结肠息肉切除后复发的相关因素研究
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摘要
结肠息肉是指结肠黏膜向肠腔内侧突出生长的一种赘生物。结肠息肉尤其是腺瘤性息肉是结肠癌的癌前病变。近年来其发病率及检出率越来越高,早期发现并切除结肠息肉是预防结肠癌的关键。目前最主要的治疗方法为内镜下结肠息肉切除术,但结肠息肉切除后仍有很高的复发率。为预防其切除后的复发及减少结直肠肿瘤的发生,本文将对结肠息肉切除后复发的相关因素作一概述。
Colonic polyps are types of neoplasm that protrudes from the colon mucosa to the inside of the intestine.Colonic polyps,especially adenomatous polyps,are precancerous lesions of colon cancer. In recent years,its incidence rate and detection rate have become higher and higher. Early detection and removal of colonic polyps are the keys to prevent colon cancer. At present,the most important treatment is endoscopic colon polypectomy,but there is still a high recurrence rate after colon polypectomy. In order to prevent its recurrence after resection and reduce the incidence of colorectal tumors,this article will review the relevant factors of recurrence after colon polypectomy.
Colonic polyps are types of neoplasm that protrudes from the colon mucosa to the inside of the intestine.Colonic polyps,especially adenomatous polyps,are precancerous lesions of colon cancer. In recent years,its incidence rate and detection rate have become higher and higher. Early detection and removal of colonic polyps are the keys to prevent colon cancer. At present,the most important treatment is endoscopic colon polypectomy,but there is still a high recurrence rate after colon polypectomy. In order to prevent its recurrence after resection and reduce the incidence of colorectal tumors,this article will review the relevant factors of recurrence after colon polypectomy.
引文
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[2] CHEN W,ZHENG R,BAADE P D,et al. Cancer statistics in China,2015[J]. CA Cancer J Clin,2016,66(2):115-132. DOI:10.3322/caac. 21338.
[3]房静远,时永全,陈萦晅,等.中国结直肠癌预防共识意见(2016年,上海)[J].胃肠病学,2016,21(11):668-686.
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[6] SHI X,YANG Z,WU Q,et al. Colorectal adenoma recurrence ratesamong post-polypectomy patients in the placebo-controlled groups ofrandomized clinical trials:a meta-analysis[J]. Oncotarget,2017,8(37):62371-62381. DOI:10. 18632/oncotarget. 18181.
[7] SONNENBERG A,TURNER K O,GENTA R M. Ethnic variations inthe occurrence of colonic neoplasms[J]. United European Gastroen-terol J,2017,5(3):424-431. DOI:10. 1177/2050640616666942.
[8] CRUZ-CORREA M. The burden of CRC among US hispanics:morepolyps,less cancer[J]. Dig Dis Sci,2017,62(6):1396-1398.DOI:10. 1007/s10620-017-4531-0.
[9]张波,邸雅南,彭德银,等.结肠息肉生物学特性与年龄的相关性研究[J].国际消化病杂志,2017,37(2):125-127. DOI:10.3969/j. issn. 1673-534X. 2017. 02. 015.
[10] JEONG Y H,KIM K O,PARK C S,et al. Risk factors of advanced ade-noma in small and Diminutive colorectal polyp[J]. J Korean Med Sci,2016,31(9):1426-1430. DOI:10. 1007/s10620-017-4531-0.
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[13] FIGUEIREDO J C,CROCKETT S D,SNOVER D C,et al. Smoking-as-sociated risks of conventional adenomas and serrated polyps in the color-ectum[J]. Cancer Causes Control,2015,26(3):377-386. DOI:10.1007/s10552-014-0513-0.
[14] SHUKLA P K,CHAUDHRY K K,MIR H,et al. Chronic ethanol feed-ing promotes azoxymethane and dextran sulfate sodium-induced colonictumorigenesis potentially by enhancing mucosal inflammation[J]. BMCCancer,2016,16:189. DOI:10. 1186/s12885-016-2180-x.
[15]刘成义,党彤.内蒙古地区生活、饮食因素对结直肠息肉的影响[J].胃肠病学,2015,20(5):287-291. DOI:10. 3969/j. issn. 1008-7125.2015. 05. 007.LIU C Y,DANG T. Impact of lifestyle and dietary factors on colorectalpolyps in inner mongolia Area[J]. Chin J Gastroenterol,2015,20(5):287-291. DOI:10. 3969/j. issn. 1008-7125. 2015. 05. 007.
[16] BAILIE L,LOUGHREY M B,COLEMAN H G. Lifestyle risk factors forserrated colorectal polyps:a systematic review and Meta-analysis[J].Gastroenterology,2017,152(1):92-104. DOI:10. 1053/j. ga-stro. 2016.09. 003.
[17]郁飞,贾平,朱海杭.红肉及加工肉制品与结直肠息肉发病相关性的研究进展[J].国际消化病杂志,2017,37(3):148-150,179.
[18]刘秀妨,刘胜男,马云芳,等.胃肠道消化过程中脂质氧化的影响因素、健康危害及控制研究进展[J].食品工业科技,2017,38(21):330-335. DOI:10. 13386/j. issn1002-0306. 2017. 21. 064.LIU X F,LIU S N,MA Y F,et al. Research progress on the influen-cing factors,health hazards,and control of lipid oxidation during gas-trointestinal digestion[J]. Science and Technology of Food Industry,2017,38(21):330-335. DOI:10. 13386/j. issn1002-0306. 2017.21. 064.
[19] ZHAN T,HAHN F,HIELSCHER T,et al. Multiple behavioral factors areassociated with occurrence of large,flat colorectal polyps[J]. Int JColorectal Dis,2017,32(4):575-582. DOI:10. 1007/s00384-016-2717-0.
[20]李光春,司志雯,吴洪磊,等.大肠腺瘤性息肉经内镜切除后高复发人群的筛查[J].山东大学学报(医学版),2014,52(3):92-95,100. DOI:10. 6040/j. issn. 1671-7554. 0. 2013. 578.LI G C,SI Z W,WU H L,et al. Screening of high-risk populationafter endoscopic polypectomy of colorectal adenomatous polyps[J].Journal of Shandong University(Health Science),2014,52(3):92-95,100. DOI:10. 6040/j. issn. 1671-7554. 0. 2013. 578.
[21] LEE H S,PARK H W,LEE J S,et al. Treatment outcomes andrecurrence following standard cold forceps polypectomy for diminutivepolyps[J]. Surg Endosc,2017,31(1):159-169. DOI:10. 1007/s00464-016-4947-1.
[22] ORTIZ A M,BHARGAVI P,ZUCKERMAN M J,et al. Endoscopicmucosal resection recurrence rate for colorectal lesions[J]. SouthMed J, 2014, 107(10):615-621. DOI:10. 14423/SMJ. 0000000000000180.
[23] MARGAGNONI G,ANGELETTI S,D’AMBRA G,et al. Outcomeand risk of recurrence for endoscopic resection of colonic superficialneoplastic lesions over 2 cm in diameter[J]. Dig Liver Dis,2016,48(4):399-403. DOI:10. 1016/j. dld. 2015. 10. 006.
[24] SIAU K,ISHAQ S,CADONI S,et al. Feasibility and outcomes ofunderwater endoscopic mucosal resection for≥10 mm colorectal pol-yps[J]. Surg Endosc,2018,32(6):2656-2663. DOI:10. 1007/s00464-017-5960-8.
[25]秦文燕,曹群奋,林琪,等.宁波地区人群肠道菌群的特点及对结直肠癌与癌前病变发生和发展的影响[J].中华全科医学,2017,15(11):1962-1966. DOI:10. 16766/j. cnki. issn. 1674-4152. 2017. 11. 042.QIN W Y,CAO Q F,LIN Q,et al. Bacterial community character-ization of intestine and its influence on the occurrence and develop-ment of colorectal cancer and precancerous lesions in Ningbo popula-tion[J]. Chinese Journal of General Practice,2017,15(11):1962-1966. DOI:10. 16766/j. cnki. issn. 1674-4152. 2017. 11. 042.
[26]聂刚,张茜玲.益生菌对结直肠息肉内镜下切除后肠道菌群的影响[J].中国医学创新,2017,14(16):9-12. DOI:10. 3969/j.issn. 1674-4985. 2017. 16. 003.NIE G,ZHANG Q L. Effect of probiotic on intestinal flora in patientsafter resection of colorectal adenomas[J]. Chinese Medical Innova-tions,2017,14(16):9-12. DOI:10. 3969/j. issn. 1674-4985.2017. 16. 003.
[27]周仪琳,于成功.结肠癌、结肠息肉患者粪便及黏膜中普拉梭菌变化的定量研究[J].南京医科大学学报(自然科学版),2017,37(4):458-460.ZHOU Y L,YU C G. Quantitative study on the changes of plasmodium infeces and mucosa of patients with colon cancer and polyps[J]. Acta Uni-versitatis Medicinalis Nanjing(Natural Science),2017,37(4):458-460.
[28] NAM J H,HONG C W,KIM B C,et al. Helicobacter pylori infection isan independent risk factor for colonic adenomatous neoplasms[J].Cancer Causes Control,2017,28(2):107-115. DOI:10. 1007/s10552-016-0839-x.
[29] SELGRAD M,BORNSCHEIN J,KANDULSKI A,et al. Helicobacterpylori but not gastrin is associated with the development of colonic neo-plasms[J]. Int J Cancer,2014,135(5):1127-1131. DOI:10. 1002/ijc. 28758.
[30]徐茜,冯如,闾永健,等.血清胃泌素-17在结肠息肉患者中的表达及临床意义[J].临床误诊误治,2017,30(7):85-88. DOI:10. 3969/j. issn. 1002-3429. 2017. 07. 026.XU Q,FENG R,LYU Y J,et al. Expression and significance ofserum gastrin-17 in patients with colon polyps[J]. Clinical Misdiag-nosis&Mistherapy,2017,30(7):85-88. DOI:10. 3969/j. issn.1002-3429. 2017. 07. 026.
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