热毒宁联合西药对耐碳青霉烯鲍曼不动杆菌体外抑菌实验研究
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摘要
目的研究中药注射液热毒宁对耐碳青霉烯鲍曼不动杆菌(CRAB)体外抑菌作用。方法采用肉汤稀释法,观察热毒宁注射液、热毒宁注射液联合头孢他啶、热毒宁注射液联合亚胺培南西司他丁钠对CRAB的体外抑菌效果。结果热毒宁对CRAB的最低抑菌浓度(MIC)为400μL/mL,热毒宁分别和头孢他啶、亚胺培南西司他丁钠联合作用于CRAB,与各自单独用药相比,其抑菌所需药物的浓度明显降低。结论热毒宁对CRAB有很好的抑制作用,中西药联用有很好的协同作用,既可以减少抗生素的用量,还能帮助临床拓宽耐药菌选择药物的思路。
Objective To study the antibacterial effect of Reduning herbal injection in vitro on carbapenem-resistant acinetobacter baumannii-resistant drugs.Methods Using the broth dilution method,Reduning injection,antimicrobial tests in vitro of Reduning injection combined with ceftazidime,Imipenem-Cilastatin sodium hydrate for the carbapenem-resistant acinetobacter baumannii were conducted.Results Reduning MIC for carbapenem-resistant acinetobacter baumannii was400 l/mL,effects of Reduning combined with,Imipenem-Cilastatin sodium hydrate on carbapenem-resistant acinetobacter baumannii greatly were reduced compared with single Reduning or ceftazidime,Imipenem-Cilastatin sodium hydrate. Conclusion Reduning for carbapenem-resistant acinetobacter baumannii has inhibitory effect,the application of traditional Chinese medicine combined with antibiotics have best coordinate effects as they can reduce the mount of antibiotic and also help solve the problem of drug resistant bacteria.
Objective To study the antibacterial effect of Reduning herbal injection in vitro on carbapenem-resistant acinetobacter baumannii-resistant drugs.Methods Using the broth dilution method,Reduning injection,antimicrobial tests in vitro of Reduning injection combined with ceftazidime,Imipenem-Cilastatin sodium hydrate for the carbapenem-resistant acinetobacter baumannii were conducted.Results Reduning MIC for carbapenem-resistant acinetobacter baumannii was400 l/mL,effects of Reduning combined with,Imipenem-Cilastatin sodium hydrate on carbapenem-resistant acinetobacter baumannii greatly were reduced compared with single Reduning or ceftazidime,Imipenem-Cilastatin sodium hydrate. Conclusion Reduning for carbapenem-resistant acinetobacter baumannii has inhibitory effect,the application of traditional Chinese medicine combined with antibiotics have best coordinate effects as they can reduce the mount of antibiotic and also help solve the problem of drug resistant bacteria.
引文
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[2] Goldstein EJ. Beyond the target pathogen: ecological effects of the hospital formulary[J].Curr Opin infect Dis,2011,24(Suppl):S21-S31.
[3] 热毒宁:病轻病重皆可用[N]. 中国中医药报,2014-3-21(1).
[4] 于南. 继手足口病等之后又列入H7N9 用药一药多用热毒宁成康缘药业“摇钱树” [N]. 证券日报,2013-4-13(C01).
[5] 吴春阳.鲍曼不动杆菌耐药机制及其对策研究的新进展[J].国际检验医学杂志,2013,34(2): 174-176.
[6] 叶丹妮,王露,王新兰,等.多药耐药菌监测分析及预防控制对策[J].贵阳中医学院学报,2014,36(3): 156-158.
[7] 姚卫海,曹迎,徐向东,等.耐药鲍曼不动杆菌肺炎临床发病特点和中医证候相关性研究[J].北京中医药,2013,32(2):83-85.
[8] 李娟,张学顺,傅春升. 中药抗菌作用的研究进展[J]. 中国药业,2014,23(2):90-92,93.
[9] 张民. 细菌耐药背景下的中药抗菌作用探析[J]. 西部中医药,2013,26(6):122-124.
[10] 王开富, 萧伟, 王振中, 等. 热毒宁注射液的解热抗炎作用及其机制[J]. 中国医院药学杂志, 2013, 33(23):1918-1922.
[11] 陈健, 常秀娟, 陈春苗, 等. 热毒宁注射液解热镇痛作用研究 [J]. 世界科学技术-中医药现代化, 2014,16(9): 1912-1915.
[12] 曹翠萍,宁海强,位朋,等.中药与抗菌药物联用对大肠杆菌抑制作用的研究[J].西南农业学报,2008,21(1) :217-219.