CXCL16在急性冠状动脉综合征患者外周血中的表达及其与冠状动脉病变的相关性分析
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摘要
目的:观察急性冠状动脉综合征(ACS)患者血浆CXCL16浓度变化情况,探究CXCL16浓度与冠状动脉(冠脉)病变Gensini积分之间的关系。方法:纳入183例ACS患者(ACS组)和88例非冠心病患者(NonCHD组),通过双抗体夹心酶联免疫法(ELISA)测定血浆CXCL16浓度,并通过Gensini积分计算冠脉病变复杂程度。采用Spearman检验进行相关性分析。结果:ACS组血浆CXCL16浓度显著高于Non-CHD组[2.662(2.183,3.202)ng/ml∶2.428(2.071,2.761)ng/ml,P=0.002]。CXCL16浓度与冠脉Gensini积分呈正相关性(r=0.279,P<0.01)。结论:ACS患者血浆CXCL16浓度升高,并且血浆CXCL16浓度与冠脉病变Gensini积分呈正相关性。血浆CXCL16可作为ACS发生以及冠脉病变程度的预测指标。
Objective:To explore the expression of plasma CXCL16 of patients with acute coronary syndrome(ACS)and its correlation with Gensini scores.Method:A total of 183 ACS patients(ACS group)and 88 non-coronary heart disease patients(Non-CHD group)were enrolled.The plasma CXCL16 concentration was measured by double enzyme-linked immunosorbent assay(ELISA),and the complexity of coronary artery disease was calculated by Gensini score.Spearman test was used for correlation analysis.Result:The plasma CXCL16 concentration in ACS group was significantly higher than that in Non-CHD group[2.662(2.183,3.202)ng/ml vs.2.428(2.071,2.761)ng/ml,P=0.002].There was a positive correlation between CXCL16 concentration and Gensini score(r=0.279,P<0.01).Conclusion:The plasma CXCL16 concentration in ACS patients is increased and correlates positively with the Gensini score.CXCL16 can be used as a predictor of ACS and severity of coronary artery disease.
Objective:To explore the expression of plasma CXCL16 of patients with acute coronary syndrome(ACS)and its correlation with Gensini scores.Method:A total of 183 ACS patients(ACS group)and 88 non-coronary heart disease patients(Non-CHD group)were enrolled.The plasma CXCL16 concentration was measured by double enzyme-linked immunosorbent assay(ELISA),and the complexity of coronary artery disease was calculated by Gensini score.Spearman test was used for correlation analysis.Result:The plasma CXCL16 concentration in ACS group was significantly higher than that in Non-CHD group[2.662(2.183,3.202)ng/ml vs.2.428(2.071,2.761)ng/ml,P=0.002].There was a positive correlation between CXCL16 concentration and Gensini score(r=0.279,P<0.01).Conclusion:The plasma CXCL16 concentration in ACS patients is increased and correlates positively with the Gensini score.CXCL16 can be used as a predictor of ACS and severity of coronary artery disease.
引文
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[12]邵启文,刘长梅,逯莹,等.急性ST段抬高型心肌梗死患者mCRP、GAS与冠状动脉病变程度相关性研究[J].临床心血管病杂志,2017,33(9):862-865.
[13]李丹华,周迎春,韩甜甜,等.冠状动脉狭窄程度与血浆脂蛋白相关磷脂酶A2的相关性研究[J].临床心血管病杂志,2017,33(8):765-767.
[14]Yu X,Zhao R,Lin S,et al.CXCL16induces angiogenesis in autocrine signaling pathway involving hypoxiainducible factor 1αin human umbilical vein endothelial cells[J].Oncol Rep,2015,35(3):1557-1565.
[15]Zhuge X,Murayama T,Arai H,et al.CXCL16is a novel angiogenic factor for human umbilical vein endothelial cells[J].Biochem Biophys Res Commun,2005,331(4):1295-1300.
[2]Xiao Z,Zhang J,Zhang J,et al.Involvement of chemokine CXCL16in myocardial infarction and its influence on phagocytic activity of macrophage in vitro[J].Zhonghua Yi Xue Za Zhi,2014,94(3):218-222.
[3]Laugsand LE,Asvold BO,Vatten LJ,et al.Soluble CXCL16 and risk of myocardial infarction:The HUNT study in Norway[J].Atherosclerosis,2016,244(7):188-194.
[4]Zivkovic M,Djuric T,Stojkovic L,et al.CXCL16haplotypes in patients with human carotid atherosclerosis:preliminary results[J].J Atheroscler Thromb,2015,22(1):10-20.
[5]Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606.
[6]Ross R.Atherosclerosis---an inflammatory disease[J].N Engl J Med,1999,340(2):115-126.
[7]Hansson GK,Libby P,Schonbeck U,et al.Innate and adaptive immunity in the pathogenesis of atherosclerosis[J].Circ Res,2002,91(4):281-291.
[8]Barlic J,Murphy PM.Chemokine regulation of atherosclerosis[J].Leukoc Biol,2007,82(2):226-236.
[9]Murdoch C,Finn A.Chemokine receptors and their role in in?ammation and infectious diseases[J].Blood,2000,95(10):3032-3043.
[10]Lehrke M,Millington SC,Lefterova M,et al.CXCL16is a marker of inflammation,atherosclerosis,and acute coronary syndromes in humans[J].J Am Coll Cardiol,2007,49(4):442-449.
[11]Smith C,Halvorsen B,Otterdal K,et al.High levels and inflammatory effects of soluble CXC ligand 16(CXCL16)in coronary artery disease:down-regulatory effects of statins[J].Cardiovasc Res,2008,79(1):195-203.
[12]邵启文,刘长梅,逯莹,等.急性ST段抬高型心肌梗死患者mCRP、GAS与冠状动脉病变程度相关性研究[J].临床心血管病杂志,2017,33(9):862-865.
[13]李丹华,周迎春,韩甜甜,等.冠状动脉狭窄程度与血浆脂蛋白相关磷脂酶A2的相关性研究[J].临床心血管病杂志,2017,33(8):765-767.
[14]Yu X,Zhao R,Lin S,et al.CXCL16induces angiogenesis in autocrine signaling pathway involving hypoxiainducible factor 1αin human umbilical vein endothelial cells[J].Oncol Rep,2015,35(3):1557-1565.
[15]Zhuge X,Murayama T,Arai H,et al.CXCL16is a novel angiogenic factor for human umbilical vein endothelial cells[J].Biochem Biophys Res Commun,2005,331(4):1295-1300.