病毒性肝炎肝硬化患者血脂水平与病性类证候要素的关系
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摘要
目的:研究不同血脂水平病毒性肝炎肝硬化患者的病性辨证结果的分布情况,探讨血脂水平与病性类证候要素的关系。方法:采用流行病学横断面调查方法,收集病毒性肝炎肝硬化患者的相关临床信息,运用SPSS20.0统计软件分析不同血脂水平病性辨证结果的构成比有无差异。结果:不同TC水平,是否判定为气滞、气虚、水停证型,构成比的差异有统计学意义(P<0.01);不同TG水平,是否判定为血瘀、阴虚、水停证型,构成比的差异有统计学意义(P<0.05,P<0.01);不同HDL水平,是否判定为血瘀、阳虚、水停证型,构成比的差异有统计学意义(P<0.05,P<0.01);不同LDL水平,是否判定为阴虚、气滞、阳虚、水停证型,构成比的差异有统计学意义(P<0.01)。结论:不同血脂水平,患者病性辨证结果的构成比有差异,说明病毒性肝炎肝硬化患者的血脂水平可能与肝藏血主疏泄生理功能失调有关。
Objective:To study the distributional differences of syndrome differentiation of disease nature in patients with viral hepatitis cirrhosis in different lipid levels,and to explore the relationship between the lipid levels and class syndrome factors.Methods:Cross-sectional epidemiological field survey was adopted to collect the main clinical data of the viral hepatitis cirrhosis patients.The differences of constituent ratio of syndrome differentiation of disease nature were compared by SPSS 20.0.Results:If all patients were grouped according to different TC levels,constituent ratios of qi stagnation and non-qi stagnation,qi deficiency and non-qi deficiency,water retention pattern and non-water retention pattern were different.The above conclusions had statistical significance(P<0.01).If all patients were grouped according to different TG levels,constituent ratios of blood stasis and non-blood stasis,yin deficiency and non-yin deficiency,water retention pattern and non-water retention pattern were different.The above conclusions had statistical significance(P<0.05,P<0.01).If all patients were grouped according to different HDL levels,constituent ratios of blood stasis and non-blood stasis,yang deficiency and non-yang deficiency,water retention pattern and non-water retention pattern were different.The above conclusions had statistical significance(P<0.05,P<0.01).If all patients were grouped according to different HDL levels,constituent ratios of yin deficiency and non-yin deficiency,qi stagnation and nonqi stagnation,yang deficiency and non-yang deficiency,water retention pattern and non-water retention pattern were different.The above conclusions had statistical significance(P<0.01).Conclusion:Nature of disease causes syndrome differentiation.The constituent ratios of syndrome differentiations are different in different lipid levels,which means blood lipids of patients with viral hepatitis cirrhosis may be related to the dysfunctions of liver storing blood and governing free flow of qi.
Objective:To study the distributional differences of syndrome differentiation of disease nature in patients with viral hepatitis cirrhosis in different lipid levels,and to explore the relationship between the lipid levels and class syndrome factors.Methods:Cross-sectional epidemiological field survey was adopted to collect the main clinical data of the viral hepatitis cirrhosis patients.The differences of constituent ratio of syndrome differentiation of disease nature were compared by SPSS 20.0.Results:If all patients were grouped according to different TC levels,constituent ratios of qi stagnation and non-qi stagnation,qi deficiency and non-qi deficiency,water retention pattern and non-water retention pattern were different.The above conclusions had statistical significance(P<0.01).If all patients were grouped according to different TG levels,constituent ratios of blood stasis and non-blood stasis,yin deficiency and non-yin deficiency,water retention pattern and non-water retention pattern were different.The above conclusions had statistical significance(P<0.05,P<0.01).If all patients were grouped according to different HDL levels,constituent ratios of blood stasis and non-blood stasis,yang deficiency and non-yang deficiency,water retention pattern and non-water retention pattern were different.The above conclusions had statistical significance(P<0.05,P<0.01).If all patients were grouped according to different HDL levels,constituent ratios of yin deficiency and non-yin deficiency,qi stagnation and nonqi stagnation,yang deficiency and non-yang deficiency,water retention pattern and non-water retention pattern were different.The above conclusions had statistical significance(P<0.01).Conclusion:Nature of disease causes syndrome differentiation.The constituent ratios of syndrome differentiations are different in different lipid levels,which means blood lipids of patients with viral hepatitis cirrhosis may be related to the dysfunctions of liver storing blood and governing free flow of qi.
引文
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[8]谭春雨,刘平.肝硬化“虚损生积”病机理论溯源及其临床意义.上海中医药大学学报,2010,24(4):25-27
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[12]李素领.李普治疗乙肝肝硬化腹水验案举隅.四川中医,2009,27(4):3
[13]李瀚旻.肝硬化“虚积互生”的病机探讨.中华中医药学刊,2015,33(12):2825-2827
[14]刘平.乙型肝炎、肝硬化、肝癌的中医发病学及其基本病机演变规律的探讨.中西医结合肝病杂志,1998(8):6-10
[15]王天芳,吴秀艳,赵燕,等.临床常见疾病中医证候要素分布特点的文献研究.中华中医药杂志,2007,22(9):594-597
[16]薛晓琳,王天芳,李昕,等.从“肝藏血主疏泄”功能失调角度探讨肝硬化的发生机理.世界中医药,2013,8(2):121-123
[2]韩英,韩者艺.高脂血症与肝病.中国实用内科杂志,2011,31(9):668-670
[3]赵丽红,王天芳,薛晓琳,等.801例肝炎肝硬化患者常见病性类证候要素.北京中医药大学学报,2015,38(4):260-265
[4]中华医学会传染病与寄生虫病学分会,中华医学会肝病学分会.病毒性肝炎防治方案.传染病信息,2000,13(4):141-150
[5]贾继东,李兰娟.慢性乙型肝炎防治指南(2010年版).临床肝胆病杂志,2011,27(1):113-128
[6]王为,王方岩,陈维亚,等.病理生理学.杭州:浙江大学出版社,2015:160-162
[7]武嫣斐,孙健民.慢性乙型肝炎致早期肝硬化辨证治疗体会.中医药研究,2002,18(2):18
[8]谭春雨,刘平.肝硬化“虚损生积”病机理论溯源及其临床意义.上海中医药大学学报,2010,24(4):25-27
[9]李德新.中医基础理论.北京:人民卫生出版社,2010:76-77,268
[10]陈辉先.泻肝活血汤治疗血脂异常33例临床观察.湖南中医杂志,2008,24(5):9-11
[11]慕永平,王磊.刘平教授治疗肝硬化经验浅析.上海中医药大学学报,2004,18(3):29-32
[12]李素领.李普治疗乙肝肝硬化腹水验案举隅.四川中医,2009,27(4):3
[13]李瀚旻.肝硬化“虚积互生”的病机探讨.中华中医药学刊,2015,33(12):2825-2827
[14]刘平.乙型肝炎、肝硬化、肝癌的中医发病学及其基本病机演变规律的探讨.中西医结合肝病杂志,1998(8):6-10
[15]王天芳,吴秀艳,赵燕,等.临床常见疾病中医证候要素分布特点的文献研究.中华中医药杂志,2007,22(9):594-597
[16]薛晓琳,王天芳,李昕,等.从“肝藏血主疏泄”功能失调角度探讨肝硬化的发生机理.世界中医药,2013,8(2):121-123