好氧堆肥降解抗生素的研究进展
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摘要
抗生素滥用导致畜禽养殖场粪便中抗生素残留情况严重,将粪便作为肥料还田使用,可能会导致抗生素在土壤中扩散和累积,对生态环境安全和人类健康带来严重威胁。好氧堆肥是畜禽粪便资源化利用的一种重要途径,可高效地去除畜禽粪便中残留的抗生素,但目前对好氧堆肥过程中抗生素的去除机理尚不清楚。综述了我国不同地区、不同畜禽粪便中抗生素的残留浓度,分析好氧堆肥过程中抗生素去除的的影响因素,总结不同种类抗生素降解的动力学模型,概述现有抗生素检测方法,并提出好氧堆肥去除抗生素未来的研究重点,以期为畜禽粪便资源化利用提供技术支撑。
The abuse of antibiotics results in serious antibiotics residual in livestock manures,and application of manures to the fields as a fertilizer would lead to antibiotics diffusion and its accumulation in soil,and pose serious threat to ecological environment security and human health. As an effective method for resource utilization of livestock manures, aerobic composting could remove the residual antibiotics efficiently in the livestock manures,however,the removal mechanism of antibiotics during the aerobic composting process is still unclear until now. This paper summarized the residual antibiotics concentration of various livestock manures in different regions in China,and analyzed the influencing factors affecting the removal of antibiotics during the aerobic composting process,summarized the kinetics models for degradation of different kinds of antibiotics as well as the existing detection methods of antibiotics,and put forward the research emphasis of degradation of antibiotics in aerobic composting,hoping to provide technical support for resource utilization of livestock manures.
The abuse of antibiotics results in serious antibiotics residual in livestock manures,and application of manures to the fields as a fertilizer would lead to antibiotics diffusion and its accumulation in soil,and pose serious threat to ecological environment security and human health. As an effective method for resource utilization of livestock manures, aerobic composting could remove the residual antibiotics efficiently in the livestock manures,however,the removal mechanism of antibiotics during the aerobic composting process is still unclear until now. This paper summarized the residual antibiotics concentration of various livestock manures in different regions in China,and analyzed the influencing factors affecting the removal of antibiotics during the aerobic composting process,summarized the kinetics models for degradation of different kinds of antibiotics as well as the existing detection methods of antibiotics,and put forward the research emphasis of degradation of antibiotics in aerobic composting,hoping to provide technical support for resource utilization of livestock manures.
引文
[1] Min Q,Guang G Y,Andrew C S,et al. Review of antibiotic resistance in China and its environment[J]. Environment International,2018,110:160-172.
[2]朱宁,马骥.中国畜禽粪便产生量的变动特征及未来发展展望[J].农业展望,2014(1):46-48.
[3] Zhang Q Q,Ying G G,Pan C G,et al. Comprehensive evaluation of antibiotics emission and fate in the river basins of China:source analysis,multimedia modeling,and linkage to bacterial resistance[J]. Environmental Science&Technology,2015,49(11):6772-6782.
[4]梁忠.中国抗生素52%为兽用[J].中国禽业导刊,2015(12):75.
[5] Doretto K M,Rath S. Sorption of sulfadiazine on Brazilian soils[J]. Chemosphere,2013,90(6):2027-2034.
[6]吴银宝,汪植三,廖新俤,等.土壤对恩诺沙星的吸附和解吸特性研究[J].生态环境学报,2005,14(5):645-649.
[7]刘伟,王慧,陈小军,等.抗生素在环境中降解的研究进展[J].动物医学进展,2009,30(3):89-94.
[8] O'Brien,T F. Emergence,spread,and environmental effect of antimicrobial resistance:how use of an antimicrobial anywhere can increase resistance to any antimicrobial anywhere else. Clin. Infect.Dis,2002,34(Suppl. 3):S78-S84.
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[10] Zhang H,Deng X,Miki D,et al. Sulfamethazine suppresses epigenetic silencing in Arabidopsis by impairing folate synthesis[J]. Plant Cell,2012,24(3):1230-1241.
[11] Boxall A B,Johnson P,Smith E J,et al. Uptake of veterinary medicines from soils into plants[J]. Journal of Agricultural&Food Chemistry,2006,54(6):2288-2297.
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[14]魏建英,张然,丁胜,等.抗生素类饲料添加剂在畜牧业中的使用[J].内蒙古农业科技,2004(4):52-53.
[15] Kumar K,Thompson A,Singh A K,et al. Enzyme-linked immunosorbent assay for ultratrace determination of antibiotics in aqueous samples[J]. Journal of Environmental Quality,2004,33(1):250-256.
[16]吴银宝,汪植三,廖新俤,等.恩诺沙星在鸡体中的排泄及其在鸡粪中的降解[J].畜牧兽医学报,2005,36(10):1069-1074.
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[18]王瑞,魏源送.畜禽粪便中残留四环素类抗生素和重金属的污染特征及其控制[J].农业环境科学学报,2013,32(9):1705-1719.
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[23] Zhang H,Luo Y,Wu L,et al. Residues and potential ecological risks of veterinary antibiotics in manures and composts associated with protected vegetable farming[J]. Environmental Science&Pollution Research,2015,22(8):5908-5918.
[24]陈昦,董元华,王辉,等.江苏省畜禽粪便中磺胺类药物残留特征[J].农业环境科学学报,2008,27(1):385-389.
[25]李彦文,莫测辉,赵娜,等.菜地土壤中磺胺类和四环素类抗生素污染特征研究[J].环境科学,2009,30(6):1762-1766.
[26]张慧敏,章明奎,顾国平.浙北地区畜禽粪便和农田土壤中四环素类抗生素残留[J].生态与农村环境学报,2008,24(3):69-73.
[27]张俊,杨晓洪,葛峰,等.长期施用四环素残留猪粪对土壤中耐药菌及抗性基因形成的影响[J].环境科学,2014(6):2374-2380.
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[29]沈颖,魏源送,郑嘉熹,等.猪粪中四环素类抗生素残留物的生物降解[J].过程工程学报,2009,9(5):962-968.
[30] Ramaswamy J,Prasher S O,Patel R M,et al. The effect of composting on the degradation of a veterinary pharmaceutical[J].Bioresource Technology,2010,101(7):2294-2299.
[31] Wu X,Wei Y,Zheng J,et al. The behavior of tetracyclines and their degradation products during swine manure composting[J].Bioresource Technology,2011,102(10):5924-5931.
[32] Arikan O A,Mulbry W,Rice C. Management of antibiotic residues from agricultural sources:use of composting to reduce chlortetracycline residues in beef manure from treated animals[J].Journal of Hazardous Materials,2009,164(2/3):483-489.
[33]李伟明,鲍艳宇,周启星.四环素类抗生素降解途径及其主要降解产物研究进展[J].应用生态学报,2012,23(8):2300-2308.
[34]许静,王娜,孔德洋,等.磺胺类药物在土壤中的降解性[J].环境化学,2013(12):2349-2356.
[35]管荷兰,于海凤,王嘉宇.氟喹诺酮类抗生素在土壤中的归趋及其生态毒性研究进展[J].生态学杂志,2012,31(12):3228-3234.
[36] Selvam A,Zhao Z,Wong J W C. Composting of swine manure spiked with sulfadiazine,chlortetracycline and ciprofloxacin[J].Bioresource Technology,2012,126(12):412-417.
[37]孟磊,杨兵,薛南冬,等.高温堆肥对鸡粪中氟喹诺酮类抗生素的去除[J].农业环境科学学报,2015,34(2):377-383.
[38] Qiu J,He J,Liu Q,et al. Effects of Conditioners on Sulfonamides Degradation during the Aerobic Composting of Animal Manures[J].Procedia Environmental Sciences,2012,16(16):17-24.
[39] Munaretto J S,Yonkos L,Aga D S. Transformation of ionophore antimicrobials in poultry litter during pilot-scale composting[J].Environmental Pollution,2016,212:392-400.
[40] Dolliver H,Gupta S,Noll S. Antibiotic degradation during manure composting[J]. Journal of Environmental Quality,2008,37(3):1245-1253.
[41]肖秋美,王建武,唐艺玲.土壤-蔬菜系统中环丙沙星的降解与生物累积特征[J].应用生态学报,2012,23(10):2708-2714.
[42]许静,王娜,孔德洋,等.有机肥源磺胺类抗生素在土壤中的降解规律及影响因素分析[J].环境科学学报,2015,35(2):550-556.
[43] Boxall A B A,Fogg L A,Blackwell P A,et al. Veterinary Medicines in the Environment[M]//Reviews of Environmental Contamination and Toxicology. Springer New York,2004:1-91.
[44] Schlüsener M P,Bester K. Persistence of antibiotics such as macrolides,tiamulin and salinomycin in soil[J]. Environmental Pollution,2006,143(3):565-571.
[45] Wang Q, Yates S R. Laboratory study of oxytetracycline degradation kinetics in animal manure and soil[J]. Journal of Agricultural&Food Chemistry,2008,56(5):1683-1688.
[46]丁志刚,王静,高红梅.抗生素残留检测技术的研究进展[J].食品与发酵工业,2005,31(6):112-116.
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[48]邵辉,吴瑕,王剑飞,等.酶联免疫法与乳及乳制品中抗生素残留的检测[J].中国乳品工业,2011,39(6):58-59.
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[2]朱宁,马骥.中国畜禽粪便产生量的变动特征及未来发展展望[J].农业展望,2014(1):46-48.
[3] Zhang Q Q,Ying G G,Pan C G,et al. Comprehensive evaluation of antibiotics emission and fate in the river basins of China:source analysis,multimedia modeling,and linkage to bacterial resistance[J]. Environmental Science&Technology,2015,49(11):6772-6782.
[4]梁忠.中国抗生素52%为兽用[J].中国禽业导刊,2015(12):75.
[5] Doretto K M,Rath S. Sorption of sulfadiazine on Brazilian soils[J]. Chemosphere,2013,90(6):2027-2034.
[6]吴银宝,汪植三,廖新俤,等.土壤对恩诺沙星的吸附和解吸特性研究[J].生态环境学报,2005,14(5):645-649.
[7]刘伟,王慧,陈小军,等.抗生素在环境中降解的研究进展[J].动物医学进展,2009,30(3):89-94.
[8] O'Brien,T F. Emergence,spread,and environmental effect of antimicrobial resistance:how use of an antimicrobial anywhere can increase resistance to any antimicrobial anywhere else. Clin. Infect.Dis,2002,34(Suppl. 3):S78-S84.
[9] Tasho R P,Cho J Y. Veterinary antibiotics in animal waste,its distribution in soil and uptake by plants:a review[J]. Science of the Total Environment,2016,563/564:366-376.
[10] Zhang H,Deng X,Miki D,et al. Sulfamethazine suppresses epigenetic silencing in Arabidopsis by impairing folate synthesis[J]. Plant Cell,2012,24(3):1230-1241.
[11] Boxall A B,Johnson P,Smith E J,et al. Uptake of veterinary medicines from soils into plants[J]. Journal of Agricultural&Food Chemistry,2006,54(6):2288-2297.
[12]张海滨,孟海波,沈玉君,等.好氧堆肥微生物研究进展[J].中国农业科技导报,2017,19(3):1-8.
[13] Wang J, Ben W, Zhang Y, et al. Effects of thermophilic composting on oxytetracycline, sulfamethazine, and their corresponding resistance genes in swine manure[J]. Environmental Science. Processes&Impacts,2015,17(9):1654-1660.
[14]魏建英,张然,丁胜,等.抗生素类饲料添加剂在畜牧业中的使用[J].内蒙古农业科技,2004(4):52-53.
[15] Kumar K,Thompson A,Singh A K,et al. Enzyme-linked immunosorbent assay for ultratrace determination of antibiotics in aqueous samples[J]. Journal of Environmental Quality,2004,33(1):250-256.
[16]吴银宝,汪植三,廖新俤,等.恩诺沙星在鸡体中的排泄及其在鸡粪中的降解[J].畜牧兽医学报,2005,36(10):1069-1074.
[17]王惠惠,王淑平.畜禽排泄物中抗生素残留与控制技术研究进展[J].土壤通报,2011,42(1):250-256.
[18]王瑞,魏源送.畜禽粪便中残留四环素类抗生素和重金属的污染特征及其控制[J].农业环境科学学报,2013,32(9):1705-1719.
[19] Zhou L J, Ying G G, Liu S, et al. Excretion masses and environmental occurrence of antibiotics in typical swine and dairy cattle farms in China[J]. Science of the Total Environment,2013,444(2):183-195.
[20]张树清,张夫道,刘秀梅,等.规模化养殖畜禽粪主要有害成分测定分析研究[J].植物营养与肥料学报,2005,11(6):822.
[21] Ling Z,Dong Y H,Hui W. Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China[J].Science of the Total Environment,2010,408(5):1069-1075.
[22] Pan X,Qiang Z,Ben W,et al. Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province,China[J]. Chemosphere,2011,84(5):695-700.
[23] Zhang H,Luo Y,Wu L,et al. Residues and potential ecological risks of veterinary antibiotics in manures and composts associated with protected vegetable farming[J]. Environmental Science&Pollution Research,2015,22(8):5908-5918.
[24]陈昦,董元华,王辉,等.江苏省畜禽粪便中磺胺类药物残留特征[J].农业环境科学学报,2008,27(1):385-389.
[25]李彦文,莫测辉,赵娜,等.菜地土壤中磺胺类和四环素类抗生素污染特征研究[J].环境科学,2009,30(6):1762-1766.
[26]张慧敏,章明奎,顾国平.浙北地区畜禽粪便和农田土壤中四环素类抗生素残留[J].生态与农村环境学报,2008,24(3):69-73.
[27]张俊,杨晓洪,葛峰,等.长期施用四环素残留猪粪对土壤中耐药菌及抗性基因形成的影响[J].环境科学,2014(6):2374-2380.
[28]潘寻,强志民,贲伟伟.高温堆肥对猪粪中多类抗生素的去除效果[J].生态与农村环境学报,2013,29(1):64-69.
[29]沈颖,魏源送,郑嘉熹,等.猪粪中四环素类抗生素残留物的生物降解[J].过程工程学报,2009,9(5):962-968.
[30] Ramaswamy J,Prasher S O,Patel R M,et al. The effect of composting on the degradation of a veterinary pharmaceutical[J].Bioresource Technology,2010,101(7):2294-2299.
[31] Wu X,Wei Y,Zheng J,et al. The behavior of tetracyclines and their degradation products during swine manure composting[J].Bioresource Technology,2011,102(10):5924-5931.
[32] Arikan O A,Mulbry W,Rice C. Management of antibiotic residues from agricultural sources:use of composting to reduce chlortetracycline residues in beef manure from treated animals[J].Journal of Hazardous Materials,2009,164(2/3):483-489.
[33]李伟明,鲍艳宇,周启星.四环素类抗生素降解途径及其主要降解产物研究进展[J].应用生态学报,2012,23(8):2300-2308.
[34]许静,王娜,孔德洋,等.磺胺类药物在土壤中的降解性[J].环境化学,2013(12):2349-2356.
[35]管荷兰,于海凤,王嘉宇.氟喹诺酮类抗生素在土壤中的归趋及其生态毒性研究进展[J].生态学杂志,2012,31(12):3228-3234.
[36] Selvam A,Zhao Z,Wong J W C. Composting of swine manure spiked with sulfadiazine,chlortetracycline and ciprofloxacin[J].Bioresource Technology,2012,126(12):412-417.
[37]孟磊,杨兵,薛南冬,等.高温堆肥对鸡粪中氟喹诺酮类抗生素的去除[J].农业环境科学学报,2015,34(2):377-383.
[38] Qiu J,He J,Liu Q,et al. Effects of Conditioners on Sulfonamides Degradation during the Aerobic Composting of Animal Manures[J].Procedia Environmental Sciences,2012,16(16):17-24.
[39] Munaretto J S,Yonkos L,Aga D S. Transformation of ionophore antimicrobials in poultry litter during pilot-scale composting[J].Environmental Pollution,2016,212:392-400.
[40] Dolliver H,Gupta S,Noll S. Antibiotic degradation during manure composting[J]. Journal of Environmental Quality,2008,37(3):1245-1253.
[41]肖秋美,王建武,唐艺玲.土壤-蔬菜系统中环丙沙星的降解与生物累积特征[J].应用生态学报,2012,23(10):2708-2714.
[42]许静,王娜,孔德洋,等.有机肥源磺胺类抗生素在土壤中的降解规律及影响因素分析[J].环境科学学报,2015,35(2):550-556.
[43] Boxall A B A,Fogg L A,Blackwell P A,et al. Veterinary Medicines in the Environment[M]//Reviews of Environmental Contamination and Toxicology. Springer New York,2004:1-91.
[44] Schlüsener M P,Bester K. Persistence of antibiotics such as macrolides,tiamulin and salinomycin in soil[J]. Environmental Pollution,2006,143(3):565-571.
[45] Wang Q, Yates S R. Laboratory study of oxytetracycline degradation kinetics in animal manure and soil[J]. Journal of Agricultural&Food Chemistry,2008,56(5):1683-1688.
[46]丁志刚,王静,高红梅.抗生素残留检测技术的研究进展[J].食品与发酵工业,2005,31(6):112-116.
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