allatostatin receptors, DAR-1 and DAR-2,expressed in CHO cells[J]. Biochem Biophys Res Commun, 2001,286(5):895-901.
[92]PALCZEWSKI K. Crystal structure of rhodopsin:A G proteincoupled receptor[J]. Science, 2000, 289(5480):739-745.
[93]CHEREZOV V, ROSENBAUM D M, HANSON M A, et al. Highresolution crystal structure of an engineered human 2-adrenergic G protein-coupled receptor[J]. Science, 2007, 318(5854):1258-1265.
[94]张莉,开振鹏,谢勇,等.抑咽侧体素受体结构的同源模建及与Allastostain类似物的分子对接研究.[C]//第十届全国农药学科教学科研研讨会,中国:青岛, 2008.ZHANG L, KAI Z P, XIE Y, et al. Homologous modeling of the allastostain receptor structure and molecular docking with allastostain analogs.[C]//The 10th national meeting of pesticide teaching and research, Qingdao, China, 2008.
[95]MANGLIK A, KRUSE A C, KOBILKA T S, et al. Crystal structure of theμ-opioid receptor bound to a morphinan antagonist[J]. Nature,2012, 485(7398):321-326.
[96]THOMPSON A A, LIU W, CHUN E, et al. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic[J]. Nature, 2012, 485(7398):395-399.
[97]刘影,胜振涛,李胜.保幼激素的分子作用机制[J].昆虫学报,2008, 51(9):974-978.LIU Y, SHENG Z T, LI S. Molecular mechanisms of juvenile hormone action[J]. Acta Entomol Sin, 2008, 51(9):974-978.
[98]HUANG J, MARCHAL E, HULT E F, et al. Characterization of the juvenile hormone pathway in the viviparous cockroach, Diploptera punctata[J]. PLoS One, 2015, 10(2):e0117291.
[99]HUANG J, MARCHAL E, HULT E F, et al. Mode of action of allatostatins in the regulation of juvenile hormone biosynthesis in the cockroach, Diploptera punctata[J]. Insect Biochem Mol Biol, 2014,54:61-68.
[100]NOUZOVA M, RIVERA-PEREZ C, NORIEGA F G. Allatostatin-C reversibly blocks the transport of citrate out of the mitochondria and inhibits juvenile hormone synthesis in mosquitoes[J]. Insect Biochem Mol Biol, 2015, 57:20-26.