多发性骨髓瘤伴椎管内浸润3例
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摘要
<正>多发性骨髓瘤(multiple myeloma,MM)是一种浆细胞的恶性克隆性增殖性疾病。随着社会老年化进程,其发病率逐渐上升,疾病初发或疾病过程中时有髓外浸润的表现,合并有髓外浸润的MM患者治疗困难,预后差,尤其是合并有椎管内浸润的患者,若不及时发现和治疗,将严重影响患者的生活质量,甚至可以危及生命。本文报道3例MM伴椎管内浸润病例。
引文
[1]Zhong YP,Chen SL,Li X,et al.Multiple myeloma complicated with spinal infiltration[J].Journal of Experimental Hematology,2010,18(2):466-468.[钟玉萍,陈世伦,李新,等.多发性骨髓瘤伴椎管浸润10例临床分析[J].中国实验血液学杂志,2010,18(2):466-468.]
[2]Zhang J,Zhong Y.Clinical analysis of 36 multiple myeloma patients with extramedullary plasmacytoma invasion of the spinal canal[J].Hematol Oncol,2015,33(2):75-79.
[3]Flouzat-Lachaniette CH,Allain J,Roudot-Thoraval F,et al Treatment of spinal epidural compression due to hematological malignancies:a single institution,s retrospective experience[J].Eur Spine J,2013,22(3):548-555.
[4]BladéJ,Fernández de Larrea C,Rosiol L,et al.Soft-tissue plasmacytomas in multiple myeloma:incidence,mechanisms of extramedullary spread,and treatment approach[J]J Clin Oncol,2011,29(28):3805-3812.
[5]Hussein MA,Vrionis FD,Allison R,et al.The role of vertebral augmentation in multiple myeloma:International Myeloma Working Group Consensus Statement[J].Leukemia,2008,22(8):1479-1484.
[6]Zhang XH,Ran QJ,Xu B,et al.A clinical analysis of 6cases of mutiple myeloma complicated with spinal cord compression syndrome[J].Journal of Internal Intensive Medicine,2016,22(4):290-293.[张新华,冉启杰,徐彪,等.多发性骨髓瘤合并脊髓压迫症6例临床分析[J].内科急危重症杂志,2016,22(4):290-293.]
[7]Rades D,Veninga T,Stalpers LJ,et al.Outcome after radiotherapy alone for metastatic spinal cord compression in patients with oligometastases[J].J Clin Oncol,2007,25(1):50-56.
[8]Akram H,Allibone J.Spinal surgery for palliation in malignant spinal cord compression[J].Clin Oncol(R Coll Radiol),2010,22(9):792-800.
[9]Shi L,Xiao B,Zuo XG,et al.The effect of Spinal canal decompression on quality of life in multiple myeloma with spinal cord compression patients[J].Shandong Medical Journal,2013,53(48):43-44.[石磊,肖斌,左杏果,等.椎管减压术对多发性骨髓瘤合并脊髓压迫症患者生活质量的影响[J].山东医药,2013,53(48):43-44.]
[10]Highsmith KN,Chen SE,Horowitz S.Carfilzomib and pomalidomide:recent advances in the treatment of multiple myeloma[J].Pharmacotherapy,2014,34(9):927-940.
[11]Spicka I.Advances in multiple myeloma therapy during two past decades[J].Comput Struct Biotechnol J,2014,10(16):38-40.
[2]Zhang J,Zhong Y.Clinical analysis of 36 multiple myeloma patients with extramedullary plasmacytoma invasion of the spinal canal[J].Hematol Oncol,2015,33(2):75-79.
[3]Flouzat-Lachaniette CH,Allain J,Roudot-Thoraval F,et al Treatment of spinal epidural compression due to hematological malignancies:a single institution,s retrospective experience[J].Eur Spine J,2013,22(3):548-555.
[4]BladéJ,Fernández de Larrea C,Rosiol L,et al.Soft-tissue plasmacytomas in multiple myeloma:incidence,mechanisms of extramedullary spread,and treatment approach[J]J Clin Oncol,2011,29(28):3805-3812.
[5]Hussein MA,Vrionis FD,Allison R,et al.The role of vertebral augmentation in multiple myeloma:International Myeloma Working Group Consensus Statement[J].Leukemia,2008,22(8):1479-1484.
[6]Zhang XH,Ran QJ,Xu B,et al.A clinical analysis of 6cases of mutiple myeloma complicated with spinal cord compression syndrome[J].Journal of Internal Intensive Medicine,2016,22(4):290-293.[张新华,冉启杰,徐彪,等.多发性骨髓瘤合并脊髓压迫症6例临床分析[J].内科急危重症杂志,2016,22(4):290-293.]
[7]Rades D,Veninga T,Stalpers LJ,et al.Outcome after radiotherapy alone for metastatic spinal cord compression in patients with oligometastases[J].J Clin Oncol,2007,25(1):50-56.
[8]Akram H,Allibone J.Spinal surgery for palliation in malignant spinal cord compression[J].Clin Oncol(R Coll Radiol),2010,22(9):792-800.
[9]Shi L,Xiao B,Zuo XG,et al.The effect of Spinal canal decompression on quality of life in multiple myeloma with spinal cord compression patients[J].Shandong Medical Journal,2013,53(48):43-44.[石磊,肖斌,左杏果,等.椎管减压术对多发性骨髓瘤合并脊髓压迫症患者生活质量的影响[J].山东医药,2013,53(48):43-44.]
[10]Highsmith KN,Chen SE,Horowitz S.Carfilzomib and pomalidomide:recent advances in the treatment of multiple myeloma[J].Pharmacotherapy,2014,34(9):927-940.
[11]Spicka I.Advances in multiple myeloma therapy during two past decades[J].Comput Struct Biotechnol J,2014,10(16):38-40.