健脾祛瘀排浊汤联合三氧疗法治疗血脂异常临床效果观察
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摘要
目的:探讨健脾祛瘀排浊汤联合三氧疗法治疗血脂异常的临床疗效。方法:2017年6月—2018年6月将符合纳入标准的152例患者随机分为治疗组和对照组两组,每组患者76例,治疗组予健脾祛瘀排浊汤联合三氧疗法治疗,对照组予辛伐他汀片治疗,治疗2周后观察两组临床治疗效果。结果:治疗组患者的总有效率、血脂水平和中医证候总改善率均高于对照组(P<0.05)。在用药期间,治疗组不良反应的发生率低于对照组(P<0.05)。结论:健脾祛瘀排浊汤联合三氧疗法治疗痰浊阻遏型血脂异常疗效明显,能有效改善患者血脂的水平,且不良反应少,安全性较高,可进一步临床推广应用。
Objective:To explore the clinical efficacy of Jianpi Quyu Paizhuo Decoction combined with triple oxygen therapy in the treatment of dyslipidemia. Methods:From June 2017 to June 2018,152 patients were randomly divided into two groups,the treatment group and the control group,with 76 cases in each group. The treatment group was given Jianpi Quyu Paizhuo Decoction combined with triple oxygen therapy,while the control group was treated with Simvastatin Tablets,and after 2 weeks of treatment,the clinical effects of the two groups were observed. Results:The total effective rate,blood lipid level and total improvement rate of TCM syndromes in the treatment group were higher than those in the control group(P<0.05). During treatment,the incidence of adverse reactions in the treatment group was lower than that in the control group(P<0.05). Conclusion:Jianpi Quyu Paizhuo Decoction combined with triple oxygen therapy has significant effect on the treating dyslipidemia of phlegm turbidity repression type. It can effectively improve the level of blood lipids with fewer adverse reactions and higher safety. It can be further applied in clinical practice.
Objective:To explore the clinical efficacy of Jianpi Quyu Paizhuo Decoction combined with triple oxygen therapy in the treatment of dyslipidemia. Methods:From June 2017 to June 2018,152 patients were randomly divided into two groups,the treatment group and the control group,with 76 cases in each group. The treatment group was given Jianpi Quyu Paizhuo Decoction combined with triple oxygen therapy,while the control group was treated with Simvastatin Tablets,and after 2 weeks of treatment,the clinical effects of the two groups were observed. Results:The total effective rate,blood lipid level and total improvement rate of TCM syndromes in the treatment group were higher than those in the control group(P<0.05). During treatment,the incidence of adverse reactions in the treatment group was lower than that in the control group(P<0.05). Conclusion:Jianpi Quyu Paizhuo Decoction combined with triple oxygen therapy has significant effect on the treating dyslipidemia of phlegm turbidity repression type. It can effectively improve the level of blood lipids with fewer adverse reactions and higher safety. It can be further applied in clinical practice.
引文
[1]韦诗友,郑莉.他汀类药物在老年患者临床应用安全性的评价进展[J].华西医学,2017(2):290-297.
[2]中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-413.
[3]国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:139-143.
[4]冷方南.中医证候辨治规范[M].北京:人民卫生出版社,1993:57-58.
[5]姜岑,舒发明,黄英,等.从伏邪学说探讨脂肪肝的治疗思路[J].中华中医药杂志,2016(3):914-917.
[6]周子严,薛晓琳,李鑫,等.从痰瘀论治血脂异常的文献研究[J].中华中医药杂志,2018(4):467.
[7]周狮驮,匡调元.匡调元辨质论治临诊经验实录(一)——总论[J].中华中医药学刊,2010(2):247-250.
[8]白艳辉,张春来,冯玉斌,等.冠心病二级预防中降脂药物服用及血脂水平控制危险因素调查研究[J].中国全科医学,2018(14):256.
[9]郭改玲,朱爱松.基于“脾主运化、统血”理论探讨脾对动脉粥样硬化的影响[J].中华中医药杂志,2016(3):802-804.
[10]尹湘君,何庆勇,王阶,等.近40年血脂异常中医证候动态演变规律的研究[J].中华中医药杂志,2018(5):746.
[11]李峥,杨关林.杨关林教授治疗胸痹心痛痰瘀互结证从脾胃论治临床经验总结[J].中华中医药学刊,2016,34(3):569-571.
[12]刘光颖,张哲,杨关林.杨关林教授从脾胃论治胸痹心痛临床经验总[J].辽宁中医药大学学报,2013,15(9):64-66.
[13]聂松柳,徐先祥,夏伦祝.党参总皂苷对实验性高脂血症大鼠血脂和NO含量的影响[J].安徽中医药大学学报,2002,21(4):40-42.
[14]刘玮玮,冯磊.植物甾醇降血脂作用研究进展[J].浙江医学,2008,30(2):202-204.
[15]刘龙涛,吴敏,王红霞,等.降脂红曲微粉治疗血脂异常合并颈动脉粥样硬化的随机对照研究[J].中国中西医结合杂志,2011,31(9):1196-1200.
[16]王卫霞,陈可冀.血脂康胶囊治疗高脂血症有效性和安全性的系统评价[J].中国循证医学杂志,2006,6(5):352-360.
[17]唐琪晶,陈素红,潘丹丹,等.白术精提物对代谢性高脂血症大鼠的药效及机制研究[J].中国中药杂志,2015,40(9):1803-1807.
[18]毛跟年,张诗韵,付超,等.茯苓皮总三萜的降血脂活性研究[J].陕西科技大学学报,2015,33(3):130-133.
[19]冯孔龙,朱晓艾,陈彤,等.川陈皮素对高脂膳食诱导大鼠的降脂减肥及预防脂肪肝形成作用[J].食品科学,2018,39(1):213-219.
[20]华冰.甘草总黄酮的降血脂作用及机制的研究[D].银川:宁夏医科大学,2015(4):1-27.
[21]龚道锋,王甫成,纪东汉,等.中药半夏化学成分及其药理、毒理活性研究进展[J].长江大学学报(自科版),2015,12(18):77-70.
[22]王自旺,韩艳,林传旭.高脂血症的中医治疗现状与展望[J].西部中医药,2011,24(8):103-104.
[23]邵淑丽.柴胡、姜黄对小白鼠实验性高血脂症的预防作用[J].中医药学报,2002,30(4):59-60.
[24]杨奕樱,陈继婷,张曼,等.姜黄素对食饵性高脂血症小鼠血脂及C反应蛋白的影响[J].时珍国医国药,2012,23(9):2204-2205.
[25]孙锡铭,蔡海江,宋素云,等.丹参的新药理作用[J].中草药,1991,22(1):20-21.
[26]罗千占.中药对高脂血症的作用机制[J].中国医药导报,2010,7(1):85-86.
[27]贺立.瓜蒌、薤白降脂作用的析因研究[J].湖南中医药导报,2002,8(4):205-206.
[28]王本祥.现代中药药理与临床[M].天津:天津科技翻译出版公司,2004:823-1205.
[29]王玲,吴军林,吴清平,等.山楂降血脂作用和机理研究进展[J].食品科学,2015,36(15):245-248.
[30]李林子,吕圭源,陈素红,等.三七叶总皂苷对高脂血症大鼠血脂、肝功能及脂质过氧化的影响[J].中国现代应用药学,2014,31(6):662-666.
[31]李瑛.高脂血症的中医研究进展[J].光明中医,2009,24(7):1412-1414.
[32]于保法.三氧医学及临床应用[M].北京:中国协和医科大学出版社,2003:42,46-49.
[33]Madej P,Plewka A,Madej JA,et al. Ozonotherapy in an induced septic shockIEffect of ozonotherapy on rat organsin evaluation of free radical reactions and selected enzymatic systems[J].Inflammation,2007,30(1-2):52-58.
[34]VerrazzoG,CoPPolaL,LuongoC,et al. HyPerbaricoxygen Oxygen-ozone therapy and rheologic Parameters of blood in Patiets with Peri Pheralocclusive arterial disease[J]. Undersea&Hyperbaic Medical Society Inc,1995,22(1):17-22.
[35]Hernandez F,Menendez S,Wong R. Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patientstreated with endovenous ozone therapy[J].Free Radic Biol Med,1995,19(1):115-119.
[36]Bocci V Zanardi I,Travagli V. Oxygen ozone as a medical gas mixture Acritical evaluation of the various methods clarifies positive and negative aspects[J].Gas Research,2001(6):1-9.
[37]Wentworth P,Nieva J,Takeuchi C,et al. Evidence for ozone forma-tion in human atherosclerotic arteries[J].Science,2003,302(7):1053-1056.
[38]Larini A,Bocci V. Effects of ozone on isolated peripheral blood mononuclear cells[J].Toxicol In Vitro,2005,19:55-61.
[2]中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-413.
[3]国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:139-143.
[4]冷方南.中医证候辨治规范[M].北京:人民卫生出版社,1993:57-58.
[5]姜岑,舒发明,黄英,等.从伏邪学说探讨脂肪肝的治疗思路[J].中华中医药杂志,2016(3):914-917.
[6]周子严,薛晓琳,李鑫,等.从痰瘀论治血脂异常的文献研究[J].中华中医药杂志,2018(4):467.
[7]周狮驮,匡调元.匡调元辨质论治临诊经验实录(一)——总论[J].中华中医药学刊,2010(2):247-250.
[8]白艳辉,张春来,冯玉斌,等.冠心病二级预防中降脂药物服用及血脂水平控制危险因素调查研究[J].中国全科医学,2018(14):256.
[9]郭改玲,朱爱松.基于“脾主运化、统血”理论探讨脾对动脉粥样硬化的影响[J].中华中医药杂志,2016(3):802-804.
[10]尹湘君,何庆勇,王阶,等.近40年血脂异常中医证候动态演变规律的研究[J].中华中医药杂志,2018(5):746.
[11]李峥,杨关林.杨关林教授治疗胸痹心痛痰瘀互结证从脾胃论治临床经验总结[J].中华中医药学刊,2016,34(3):569-571.
[12]刘光颖,张哲,杨关林.杨关林教授从脾胃论治胸痹心痛临床经验总[J].辽宁中医药大学学报,2013,15(9):64-66.
[13]聂松柳,徐先祥,夏伦祝.党参总皂苷对实验性高脂血症大鼠血脂和NO含量的影响[J].安徽中医药大学学报,2002,21(4):40-42.
[14]刘玮玮,冯磊.植物甾醇降血脂作用研究进展[J].浙江医学,2008,30(2):202-204.
[15]刘龙涛,吴敏,王红霞,等.降脂红曲微粉治疗血脂异常合并颈动脉粥样硬化的随机对照研究[J].中国中西医结合杂志,2011,31(9):1196-1200.
[16]王卫霞,陈可冀.血脂康胶囊治疗高脂血症有效性和安全性的系统评价[J].中国循证医学杂志,2006,6(5):352-360.
[17]唐琪晶,陈素红,潘丹丹,等.白术精提物对代谢性高脂血症大鼠的药效及机制研究[J].中国中药杂志,2015,40(9):1803-1807.
[18]毛跟年,张诗韵,付超,等.茯苓皮总三萜的降血脂活性研究[J].陕西科技大学学报,2015,33(3):130-133.
[19]冯孔龙,朱晓艾,陈彤,等.川陈皮素对高脂膳食诱导大鼠的降脂减肥及预防脂肪肝形成作用[J].食品科学,2018,39(1):213-219.
[20]华冰.甘草总黄酮的降血脂作用及机制的研究[D].银川:宁夏医科大学,2015(4):1-27.
[21]龚道锋,王甫成,纪东汉,等.中药半夏化学成分及其药理、毒理活性研究进展[J].长江大学学报(自科版),2015,12(18):77-70.
[22]王自旺,韩艳,林传旭.高脂血症的中医治疗现状与展望[J].西部中医药,2011,24(8):103-104.
[23]邵淑丽.柴胡、姜黄对小白鼠实验性高血脂症的预防作用[J].中医药学报,2002,30(4):59-60.
[24]杨奕樱,陈继婷,张曼,等.姜黄素对食饵性高脂血症小鼠血脂及C反应蛋白的影响[J].时珍国医国药,2012,23(9):2204-2205.
[25]孙锡铭,蔡海江,宋素云,等.丹参的新药理作用[J].中草药,1991,22(1):20-21.
[26]罗千占.中药对高脂血症的作用机制[J].中国医药导报,2010,7(1):85-86.
[27]贺立.瓜蒌、薤白降脂作用的析因研究[J].湖南中医药导报,2002,8(4):205-206.
[28]王本祥.现代中药药理与临床[M].天津:天津科技翻译出版公司,2004:823-1205.
[29]王玲,吴军林,吴清平,等.山楂降血脂作用和机理研究进展[J].食品科学,2015,36(15):245-248.
[30]李林子,吕圭源,陈素红,等.三七叶总皂苷对高脂血症大鼠血脂、肝功能及脂质过氧化的影响[J].中国现代应用药学,2014,31(6):662-666.
[31]李瑛.高脂血症的中医研究进展[J].光明中医,2009,24(7):1412-1414.
[32]于保法.三氧医学及临床应用[M].北京:中国协和医科大学出版社,2003:42,46-49.
[33]Madej P,Plewka A,Madej JA,et al. Ozonotherapy in an induced septic shockIEffect of ozonotherapy on rat organsin evaluation of free radical reactions and selected enzymatic systems[J].Inflammation,2007,30(1-2):52-58.
[34]VerrazzoG,CoPPolaL,LuongoC,et al. HyPerbaricoxygen Oxygen-ozone therapy and rheologic Parameters of blood in Patiets with Peri Pheralocclusive arterial disease[J]. Undersea&Hyperbaic Medical Society Inc,1995,22(1):17-22.
[35]Hernandez F,Menendez S,Wong R. Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patientstreated with endovenous ozone therapy[J].Free Radic Biol Med,1995,19(1):115-119.
[36]Bocci V Zanardi I,Travagli V. Oxygen ozone as a medical gas mixture Acritical evaluation of the various methods clarifies positive and negative aspects[J].Gas Research,2001(6):1-9.
[37]Wentworth P,Nieva J,Takeuchi C,et al. Evidence for ozone forma-tion in human atherosclerotic arteries[J].Science,2003,302(7):1053-1056.
[38]Larini A,Bocci V. Effects of ozone on isolated peripheral blood mononuclear cells[J].Toxicol In Vitro,2005,19:55-61.