胎盘生长因子在非小细胞肺癌胸腔积液中的临床价值
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摘要
目的探讨检测胎盘生长因子(PIGF)在非小细胞肺癌胸腔积液中的临床价值。方法选择在我医院就诊的非小细胞肺癌合并胸腔积液的患者117例的资料进行分析,对PIGF在非小细胞肺癌胸腔积液中的表达及其对临床疗效的影响进行探讨。结果 117例患者中,按照PIGF表达结果分为PIFG阳性组51名,PIFG阴性组66名,PIFG阴性组患者的胸腔积液治疗效果优于PIFG阳性组,PIFG阴性组患者的微血管密度值低于PIFG阳性组患者,PIFG阳性组患者的无进展生存时间与总生存时间均低于PIFG阴性组患者(P<0.05),年龄,TNM分期,淋巴转移,手术切除和PIGF表达是否阳性均为非小细胞肺癌并发胸腔积液患者死亡的独立危险因素(P<0.05)。结论对于胎盘生长因子表达阳性的非小细胞肺癌患者,其胸腔积液的治疗效果相对较差,而胎盘生长因子表达阳性也是非小细胞肺癌患者治疗效果的独立影响因素,可以作为精准医疗的一个新靶点进行开发。
Objective To investigate the clinical value of placental growth factor( PIGF) detection in pleural effusion of non-small cell lung cancer. Methods The data of 117 patients with non small cell lung cancer complicated with pleural effusion in our hospital were analyzed,and the expression of PIGF in pleural effusion of nonsmall cell lung cancer and its influence on clinical efficacy were investigated. Results Among the 117 patients,51 cases were PIFG-positive,and 66 cases were PIFG-negative. The clinical effiecacy of the PIFG-negative group was better than that of the PIFG-positive group. The microvessel density of PIFG-negative patients was lower than that of PIFG-positive patients. The progression-free survival time and total survival time of the PIFG-positive group were lower than those of the PIFG-negative group( P < 0. 05). Age,TNM stage,lymph node metastasis,surgical resection and positive expression of PIGF were independent risk factors for non-small cell lung cancer complicated with pleural effusion( P < 0. 05). Conclusion The treatment effect of pleural effusion is relatively poor for positive placenta growth factor expression in non-small cell lung cancer patients,and the independent risk factor is positive placenta growth factor expression in treatment of patients with non-small cell lung cancer,which can also be used as a new target for the development of precision in medical care.
Objective To investigate the clinical value of placental growth factor( PIGF) detection in pleural effusion of non-small cell lung cancer. Methods The data of 117 patients with non small cell lung cancer complicated with pleural effusion in our hospital were analyzed,and the expression of PIGF in pleural effusion of nonsmall cell lung cancer and its influence on clinical efficacy were investigated. Results Among the 117 patients,51 cases were PIFG-positive,and 66 cases were PIFG-negative. The clinical effiecacy of the PIFG-negative group was better than that of the PIFG-positive group. The microvessel density of PIFG-negative patients was lower than that of PIFG-positive patients. The progression-free survival time and total survival time of the PIFG-positive group were lower than those of the PIFG-negative group( P < 0. 05). Age,TNM stage,lymph node metastasis,surgical resection and positive expression of PIGF were independent risk factors for non-small cell lung cancer complicated with pleural effusion( P < 0. 05). Conclusion The treatment effect of pleural effusion is relatively poor for positive placenta growth factor expression in non-small cell lung cancer patients,and the independent risk factor is positive placenta growth factor expression in treatment of patients with non-small cell lung cancer,which can also be used as a new target for the development of precision in medical care.
引文
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[6]王丽红,刘巍,刘华.肺癌患者血清VEGF-B和PIGF的表达及临床意义[J].国际呼吸杂志,2013,33(4):254-257.
[7]张力建,陈晋峰,陆爱萍,等.胎盘生长因子和色素上皮衍生因子在非小细胞肺癌中的表达及其与预后的关系[J].中华医学杂志,2005,85(47):3328-3331.
[8]Roberts ME,Neville E,Berrisford RG,et al.Management of a malignant pleural effusion:British Thoracic Society Pleural Diease Guideline 2010[J].Thorax,2010,65(Suppl 2):ii32-ii40.
[9]桂萍,宋盈,郭光云.恩度联合顺铂腔内化疗对中晚期非小细胞肺癌患者外周血s PD-L1、CEA水平的影响[J].临床肺科杂志,2017,22(7):1218-1221.
[10]Jiménez B,Volpert OV.Mechanistic insights on the inhibition of tumor angiogenesis[J].J Mol Med,2001,78(l2):663-672.
[11]Yano S,Nishioka Y,Goto H,et al.Molecular mechanisms of angiogenesis in non-small cell lung cancer,and therapeutics targeting related molecules[J].Cancer Sci,2003,94(6):479-485.
[12]Dewerchin M,Carmeliet P.PIGF:a multitasking cytokine with disease-restricted antivity[J].Cold Spring Harb Perspect Med,2012,2(8):56.
[13]Zhang W,Zhang T,Lou Y,et al.Placental growth factor promotes metastases of non-small cell lung cancer through MMP9[J].Cell Physiol Biochem,2015,37(3):1210-1218.
[14]Gkiozos I,Tsagouli S,Charpidou A,et al.Levels of vascular endothelial growth factor in serum and pleural fluid are independent predictors of survival in advanced non-small lung cancer:results of a prospective study[J].Anticancer Res,2015,35(2):1129-1137.
[15]朱江红,高云,杨胜利,等.全身化疗联合顺铂胸腔灌注治疗非小细胞肺癌恶性胸腔积液的临床观察[J].西部医学,2013,25(7):1012-1014.
[2]赵静,武二伟,邢爱民,等.119例局部晚期非小细胞肺癌放化疗后预后分析[J].临床肺科杂志,2017,22(8):1481-1485.
[3]Froudarakis ME.Pleural effusion in lung cancer:more question than answers[J].Respiration,2012,83(5):367-376.
[4]Sandler AB,Johnson DH,Herbst RS.Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer[J].Clin Cancer Res,2004,10(12 Pt 2):4258s-4262s.
[5]Kleinrouweler CE,Wiegerinck MM,Ris-Stalpers C,et al.Accuracy of circulating placental growth factor,vascular endothelial growth factor,soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia:a systematic review and meta-analysis[J].BJOG,2012,119(7):778-787.
[6]王丽红,刘巍,刘华.肺癌患者血清VEGF-B和PIGF的表达及临床意义[J].国际呼吸杂志,2013,33(4):254-257.
[7]张力建,陈晋峰,陆爱萍,等.胎盘生长因子和色素上皮衍生因子在非小细胞肺癌中的表达及其与预后的关系[J].中华医学杂志,2005,85(47):3328-3331.
[8]Roberts ME,Neville E,Berrisford RG,et al.Management of a malignant pleural effusion:British Thoracic Society Pleural Diease Guideline 2010[J].Thorax,2010,65(Suppl 2):ii32-ii40.
[9]桂萍,宋盈,郭光云.恩度联合顺铂腔内化疗对中晚期非小细胞肺癌患者外周血s PD-L1、CEA水平的影响[J].临床肺科杂志,2017,22(7):1218-1221.
[10]Jiménez B,Volpert OV.Mechanistic insights on the inhibition of tumor angiogenesis[J].J Mol Med,2001,78(l2):663-672.
[11]Yano S,Nishioka Y,Goto H,et al.Molecular mechanisms of angiogenesis in non-small cell lung cancer,and therapeutics targeting related molecules[J].Cancer Sci,2003,94(6):479-485.
[12]Dewerchin M,Carmeliet P.PIGF:a multitasking cytokine with disease-restricted antivity[J].Cold Spring Harb Perspect Med,2012,2(8):56.
[13]Zhang W,Zhang T,Lou Y,et al.Placental growth factor promotes metastases of non-small cell lung cancer through MMP9[J].Cell Physiol Biochem,2015,37(3):1210-1218.
[14]Gkiozos I,Tsagouli S,Charpidou A,et al.Levels of vascular endothelial growth factor in serum and pleural fluid are independent predictors of survival in advanced non-small lung cancer:results of a prospective study[J].Anticancer Res,2015,35(2):1129-1137.
[15]朱江红,高云,杨胜利,等.全身化疗联合顺铂胸腔灌注治疗非小细胞肺癌恶性胸腔积液的临床观察[J].西部医学,2013,25(7):1012-1014.