双色黄疸仪检测新生儿黄疸的研究
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摘要
目的本研究旨在评估双色黄疸仪是否可能作为早期筛查黄疸的性能。方法母亲在住院期间学会使用双色黄疸仪鉴别有无黄疸,婴儿则采用经皮测黄疸(TcB),必要时查血清胆红素(TSB)。在不同阈值下,确定双色黄疸仪作为重要筛选黄疸的可靠性。采用回归分析对双色黄疸仪的性能进行评价。结果大约有1991对母婴进入研究,其中279对选择深黄色。选择深黄色的平均TcB显著高于浅黄色(p<0.001)。随着TcB阈值增加,双色黄疸仪显示出更高的灵敏度和阴性预测值。仅有1例需要治疗的新生儿用双色黄疸仪没有检测出来。结论双色黄疸仪可以作为一种简单易行的工具用来早期识别出需要密切观察或治疗的新生儿黄疸。
A total of 1991 mother-infants dyads entered the study.The two-color jaundice meter shows high sensitivity and negative predictive value.Only one case of neonatal jaundice is undetectable.This method can be used for early identification of neonatal jaundice.
A total of 1991 mother-infants dyads entered the study.The two-color jaundice meter shows high sensitivity and negative predictive value.Only one case of neonatal jaundice is undetectable.This method can be used for early identification of neonatal jaundice.
引文
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[2]Bhutta Z A,Darmstadt G L,Hasan B S,Haws R A.Community-based interventions for improving perinatal and neonatal health outcomes in developing countries:a review of the evidence[J]. Pediatrics,2005,115(2Suppl):519-617.
[3]Olusanya B O,Osibanjo F B,Mabogunje C A,Slusher T M,Olowe S A.The burden and management of neonatal jaundice in Nigeria:a scoping review of the literature[J].Niger J Clin Pract,2016,19:1-17.
[4]Ezeaka C V,Ugwu R O,Mukhtar Y M,Ekure E N,Olusanya B O.Pattern and predictors of maternal careseeking practices for severe neonatal jaundice in Nigeria:a multi-centre survey[J].BMC Health Serv Res,2014,14:192
[5]Olusanya B O,Ogunlesi T A,Slusher T M.Why is kernicterus still a major cause of death and disability in lowincome and middle-income countries?[J].Arch Dis Child,2014,99:1117-1121.
[6]Luu M N,Le L T,Tran B H,Duong T K,Nguyen H T,Le V T,et al.Home-use icterometry in neonatal hyperbilirubinaemia:Cluster-randomised controlled trial in Vietnam[J].J Paediatr Child Health,2014,50:674-679.