细胞间黏附分子1及血清可溶性细胞间黏附分子1与肿瘤关系的研究进展
摘要
目的细胞间黏附分子1(ICAM-1)及血清可溶性细胞间黏附分子1(sICAM-1)是一类黏附分子,其主要功能是介导细胞间接触、黏附及淋巴细胞的穿内皮。ICAM-1作为共刺激分子和信号转导分子来激活细胞内的信号通路,导致淋巴细胞的活化,细胞因子的分泌和促炎性瀑布的激发。ICAM-1能够介导细胞间连接,恶性肿瘤组织通过表达ICAM-1使得肿瘤细胞转移和侵袭能力增强,而血清sICAM-1不但是肿瘤免疫逃逸的重要手段,也与肿瘤的侵袭和转移密切相关。近年来研究发现,ICAM-1/sICAM-1在肿瘤中表达量增加与肿瘤的治疗效果及预后密切相关。
引文
[1]王会中,王贻霞,王关嵩.细胞间黏附分子-1对肺癌进程和预后的影响[J].中华肺部疾病杂志,2015,8(1):86-88.
[2]ISKANDARSYSH,TEJO B A,TAMBUNAN U S,et al.Structural modifications of ICAM-1cyclic peptides to improve the activity to inhibit heterotypic adhesion of T cells[J].Chem Biol Drug Des,2008,72(1):27-33.
[3]JUNG W C,JANG Y J,KIM J H,et al.Expression of intercellular adhesion molecule-1and e-selectin in gastric cancer and their clinical significance[J].J Gastric Cancer,2012,12(3):140-148.
[4]CHEN C,Diao D,Guo L,et al.All-trans-retinoic acid modulates ICAM-1 N-glycan composition by influencing GnT-Ⅲlevels and inhibits cell adhesion and trans-endothelial migration[J].PLoS One,2012,7(12):e52975.
[5]牟时斌,高峰.胃癌中细胞间黏附分子-1的表达及其临床意义[J].临床荟萃,2015,2(30):206-209.
[6]ZIMMERMAN T,BLANCO FJ.Inhibitors targeting the LFA-1/ICAM-1 cell-adhesion interaction:design and mechanism of action[J].Curr Pharm Des,2008,14(22):2128-2139.
[7]KEATING S M,CLARK K R,STEFANICH L D,et al.Competition between intercellular adhesion molecule-1and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1[J].Protein Sci,2006,15(2):290-303.
[8]FU C,Tong C,WANG M,et al.Determining beta2-integrin and intercellular adhesion molecule 1binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by agas-driven micropipette assay[J].J Biol Chem,2011,286(40):34777-34787.
[9]葛谭.原发性肝癌患者手术前后血清sICAM-1、VEGF水平检测的临床意义[J].放射免疫学杂志,2005,18(1):73-74.
[10]TOIYAMA Y,MIKI C,INOUE Y et al.Soluble intercellular adhesion molecule-1as a prognostic marker for stageⅡcolorectal cancer patients[J].Ann Surg Oncol,2008,15(6):1617-1624.
[11]LAWSON C,WOLF S.ICAM-1signaling in endothelial cells[J].Pharmacol Rep,2009,61(1):22-32.
[12]FINZEL A H,REININGER A J,BODE P A,et al.ICAM-1supports adhesion of human small-cell lung carcinoma to endothelial cellsy[J].Clin Exp Metastasis,2004,21(3):185-189.
[13]PORTER J C,HALL A.Epithelial ICAM-1and ICAM-2regulate the egression of human T cells across the bronchial epithelium[J].Faseb J,2009,23(2):492-502.
[14]CHITTASUPHO C,XIE S X,BAOUM A,et al.ICAM-1targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cells[J].Eur J Pharm Sci,2009,37(2):141-150.
[15]GUNEY N,SOYDINC HO,DERIN D,et al.Serum levels of intercellular adhesion molecule ICAM-1and E-selectin in advanced stage non-small cell lung cancer[J].Med Oncol,2008,25(2):194-200.
[16]潘建平,瞿幼存,祝文娴,等.肺癌患者血清可溶性细胞间黏附分子-1水平及其意义[J].实用肿瘤杂志,2000,15(5):301-303.
[17]束美宝,王连聪,魏启春,等.肺癌细胞间黏附分子-1的表达及其意义[J].实用肿瘤杂志,2002,17(5):314-316.
[18]范素青,应晓,王浩.sICAM-1在肺癌表达的初步研究[J].中国卫生检验杂志,2011,21(6):1553-1556.
[19]周人杰,陈伟,闵家新,等.ICAM-1和PCNA在肺癌中的表达及其意义[J].重庆医学,2007,36(1):1834-1835.
[20]MARKOCK A,MACZKA K.Concentration of serum soluble forms of ICAM-1(sVCAM-1)and VCAM-1(sVCAM-1)in patients with chronic pancreatitis and in patients with pancreatic carcinoma[J].Wiad Lek,2003,56(3/4):147-151.
[21]钱剑,陈瑶,齐乐龙.组织内及外周血细胞间黏附分子-1与血管细胞间黏附分子-1在胰腺癌患者中的变化研究[J].中国生化药物杂志,2015,6(35):77-80.
[22]段升军.胰腺癌患者瘤体及外周血ICAM-1和VCAM-1的表达研究[D].济南:山东大学,2006.
[23]朱伟,黄文,武新颖,等.sICAM-1、sVCAM-1和P选择素检测对胰腺癌诊断和预后评估的价值[J].解放军医学杂志,2009,34(1):10-12.
[24]KANG X,WANG F,XIE J D,et al.Clinical evaluation of serum concentrations of intercellular adhesion molecule-1in patients with colorectal cancer[J].World J Gastroenterol,2005,11(27):4250-4253.
[25]TESAROVA P,KVASNICKA J,UMLAFOVA A,et al.Soluble adhesion molecules in female patients with breast carcinoma[J].Cas Lek Cesk,2003,142(5):292-299.
[26]TOUVIER M,FEZEU L,AHLUWALIA N,et al.Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1are associated with colorectal cancer risk[J].World J Gastroenterol,2012,18(22):2805-2812.
[27]MANTUR M,SNARSKA J,KOPER O,et al.Serum sICAM,sVCAM and sE-selectin levels in colorectal cancer patients[J].Folia Histochem Cytobiol,2009,47(4):621-625.
[28]张英兰,范凝芳,石红梅,等.大肠癌患者sICAM-1和TSGF检测的临床意义[J].长治医学院学报,2011,25(5):378-379.
[29]陈春生,张宏,丛进春,等.结肠癌患者血中sICAM-1和sVCAM-1变化的临床意义[J].世界华人消化杂志,2003,11(1):115-116.
[30]魏志江,贾圆圆,张维.ICAM-1、CD82的表达差异对结直肠癌肝转移影响的临床研究[J].中国现代药物应用,2015,9(8):31-33.
[31]陈仲武,陈济铭,陈一平,等.肝细胞肝癌患者TACE前后血清sICAM-1的表达及其意义[J].中国介入影响与治疗学,2009,6(1):226-229.
[32]熊枝繁,刘菊,曹仕琼,等.肝细胞肝癌组织ICAM-1及血清sICAM-1水平变化的临床意义[J].实用医学杂志,2006,22(1):274-276.
[33]ZHOU S L,CHENY L,PENG X Z,et al.Expression of serum sICAM-1in patients with primary hepatocellular carcinoma and its relationship with liver fibrosis[J].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi,2012,28(2):181-182.
[34]赵雪娥,赵斌,王丽梅,等.Notch1和细胞间黏附分子-1在原发性肝癌细胞中的作用[J].现代中西医结合杂志,2013,9,22(27):2976-2979.
[35]刘鸣,韦德英,汤春生.细胞间黏附分子1在卵巢肿瘤的表达及其对癌细胞黏附侵袭能力的影响[J].实用妇产科杂志,2005,21(5):279-281.
[36]王旭平,郭丽娜,杨海英.卵巢癌患者围手术期血清sICAM-1和P-Selectin检测的临床意义[J].河北医药,2010,32(1):1693-1694.
[37]方小桂,童方方,何克钢.卵巢癌患者围术期血清可溶性细胞间黏附分子-1和P选择素检测的临床价值[J].实用临床医药志,2015,19(7):101-103.
[38]王忠民,姜继勇.血清sICAM-l/sVCAM-l水平与上皮性卵巢癌关系的研究[J].中国老年病学杂志,2006,26(9):1189-1191.
[39]BEWICK M,CONLON M,LEE H,et al.Evaluation of sICAM-1,sVCAM-1,and sE-Selectin levels in patients with metastatic breast cancer receiving high-dose chemotherapy[J].Stem Cells Dev,2004,13(3):281-294.
[40]何军,杨树才,张雅芳.ICAM-1/LFA-1在乳腺癌淋巴转移中表达的研究[J].医学研究杂志,2008,37(1):34-37.
[41]何俊玲.ICAM-1在乳腺癌良恶性肿瘤组织中的表达研究[D].杭州:浙江大学医学院,2009.
[42]HANAHAN D,WEINBERG R A.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-674.
[2]ISKANDARSYSH,TEJO B A,TAMBUNAN U S,et al.Structural modifications of ICAM-1cyclic peptides to improve the activity to inhibit heterotypic adhesion of T cells[J].Chem Biol Drug Des,2008,72(1):27-33.
[3]JUNG W C,JANG Y J,KIM J H,et al.Expression of intercellular adhesion molecule-1and e-selectin in gastric cancer and their clinical significance[J].J Gastric Cancer,2012,12(3):140-148.
[4]CHEN C,Diao D,Guo L,et al.All-trans-retinoic acid modulates ICAM-1 N-glycan composition by influencing GnT-Ⅲlevels and inhibits cell adhesion and trans-endothelial migration[J].PLoS One,2012,7(12):e52975.
[5]牟时斌,高峰.胃癌中细胞间黏附分子-1的表达及其临床意义[J].临床荟萃,2015,2(30):206-209.
[6]ZIMMERMAN T,BLANCO FJ.Inhibitors targeting the LFA-1/ICAM-1 cell-adhesion interaction:design and mechanism of action[J].Curr Pharm Des,2008,14(22):2128-2139.
[7]KEATING S M,CLARK K R,STEFANICH L D,et al.Competition between intercellular adhesion molecule-1and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1[J].Protein Sci,2006,15(2):290-303.
[8]FU C,Tong C,WANG M,et al.Determining beta2-integrin and intercellular adhesion molecule 1binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by agas-driven micropipette assay[J].J Biol Chem,2011,286(40):34777-34787.
[9]葛谭.原发性肝癌患者手术前后血清sICAM-1、VEGF水平检测的临床意义[J].放射免疫学杂志,2005,18(1):73-74.
[10]TOIYAMA Y,MIKI C,INOUE Y et al.Soluble intercellular adhesion molecule-1as a prognostic marker for stageⅡcolorectal cancer patients[J].Ann Surg Oncol,2008,15(6):1617-1624.
[11]LAWSON C,WOLF S.ICAM-1signaling in endothelial cells[J].Pharmacol Rep,2009,61(1):22-32.
[12]FINZEL A H,REININGER A J,BODE P A,et al.ICAM-1supports adhesion of human small-cell lung carcinoma to endothelial cellsy[J].Clin Exp Metastasis,2004,21(3):185-189.
[13]PORTER J C,HALL A.Epithelial ICAM-1and ICAM-2regulate the egression of human T cells across the bronchial epithelium[J].Faseb J,2009,23(2):492-502.
[14]CHITTASUPHO C,XIE S X,BAOUM A,et al.ICAM-1targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cells[J].Eur J Pharm Sci,2009,37(2):141-150.
[15]GUNEY N,SOYDINC HO,DERIN D,et al.Serum levels of intercellular adhesion molecule ICAM-1and E-selectin in advanced stage non-small cell lung cancer[J].Med Oncol,2008,25(2):194-200.
[16]潘建平,瞿幼存,祝文娴,等.肺癌患者血清可溶性细胞间黏附分子-1水平及其意义[J].实用肿瘤杂志,2000,15(5):301-303.
[17]束美宝,王连聪,魏启春,等.肺癌细胞间黏附分子-1的表达及其意义[J].实用肿瘤杂志,2002,17(5):314-316.
[18]范素青,应晓,王浩.sICAM-1在肺癌表达的初步研究[J].中国卫生检验杂志,2011,21(6):1553-1556.
[19]周人杰,陈伟,闵家新,等.ICAM-1和PCNA在肺癌中的表达及其意义[J].重庆医学,2007,36(1):1834-1835.
[20]MARKOCK A,MACZKA K.Concentration of serum soluble forms of ICAM-1(sVCAM-1)and VCAM-1(sVCAM-1)in patients with chronic pancreatitis and in patients with pancreatic carcinoma[J].Wiad Lek,2003,56(3/4):147-151.
[21]钱剑,陈瑶,齐乐龙.组织内及外周血细胞间黏附分子-1与血管细胞间黏附分子-1在胰腺癌患者中的变化研究[J].中国生化药物杂志,2015,6(35):77-80.
[22]段升军.胰腺癌患者瘤体及外周血ICAM-1和VCAM-1的表达研究[D].济南:山东大学,2006.
[23]朱伟,黄文,武新颖,等.sICAM-1、sVCAM-1和P选择素检测对胰腺癌诊断和预后评估的价值[J].解放军医学杂志,2009,34(1):10-12.
[24]KANG X,WANG F,XIE J D,et al.Clinical evaluation of serum concentrations of intercellular adhesion molecule-1in patients with colorectal cancer[J].World J Gastroenterol,2005,11(27):4250-4253.
[25]TESAROVA P,KVASNICKA J,UMLAFOVA A,et al.Soluble adhesion molecules in female patients with breast carcinoma[J].Cas Lek Cesk,2003,142(5):292-299.
[26]TOUVIER M,FEZEU L,AHLUWALIA N,et al.Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1are associated with colorectal cancer risk[J].World J Gastroenterol,2012,18(22):2805-2812.
[27]MANTUR M,SNARSKA J,KOPER O,et al.Serum sICAM,sVCAM and sE-selectin levels in colorectal cancer patients[J].Folia Histochem Cytobiol,2009,47(4):621-625.
[28]张英兰,范凝芳,石红梅,等.大肠癌患者sICAM-1和TSGF检测的临床意义[J].长治医学院学报,2011,25(5):378-379.
[29]陈春生,张宏,丛进春,等.结肠癌患者血中sICAM-1和sVCAM-1变化的临床意义[J].世界华人消化杂志,2003,11(1):115-116.
[30]魏志江,贾圆圆,张维.ICAM-1、CD82的表达差异对结直肠癌肝转移影响的临床研究[J].中国现代药物应用,2015,9(8):31-33.
[31]陈仲武,陈济铭,陈一平,等.肝细胞肝癌患者TACE前后血清sICAM-1的表达及其意义[J].中国介入影响与治疗学,2009,6(1):226-229.
[32]熊枝繁,刘菊,曹仕琼,等.肝细胞肝癌组织ICAM-1及血清sICAM-1水平变化的临床意义[J].实用医学杂志,2006,22(1):274-276.
[33]ZHOU S L,CHENY L,PENG X Z,et al.Expression of serum sICAM-1in patients with primary hepatocellular carcinoma and its relationship with liver fibrosis[J].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi,2012,28(2):181-182.
[34]赵雪娥,赵斌,王丽梅,等.Notch1和细胞间黏附分子-1在原发性肝癌细胞中的作用[J].现代中西医结合杂志,2013,9,22(27):2976-2979.
[35]刘鸣,韦德英,汤春生.细胞间黏附分子1在卵巢肿瘤的表达及其对癌细胞黏附侵袭能力的影响[J].实用妇产科杂志,2005,21(5):279-281.
[36]王旭平,郭丽娜,杨海英.卵巢癌患者围手术期血清sICAM-1和P-Selectin检测的临床意义[J].河北医药,2010,32(1):1693-1694.
[37]方小桂,童方方,何克钢.卵巢癌患者围术期血清可溶性细胞间黏附分子-1和P选择素检测的临床价值[J].实用临床医药志,2015,19(7):101-103.
[38]王忠民,姜继勇.血清sICAM-l/sVCAM-l水平与上皮性卵巢癌关系的研究[J].中国老年病学杂志,2006,26(9):1189-1191.
[39]BEWICK M,CONLON M,LEE H,et al.Evaluation of sICAM-1,sVCAM-1,and sE-Selectin levels in patients with metastatic breast cancer receiving high-dose chemotherapy[J].Stem Cells Dev,2004,13(3):281-294.
[40]何军,杨树才,张雅芳.ICAM-1/LFA-1在乳腺癌淋巴转移中表达的研究[J].医学研究杂志,2008,37(1):34-37.
[41]何俊玲.ICAM-1在乳腺癌良恶性肿瘤组织中的表达研究[D].杭州:浙江大学医学院,2009.
[42]HANAHAN D,WEINBERG R A.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-674.