滋阴疏肝汤治疗卵巢储备功能减退致不孕不育临床研究
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摘要
目的:观察滋阴疏肝汤治疗卵巢储备功能减退致不孕不育的临床疗效。方法:选取90例卵巢储备功能减退致不孕不育患者作为研究对象,按随机数字表法分为观察组和对照组各45例。对照组给予常规激素治疗,观察组在对照组基础上口服滋阴疏肝汤。比较2组患者临床疗效、性激素水平和中医证候积分。结果:观察组总有效率为95.56%,显著高于对照组的82.22%,差异有统计学意义(χ~2=4.05,P <0.05)。治疗前,2组促卵泡激素(FSH)、雌二醇(E)2、孕酮(P)、黄体生成素(LH)水平比较,差异无统计学意义(P> 0.05)。治疗后,2组FSH、E_2、P、LH水平均显著下降(P <0.05),且观察组性激素水平均显著低于对照组(P <0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P> 0.05)。治疗后,2组中医证候积分均较治疗前降低,且观察组低于对照组,差异有统计学意义(P <0.05)。结论:对卵巢储备功能减退致不孕不育患者联合滋阴疏肝汤治疗,能够提高治疗效果,改善性激素水平。
Objective:To observe the clinical effect of Ziyin Shugan tang for infertility due to decreased ovarian reserve.Methods: Selected 90 cases of patients with infertility due to decreased ovarian reserve as study subjects, and divided them into the observation group and the control group randomly,45 cases in each group. The control group received routine hormone therapy,while the observation group additionally received the oral administration of Ziyin Shugan tang. Compared the clinical effect,levels of sex hormones and Chinese medicine syndrome scores of patients in both groups. Results:The total effective rate was 95.56% in the observation group, being significantly higher than 82.22% in the control group,difference being significant( χ~2=4.05,P < 0.05). Before treatment,comparing the levels of follicle stimulating hormone(FSH),estradiol(E_2),progesterone(P) and luteinizing hormone(LH) in both groups,there was no significant difference being found(P> 0.05). After treatment,the levels of FSH,E_2,P and LH in both groups were significantly decreased(P < 0.05),and the levels of sex hormones above in the observation group were significantly lower than those in the control group(P < 0.05).Before treatment,comparing Chinese medicine syndrome scores in both groups,there was no significant difference being found(P > 0.05). After treatment,Chinese medicine syndrome scores in both groups were lower than those before treatment,and Chinese medicine syndrome scores in the observation group were lower than those in the control group, difference being significant( P < 0. 05). Conclusion : The combined application of Ziyin Shugan tang in treating patients with infertility due to decreased ovarian reserve can promote the clinical effect and improve the levels of sex hormones.
Objective:To observe the clinical effect of Ziyin Shugan tang for infertility due to decreased ovarian reserve.Methods: Selected 90 cases of patients with infertility due to decreased ovarian reserve as study subjects, and divided them into the observation group and the control group randomly,45 cases in each group. The control group received routine hormone therapy,while the observation group additionally received the oral administration of Ziyin Shugan tang. Compared the clinical effect,levels of sex hormones and Chinese medicine syndrome scores of patients in both groups. Results:The total effective rate was 95.56% in the observation group, being significantly higher than 82.22% in the control group,difference being significant( χ~2=4.05,P < 0.05). Before treatment,comparing the levels of follicle stimulating hormone(FSH),estradiol(E_2),progesterone(P) and luteinizing hormone(LH) in both groups,there was no significant difference being found(P> 0.05). After treatment,the levels of FSH,E_2,P and LH in both groups were significantly decreased(P < 0.05),and the levels of sex hormones above in the observation group were significantly lower than those in the control group(P < 0.05).Before treatment,comparing Chinese medicine syndrome scores in both groups,there was no significant difference being found(P > 0.05). After treatment,Chinese medicine syndrome scores in both groups were lower than those before treatment,and Chinese medicine syndrome scores in the observation group were lower than those in the control group, difference being significant( P < 0. 05). Conclusion : The combined application of Ziyin Shugan tang in treating patients with infertility due to decreased ovarian reserve can promote the clinical effect and improve the levels of sex hormones.
引文
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[6]韩晓霞,左瑞菊,马肖.窦卵泡计数、抗苗勒管激素与性激素检测评价卵巢储备的研究[J].中国医药导报,2017,14(18):117-120.
[7]向悦,施艳秋.从文献分析探讨卵巢储备功能下降的病机[J].西部中医药,2016,29(6):53-56.
[2]范柳,施艳秋.卵巢储备功能下降中西医治疗研究进展[J].中国医药导报,2015,12(33):65-68.
[3]于传鑫,李诵弦.实用妇科内分泌学[M].2版.上海:复旦大学出版社,2004.
[4]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[5]陈文俊,李慧芳,周蓓蓓,等.卵巢储备功能低下评估及治疗方法研究进展[J].实用医学杂志,2016,32(1):19-22.
[6]韩晓霞,左瑞菊,马肖.窦卵泡计数、抗苗勒管激素与性激素检测评价卵巢储备的研究[J].中国医药导报,2017,14(18):117-120.
[7]向悦,施艳秋.从文献分析探讨卵巢储备功能下降的病机[J].西部中医药,2016,29(6):53-56.