还原型谷胱甘肽联合神经营养药物治疗新生儿缺氧缺血性脑病的临床观察
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摘要
目的研究还原型谷胱甘肽联合神经营养药物治疗新生儿缺氧缺血性脑病的临床效果。方法选择2014-04～2016-04该院收治的110例新生儿缺氧缺血性脑病患儿作为研究对象,随机将其分为观察组和对照组,各55例。对照组采用神经节苷脂联合胞二磷胆碱治疗,观察组在对照组治疗的基础上加用还原型谷胱甘肽治疗,比较两组治疗前后神经行为测定(neonatal behavioral neurological assessment,NBNA)评分、脑白质区域低密度病灶CT值、临床疗效及不良反应。结果两组治疗后新生儿NBNA评分、脑白质区域低密度病灶CT值均高于治疗前,且观察组高于对照组,差异有统计学意义(P <0. 05);观察组临床疗效优于对照组,差异有统计学意义(P <0. 05);两组不良反应发生率比较差异无统计学意义(P> 0. 05)。结论对新生儿缺氧缺血性脑病采用还原型谷胱甘肽联合神经营养药物治疗效果较好,可有效改善新生儿神经行为。
Objective To study the clinical efficacy of reduced glutathione combined with neurotrophic drugs in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods 110 neonates with hypoxic ischemic encephalopathy treated in our hospital from April 2014 to April 2016 were randomly divided into the observation group andthe control group,with 55 cases in each group. The control group received ganglioside combined with citicoline treatment,and the observation group received the same treatment as the control group plus glutathione. The clinical efficacy,adverse reactions,neonatal behavioral neurological assessment(NBNA) scores,low density CT values of the white matter of brain lesions were compared between the two groups before and after treatment. Results After treatment,NBNA scores and low density CT values of the white matter of brain lesions were higher than those before treatment in both of the two groups,with significantly higher NBNA scores and CT values in the observation group than those in the control group(P < 0. 05). The clinical curative effect of the observation group was better than that of the control group(P < 0. 05). There was no significantly different in adverse reation rate between the two groups. Conclusion Reduced glutathione combined with neurotrophic drugs is effective in the treatment of neonatal hypoxic-ischemic encephalopathy. It can effectively improve the neonatal neurological behavior.
Objective To study the clinical efficacy of reduced glutathione combined with neurotrophic drugs in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods 110 neonates with hypoxic ischemic encephalopathy treated in our hospital from April 2014 to April 2016 were randomly divided into the observation group andthe control group,with 55 cases in each group. The control group received ganglioside combined with citicoline treatment,and the observation group received the same treatment as the control group plus glutathione. The clinical efficacy,adverse reactions,neonatal behavioral neurological assessment(NBNA) scores,low density CT values of the white matter of brain lesions were compared between the two groups before and after treatment. Results After treatment,NBNA scores and low density CT values of the white matter of brain lesions were higher than those before treatment in both of the two groups,with significantly higher NBNA scores and CT values in the observation group than those in the control group(P < 0. 05). The clinical curative effect of the observation group was better than that of the control group(P < 0. 05). There was no significantly different in adverse reation rate between the two groups. Conclusion Reduced glutathione combined with neurotrophic drugs is effective in the treatment of neonatal hypoxic-ischemic encephalopathy. It can effectively improve the neonatal neurological behavior.
引文
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6 林春雨,梁锦俊.脑苷肌肽注射液联合胞二磷胆碱对新生儿缺氧缺血性脑病的影响[J].西北药学杂志,2015,30(4):410-412.
7 姜琴,张文凯.脂多糖致急性肺损伤机制研究进展及还原型谷胱甘肽保护作用[J].中华临床医师杂志(电子版),2017,11(4):645-649.
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9 邓素翰,何斌.神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病的临床研究[J].中国妇幼保健,2017,32(4):749-750.
2 王玉梅,郭银谋,袁向东.神经节苷脂结合高压氧对新生儿缺氧缺血性脑病的治疗效果[J].中国妇幼保健,2017,32(7):1490-1492.
3 张秋英,马金春.还原型谷胱甘肽治疗妊娠期肝功能异常63例[J].中西医结合肝病杂志,2017,27(1):58-59.
4 堇书宇,周超,张倩,等.新生儿缺血缺氧性脑病的治疗进展[J].解剖科学进展,2017,23(5):514-517.
5 陈茜娜,徐棉,林振浪,等.单唾液酸四己糖神经节苷脂联合头部亚低温治疗对新生儿缺氧缺血性脑病的疗效观察[J].浙江医学,2017,39(1):40-42.
6 林春雨,梁锦俊.脑苷肌肽注射液联合胞二磷胆碱对新生儿缺氧缺血性脑病的影响[J].西北药学杂志,2015,30(4):410-412.
7 姜琴,张文凯.脂多糖致急性肺损伤机制研究进展及还原型谷胱甘肽保护作用[J].中华临床医师杂志(电子版),2017,11(4):645-649.
8 谢思远,王晓蓉,张立新,等.亚低温治疗新生儿缺氧缺血性脑病研究进展[J].中国医药,2017,12(6):942-946.
9 邓素翰,何斌.神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病的临床研究[J].中国妇幼保健,2017,32(4):749-750.