肝肾同治法联合西药治疗小儿过敏性紫癜性肾炎临床研究
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摘要
目的观察临床常用基本原则联合肝肾同治法对过敏性紫癜性肾炎患者的治疗作用。方法67例过敏性紫癜性肾炎患者随机分为治疗组(34例)和对照组(33例)。在基础治疗的基础上,观察采用肝肾同治法治疗前后患者临床症状、24h尿蛋白及尿红细胞计数变化。结果经过3个月的治疗,两组患者治疗前后临床症状均明显改善,24h尿蛋白定量及尿红细胞计数、补体C3和C4、IgM和IgE均明显降低(P<0.05或P<0.01),且治疗组疗效明显优于对照组(P<0.05)。结论肝肾同治法联合常规治疗对于湿热瘀阻型的过敏性紫癜性肾炎的临床效果明显优于单纯应用常规治疗,其临床疗效肯定。
Objective To observe the therapeutic effect of common clinical principle integrated with simultaneous treatment of liver and kidney on Henoch-Schonlein purpura nephritis(HSPN). Methods 67 cases of patients with HSPN were randomly divided into treatment group(34 cases) and control group(33 cases). On the basis of basic treatment,the changes of clinical symptoms,24 h urinary protein and urinary erythrocyte count before and after treatment of liver and kidney were observed.Results After 3 months of treatment,both groups got significant improvement. 24 h urinary protein and urine erythrocyte cell counts,complement C3 and C4,IgM and IgE were significantly decreased(P<0.05 or P<0.01),and the curative effect of treatment group was better than that of control group(P<0.05). Conclusion Simultaneous treatment of liver and kidney combined with western medicine for dampness and heat stasis type of HSPN is more effective than routine treatment.
Objective To observe the therapeutic effect of common clinical principle integrated with simultaneous treatment of liver and kidney on Henoch-Schonlein purpura nephritis(HSPN). Methods 67 cases of patients with HSPN were randomly divided into treatment group(34 cases) and control group(33 cases). On the basis of basic treatment,the changes of clinical symptoms,24 h urinary protein and urinary erythrocyte count before and after treatment of liver and kidney were observed.Results After 3 months of treatment,both groups got significant improvement. 24 h urinary protein and urine erythrocyte cell counts,complement C3 and C4,IgM and IgE were significantly decreased(P<0.05 or P<0.01),and the curative effect of treatment group was better than that of control group(P<0.05). Conclusion Simultaneous treatment of liver and kidney combined with western medicine for dampness and heat stasis type of HSPN is more effective than routine treatment.
引文
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[9]Leu KK,Wyatt RJ,Moldoveanu Z,et al.Serum levels of galactose-deficient Ig A in children with Ig A nephropathy and Henoch-Schoenleinpurpura[J].Pediatr Nephrol,2007,22(12):2067-2072.
[10]汪受传.中医儿科学[M].北京:人民卫生出版社,2008:238-241.
[11]于文静,丁樱,郭庆寅,等.丁樱教授治疗小儿过敏性紫癜经验撷菁[J].中医临床研究,2011,24(3):109-110.
[2]易著文.实用小儿肾脏病手册[M].北京:人民卫生出版社,2005:388.
[3]Davin JC,Weening JJ.Henoch-Schonlein purpura nephritis:an update[J].Eur J Pediatr,2001,160(12):689-695.
[4]Szeto CC,Choi PC,To KF,et al.Grading of acute and cronic renal lesions in Henoch-Schonlein purpura[J].Mod Pathol,2001,14(7):635-640.
[5]胡亚美,江载芳.诸福堂实用儿科学[M].第7版.北京:人民卫生出版社,2005:773-775.
[6]中华医学会儿科学分会肾脏病学组.紫癜性肾炎诊治循证指南(2016)[J].中华儿科杂志,2017,55(9):647-651.
[7]汪受传.中医儿科学[M].北京:中国中医药出版社,2002:238.
[8]Ozen S,Pistorio A,Iusan S,et al.EULAR/PRINTO/PREScriteria forHenoch-Schonlein purpura,childhood polyarteritis nodosa,childhoodWegener granulomatosis and childhood Takayasu arteritis:Ankara,2008.PartⅡ:Final classification criteria[J].Ann Rheum Dis,2010,69(5):798-806.
[9]Leu KK,Wyatt RJ,Moldoveanu Z,et al.Serum levels of galactose-deficient Ig A in children with Ig A nephropathy and Henoch-Schoenleinpurpura[J].Pediatr Nephrol,2007,22(12):2067-2072.
[10]汪受传.中医儿科学[M].北京:人民卫生出版社,2008:238-241.
[11]于文静,丁樱,郭庆寅,等.丁樱教授治疗小儿过敏性紫癜经验撷菁[J].中医临床研究,2011,24(3):109-110.