头部亚低温不同治疗时间对新生儿中重度缺氧缺血性脑病的疗效观察
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摘要
目的研究头部亚低温不同治疗时间对新生儿中重度缺氧缺血性脑病的疗效。方法选取我院2015年3月~2017年3月收治的新生儿中重度缺氧缺血性脑病患儿96例,均采用头部亚低温治疗,根据不同的治疗时间,分为48 h组、72 h组、96 h组,各32例。所有患儿均在出生后6 h内开始治疗。患儿出生后28 d采用NBNA评分进行评定,并对比三组患儿不良反应。结果三组患儿中,72 h组患儿28 d的NBNA评分(39.8±3.5)分,高于其它两组;差异有统计学意义(P<0.05)。三组患儿中,96 h组患儿不良反应发生率为62.50%,高于其它两组;差异有统计学意义(P<0.05)。结论对新生儿中重度缺氧缺血性脑病,采取头部亚低温治疗,持续治疗72 h效果最理想,且不良反应少。
Objective To study the therapeutic effect of head mild hypothermia for moderate and severe hypoxic ischemic encephalopathy(HIE) in neonates.Methods 96 neonates with moderate and severe hypoxicischemic encephalopathy were selected from March 2015 to March 2017.All of them were treated with mild hypothermia.According to different treatment time,they were divided into 48 h group,72 h group and 96 h group,32 cases in each group.All the children were treated within 6 hours after birth.28 days after birth,the children were assessed with NBNA score,and the adverse reactions were compared among the three groups.Results The NBNA score of 28 days in 72 h group(P<0.05).The score of 39.8±3.5 was higher than that of the other two groups(P<0.05).The incidence of adverse reactions in 96 h group was 62.50,higher than that in the other two groups(P<0.05).Conclusion For moderate and severe hypoxic ischemic encephalopathy of newborn,head mild hypothermia therapy is the most effective treatment for 72 hours,and the adverse reaction is less.
Objective To study the therapeutic effect of head mild hypothermia for moderate and severe hypoxic ischemic encephalopathy(HIE) in neonates.Methods 96 neonates with moderate and severe hypoxicischemic encephalopathy were selected from March 2015 to March 2017.All of them were treated with mild hypothermia.According to different treatment time,they were divided into 48 h group,72 h group and 96 h group,32 cases in each group.All the children were treated within 6 hours after birth.28 days after birth,the children were assessed with NBNA score,and the adverse reactions were compared among the three groups.Results The NBNA score of 28 days in 72 h group(P<0.05).The score of 39.8±3.5 was higher than that of the other two groups(P<0.05).The incidence of adverse reactions in 96 h group was 62.50,higher than that in the other two groups(P<0.05).Conclusion For moderate and severe hypoxic ischemic encephalopathy of newborn,head mild hypothermia therapy is the most effective treatment for 72 hours,and the adverse reaction is less.
引文
[1]黄默荷,苏菲菲,杨守峰.单唾液酸四己糖神经节苷脂联合头部亚低温治疗新生儿缺氧缺血性脑病效果观察[J].中国乡村医药,2017(21).
[2]陈茜娜,徐棉,林振浪,等.单唾液酸四己糖神经节苷脂联合头部亚低温治疗对新生儿缺氧缺血性脑病的疗效观察[J].浙江医学,2017,39(1):40-42.
[3]轩妍.头部亚低温治疗新生儿缺氧缺血性脑病不同持续时间对神经系统保护的影响[J].中国实用神经疾病杂志,2016,19(22):65-66.
[4]侯秋英,滕懿群,朱雯,等.头部亚低温联合鼠神经生长因子治疗新生儿中重度缺氧缺血性脑病疗效观察[J].中国基层医药,2017,24(3):338-341.
[5]李广红,李春.头部亚低温不同治疗时间对新生儿中重度缺氧缺血性脑病的疗效观察[J].中外女性健康研究,2016(13):3-4.
[2]陈茜娜,徐棉,林振浪,等.单唾液酸四己糖神经节苷脂联合头部亚低温治疗对新生儿缺氧缺血性脑病的疗效观察[J].浙江医学,2017,39(1):40-42.
[3]轩妍.头部亚低温治疗新生儿缺氧缺血性脑病不同持续时间对神经系统保护的影响[J].中国实用神经疾病杂志,2016,19(22):65-66.
[4]侯秋英,滕懿群,朱雯,等.头部亚低温联合鼠神经生长因子治疗新生儿中重度缺氧缺血性脑病疗效观察[J].中国基层医药,2017,24(3):338-341.
[5]李广红,李春.头部亚低温不同治疗时间对新生儿中重度缺氧缺血性脑病的疗效观察[J].中外女性健康研究,2016(13):3-4.