干扰素凝胶联合冷冻治疗女性外阴尖锐湿疣的疗效研究
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摘要
目的评价干扰素凝胶联合冷冻治疗女性外阴尖锐湿疣的临床疗效及复发率。方法将200例患者随机分为对照组与试验组,每组100例。对照组采用单纯冷冻治疗疗法,而试验组则采用冷冻联合人α-2b干扰素凝胶疗法;观察2组间治疗有效率、患处面积、炎性因子水平、复发率之间的差异。结果试验组总有效率可达85%,而对照组总有效率为64%,试验组治疗效果优于对照组(P=0.001);经治疗后,试验组比对照组更能减轻患处受损面积(P=0.000);与对照组相比,试验组IL-6、IL-18、hs-CRP水平的改善效果更好(P=0.000);另外,治疗6个月后,试验组复发率显著低于对照组(P=0.001)。结论冷冻联合干扰素α-2b疗法能显著提高女性外阴尖锐湿疣治疗疗效、降低治疗后复发率,治疗效果明确,值得推广。
Objective To evaluate the clinical efficacy and recurrence rate of interferon gel combined with cryotherapy in treatment of female genital condyloma acuminatum. Methods Two hundred patients with condyloma acuminatum of female vulva were randomly divided into control group(n=100) and experimental group(n=100).The patients in control group were treated by simple cryotherapy,however,the patients in experimental group were treated by cryotherapy combined with alpha-2 b interferon gel.The effective rate,the area of the affected area,the levels of inflammatory factors and the recurrence rate were observed and compared between the two groups.Results The total effective rate in experimental group was 85%,which was superior to that(64%) in control group(P<0.01). as compared with control group,the experimental group could significantly reduce the damaged area(P<0.01).In addition,the levels of IL-6,IL-18 and hs-CRP were significantly were decreased in experimental group.And the recurrence rate in experimental group was significantly lower than that in control group after 6-month treatment(P<0.01).Conclusion Cryotherapy combined with interferon alpha-2 b can significantly improve the therapeutic effects on female condyloma acuminatum and can reduce the recurrence rate,therefor, which is worthy of clinical promotion.
Objective To evaluate the clinical efficacy and recurrence rate of interferon gel combined with cryotherapy in treatment of female genital condyloma acuminatum. Methods Two hundred patients with condyloma acuminatum of female vulva were randomly divided into control group(n=100) and experimental group(n=100).The patients in control group were treated by simple cryotherapy,however,the patients in experimental group were treated by cryotherapy combined with alpha-2 b interferon gel.The effective rate,the area of the affected area,the levels of inflammatory factors and the recurrence rate were observed and compared between the two groups.Results The total effective rate in experimental group was 85%,which was superior to that(64%) in control group(P<0.01). as compared with control group,the experimental group could significantly reduce the damaged area(P<0.01).In addition,the levels of IL-6,IL-18 and hs-CRP were significantly were decreased in experimental group.And the recurrence rate in experimental group was significantly lower than that in control group after 6-month treatment(P<0.01).Conclusion Cryotherapy combined with interferon alpha-2 b can significantly improve the therapeutic effects on female condyloma acuminatum and can reduce the recurrence rate,therefor, which is worthy of clinical promotion.
引文
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8 潘选长,林仲法,兰倩华.CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣疗效观察.中外医疗,2017,36:39-41.
9 杨伯艳.女性尖锐湿疣患者人乳头瘤病毒基因分型与复发的相关性研究.世界最新医学信息文摘,2017,102:119-120.
10 Chang DY,Chen RJ,Lee SC,et al.Prevalence of single and multiple infection with human papillomaviruses in various grades of cervical neoplasis.J Med Micro boil,2015,46:54-60.
11 陈湘玲.CO2激光联合咪喹莫特乳膏和干扰素α-2b治疗妇科尖锐湿疣的疗效及不良反应.实用临床医药杂志,2016,20:129-130.
12 Mistrangelo M,Dal Conte I,Volpatto S,et al.Current treatments for anal condylomata acuminata.Minerva chirurgica,2018,73:100-106.
13 American Diabetes Association.Diagnosis and classification of diabetes mellitus.Diabetes Care,2011,33:62-69.
14 任延波,张彧.多媒体技术结合高端模拟系统教学方法在急诊医学临床教学中的应用.中国急救医学,2012,32:562-563.
15 马军格,李辉霞,牛润婷.冷冻联合派特灵治疗女性外阴尖锐湿疣疗效观察.健康前沿,2018,11:283.
16 邬清芝,汪春英.液氮冷冻联合香菇菌多糖片治疗女性尖锐湿疣28例.中国药业,2011,20:67.
17 陈金芳.中药坐浴联合重组人干扰素α-2b凝胶维持使用对女性尖锐湿疣复发的影响.影像研究与医学应用,2017,1:189-191.
18 于子红,刘全喜,刘雪飞.微波联合干扰素α-2b治疗女性生殖器尖锐湿疣临床效果研究.社区医学杂志,2016,4:66-67.
2 Harshila P,Monika W,Puneet S,et al.Systematic review of the incidence and prevalence of genital warts.BMC Infect Dis,2013,13:39.
3 Sudenga SL,Ingles DJ,Pierce Campbell CM,et al.Genital human papillomavirus infection progression to external genital lesions:The HIM study.Eur Urol,2016,69:166-173.
4 Anic GM,Lee J,Stockwell H,et al.Incidence and human papillomavirus(HPV) type distribution of genital warts in a multinational cohort of men:The HPV in men study.J Infect Dis,2011,204:1886-1892.
5 Arima Y,Winer RL,Feng QH,et al.Development of genital warts after incident detection of human papillomavirus infection inyoung men.J Infect Dis,2010,202:1181-1184.
6 中华医学会皮肤性病学分会性病学组,中国医师协会皮肤科分会性病亚专业委员会.尖锐湿疣诊疗指南(2014).中华皮肤科杂志,2014,47:598-599.
7 肖德奇,李培,丁徐安.咪喹莫特乳膏与二氧化碳激光治疗尖锐湿疣的临床疗效比较.中国性科学,2014,23:64-65.
8 潘选长,林仲法,兰倩华.CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣疗效观察.中外医疗,2017,36:39-41.
9 杨伯艳.女性尖锐湿疣患者人乳头瘤病毒基因分型与复发的相关性研究.世界最新医学信息文摘,2017,102:119-120.
10 Chang DY,Chen RJ,Lee SC,et al.Prevalence of single and multiple infection with human papillomaviruses in various grades of cervical neoplasis.J Med Micro boil,2015,46:54-60.
11 陈湘玲.CO2激光联合咪喹莫特乳膏和干扰素α-2b治疗妇科尖锐湿疣的疗效及不良反应.实用临床医药杂志,2016,20:129-130.
12 Mistrangelo M,Dal Conte I,Volpatto S,et al.Current treatments for anal condylomata acuminata.Minerva chirurgica,2018,73:100-106.
13 American Diabetes Association.Diagnosis and classification of diabetes mellitus.Diabetes Care,2011,33:62-69.
14 任延波,张彧.多媒体技术结合高端模拟系统教学方法在急诊医学临床教学中的应用.中国急救医学,2012,32:562-563.
15 马军格,李辉霞,牛润婷.冷冻联合派特灵治疗女性外阴尖锐湿疣疗效观察.健康前沿,2018,11:283.
16 邬清芝,汪春英.液氮冷冻联合香菇菌多糖片治疗女性尖锐湿疣28例.中国药业,2011,20:67.
17 陈金芳.中药坐浴联合重组人干扰素α-2b凝胶维持使用对女性尖锐湿疣复发的影响.影像研究与医学应用,2017,1:189-191.
18 于子红,刘全喜,刘雪飞.微波联合干扰素α-2b治疗女性生殖器尖锐湿疣临床效果研究.社区医学杂志,2016,4:66-67.