食管癌患者血清中多项肿瘤标志物测定的临床意义
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摘要
目的探讨食管癌患者血清中甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、铁蛋白(FERRITIN)测定在诊治及病情评估中的临床意义。方法选用1 028例健康体检者为对照组,1 047例食管癌患者为观察组,采用化学发光分析仪测定AFP、CEA、CA125、CA19-9、FERRITIN浓度与阳性率;比较各指标在肿瘤转移中的情况,并进行统计学分析。结果与对照组比较,观察组患者AFP、CEA、CA125、CA19-9、FERRITIN水平与阳性率显著升高;肿瘤转移患者的阳性率显著高于肿瘤未转移患者,差异均有统计学意义(P<0.05)。结论血清中多项肿瘤标志物测定可提高食管癌患者诊治的准确性、在肿瘤转移的评估中具重要的临床意义。
Objective To investigate the clinical detection significance of serum alpha fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9) and ferritin(FERRITIN) in patients with esophageal cancer. Methods A total of 1 028 healthy subjects were selected as the control group and 1 047 patients with esophageal cancer were selected as the observation group. The concentrations and positive rates of AFP,CEA,CA125,CA19-9 and FERRITIN were measured by chemiluminescence analyzer. Various clinical index in tumor metastasis were compared and analyzed statistically. Results Compared to the control group,the levels and positive rates of AFP,CEA,CA125,CA19-9 and FERRITIN in the control group significantly increased. The positive rates of tumor metastasis patients were significantly higher than that of the patients without tumor metastasis,with the differences statistically significant(P <0. 05). Conclusion The determination of multiple tumor markers in the serum can improve the accuracy of the diagnosis,and it has important clinical significance in the evaluation of tumor metastasis.
Objective To investigate the clinical detection significance of serum alpha fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9) and ferritin(FERRITIN) in patients with esophageal cancer. Methods A total of 1 028 healthy subjects were selected as the control group and 1 047 patients with esophageal cancer were selected as the observation group. The concentrations and positive rates of AFP,CEA,CA125,CA19-9 and FERRITIN were measured by chemiluminescence analyzer. Various clinical index in tumor metastasis were compared and analyzed statistically. Results Compared to the control group,the levels and positive rates of AFP,CEA,CA125,CA19-9 and FERRITIN in the control group significantly increased. The positive rates of tumor metastasis patients were significantly higher than that of the patients without tumor metastasis,with the differences statistically significant(P <0. 05). Conclusion The determination of multiple tumor markers in the serum can improve the accuracy of the diagnosis,and it has important clinical significance in the evaluation of tumor metastasis.
引文
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[13]Feng JF,Chen QX.Prognostic Significance of Preoperative CA72-4 in Patients with Esophageal Squamous Cell Carcinoma[J].Arch Iran Med,2013,16(6):338-342.
[14]Wang XB,Jiang XR,Yu XY,et al.Macrophagc inhibitory factor1acts as a potential biomarker in patients with esophageal squamouscell carcinoma and is a target for antibody-based therapy[J].Cancer Sci,2014,105(2):176-185.
[15]周永美.血清CA125、CA724、AFP联合检测在卵巢肿瘤鉴别诊断及临床分期中的应用[J].山东医药,2014,54(24):56-57.
[2]Scarpa M,Noaro G,Saadeh L,et al.Esophageal cancer management:preoperative CA19-9 and CEA serum levels may identify occult advanced adenocarcinoma[J].World J Surg,2015,39(2):424-432.
[3]Haas M,Heinemann V,Kullmann F,et al.Prognostic value of CA19-9,CEA,CRP,LDH and bilirubin levels in locally advanced and metastatic pancreatic cancer:Results from a multicenter,pooled analysis of patients receiving palliative chemotherapy[J].J Cancer Res Clin Oncol,2013,139(4):681-689.
[4]黄国福,冷晓玲.三种血清学肿瘤标志物与食管癌分期的价值[J].标记免疫分析与临床,2014,21(4):380-382.
[5]唐菁,陈海霞,李笃军.CRP联合CEA、CA724检测对胃癌早期诊断及病情判断的临床应用价值[J].重庆医学,2013,42(1):63-65.
[6]卢晨,于在诚.食管癌相关血清肿瘤标志物的临床应用[J].安徽医科大学学报,2013,48(2):192-193.
[7]Wallin U,Rothenberger D,Lowry A,et al.CEA-a predictor for pathologic complete response after neoadjuvant therapy for rectal cancer[J].Dis Colon Rectum,2013,56(7):859-868.
[8]郭小林,张宁.肿瘤标志物的联合检测在肺癌诊断中的临床价值[J].中国当代医药,2013,20(21):35-36,38.
[9]Cui C,Niu GP.Multi-tumor markers combined detection in diagnosis of primary hepatocellular carcinoma[J].Modern Oncology,2015,23(9):1262-1265.
[10]Giannini EG,Sammito G,Farinati F,et al.Determinants of alphafetoprotein levels in patients with hepatocellular carcinoma:Implications for its clinical use[J].Cancer,2014,120(14):2150-2157.
[11]Lai Q,Avolio AW,Graziadei I,et al.Alpha-fetoprotein and modified response evaluation criteria in solid tumors progression after locoregional therapy as predictors of hepatocellular cancer recurrence and death after transplantation[J].Liver Transpl,2013,19(10):11O8-1118.
[12]Chen YY,Hsu WH,Hu HM,et al.A case of alpha-fetoproteinproducing esophageal adenocarcinoma[J].Kaohsiung J Med Sci,2013,29(2):106-110.
[13]Feng JF,Chen QX.Prognostic Significance of Preoperative CA72-4 in Patients with Esophageal Squamous Cell Carcinoma[J].Arch Iran Med,2013,16(6):338-342.
[14]Wang XB,Jiang XR,Yu XY,et al.Macrophagc inhibitory factor1acts as a potential biomarker in patients with esophageal squamouscell carcinoma and is a target for antibody-based therapy[J].Cancer Sci,2014,105(2):176-185.
[15]周永美.血清CA125、CA724、AFP联合检测在卵巢肿瘤鉴别诊断及临床分期中的应用[J].山东医药,2014,54(24):56-57.