新生儿缺氧缺血性脑损伤动物模型的研究进展
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摘要
新生儿缺氧缺血性脑损伤动物模型是指在围生期动物建立缺氧、缺血条件,模拟其病理过程的模型。主要的造模方法包括阻断动脉血管、夹闭气管和产前造成宫内缺氧等。本文对缺氧缺血性脑损伤动物模型的进展和模型评估等方面进行综述。
The animal model of neonatal hypoxic-ischemic brain damage refers to ischemia and hypoxia conditions to duplicate the pathogenesis and pathological progress in the perinatal animals. The main modeling methods include blocking arterial vessels, clipping trachea and prenatal intrauterine anoxia and so on. The paper mainly reviewed the progress and evaluation of neonatal hypoxic-ischemic brain damage animal models.
The animal model of neonatal hypoxic-ischemic brain damage refers to ischemia and hypoxia conditions to duplicate the pathogenesis and pathological progress in the perinatal animals. The main modeling methods include blocking arterial vessels, clipping trachea and prenatal intrauterine anoxia and so on. The paper mainly reviewed the progress and evaluation of neonatal hypoxic-ischemic brain damage animal models.
引文
[1]Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy[J]. Early Hum Dev, 2010, 86(6):329-338.
[2]Yager JY. Animal models of hypoxic-ischemic brain damage in the newborn[J]. Semin Pediatr Neurol, 2004, 11(1):31-46.
[3]Teo L, Bourne JA. A reproducible and translatable model of focal ischemia in the visual cortex of infant and adult marmoset monkeys[J]. Brain Pathol, 2014, 24(5):459-474.
[4]Rice JE 3rd, Vannucci RC, Brierley JB. The influence of immaturity on hypoxic-ischemic brain damage in the rat[J]. Ann Neurol, 1981, 9(2):131-141.
[5]Allah YR, Akbar A, Iqbal F. Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice[J]. Brain Res, 2015, 1595:92-100.
[6]Bjelke B, Andersson K, Ogren S, et al. Asphyctic lesion:proliferation of tyrosine hydroxylase-immunoreactive nerve cell bodies in the rat substantia nigra and functional changes in dopamine neurotransmission[J]. Brain Res, 1991, 543(1):1-9.
[7]Chen H, Burris M, Fajilan A, et al. Prolonged exposure to isoflurane ameliorates infarction severity in the rat pup model of neonatal hypoxia-ischemia[J]. Transl Stroke Res, 2011, 2(3):382-390.
[8]骆健明,庄明华,刘明发,等.两种新生儿缺血缺氧性脑病模型建模方法的比较[J].中国康复理论与实践, 2005, 11(7):548-549.
[9]Levine S. Anoxic-ischemic encephalopathy in rats[J]. Am J Pathol, 1960, 36(1):1-17.
[10]Gonzalez-Rodriguez PJ, Xiong F, Li Y, et al. Fetal hypoxia increases vulnerability of hypoxic-ischemic brain injury in neonatal rats:role of glucocorticoid receptors[J]. Neurobiol Dis,2014, 65:172-179.
[11]Silachev DN, Plotnikov EY, Babenko VA, et al. Protection of neurovascular unit cells with lithium chloride and sodium valproate prevents brain damage in neonatal ischemia/hypoxia[J].Bull Exp Biol Med, 2016, 160(9):313-318.
[12]Taniguchi H, Andreasson K. The hypoxic-ischemic encephalopathy model of perinatal ischemia[J]. J Vis Exp, 2008(21)pii:955. doi:10.3791/955.
[13]Peterson BL, Won S, Geddes RI, et al. Sex-related differences in effects of progesterone following neonatal hypoxic brain injury[J]. Behav Brain Res, 2015, 286:152-165.
[14]Talhouk RS, Zeinieh MP, Mikati MA, et al. Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury[J]. Prog Neurobiol, 2008, 84(1):57-76.
[15]Askalan R, Gabarin N, Armstrong E, et al. Mechanisms of neurodegeneration after severe hypoxic-ischemic injury in the neonatal rat brain[J]. Brain Res, 2015, 1629:94-103.
[16]Vannucci RC,Vannucci SJ. Perinatal hypoxic-ischemic brain damage:evolution of an animal model[J]. Dev Neurosci,2005, 27(2-4):81-86.
[17]Sampath D, White AM, Raol YH. Characterization of neonatal seizures in an animal model of hypoxic-ischemic encephalopathy[J]. Epilepsia, 2014, 55(7):985-993.
[18]Kadam SD, White AM, Staley KJ, et al. Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy[J]. J Neurosci, 2010, 30(1):404-415.
[19]Schwartz PH, Massarweh WF, Vinters HV, et al. A rat model of severe neonatal hypoxic-ischemic brain injury[J]. Stroke,1992, 23(4):539-546.
[20]Le Blanc MH, Qian XB, Cai ZW. The effect of glucose during ischemia on brain ATP, lactate, and glutamate in piglets[J]. Biol Neonate, 1997, 72(1):243-254.
[21]Zhao B, Quan H, Ma T, et al. 4,4'-Diisothiocyanostilbene-2,2'-disulfonic acid(DIDS)ameliorates ischemia-hypoxia-induced white matter damage in neonatal rats through inhibition of the voltage-gated chloride channel ClC-2[J]. Int J Mol Sci,2015, 16(5):10457-10469.
[22]Derugin N, Ferriero DM, Vexler ZS. Neonatal reversible focal cerebral ischemia:a new model[J]. Neurosci Res 1998, 32(4):349-353.
[23]Renolleau S, Aggoun-Zouaoui D, Ben-Ari Y, et al. A Model of Transient unilateral focal ischemia with reperfusion in the P7neonatal rat morphological changes indicative of apoptosis[J].Stroke, 1998, 29(7):1454-1461.
[24]徐颖,杨长仪,熊秀梅,等.缺氧缺血性脑病动物模型建立新方法:气管夹闭术[J].中华围产医学杂志, 2017, 20(12):882-887.
[25]Yang T, Zhuang L,Terrando N, et al. A clinically relevant model of perinatal global ischemic brain damage in rats[J]. Brain Res, 2011, 1383:317-323.
[26]薄涛,严超英,霍淑芳,等.结扎孕鼠双侧子宫动脉复制围产期缺氧缺血性脑损伤动物模型[J].中风与神经疾病杂志,2001, 18(1):40-41.
[27]Tan S, Drobyshevsky A, Jilling T, et al. Model of cerebral palsy in the perinatal rabbit[J]. J Child Neurol, 2005, 20(12):972-979.
[28]王能里,南燕,柳艳丽,等.近足月胎兔持续宫内缺氧缺血性脑损伤模型的建立[J].中国病理生理杂志, 2012, 28(4):760-764.
[29]左富凤,李树军,常晓,等.缺氧缺血3日龄大鼠脑室周围白质软化动物模型的建立[J].实用儿科临床杂志, 2010, 25(18):1449-1450.
[30]Liu SJ, Zhu SY, Zou Y, et al. Knockdown of IL-1beta improves hypoxia-ischemia brain associated with IL-6 up-regulation in cell and animal models[J]. Mol Neurobiol, 2015, 51(2):743-752.
[31]Arteni NS, Salgueiro J, Torres I, et al. Neonatal cerebral hypoxia-ischemia causes lateralized memory impairments in the adult rat[J]. Brain Res, 2003, 973(2):171-178.
[32]余智,于民,顾苏兵,等.[Gly14]-Humanin对局灶性脑缺血再灌注损伤大鼠氧化应激及神经细胞凋亡的影响[J].预防医学, 2018, 30(1):55-58.
[33]Lin EP, Miles LL, Hughes EA, et al. A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia[J]. Pediatr Neurosci, 2014, 119(5):1158-1173.
[34]李玉宇,徐剑文.新生大鼠缺氧性脑损伤模型的建立及评价[J].山西医科大学学报, 2017, 48(8):795-799.
[35]Kannan S, Saadani-Makki F, Balakrishnan B, et al. Magnitude of[(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure[J]. Dev Neurosci, 2011, 33(3-4):231-240.
[36]Vial F, Serriere S, Barantin L, et al. A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI[J]. Magn Reson Imaging, 2004, 22(4):457-465.
[37]Ten VS, Bradley-Moor M, Gingrich JA, et al. Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy[J]. Behav Brain Res, 2003, 145(1-2):209-219.
[38]Ikeda T, Mishima K, Yoshikawa T, et al. Selective and long-term learning impairment following neonatal hypoxic-ischemic brain insult in rats[J]. Behav brain res, 2001, 118(1):17-25.
[39]Smith AL, Alexander M, Rosenkrantz TS, et al. Sex differences in behavioral outcome following neonatal hypoxia ischemia:insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic brain injury[J]. Exp Neurol, 2014,254:54-67.
[40]Iqbal S, Ali M, Akbar A, et al. Effects of dietary creatine supplementation for 8 weeks on neuromuscular coordination and learning in male albino mouse following neonatal hypoxic ischemic insult[J]. Neurol Sci, 2015, 36(5):765-770.
[41]陈飞.针刺对HIBD模型大鼠行为学及BDNF、EPO表达的影响[D].广州:广州中医药大学, 2013.
[42]陈刚,王伟哲,陈明钊,等.新生幼鼠缺血缺氧性脑损伤模型的实验研究[J].中国康复理论与实践, 2012, 18(7):612-614.
[43]庄蕾,于布为,马大青.惰性气体神经保护作用的行为学研究[J].上海医学, 2017, 40(9):561-566.
[2]Yager JY. Animal models of hypoxic-ischemic brain damage in the newborn[J]. Semin Pediatr Neurol, 2004, 11(1):31-46.
[3]Teo L, Bourne JA. A reproducible and translatable model of focal ischemia in the visual cortex of infant and adult marmoset monkeys[J]. Brain Pathol, 2014, 24(5):459-474.
[4]Rice JE 3rd, Vannucci RC, Brierley JB. The influence of immaturity on hypoxic-ischemic brain damage in the rat[J]. Ann Neurol, 1981, 9(2):131-141.
[5]Allah YR, Akbar A, Iqbal F. Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice[J]. Brain Res, 2015, 1595:92-100.
[6]Bjelke B, Andersson K, Ogren S, et al. Asphyctic lesion:proliferation of tyrosine hydroxylase-immunoreactive nerve cell bodies in the rat substantia nigra and functional changes in dopamine neurotransmission[J]. Brain Res, 1991, 543(1):1-9.
[7]Chen H, Burris M, Fajilan A, et al. Prolonged exposure to isoflurane ameliorates infarction severity in the rat pup model of neonatal hypoxia-ischemia[J]. Transl Stroke Res, 2011, 2(3):382-390.
[8]骆健明,庄明华,刘明发,等.两种新生儿缺血缺氧性脑病模型建模方法的比较[J].中国康复理论与实践, 2005, 11(7):548-549.
[9]Levine S. Anoxic-ischemic encephalopathy in rats[J]. Am J Pathol, 1960, 36(1):1-17.
[10]Gonzalez-Rodriguez PJ, Xiong F, Li Y, et al. Fetal hypoxia increases vulnerability of hypoxic-ischemic brain injury in neonatal rats:role of glucocorticoid receptors[J]. Neurobiol Dis,2014, 65:172-179.
[11]Silachev DN, Plotnikov EY, Babenko VA, et al. Protection of neurovascular unit cells with lithium chloride and sodium valproate prevents brain damage in neonatal ischemia/hypoxia[J].Bull Exp Biol Med, 2016, 160(9):313-318.
[12]Taniguchi H, Andreasson K. The hypoxic-ischemic encephalopathy model of perinatal ischemia[J]. J Vis Exp, 2008(21)pii:955. doi:10.3791/955.
[13]Peterson BL, Won S, Geddes RI, et al. Sex-related differences in effects of progesterone following neonatal hypoxic brain injury[J]. Behav Brain Res, 2015, 286:152-165.
[14]Talhouk RS, Zeinieh MP, Mikati MA, et al. Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury[J]. Prog Neurobiol, 2008, 84(1):57-76.
[15]Askalan R, Gabarin N, Armstrong E, et al. Mechanisms of neurodegeneration after severe hypoxic-ischemic injury in the neonatal rat brain[J]. Brain Res, 2015, 1629:94-103.
[16]Vannucci RC,Vannucci SJ. Perinatal hypoxic-ischemic brain damage:evolution of an animal model[J]. Dev Neurosci,2005, 27(2-4):81-86.
[17]Sampath D, White AM, Raol YH. Characterization of neonatal seizures in an animal model of hypoxic-ischemic encephalopathy[J]. Epilepsia, 2014, 55(7):985-993.
[18]Kadam SD, White AM, Staley KJ, et al. Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy[J]. J Neurosci, 2010, 30(1):404-415.
[19]Schwartz PH, Massarweh WF, Vinters HV, et al. A rat model of severe neonatal hypoxic-ischemic brain injury[J]. Stroke,1992, 23(4):539-546.
[20]Le Blanc MH, Qian XB, Cai ZW. The effect of glucose during ischemia on brain ATP, lactate, and glutamate in piglets[J]. Biol Neonate, 1997, 72(1):243-254.
[21]Zhao B, Quan H, Ma T, et al. 4,4'-Diisothiocyanostilbene-2,2'-disulfonic acid(DIDS)ameliorates ischemia-hypoxia-induced white matter damage in neonatal rats through inhibition of the voltage-gated chloride channel ClC-2[J]. Int J Mol Sci,2015, 16(5):10457-10469.
[22]Derugin N, Ferriero DM, Vexler ZS. Neonatal reversible focal cerebral ischemia:a new model[J]. Neurosci Res 1998, 32(4):349-353.
[23]Renolleau S, Aggoun-Zouaoui D, Ben-Ari Y, et al. A Model of Transient unilateral focal ischemia with reperfusion in the P7neonatal rat morphological changes indicative of apoptosis[J].Stroke, 1998, 29(7):1454-1461.
[24]徐颖,杨长仪,熊秀梅,等.缺氧缺血性脑病动物模型建立新方法:气管夹闭术[J].中华围产医学杂志, 2017, 20(12):882-887.
[25]Yang T, Zhuang L,Terrando N, et al. A clinically relevant model of perinatal global ischemic brain damage in rats[J]. Brain Res, 2011, 1383:317-323.
[26]薄涛,严超英,霍淑芳,等.结扎孕鼠双侧子宫动脉复制围产期缺氧缺血性脑损伤动物模型[J].中风与神经疾病杂志,2001, 18(1):40-41.
[27]Tan S, Drobyshevsky A, Jilling T, et al. Model of cerebral palsy in the perinatal rabbit[J]. J Child Neurol, 2005, 20(12):972-979.
[28]王能里,南燕,柳艳丽,等.近足月胎兔持续宫内缺氧缺血性脑损伤模型的建立[J].中国病理生理杂志, 2012, 28(4):760-764.
[29]左富凤,李树军,常晓,等.缺氧缺血3日龄大鼠脑室周围白质软化动物模型的建立[J].实用儿科临床杂志, 2010, 25(18):1449-1450.
[30]Liu SJ, Zhu SY, Zou Y, et al. Knockdown of IL-1beta improves hypoxia-ischemia brain associated with IL-6 up-regulation in cell and animal models[J]. Mol Neurobiol, 2015, 51(2):743-752.
[31]Arteni NS, Salgueiro J, Torres I, et al. Neonatal cerebral hypoxia-ischemia causes lateralized memory impairments in the adult rat[J]. Brain Res, 2003, 973(2):171-178.
[32]余智,于民,顾苏兵,等.[Gly14]-Humanin对局灶性脑缺血再灌注损伤大鼠氧化应激及神经细胞凋亡的影响[J].预防医学, 2018, 30(1):55-58.
[33]Lin EP, Miles LL, Hughes EA, et al. A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia[J]. Pediatr Neurosci, 2014, 119(5):1158-1173.
[34]李玉宇,徐剑文.新生大鼠缺氧性脑损伤模型的建立及评价[J].山西医科大学学报, 2017, 48(8):795-799.
[35]Kannan S, Saadani-Makki F, Balakrishnan B, et al. Magnitude of[(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure[J]. Dev Neurosci, 2011, 33(3-4):231-240.
[36]Vial F, Serriere S, Barantin L, et al. A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI[J]. Magn Reson Imaging, 2004, 22(4):457-465.
[37]Ten VS, Bradley-Moor M, Gingrich JA, et al. Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy[J]. Behav Brain Res, 2003, 145(1-2):209-219.
[38]Ikeda T, Mishima K, Yoshikawa T, et al. Selective and long-term learning impairment following neonatal hypoxic-ischemic brain insult in rats[J]. Behav brain res, 2001, 118(1):17-25.
[39]Smith AL, Alexander M, Rosenkrantz TS, et al. Sex differences in behavioral outcome following neonatal hypoxia ischemia:insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic brain injury[J]. Exp Neurol, 2014,254:54-67.
[40]Iqbal S, Ali M, Akbar A, et al. Effects of dietary creatine supplementation for 8 weeks on neuromuscular coordination and learning in male albino mouse following neonatal hypoxic ischemic insult[J]. Neurol Sci, 2015, 36(5):765-770.
[41]陈飞.针刺对HIBD模型大鼠行为学及BDNF、EPO表达的影响[D].广州:广州中医药大学, 2013.
[42]陈刚,王伟哲,陈明钊,等.新生幼鼠缺血缺氧性脑损伤模型的实验研究[J].中国康复理论与实践, 2012, 18(7):612-614.
[43]庄蕾,于布为,马大青.惰性气体神经保护作用的行为学研究[J].上海医学, 2017, 40(9):561-566.