真性红细胞增多症的中医药治疗研究进展
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摘要
真性红细胞增多症(polycythemia vera,PV)简称真红,是一种以克隆性红细胞异常增多为主的慢性骨髓增生性疾病。其外周血红细胞比容增加,血液粘稠度增高,常伴有白细胞和血小板增高,脾大,病程中可出现血栓和出血等并发症。随着中医学对本病病因病机的认识逐渐加深,辨证治疗手段丰富,病理及药理实验研究不断深入,中医药治疗真性红细胞增多症已经取得了长足进展。兹将近十多年来中医药治疗PV研究进展作一综述,为今后进一步研究,治疗本病提供理论依据和思路。
Polycythemia vera(PV) is a chronic myeloproliferative disorders mainly with abnormal increase of erythrocytes.Increasing the hematocrit of peripheral erythrocyte and blood viscosity,this disease usually accompanies with the elevation of erythrocytes,leukocyte and splenomegaly.What more,the disease complication contains the thrombus and hemorrhage during the course.As the development of traditional Chinese medicine about the etiology and pathogenesis,syndrome differentiation treatment,pathological and pharmacodynamics,rapid progress have been made in traditional Chinese medicine with PV.These review mainly have summarized the traditional Chinese medicine with PV,exploring the next research direction and providing theoretical basis and ideas.
Polycythemia vera(PV) is a chronic myeloproliferative disorders mainly with abnormal increase of erythrocytes.Increasing the hematocrit of peripheral erythrocyte and blood viscosity,this disease usually accompanies with the elevation of erythrocytes,leukocyte and splenomegaly.What more,the disease complication contains the thrombus and hemorrhage during the course.As the development of traditional Chinese medicine about the etiology and pathogenesis,syndrome differentiation treatment,pathological and pharmacodynamics,rapid progress have been made in traditional Chinese medicine with PV.These review mainly have summarized the traditional Chinese medicine with PV,exploring the next research direction and providing theoretical basis and ideas.
引文
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[24]许崇艳.清肝凉血汤剂联合羟基脲、干扰素治疗真性红细胞增多症观察[J].中医药临床杂志,2013,(10):866~868
[25]杨丽辉.中西医结合治疗真性红细胞增多症6例[J].辽宁医学杂志,2007,21(3):239~239
[26]程志.中西医结合治疗真性细胞增多症22例[J].陕西中医,2005,26(5):432~432
[27]马怀安,熊丽丽,张长军,等.活血化瘀法对真性红细胞增多症CD34+细胞凋亡的影响[J].中国中医基础医学杂志,2007,13(6):447~448
[28]杨洪涌,孙金芳,陈志雄,等.活血祛瘀法对真性红细胞增多症细胞凋亡及相关基因表达的影响[J].中药新药与临床药理,2004,15(3):208~211
[2]张伟锋,王兴丽,杨向东,等.杨文华治疗真性红细胞增多症1例报告[J].湖南中医杂志,2014,30(11):115~115
[3]张晓韵,解建国.解建国治疗真性红细胞增多症经验探析[J].上海中医药杂志,2015,(3):17~18
[4]王丽,刘宝文.刘宝文教授辨证治疗真性红细胞增多症[J].实用中医内科杂志,2012,(6):21~22
[5]陈贝贝,张杰,李秀荣.李秀荣治疗真性红细胞增多症的经验[J].现代中医药,2015,(5):7~8
[6]詹继红,郭银雪,谢恂,等.傅汝林治疗真性红细胞增多症经验[J].中医杂志,2015,56(8):645~647
[7]王文娟.高益民治疗真性红细胞增多症验案1则[J].江苏中医药,2011,43(12):54~56
[8]许秉诚,陈斌.活血化瘀法治疗真性红细胞增多症[J].中西医结合研究,2010,02(4):213~214
[9]陈晓云,张宝文,姜松鹤.姜松鹤辨治真性红细胞增多症验案[J].四川中医,2011,(10):9~10
[10]余丹,程辉,张婷,等.血栓通联合参芪扶正注射液治疗真性红细胞增多症的疗效观察[J].实用临床医药杂志,2012,16(1):45~47
[11]肖汇颖,胡冬菊,张雪娟.活血通络方在治疗真性红细胞增多症中的临床疗效观察[J].中国中医基础医学杂志,2013,(6):704~704
[12]侯淑英,樊华,郑华川,等.龙胆泻肝饮治疗真性红细胞增多症42例分析[J].中医药学刊,2003,21(9):1471~1471
[13]高丽娜,杨文华.浅谈清肝化瘀法治疗真性红细胞增多症[J].新中医,2009,(12):105~106
[14]靳旭红,俞姗姗.真性红细胞增多症从脾论治[J].杭州医学高等专科学校学报,2002,23(4):172~173
[15]潘铭,楚文瑛.中西医结合治疗真性红细胞增多症19例[J].中医研究,2010,23(4):39~42
[16]朱建平.辨证分型治疗真性红细胞增多症[J].实用中医内科杂志,2014,(12):41~41
[17]肖海燕,方苏,胡晓梅,等.邓成珊论治真性红细胞增多症经验撷英[J].上海中医药杂志,2014,(2):1~3
[18]代喜平,梁冰.应用虫类药物治疗真性红细胞增多症初探[J].浙江中西医结合杂志,2012,22(7):519~520
[19]张子臻,李刚.玄参治疗真性红细胞增多症[J].中医杂志,2009,50(6):534~535
[20]朱小勤,邱仲川,陈珮,等.清肝化瘀汤治疗真性红细胞增多症临床研究[J].辽宁中医杂志,2013,(5):958~962
[21]李海霞,向阳.白消安联合龙胆泻肝汤治疗真性红细胞增多症疗效观察[J].广州中医药大学学报,2011,28(6):596~598
[22]韩伟,冉俊丽.血府逐瘀胶囊治疗真性红细胞增多症合并栓塞的疗效观察[J].中外健康文摘,2010,07(31)
[23]李芳,姚建华.舒血宁配合羟基脲治疗真性红细胞增多症22例临床分析[J].中国全科医学,2007,10(3):232~233
[24]许崇艳.清肝凉血汤剂联合羟基脲、干扰素治疗真性红细胞增多症观察[J].中医药临床杂志,2013,(10):866~868
[25]杨丽辉.中西医结合治疗真性红细胞增多症6例[J].辽宁医学杂志,2007,21(3):239~239
[26]程志.中西医结合治疗真性细胞增多症22例[J].陕西中医,2005,26(5):432~432
[27]马怀安,熊丽丽,张长军,等.活血化瘀法对真性红细胞增多症CD34+细胞凋亡的影响[J].中国中医基础医学杂志,2007,13(6):447~448
[28]杨洪涌,孙金芳,陈志雄,等.活血祛瘀法对真性红细胞增多症细胞凋亡及相关基因表达的影响[J].中药新药与临床药理,2004,15(3):208~211